scholarly journals ABO Blood Groups and Risk of Glioma

2021 ◽  
Author(s):  
Ana Azanjac Arsic
Keyword(s):  
Blood Group ◽  
Blood Groups ◽  
Abo Blood Groups ◽  
Increased Risk ◽  
Hereditary Factors ◽  
The One ◽  
Von Willebrand ◽  
Relationship Of ◽  
The Relationship

Gliomas are one of the most common primary brain tumors and the etiology of gliomas remains unknown in most cases. The aim of this case–control study was to investigate possible association between incidence in relation to glioma and certain blood groups. This study included 100 histopathologically verified cases of glioma and 200 age and sex-matched controls without malignant diseases that were admitted to the same hospital. The results revealed that the patients with group AB were at 3.5-fold increased risk of developing glioma compared to the patients with other ABO blood groups. In this particular study, there was more male patients with glioma with the blood group AB. However, mechanisms that explain the relationship between the blood groups ABO and a cancer risk are unclear. Several hypotheses have been proposed, including the one with a modulatory role of blood group ABO antigens. In addition, the blood group ABO system regulates the level of circulating proinflammatory and adhesion molecules which play a significant role in the tumorigenesis process. Additionally, the recent discovery that includes the von Willebrand factor (vWF) as an important modulator of angiogenesis and apoptosis provides one plausible explanation as regards the role of the blood group ABO in the tumorigenesis process. To our knowledge, this is the first study that examined the relationship of blood group in patients diagnosed with glioma among the Serbian population. Moreover, for the first time our study results suggested that blood group AB increased the risk of glioma. The results of this study suggested that the blood group AB could be one of hereditary factors which had an influence on the occurrence of glioma. The further research is needed on a larger sample, to confirm these findings and the possible mechanisms by which the ABO system contributes to the pathology of glioma.

scholarly journals Elucidating the Thrombogenic Risk of Non-O Blood Groups in Children with Acute Lymphoblastic Leukemia (ALL): Is Von Willebrand Factor a Culprit ?

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 4990-4990
Author(s):  
Terry Mizrahi ◽  
Caroline Laverdière ◽  
Michele David ◽  
Jean-Marie Leclerc ◽  
Lehana Thabane ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Group ◽  
Lymphoblastic Leukemia ◽  
Blood Groups ◽  
Older Age ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Increased Risk ◽  
Von Willebrand ◽  
The Relationship

Abstract Background: Individuals with non-O blood group are shown to have increased risk of thromboembolism (TE). The exact pathogenesis of the prothrombotic effect of non-O blood group, is however not known. Because individuals with O-blood group have low levels of von Willebrand factor (vWF) compared to those with non-O blood group, vWF has been contemplated as a pathogenetic mechanism in ABO blood group-related prothrombotic risk. However, the available data regarding the role of vWF in the thrombotic risk of non-O blood group are inconclusive. Children with acute lymphoblastic leukemia (ALL) are at increased risk of TE. Several factors such as older age, leukemia phenotype and asparaginase have been shown to impact the risk of TE in children with ALL. We have recently shown that non-O blood group and circulating blasts were significant risk factors for TE in children with ALL. We have also shown that at diagnosis of ALL patients with circulating blasts have significantly higher levels of vWF compared to those without circulating blasts.  Within the context of a larger study aimed to define risk factors for symptomatic TE (sTE) in children with de novo ALL, we undertook a sub-study to evaluate the relationship of ABO blood groups and vWF level at diagnosis of ALL, and to evaluate the impact of circulating blasts on the vWF levels in children with O and non-O blood groups. We hypothesized that compared to patients with O-blood group, those with non-O blood group will have significantly higher levels of vWF and that circulating blasts will have additive effect on the vWF levels in patients with non-O blood group.  Methods : The multicenter, prospective, analytical cohort study included consenting patients (1-≤18 yrs. of age) with de novo ALL enrolled on the Dana-Farber Cancer Institute 05-001 therapeutic trial. Details of patient demography including ABO blood group, ALL diagnosis, therapy and symptomatic TE (sTE) were collected. Samples collected prior to starting ALL-therapy were analyzed centrally for prothrombotic defects (PD) including [protein C, S, antithrombin, Factor VIII:C, vWF, anticardiolipin antibodies and gene polymorphisms of methylene tetrahydrofolate reductase C677T, prothrombin G20210A, Factor V Leiden]. Age-adjusted standardized laboratory data defined PD. Regression analyses evaluated relationship between risk factors and sTE. Thrombosis-free survival was estimated using Kaplan-Meier method.  Results : Of 131 enrolled patients [mean age (range) 6.4 (1-17) yrs.; 70 boys], 21 (16%) developed sTE. ABO blood group information was available for 127 patients; 51 patients had blood group O and 76 non-O (57 with blood group A, 15 with B, and 4 with AB). There was no impact of PD including vWF on the risk of sTE. Older age compared to age ≤ 5 yr. [Odds Ratio (OR) 1.9, p=0.029] and non-O blood-group (OR 4.27, p=0.028) compared to O group were identified as independent predictors for development of sTE. Patients with peripheral blasts had higher odds of developing sTE (OR 7.79; p=0.059).The sTE-free survival was affected by older age (Hazard ratio (HR) 1.1, p 0.03), ALL risk type (HR 3.0, p 0.025) and blood group (O blood group vs non-O blood group, HR 0.23, p 0.03). Table 1 compares the vWF levels in patients with O and non-O blood group and those with and without circulating blasts. Overall, there was no difference in the vWF level at ALL diagnosis between patients with O vs. Non-O blood group. Patients with circulating blasts had higher levels of vWF at ALL diagnosis compared to those without circulating blasts; this comparison was statistically significant for non-O blood group. However, there was no interaction between ABO blood group and circulating blasts on vWF levels (p=0.723)  Conclusion : There was no effect of blood group type on the vWF level at diagnosis of ALL. Patients with circulating blasts had significantly higher levels of vWF at ALL diagnosis and the vWF levels were significantly higher in patients with non-O blood group and circulating blasts. Although it is likely that the relationship between blood group and vWF may be affected by effect of circulating blasts on vWF, we showed no interaction between ABO blood groups and circulating blasts on the vWF levels at diagnosis of ALL in children. Small sample size is a limitation of current study. Further studies with larger sample size are needed to elaborate the relationship between vWF, ABO blood groups, and circulating blasts. Disclosures No relevant conflicts of interest to declare.

scholarly journals Socio-legal studies and the humanities – law, interdisciplinarity and integrity

2009 ◽  
Vol 5 (3) ◽  
pp. 243-261 ◽  
Author(s):  
Melanie L. Williams
Keyword(s):  
Human Experience ◽  
Normative Values ◽  
Moral Sensibility ◽  
Hard Data ◽  
Legal Studies ◽  
Psychological Significance ◽  
The One ◽  
Relationship Of ◽  
The Relationship

This paper was delivered as a plenary lecture, designed to respond to the one-day special conference focus upon links between socio-legal studies and the humanities.1 The paper focuses in particular upon the relationship between law and the humanities. It may be argued that the role of empirically sourced socio-legal research is well accepted, given its tangible utility in terms of producing hard data which can inform and transform policy perspectives. However, scholarly speculation about the relationship between law and the humanities ranges from the indulgent to the hostile. In particular, legal scholars aligning themselves as ‘black letter’ commentators express strong opinions about such links, suggesting that scholarship purporting to establish links between the two fields is essentially spurious, bearing in mind the purposive role of law as a problem-solving mechanism. The paper sets out to challenge such assertions, indicating the natural connections between the two fields and the philosophical necessity of continued interaction, given the fact that certain aspects of human experience and nature cannot be plumbed by doctrine or empiricism or even by combinations of the two. Law must be understood to stand at the nexus of human experience, in a relationship of integrity, where the word is understood to mean both morally principled and culturally integrated. In particular, the development of human qualities, of character and moral sensibility informing normative values – and, ultimately, engagement with the world of law – is a process of subtle cultural as well as psychological significance, and may benefit from interrogation deriving from the wider fields of human discourse.

The Use of Blood Money in the Establishment of Non-Justice: Necrodomination and Resistance

2019 ◽  
pp. 160-186
Author(s):  
Cem Özatalay ◽  
Gözde Aytemur Nüfusçu ◽  
Gülistan Zeren
Keyword(s):  
Social Hierarchy ◽  
Judicial Process ◽  
The Social ◽  
Blood Money ◽  
Perpetrators And Victims ◽  
The One ◽  
The Right ◽  
Relationship Of ◽  
The Relationship

The use of blood money by powerful people during the judicial process following different kinds of homicides (workplace homicides, state homicides, gun homicides and so on) has become commonplace within the neoliberal context. Based on data obtained from five cases in Turkey, this chapter shows, on the one hand, how the use of blood money serves as an effective tool in the hands of powerful people to consolidate power relations, particularly necropower, as well as the relationship of domination, which rests upon class and identity-based inequalities. The analysis indicates that the blood money offers made by powerful people allows them to minimize potential penalties within penal courts and also to keep their privileged positions in the social hierarchy by purchasing the ‘right to kill’. On the other hand, the resistance of the oppressed and aggrieved people to the subjugation of life to the power of death is analysed with a particular focus on the role of power asymmetries between perpetrators and victims and their unequal positions in the social hierarchy. This conflictual relationship, which we qualify as an expression of necrodomination, offers novel insights into Turkey’s historically shaped system of domination.

The Relationship of the H Specificity to the ABO Blood Groups

Vox Sanguinis ◽  
1972 ◽  
Vol 22 (2) ◽  
pp. 97-106
Author(s):  
A.S. Wiener ◽  
W.W. Socha ◽  
E.B. Gordon
Keyword(s):  
Blood Groups ◽  
Abo Blood Groups ◽  
Relationship Of ◽  
The Relationship

The Relationship of theHSpecificity to the ABO Blood Groups

Vox Sanguinis ◽  
1972 ◽  
Vol 22 (2) ◽  
pp. 97-106 ◽  
Author(s):  
A. S. Wiener ◽  
W. W. Socha ◽  
E. B. Gordon
Keyword(s):  
Blood Groups ◽  
Abo Blood Groups ◽  
Relationship Of ◽  
The Relationship

scholarly journals Human ABO Blood Groups and Their Associations with Different Diseases

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Silamlak Birhanu Abegaz
Keyword(s):  
Cognitive Impairment ◽  
Cardiovascular Diseases ◽  
Blood Group ◽  
Blood Groups ◽  
Blood Type ◽  
Abo Blood Groups ◽  
E Coli ◽  
Salmonella Infections ◽  
Increased Risk ◽  
Abo Blood Type

Introduction. Human ABO blood type antigens exhibit alternative phenotypes and genetically derived glycoconjugate structures that are located on the red cell surface which play an active role in the cells’ physiology and pathology. Associations between the blood type and disease have been studied since the early 1900s when researchers determined that antibodies and antigens are inherited. However, due to lack of antigens of some blood groups, there have been some contentious issues with the association between the ABO blood group and vulnerability to certain infectious and noninfectious diseases. Objective. To review different literatures that show the association between ABO blood groups and different diseases. Method. Original, adequate, and recent articles on the same field were researched, and the researcher conducted a comprehensive review on this topic. Thus, taking out critical discussions, not only a descriptive summary of the topic but also contradictory ideas were fully retrieved and presented in a clear impression. In addition, some relevant scientific papers published in previous years were included. The article search was performed by matching the terms blood types/groups with a group of terms related to different diseases. The articles were screened and selected based on the title and abstract presented. Results. The susceptibility to various diseases, such as cancer, cardiovascular diseases, infections and hematologic disorders, cognitive disorders, circulatory diseases, metabolic diseases, and malaria, has been linked with ABO blood groups. Moreover, blood group AB individuals were found to be susceptible to an increased risk of cognitive impairment which was independent of geographic region, age, race, and gender. Disorders such as hypertension, obesity, dyslipidemia, cardiovascular disease (CVD), and diabetes were also more prevalent in individuals with cognitive impairment. Early etiological studies indicated that blood type O has a connection with increased incidence of cholera, plague, tuberculosis infections, and mumps, whereas blood type A is linked with increased incidence of smallpox and Pseudomonas aeruginosa infection; blood type B is also associated with increased incidence of gonorrhea, tuberculosis, and Streptococcus pneumoniae, E. coli, and salmonella infections; and blood type AB is associated with increased incidence of smallpox and E. coli and salmonella infections. Diabetes mellitus, hypercholesterolemia, arterial hypertension, and family history for ischemic heart disease are the most common risk factors for cardiovascular diseases and can be genetically transmitted to offspring. Higher incidence of cancers in the stomach, ovaries, salivary glands, cervix, uterus, and colon/rectum was common in blood type A people than in O type people. The link between the ABO blood type and thromboembolic diseases and bleeding risk are intervened by the glycosyltransferase activity and plasma levels and biologic activity of vWF (Von Willebrand factor), a carrier protein for coagulation factor VIII which is low in O type. Conclusion. Several studies related to the ABO phenotype show that genetically determined human ABO blood groups were correspondingly linked with an increased risk of various infectious and noninfectious diseases. However, further investigations are needed particularly on the molecular level of ABO blood groups and their association with various diseases.

scholarly journals The Role of Grit in Students’ L2 Engagement in the English as a Foreign Language Classroom

2021 ◽  
Vol 12 ◽  
Author(s):  
Juan Liu
Keyword(s):  
Foreign Language ◽  
Teaching And Learning ◽  
Rapid Development ◽  
Language Education ◽  
Academic Field ◽  
Language Classroom ◽  
The One ◽  
Relationship Of ◽  
The Relationship

Due to the rapid development of teaching and learning English as a Foreign Language (EFL), on the one hand, and the arrival of positive psychology (PP) in the process of language education, on the other hand, student engagement has been burgeoned and got a noteworthy role in the academic field. The present review attempts to investigate the relationship of grit with students’ L2 engagement, by examining both backgrounds and consequences of grit. Consequently, the effectiveness of findings for policymakers and academic experts is discussed, along with the prominence of strengthening grit in the scholastic contexts in order to cultivate character in learners and improve their prospects.

scholarly journals Correlation between ABO blood groups and various cancers in the north eastern region of India: a retrospective observational study

2018 ◽  
Vol 6 (11) ◽  
pp. 3643
Author(s):  
Chandana Kalita ◽  
Anupam Sarma ◽  
Jagannath Dev Sharma ◽  
Manoj Kalita ◽  
Manigreeva Krishnatreya ◽  
...  
Keyword(s):  
Observational Study ◽  
Head And Neck ◽  
Blood Group ◽  
Blood Groups ◽  
Retrospective Observational Study ◽  
Eastern Region ◽  
Abo Blood Groups ◽  
The North ◽  
Increased Risk ◽  
North Eastern

Background: Numerous studies have documented the association of the ABO blood groups with the occurrence of cancers. Aim was to find out an association of ABO blood groups and various cancers in the North Eastern region of India.Methods: The study was a retrospective observational study that included 1000 cases and 1000 controls. The data included the ABO blood typing of the selected cancer sites which were head and neck, esophagus, stomach, breast, cervix, and ovary. Patients who attended blood bank of regional cancer center with requisition for blood transfusion from 2014 to 2016 were included. The control group was healthy blood donors. Chi square test was used to assess the difference among the compared groups. Risk was calculated by regression analysis. P value <0.05 was considered as statistically significant at 95% confidence interval.Results: Out of 1000 cases and 1000 controls, O blood group were seen in 377 (37.7%) and 395 (39.5%) cases and control, respectively. Significant reduced odds ratio (OR) in non O blood groups for head and neck, esophagus, stomach, and breast was observed. In case of carcinoma cervix, OR for B group was 1.5 (P=0.05), and for blood group A OR=2.2 (P=0.02) was seen in carcinoma ovary.Conclusions: In the studied population, patients with O blood group are at an increased risk of developing head and neck, esophagus, stomach, and breast cancers.

ABO blood group and the risk of breast cancer: Multicenter, case-control, observational study.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1572-1572
Author(s):  
Yuksel Urun ◽  
Tulay Koru-Sengul ◽  
Kadri Altundag ◽  
Gungor Utkan ◽  
Handan Onur ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Blood Group ◽  
Blood Groups ◽  
Blood Type ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Blood Types ◽  
Abo Blood Type

1572 Background: The role of genetic factors in the development of cancer is widely accepted. ABO blood type is an inherited characteristic and previous studies have observed an association between ABO blood group and risk of certain malignancies, including pancreatic and gastric cancer. The data on the role of ABO blood group and Rh factor in breast cancer is inconclusive. Methods: All patients who had breast cancer (BC) and treated between 2000-2010 at the Departments of Medical Oncology of both Ankara and Hacettepe Universities (Ankara, Turkey) with defined ABO blood type and Rh factor were included in our retrospective reviews of tumor registry records. A group of volunteer healthy women donors of Turkish Red Crescent between 2004-2011 were identified as a control group, without any matching factors. The relationship of ABO blood types and Rh factor with various prognostic factors such as age at diagnosis, menopausal status, family history of breast cancer, and ER/PR/HER2 status were evaluated from 1740 BC patients. We compared the distributions of ABO blood types, Rh factors among 1740 patients and 204,553 healthy controls. Among BC patients, differences between each of aforementioned ABO blood groups and Rh factors with respect to various prognostic factors were explored, respectively. Results: Overall distributions of ABO blood groups as well as Rh factor were comparable between patients (44% A, 8% AB, 16% B, 32% O, 88% Rh+) and controls (41% A, 8% AB, 16% B, 35% O, 87% Rh+). However, there were statistically significant differences between patients and controls with respect to A vs. nonA (p=0.019) and marginal significance (p=0.051) for O vs. nonO. Among patients, there were statistically significant differences between A and nonA with respect to HER2 (p=0.0421), M stage (p=0.0447), T stage (p=0.0020). Only T stage (p=0.0337) were significantly different between O vs nonO. Grade (p=0.0227) and M stage (p=0.0107) were significantly different between Rh factors. Conclusions: In our study sample, ABO blood type was statistically significantly associated with breast cancer. Additional studies are necessary to determine the mechanisms by which ABO blood type may influence the risk of breast cancer.

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