scholarly journals Clinical and microbiological profile of type 2 diabetic patients with urinary tract infections

2020 ◽  
Vol 8 (3) ◽  
pp. 954
Author(s):  
Sandinti Deepa ◽  
V. Lakshmaiah ◽  
Arvind Natarajan ◽  
Prabhakar K. ◽  
Raveesha A.
Keyword(s):  
Urinary Tract ◽  
Antibiotic Sensitivity ◽  
Diabetic Patients ◽  
Gram Negative ◽  
Microbiological Profile ◽  
Sensitivity Pattern ◽  
Tract Infections ◽  
Culture Positive ◽  
Type 2 Diabetic

Background: Diabetes Mellitus is reported to increase the risk of Urinary Tract Infection (UTI) with higher probability of drug resistant organisms. Understanding the burden, microbiological profile and antibiotic sensitivity pattern is vital for effective prevention and management. To assess the microbiological profile and antibiotic sensitivity pattern of Urinary Tract infections among type 2 diabetes mellitus patients.Methods: The study was A prospective observational study done on 117 type 2 diabetic subjects aged above 18 years presenting with symptoms of UTI in a tertiary care hospital Urine was analyzed for urine routine examination, culture and antibiotic sensitivity using standard testing methods on a midstream urine sample. Descriptive analysis was carried out by mean and standard deviation for quantitative variables, frequency and proportion for categorical variables.Results: The mean age of the study population was 57 years. Females constituted 62.39% of participants. Burning micturition (52.99%) was the most common presenting symptom. The prevalence of culture positive UTI was 51.28%. Among gram-negative bacilli, Escherichia coli (20.51%), Klebsiella (6.85%) dominated the culture reports. Enterococcus (4.27%) and Staphylococcus aureus (2.6%) were the common gram-positive organisms isolated.  Meropenem was the most effective antibiotic against E. coli (87.5%) and Klebsiella (95%) Vancomycin had 100% sensitivity against Enterococci and S. aureus.Conclusions: More than half of diabetic patients presenting with symptoms of UTI had culture positive UTI, predominantly caused by gram negative organisms. There is a need for comparative studies of Diabetes and controls to explore the key differences in the pattern of UTI.

Bacterial urinary tract infection and antibiotic sensitivity pattern among type II diabetic patients – A cross-sectional study from tertiary care teaching hospital in Central Lahore

2020 ◽  
Vol 13 (4) ◽  
pp. 180-183
Author(s):  
Khadija Muneer ◽  
Kaneez Fatima ◽  
Naheed Hashmat ◽  
Sana Humayun ◽  
Qaiser Pervaiz ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urine Culture ◽  
Antibiotic Sensitivity ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Sensitivity Pattern ◽  
Type 2 Diabetic

ABSTRACT Background: Diabetes mellitus is the fifth leading cause of death in developed countries.Risk of infections is increased in diabetic patients with urinary tract being the most common site of infection. Worldwide, the prevalence of urinary tract infections (UTI) is estimated to be around 150 million persons per year . UTI exhibit a poorer prognosis in patients of type 2 diabetes mellitus (T2DM) due to a compromise in their immune status in addition to emerging antimicrobial resistance due to widespread use of antimicrobial agents. This study aims to determine frequency of common bacterial pathogens causing UTI and antibiotic sensitivity pattern among type 2 diabetic patients. This may help to guide physicians regarding appropriate management of UTI in the local population to avoid multidrug resistance. Patients and Methods: This cross sectional study involved 215 type 2 diabetic patients admitted to Medical Unit-III of Sir Ganga Ram hospital, Lahore from 01-12-2016 to 31-05-2017. Type 2 adult diabetic patients (diagnosed for at least 1 year) of age 40-80 years, either male or female , with urine pus cells ≥5/HPF performed as baseline investigation at admission were included in the study. Further urine samples were obtained (clean catch midstream urine 10cc in two wide mouth sterile screw capped plastic jars) before starting treatment. Samples were sent for microscopy and culture. Culture results and antibiotic sensitivities were recorded. Data was analyzed using SPSS for windows version 23.0. Categorical variables like gender, organisms and antibiotic sensitivitywas presented in Frequency or Percentage form. Numerical variables like age and duration of diabetes were presented as Mean± SD. Data was stratified for age, gender and duration of DM to deal with effect modifiers. Post stratification chi-square test was applied. P-value of ≤0.05 was considered significant. Results: Total of 215 patients were included. Mean age was 63.76±10.342 years of which 164 (76.3%) were females, while 51 (23.7%) were males reflecting female predominance.Most common isolated organism in urine culture was E.coli (58.6%), followed by Klebsiella (20.5%), Proteus(9.3%), Pseudomonas(8.4%) and Enterococcus (3.3%)species.Most of the patients (76.7%) were sensitive to piperacillin-tazobactam followed bycarbapenems (67%) and Gentamycin(56.7%), whereas 24.2% showed sensitivity to all antibiotics. Conclusion: Females are most commonly affected among diabetic patients. The commonest isolate was E.coli among culture positive UTIs. E.coli was most sensitive to piperacillin-tazobactam and carbapenems followed by Gentamycin while least sensitive to Ceftriaxone.The results emphasize the importance of practcse of urine culture and sensitivity testing in diabetic patients and cautious approach to use of commonly used antibiotic ceftriaxone and ciprofloxacin as empirical treatment for UTI despite the low sensitivityof the drug to the most prevailing organism.

scholarly journals Diabetes mellitus and Urinary Tract Infection: Spectrum of Uropathogens and their Antibiotic Sensitivity

2015 ◽  
Vol 1 (4) ◽  
pp. 24-28 ◽  
Author(s):  
Dhruba Acharya ◽  
B Bogati ◽  
GT Shrestha ◽  
P Gyawali
Keyword(s):  
Urinary Tract ◽  
Antibiotic Sensitivity ◽  
University Hospital ◽  
Resistance Pattern ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
E Coli ◽  
Sensitivity Pattern ◽  
Significant Difference ◽  
Tract Infections

The incidence of urinary tract infections (UTIs) is common in both diabetic and non diabetic patients. Since the microorganisms causing UTI vary in their susceptibility to antimicrobials from place to place and time to time, hence constant screening of trends and susceptibility pattern of predominant   organisms against antimicrobials is essential. The study aims to determine the spectrum of  ropathogens and antibiotic sensitivity pattern in both diabetic and non diabetic patients with clinically suspected UTI .A prospective cross sectional study was conducted during period of February 2013 to July 2013 among 90 diabetic and 90 non diabetic patients attending Dhulikhel Hospital-Kathmandu University Hospital,  Dhulikhel, Kavre (DH-KUH). All samples and isolates were investigated by standard laboratory rocedures. A total of 55 (30.5%) samples showed significant growth. No significant difference among culture positivity rate was noted between diabetic and non diabetic patients (34.5% Vs 26.7%). Escherichia coli was the most frequent organism (64.5% in diabetic and 66.7% non diabetic) followed by Klebsiella sps (22.6% in diabetic and 12.5% in non diabetic). Gentamycin and nitrofurantoin were highly sensitive to E. coli isolated in diabetic patients among the tested antimicrobials followed by  otrimoxazole, norfloxacin and ciprofloxacin. Least sensitivity rate was observed with ampicillin and cephalexin. However, no difference was noted on the sensitivity pattern of the antimicrobials among E. coli isolated between diabetic and non diabetic patients. In this study high proportion of gram negative bacilli with predominant uropathogen being E. coli was noted. Irrespective of the status of diabetes, Staphylococcus sps and Pseudomonas sps were not isolated from UTI patients in our study. The isolation of organisms and their resistance pattern was almost similar between diabetic and non diabetic patients.DOI: http://dx.doi.org/10.3126/jmmihs.v1i4.11998Journal of Manmohan Memorial Institute of Health SciencesVol. 1, Issue 4, 2015Page : 24-28

scholarly journals Pattern of antibiotic sensitivity of bacteria causing urinary tract infection in a private medical college hospital in Dhaka

2015 ◽  
Vol 14 (1) ◽  
pp. 70-74
Author(s):  
Shahin Sultana ◽  
Marium Khatun ◽  
Md Khoybar Ali ◽  
Nurunnahar Mawla ◽  
Nayareen Akhter
Keyword(s):  
Urinary Tract ◽  
Medical Science ◽  
Antibiotic Sensitivity ◽  
Urine Samples ◽  
Resistance Pattern ◽  
Medical College ◽  
Frequency Rate ◽  
Sensitivity Pattern ◽  
Tract Infections ◽  
Culture Positive

Background: Urinary tract infections (UTI), being the most common infections diagnosed in community and hospital, are to be treated scrupulously considering the type of infecting organism and its antibiotic sensitivity and resistance pattern. Aims and objectives: The aim of the present study was to observe the antibiotic sensitivity pattern of isolated uropathogens from urine samples of patients attending at Shahabuddin Medical College & Hospital, Dhaka, during the period of July 2008 to June 2009. Result: A total of 555 urine samples were studied; of which 84 (15.13%) were culture positive. Among 84 culture positive cases, 84 isolates were identified. Among the isolates, E.coli was the most predominant 61 (62.88%) followed by Enterococci 11 (11.34%), proteus 4 (4.13%) and Pseudomonas 3 (3.09%). Whereas Staphylococcus saprophyticus and Klebsiella showed frequency rate of 2 (2.06%) for each. However Gram positive cocci showed lowest frequency rate of 1 (1.03%). All of the isolates were sensitive to Netilmicin. The majority of isolates were sensitive to Imipenam (92.3%) followed by Amikacin (91.1%), Meropenam (83.3 %), Tetracycline (70%). Sensitivity & resistance rate were same (50%) in Vancomycin & Cefodoxime. Where complete (100%) resistance was shown to Ampicillin, Azithromycin and Cefoxitin. However all isolates were poorly sensitive to cotrimoxazole (35.7%), ciprofloxacin (43%) and nitrofurantoin (44.8%). Conclusion: So, routine urine culture and susceptibility before therapy should be encouraged and periodic evaluation of predominant organisms and their antimicrobial susceptibility pattern should be studied for appropriate selection of antibiotic for effective management of UTI cases.DOI: http://dx.doi.org/10.3329/bjms.v14i1.21562 Bangladesh Journal of Medical Science Vol.14(1) 2015 p.70-74

scholarly journals Asymptomatic Urinary Tract Infections and Associated Risk Factors in Pakistani Muslim Type 2 Diabetic Patients

2021 ◽  
Author(s):  
Azizul Hasan Aamir ◽  
Umar Yousuf Raja ◽  
Ali Asghar ◽  
Saeed Ahmed Mahar ◽  
Tahir Ghaffar ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Urine Culture ◽  
Diabetic Patients ◽  
Positive Urine Culture ◽  
Type 2 Diabetic Patients ◽  
Positive Urine ◽  
Tract Infections ◽  
Type 2 Diabetic

Abstract Background: One of the leading long-term complications of type 2 diabetes mellitus (T2DM) includes renal dysfunction and urinary tract infections (UTI) which are considered to be prevalent in uncontrolled diabetes. Moreover, physiological factors like age, gender, duration of diabetes, other diabetic complications like neuropathy, autonomic neuropathy and glycosuria are also considered as predisposing factors for increased prevalence of UTI in diabetes which can be symptomatic or asymptomatic. Methods: This was a cross-sectional, multi-centre study including diabetic patients from 12 clinical sites spread across major cities of Pakistan. The inclusion criteria were adult Pakistani population of age between 18 to 75 years both genders and suffering from T2DM irrespective of duration. A detailed clinical history of the past 3 months was recorded and, biochemical investigations of blood samples were conducted. Urine culture analysis performed identified the type of pathogen present and was done only for asymptomatic patients. Results: A total of 745 type 2 diabetic patients were initially screened, out of 545 patients considered for final analysis 501 (91.92%) were negative and the rest 44 (8.08%) had positive urine culture. Female gender had a significantly higher proportion of positive urine culture (77.27%, p-value<0.001). Body mass index and mean age had insignificant distribution among the two groups of positive and negative urine culture, with age 40-59 years having higher proportion (70.45%) in the positive group. Escherichia coli was detected in most of the positive samples (52.3%). All bacterial samples were found resistant to Ciprofloxacin. Conclusion: Diabetic female patients are identified to be at high risk of suffering from UTI and age more than 40 years is an important risk factor. Escherichia coli was the most common causative organism among people living in this geographical area.

scholarly journals Assessment of urinary tract infection and their resistance to antibiotics in diabetic and non-diabetic patients

2016 ◽  
Vol 9 (3) ◽  
pp. 151 ◽  
Author(s):  
Nureen Zahra ◽  
Kanwal Rehman ◽  
Rana Aqeel ◽  
Asia Parveen ◽  
Muhammad Sajid Hamid Akash
Keyword(s):  
Urinary Tract ◽  
Study Participant ◽  
Antibiotic Sensitivity ◽  
Positive Culture ◽  
Diabetic Patients ◽  
Candida Spp ◽  
Cross Sectional ◽  
E Coli ◽  
Sensitivity Pattern ◽  
Tract Infections

Diabetic patients are more susceptible to urinary tract infections (UTIs) than non-diabetic patients and due to the development of multidrug resistant uropathogenic strains, the choice of antibacterial agents is being limited. The study was undertaken to determine the influence of diabetes mellitus on the uropathogens and antibiotic sensitivity pattern among patients with UTIs. A cross-sectional study was conducted in which total of 400 patients were studied out of which 150 were diabetics and 250 were non-diabetics. Patients with negative urine culture (n = 240) were excluded from the study and 160 patients with positive culture of UTIs of which 80 were diabetics and 80 were non-diabetics, included in this study. Clinical data were obtained from individual study participant with informed written consent using pre-tested questionnaire. According to the clean-catch procedure, midstream urine samples were collected and cultured for the diagnosis and susceptibility of bacteriuria. Out of 160 uropathogenic isolates, <em>E. coli</em> was found as a leading pathogen i.e. 46.25% followed by <em>Candida spp</em>. 30.62%, <em>S. Faecalis</em> 15.62%, <em>P. aeruginosa</em> 3.13%, <em>Pneumococcus</em>. 1.25%, MSSA 1.25%, MRSA 0.63%, <em>Proteus spp</em>. 0.63% and <em>Vancomycin resistant enterococcus spp.</em> 0.63%. The results indicated that prevalence of UTIs was significantly higher in diabetic patients than in non-diabetic subjects. <em>E. coli</em> was found to be the most common isolate. It was observed that UTIs in diabetic patients was more in female diabetic patients than in male patients. Investigation of bacteriuria in diabetic patients for UTIs is an important tool for the treatment and prevention of renal complications.

scholarly journals Asymptomatic urinary tract infections and associated risk factors in Pakistani Muslim type 2 diabetic patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Azizul Hasan Aamir ◽  
Umar Yousuf Raja ◽  
Ali Asghar ◽  
Saeed Ahmed Mahar ◽  
Tahir Ghaffar ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Urine Culture ◽  
Diabetic Patients ◽  
Positive Urine Culture ◽  
Type 2 Diabetic Patients ◽  
Positive Urine ◽  
Tract Infections ◽  
Type 2 Diabetic

Abstract Background One of the leading long-term complications of type 2 diabetes mellitus (T2DM) includes renal dysfunction and urinary tract infections (UTI) which are considered to be prevalent in uncontrolled diabetes. Moreover, physiological factors like age, gender, duration of diabetes, other diabetic complications like neuropathy, autonomic neuropathy and glycosuria are also considered as predisposing factors for increased prevalence of UTI in diabetes which can be symptomatic or asymptomatic. Methods This was a cross-sectional, multi-centre study including diabetic patients from 12 clinical sites spread across major cities of Pakistan. The inclusion criteria were adult Pakistani population of age between 18 to 75 years both genders and suffering from T2DM irrespective of duration. A detailed clinical history of the past 3 months was recorded and, biochemical investigations of blood samples were conducted. Urine culture analysis performed identified the type of pathogen present and was done only for asymptomatic patients. Results A total of 745 type 2 diabetic patients were initially screened, out of 545 patients considered for final analysis 501 (91.92%) were negative and the rest 44 (8.08%) had positive urine culture. Female gender had a significantly higher proportion of positive urine culture (77.27%, p-value< 0.001). Body mass index and mean age had insignificant distribution among the two groups of positive and negative urine culture, with age 40–59 years having higher proportion (70.45%) in the positive group. Escherichia coli was detected in most of the positive samples (52.3%). All bacterial samples were found resistant to Ciprofloxacin. Conclusion Diabetic Pakistani muslim female patients are identified to be at high risk of suffering from asymptomatic UTI and age more than 40 years is an important risk factor. Escherichia coli was the most common causative organism among people living in this geographical area.

scholarly journals Spectrum of uropathogens and their antibiotic sensitivity pattern in diabetes mellitus patients at a tertiary care hospital in Odisha, India

2018 ◽  
Vol 6 (5) ◽  
pp. 1549
Author(s):  
Malati Murmu ◽  
Karun Mahesh K. P. ◽  
Rajesh Kumar Meher ◽  
Butungeshwar Pradhan ◽  
Ayaskanta Kar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
Diabetic Patients ◽  
Care Hospital ◽  
Number Of Patients ◽  
Sensitivity Pattern ◽  
Tract Infections ◽  
Culture Positive

Background: Diabetes Mellitus is the most common endocrine disorder involving almost all systems of body. Untreated or poorly treated Diabetics are susceptible to develop a series of complications responsible for raised morbidity and mortality. Diabetes Mellitus has a number of long term effects on the Genitourinary system. Urinary tract infections have long been recognised as a significant problem in patients with Diabetes Mellitus.Methods: Prospective observational study. Diabetic patients with culture positive UTI were included. Gestational diabetes, Immunocompromised patients and patients with congenital renal anatomical abnormalities were excluded.Results: Authors included 211 numbers of culture positive UTI among diabetic patients. Out of which, 65 were male and 146 were female. Maximum number of patients belong to 56-65 years age group. Escherichia coli was the predominant organism isolated. Gram positive organisms showed 100% sensitivity to Vancomycin and Linezolid. Gram negative organisms showed 100% sensitivity to Polymyxin B.Conclusions: Genitourinary tract infection is not an infrequent complication seen in diabetes patients. Most common causative organism and their antibiotic sensitivity pattern should be done in tertiary care hospital for a better antibiotic policy.

scholarly journals Antibiotic Sensitivity Pattern of Uropathogens in Diabetic Women with Asymptomatic Bacteriuria

2020 ◽  
Vol 9 (2) ◽  
pp. 40-144
Author(s):  
Nadeem Islam Sheikh ◽  
Ambreen Zahoor ◽  
Mehreen Baber ◽  
Zaidan Idrees Choudhary
Keyword(s):  
Asymptomatic Bacteriuria ◽  
Antibiotic Sensitivity ◽  
Sensitivity Testing ◽  
E Coli ◽  
Common Organism ◽  
Sensitivity Pattern ◽  
The Mean ◽  
Tract Infections ◽  
Type 2 Diabetic

Background: More than 150 million people around the globe are diagnosed with urinary tract infections every year. Failure to treat these infections with proper antibiotics can lead to serious complications. The objective of this study was to investigate antibiotic sensitivity and resistance pattern of urinary isolates in type-2 diabetic women with asymptomatic bacteriuria. Material and Methods: This cross-sectional descriptive study was conducted at the HBS General Hospital, Islamabad, from March 2017 to August 2019. A total of 270 females with the diagnosis of type-2 diabetes mellitus were included in the study. Uropathogens were isolated from urine samples and antibiotic sensitivity testing was conducted. Demographic and clinical information was recorded on a pre-designed proforma. The data was analyzed using SPSS version 20. Results: The mean age of the study sample was 50 years (SD ± 5.5) while the mean HbA1c levels were 8.98 g/dL (SD ± 0.8 g/dl). Uropathogens were found in the urine cultures of 106 (39.3%) patients. Extended Spectrum Beta-Lactamase producing (ESBL) Escherichia coli (E. coli) was the most common organism (n=46, 43.4%) which was sensitive to tazobactam, tazocin and co-trimoxazole. Nitrofurantoin was the most effective antibiotic with 62.5% isolates sensitive to it. All of the pathogens were resistant to ciprofloxacin. Conclusions: Asymptomatic bacteriuria is common in type-2 diabetic women with ESBL E. Coli being the most common organism isolated from urine cultures. There is a significant resistance to antibiotics among the uropathogens isolated from these patients.

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