scholarly journals High incidences of low serum magnesium in pre-eclampsia and eclampsia than in normal pregnancy

2021 ◽  
Author(s):  
Chaitali Mondal ◽  
Dipak Das
Keyword(s):  
Pregnant Women ◽  
Serum Magnesium ◽  
Neonatal Morbidity ◽  
Normal Pregnancy ◽  
Antenatal Clinic ◽  
Age Group ◽  
Irregular Pattern ◽  
The Mean ◽  
The Difference ◽  
Low Serum

Background: Hypertension is one of the most frequently encountered medical disorder in obstetrics practice and remain a major cause of maternal, fetal and neonatal morbidity and mortality. Objectives was to find out the high incidences of low serum magnesium in pre-eclampsia and eclampsia than in normal pregnancy.Methods: All consenting 50 cases of normal pregnant women and 50 women with pre-eclampsia attending antenatal clinic for checkup of ≥20 weeks who fulfills the inclusion and exclusion criteria were included in the study. Serum magnesium was measured by Calmagite method.Results: Out of 100 primigravidae 50 cases of pre-eclampsia women were in the age group of 18-30 years and the mean serum magnesium was 1.156±0.328. In contrast out of 50 cases of pregnant women were in the age group of 18-30 years and the mean serum magnesium was 1.907±0.321. The difference between the mean serum magnesium level in pre-eclampsia and normal pregnant women cases were statistically significant (p=0.0016). The study presented below it is clear that there are numerous factors that contribute to the causality of pre-eclampsia and from our analysis it was clear that the serum magnesium levels show an irregular pattern of fluctuations in cases suffering from pre-eclampsia and can be attributed to numerous physiological causes.Conclusions: Our study shows a significant reduction of serum magnesium levels in pre-eclampsia cases compared to normal pregnant women and occurrence of both maternal and neonatal complications with the serum magnesium levels decreased.

scholarly journals A comparative study of serum uric acid, glucose, calcium and magnesium in pre-eclampsia and normal pregnancy

2017 ◽  
Vol 7 (2) ◽  
pp. 1155-1161
Author(s):  
Arun Dhungana ◽  
Aakriti Bharati ◽  
Rosina Manandhar ◽  
Chanda Karki
Keyword(s):  
Uric Acid ◽  
Lactate Dehydrogenase ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Serum Magnesium ◽  
Normal Pregnancy ◽  
Age Group ◽  
Serum Magnesium Level ◽  
Function Impairment ◽  
Calcium And Magnesium

Background: Preeclampsia is associated with liver function abnormalities and renal function impairment. The objective of this study is to compare serum uric acid, glucose, calcium and magnesium in pre-eclampsia with normal pregnancy. Materials and Methods: Normal pregnant women and pre eclamptic women of age group 20-40 years were included. Serum magnesium, calcium, glucose, uric acid were analyzed.Results: Mean serum magnesium level in preeclampsia (1.83 ± 0.21mg/dl) was lesser in comparison to normal pregnant women (2.03 ± 0.16 mg/dl). Serum calcium level was lower (8.10 ±0.56mg/dl) than control (9.59 ±0.62 mg/dl) with p<0.001. Uric acid, glucose and lactate dehydrogenase in preeclamptic women was significantly higher than that in normal pregnant women (6.14 ± 0.85 vs.4.01 ± 0.62, p=<0.001), (94.17± 18.65 vs.86.34 ± 10.19, p=0.033) and ( 466.80 ± 97.29 vs. 194.22 ± 39.76, p=<0.001) respectively.Conclusion: There were significant changes in serum magnesium, uric acid, calcium, glucose, lactate dehydrogenase and total protein in pregnant women.

scholarly journals A Study on Prevalence of Anaemia in Pregnancy among the Women Reporting for Antenatal Care in Combined Military Hospital, Dhaka Cantonment

2018 ◽  
Vol 26 (2) ◽  
pp. 103-110
Author(s):  
Md Lutfur Rahman ◽  
Zebun Nessa ◽  
Sabrina Yesmin ◽  
Md Hafizur Rahman ◽  
Choudhury Faisal Md Manzurur Rahman
Keyword(s):  
Pregnant Women ◽  
Family Size ◽  
Income Group ◽  
Antenatal Clinic ◽  
Military Hospital ◽  
Age Group ◽  
Cultural Belief ◽  
The Difference ◽  
Anaemia In Pregnancy ◽  
In Pregnancy

Background: Anemia is regarded as a major risk factor for unfavorable outcome of pregnancy both for the mother and the fetus. Maternal anaemia is a common problem in pregnancy, particularly in developing countries.Aims: To determine the prevalence of anaemia in pregnancy and to find out the haemoglobin level of pregnant women reporting for antenatal checkup among the women reporting for antenatal care in Combined Military Hospital Dhaka.Method: This is a descriptive cross sectional study was done in the antenatal clinic at CMH Dhaka. One eighty four (184) pregnant women attending antenatal clinic at CMH Dhaka including CWC under CMH Dhaka were included for the study. The data were collected from 1st May 2001 to 31st May 2001 at the antenatal clinic, combined Military Hospital. Dhaka where pregnant women reported for antenatal check up. The data were collected by interviewing respondents in different dates & day of the week at different CWC and CMI-I Dhaka. Prior to the interview the respondents were explained clearly the objective of the study and sought their co-operation. The authority of CMH Dhaka was given prior information through issuing letter from AFMI. The respondent was assured on ethical point of view that strict secrecy would be maintained. Data were collected by the following methods: Interview Method; Laboratory Investigation for Hb estimation and Scrutinization of antenatal check up card.Results: A total of 184 pregnant women of them 70 were primi gravida and 114 were multigravida. The prevalence of anaemia as per WHO cutoff points was 56.52% (<11.0 g/dl). The mean age was 24.96 ± 4.49 years. The age groups 20-24 was the maximum. Out of 184 women 104 women was ariaemic. 15-24 age group was more anaemic (57.42%) than the 25-39 age group (55.42%) but the difference was not statistically significant, P>0.05. The prevalence of anaemia was higher in Illiterate (100%), lowest in degree and above level education group (48.48%). The maximum women (64.13%) belong to lowest income group. (Tk 2500-5000) Anaemia was the most common in the lowest income group (60.50%). The prevalence of anaemia was the highest among the family size 6 and above group (75%) and lowest in 2-3 family size group. Anaemia was more prevalent among high parity group (75%) and lowest in ‘0’ parity group (52.28%) but the difference was not statistically significant (P > 0.05). Multigravida were found more anaemic (62.28%) contrast to prirnigravida (47.14%) which was statistically significant (P<0.05). The prevalence of anaemia was less in higher birth interval group but the difference was not statistically significant (P>0.05). About the cultural belief only 33 women were found having cultural belief of avoiding food during pregnancy (17.93%) and anaemia was more prevalent among them (57.57%) but the difference was statistically significant (P>.05). In this study 14.13% women had concomitant illness during pregnancy. In this study 15 women had caesarian section of which 10 were anaemic (75%) and there was one Forcep delivery (non-anaemic).Conclusion: In this study anaemia is more prevalent among younger age group women (15-24), with less educated group low income group, large family size group, high parity and high gravida, less birth spacing and also in women having concomitant illness. Anaemia is more prevalent among women having cultural belief on avoiding food during pregnancy. The findings of this study may not reflect the overall picture of the country. It does not differ much from the results of similar studies at national level. However, this study can be a base for further studies in a broader perspective.J Dhaka Medical College, Vol. 26, No.2, October, 2017, Page 103-110

scholarly journals Serum Magnesium in Pre-eclampsia and Eclampsia

2013 ◽  
Vol 25 (1) ◽  
pp. 15-19
Author(s):  
K Nahar ◽  
H Yasmin ◽  
L Shamsuzzaman
Keyword(s):  
Pregnant Women ◽  
Serum Magnesium ◽  
Cross Sectional Study ◽  
Magnesium Level ◽  
Study Group ◽  
Serum Magnesium Level ◽  
Cross Sectional ◽  
Medical College ◽  
The Mean ◽  
The Difference

Objective: To assess the serum magnesium level of pregnant women with pre-eclampsia and eclampsia in Mymensingh Medical College & Hospital (MMCH).   Materials and Methods: This descriptive cross-sectional study was carried out in the   department of Obstetrics and Gynaecology of Mymensingh Medical College & Hospital (MMCH) and “ Prof. Muhammed Hossain Central Laboratory” of Bangladesh Agricultural University (BAU). The serum magnesium level were estimated in 60 study subjects who were pregnant   women with pre-eclampsia & eclampsia and of 60 control subjects who were the normotensive pregnant women by photometric test using xylidyl blue.   Results: The mean (±SD) serum magnesium of the control and study group were (2.29 ± 0.28 mg/dl) & (1.84 ±0.26 mg/dl) respectively. The difference in serum magnesium level between the two groups was statistically highly significant (p=<0.001). In the study group the mean (±SD) serum magnesium level of the pre-eclamptic & eclamptic groups were (1.9150 ± 0.26 mg/dl) & (1.8063 ±0.25 mg/dl) respectively and the difference between them was also statistically significant (p=<0.05).   Conclusion: From the result it could be concluded that hypomagnesaemia can be said to be one of the etiological factors in pre-eclampsia and eclampsia. Hence by estimating serum magnesium during antenatal period pre-eclampsia can be predicted and eclampsia can be   prevented early. DOI: http://dx.doi.org/10.3329/bjog.v25i1.13725 Bangladesh J Obstet Gynaecol, 2010; Vol. 25(1) : 15-19

scholarly journals Prevalence of abnormal PAP smears in antenatal women in a tertiary hospital in India

2016 ◽  
Author(s):  
Saritha Shamsunder ◽  
Akriti Gautam ◽  
Geetika Khanna ◽  
Sunita Malik
Keyword(s):  
Pregnant Women ◽  
Pap Smear ◽  
Cervical Screening ◽  
Developed Countries ◽  
Antenatal Clinic ◽  
Comfort Level ◽  
Good Time ◽  
Pap Smears ◽  
Minor Bleeding ◽  
The Mean

Background: Pregnancy provides a good time for opportunistic screening of our women who rarely attend for cervical screening. The prevalence of abnormal PAP smear in pregnant women in developed countries was 5-6%, however, no literature was available from India. Aim: To determine the prevalence of abnormal PAP smears in antenatal women presenting to our antenatal clinic. Methods: Women attending the antenatal clinic with gestation of <28 weeks were recruited after an informed consent and had a PAP smear by Ayre spatula and cytobrush or a broom type of cytobrush. The comfort level during smear taking & any problems noted were recorded using a pain score. The smears were stained using the PAP stain, were categorized as adequate or inadequate & classified as per Bethesda classification. Results: We had 150 women participating, the mean age was 24.2 yrs, the mean period of gestation was 17 weeks; 43.9% were nulliparous. Smear adequacy rate was 71.5% overall. Pain during procedure was reported in 2.9% of women, 18.3% had minor discomfort; 78.6% were comfortable. Minor bleeding during smear taking was noted in 15%; this was more with the cytobrush & broom than the Ayre spatula alone. Abnormal smears were seen in three women; two had AGC & one had LSIL. Conclusions: Opportunistic cervical screening during pregnancy is safe and well tolerated. Abnormal Cervical smears were seen in 2% of our pregnant women.

scholarly journals Comparison of Transforming Growth Factor-Beta 1 Concentration in Preeclampsia and Normal Pregnancy Women

2017 ◽  
Vol 9 (1) ◽  
pp. 49 ◽  
Author(s):  
Yusrawati Yusrawati ◽  
Dyka Aidina ◽  
Eti Yerizel
Keyword(s):  
Growth Factor ◽  
Pregnant Women ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Normal Pregnancy ◽  
Mean Difference ◽  
Blood Samples ◽  
The Mean ◽  
Growth Factor Beta ◽  
Tgf Β1

BACKGROUND: According to the theory of endothelial dysfunction, the pathogenesis of preeclampsia is associated with the imbalance of angiogenic and anti-angiogenic factors. Transforming growth factor-beta 1 (TGF-β1) has also proposed as a proangiogenic factor that influences preeclampsia. This study was conducted to compare a mean difference of TGF-β1 between preeclampsia and normal pregnancy.METHODS: This study was an observational crosssectional study with 25 subjects of pregnant women with preeclampsia and 25 subjects of normotensive pregnant women. The study was conducted in Dr. Reksodiwiryo Hospital, Bhayangkara Hospital, and Dr. Rasidin Hospital in Padang, Indonesia from October 2015 to January 2016. For the determination of TGF-β1 concentration, peripheral Abstract venous blood samples were taken. The blood samples wereanalyzed by enzyme-linked immunosorbent assay (ELISA) in Biomedical Laboratory, Faculty of Medicine, Andalas University. The mean difference was statically analyzed by independent samples T-test.RESULTS: The mean difference of TGF-β1 was lower in preeclampsia group than normal pregnancy group (2.02±0.99 ng/mL vs. 3.24±2.67 ng/mL; p<0.05).CONCLUSION: The TGF-β1 concentration was lower in pregnant women with preeclampsia. Thus, it may have a role as a marker in preeclampsia.KEYWORDS: preeclampsia, normal pregnancy, transforming growth factor-beta1, TGF-β1

scholarly journals Study of outcome of the treatment with intravenous iron sucrose in moderately anaemic pregnant women

2019 ◽  
Vol 8 (9) ◽  
pp. 3480
Author(s):  
Kohila Kalimuthu ◽  
Vanusha Avudaithangam
Keyword(s):  
Standard Deviation ◽  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anaemia ◽  
Intravenous Iron ◽  
Iron Sucrose ◽  
P Value ◽  
Deficiency Anaemia ◽  
The Mean ◽  
The Difference

Background: Moderate anaemia seen in about 15-20% of pregnant women. Iron sucrose complex which is used intravenously for the correction of Iron deficiency anaemia. The drug has been able to raise the haemoglobin to satisfactory level when used in moderately anaemic iron deficient pregnant women. The objective of this study was to study the improvement of Hb% after treatment with intravenous Iron sucrose complex in moderately anaemic pregnant women belonging to 24-32 weeks of gestational age.Methods: 50 antenatal patients between gestational age 24-32 weeks with hemoglobin between 8-9.5g/dl were selected and included in this study. They were subjected to blood hemoglobin estimation, hematocrit and peripheral smear study. In each infusion, the maximum total dose administered was 200 mg iron sucrose in 100 ml of normal saline, slow IV infused over 30 minutes. Monitoring was done throughout the infusion to observe for any side effects.Results: Mean hemoglobin among the 50 patients before starting the therapy was 8.172g/dl and the mean hemoglobin at the end of one month of completing the therapy was 11.066g/dl. The rise in mean hemoglobin i.e. the difference in the mean hemoglobin before and after treatment was 2.894g/dl. The p value is 0.0001 which is statistically significant. The mean hematocrit of the 50 patients studied before starting the treatment was 26.772% with a standard deviation of 1.914. The mean hematocrit after completing the therapy was 33.872% with a standard deviation of 1.321. The difference in the mean hematocrit was 7.100% with a p value of 0.0001 which is statistically significant.Conclusions: Intravenous iron sucrose complex is well tolerated and highly efficacious in improving hemoglobin, hematocrit in the treatment of iron deficiency anaemia in antenatal women.

The effect of ear acupressure medicine at the “Shen Men” point on the nausea and vomiting during pregnancy

2021 ◽  
Vol 15 (5) ◽  
pp. 1774-1779
Author(s):  
Sanaz Nehbandani ◽  
Hajar Salehi ◽  
Khadije Rezaie Keikhaie ◽  
Hossein Rashki Ghalenow ◽  
Fatemeh Mirzaie ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Intervention Group ◽  
Nausea And Vomiting ◽  
Control Group ◽  
Health Clinics ◽  
Significant Difference ◽  
Quasi Experimental ◽  
The Mean ◽  
The Difference

Introduction & Objective: Nausea and vomiting during pregnancy is one of the most common gastrointestinal disorders that more than 85% of pregnant women experience. However, controlling and treating this complication is still one of the most important issues in antenatal care. Therefore, the aim of this study was to investigate the effect of ear acupressure at Shen Men point on relieving nausea, vomiting and retching during pregnancy. Materials and Methods: In this quasi-experimental study, 100 pregnant women with a gestational age of less than 16 weeks attending the health clinics of Zabol city during 2019-2020 were studied in two control and intervention groups (n = 50 in each group). The samples in the intervention group were trained to apply pressure on their ears’ Shen Men point with the thumb for three minutes three times a day (morning, noon, and night), for a duration of one month. At the end of second and fourth weeks, the data were collected using the Rhodes index form and then, were analyzed by SPSS software version 22. Results: According to the results, there was no significant difference between the two groups in terms of age, gestational age, occupation and education. The difference in the mean scores of nausea, vomiting and retching was not statistically significant between the control and intervention groups before the study. But four weeks after the study, a significant difference was observed in the mean scores of vomiting, nausea and retching between the two groups, so that the mean scores of vomiting, nausea and retching were significantly lower in the intervention group than in the control group. Conclusion: The ear acupressure medicine at the Shen men point can be used as a non-invasive, safe and inexpensive method to relieve nausea, vomiting and retching during pregnancy. Keywords: Acupressure medicine, Shen Men, Vomiting, Pregnancy, Nausea, Retching, Rhodosis

scholarly journals Study of endothelial function in pregnant women with gestational diabetes mellitus by flow mediated dilation of brachial artery

2020 ◽  
Vol 9 (6) ◽  
pp. 2377
Author(s):  
Nidhi Pandey ◽  
Poonam Goel ◽  
Anita Malhotra ◽  
Reeti Mehra ◽  
Navjot Kaur
Keyword(s):  
Gestational Diabetes ◽  
Endothelial Function ◽  
Pregnant Women ◽  
Brachial Artery ◽  
Vascular Function ◽  
Post Partum ◽  
Control Group ◽  
Flow Mediated Dilation ◽  
The Mean ◽  
The Difference

Background: The objective of the study was to assess vascular function in normal pregnant women and women with gestational diabetes and to study its temporal relationship with gestational age at 24-28-week POG and at 36-38-week POG and changes in FMD in postpartum period.Methods: Assessment of vascular function was done at 24-28-week POG, 36-38-week POG and at 6-12-week postpartum by flow mediated dilation of brachial artery in 37 healthy pregnant women and 37 pregnant women with GDM.Results: In GDM group mean FMD at 24-28 weeks of POG, at 36-38 weeks POG was lower as compared to the control group (11.225±6.20,8.464±6.09 versus 14.49±5.21, 10.898±4.12) although the difference in mean FMD in two groups was not statistically significant. It was found that the decrease in FMD at 36-38-week POG as compared to 24-28 weeks POG was statistically significant in both the groups (p<0.001).Conclusions: This study revealed that when endothelial function as assessed by FMD was compared at different period of gestation, the mean decrease in FMD at 36-38-week POG as compared to 24-28-week POG and 6-week post-partum was statistically significant in patients with GDM and as well as the control group, however this trend of change was same in both the groups and was not statistically significant when compared between the two group (GDM versus control). A negative correlation of FMD was found with BMI, and HBA1c, that was stronger in GDM group.

scholarly journals Functional Status of Maternal Thyroid Gland in Eclampsia

2019 ◽  
Vol 31 (1) ◽  
pp. 9-14
Author(s):  
M Hafizur Rahman ◽  
Mahbub Ara Chowdhury ◽  
Shahin Mahmuda
Keyword(s):  
Pregnant Women ◽  
Normal Pregnancy ◽  
Hormonal Changes ◽  
Free Triiodothyronine ◽  
College Hospital ◽  
Medical College ◽  
The Mean ◽  
Maternal Thyroid ◽  
Complicated Pregnancy ◽  
In Pregnancy

Marked changes in maternal thyroid activity occur in pregnancy. During pregnancy bodily hormonal changes and metabolic demands result in complex alteration in the bio-chemical parameters of thyroid activities. Besides these, thyroid enlargement, increased thyroid capability for iodine uptake and increase in basal metabolic rate are evidential though these findings are not usually associated with symptoms of hyperthyroidism in pregnancy. Serum concentration of thyroid hormone thyroxine and triiodothyronine in complicated pregnancy like eclamptic toxemia is another field of controversy. To evaluate the changes in thyroid function in normal pregnancy and eclamptic toxemia, a study was undertaken in Rajshahi Medical College Hospital. We collected serum specimens from non pregnant but married women, normal 3rd trimester pregnant women and patients with eclampsia at 3rd trimester of pregnancy and measured serum concentrations of total and free thyroxine (TT4 & FT4) and total and free triiodothyronine (TT3 & FT3 ) by using RIA. Among the study subjects, 10 women were married but non pregnant, 12 women were in their 3rd trimester of normal pregnancy and 32 patients of eclamptic toxemia with 3rd trimester of pregnancy. In normal pregnancy, FT4 and FT3 levels remained normal while TT4 and TT3 levels were elevated. In patients with toxemia of pregnancy, the mean serum TT3 concentration was significantly lower than that of normal pregnancy and the serum FT3 concentrations were below the normal pregnancy range. The mean serum TT4 and FT4 concentrations in patients with eclampsia were however, significantly higher than those in normal pregnant women. TAJ 2018; 31(1): 9-14

scholarly journals A Study on the Association between Low Maternal Serum Magnesium Level and Preterm Labour

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Kehinde S. Okunade ◽  
Ayodeji A. Oluwole ◽  
Maymunah A. Adegbesan-Omilabu
Keyword(s):  
Preterm Labour ◽  
Serum Magnesium ◽  
Tertiary Hospital ◽  
Maternal Serum ◽  
Magnesium Supplementation ◽  
Cross Sectional ◽  
The Mean ◽  
Labour Ward ◽  
Control Study ◽  
Low Serum

Objectives.The study was aimed to assess the association between low maternal serum magnesium levels and preterm labour.Methods.It is a cross-sectional case-control study in which eligible participants were pregnant women admitted in labour within the labour ward complex of a Lagos tertiary hospital. Relevant data were extracted from the case records of these women and blood samples were obtained from all participants and serum magnesium levels measured.Results.The study showed that 36% of the study patients had varying degrees of hypomagnesaemia. The relative risk indicates that preterm labour is 1.83 times higher among the patients with low serum magnesium (less than 1.6 mg/dL). The mean difference in serum magnesium levels in both groups was statistically significant (P<0.05).Conclusion.We can infer that low serum magnesium (hypomagnesaemia) is associated with preterm onset of labour. We can, also from this finding, formulate a proposition that would help in preventing preterm labour and birth with the use of prophylactic oral magnesium supplementation among patients with higher risk for development of preterm labour.

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