scholarly journals Profile of children with seizures in a tertiary care hospital at VCSGGIMS and R Srinagar Pauri, Gharwal, Uttarakhand, India

2019 ◽  
Vol 6 (3) ◽  
pp. 1113
Author(s):  
Rohit Chib ◽  
Manju Devi
Keyword(s):  
Tertiary Care ◽  
Age Groups ◽  
Febrile Seizures ◽  
Clonic Seizure ◽  
Seizure Type ◽  
Care Hospital ◽  
Unprovoked Seizure ◽  
Mortality And Morbidity ◽  
Cns Infections ◽  
Tertiary Center

Background: Seizure is one of the common causes of childhood hospitalization with significant mortality and morbidity. Current study is to find the etiology of seizure and classify seizure into various types and age groups presenting to tertiary center in Department of pediatrics VCSGGIMS and R Srinagar Pauri, Gharwal, Uttrakhand, India.Methods: This was a hospital based prospective study carried out from 1st Jan. 2014 to 31st Dec 2014. Variables collected were demographics, clinical presentations, laboratory tests, brain imaging studies, electroencephalography, diagnosis and hospital course.Results: A total of 276 patients were admitted for seizures with 172 (62.3%) males and 104 (37.7%) females. Among these patients, 148 (53.5%) presented with fever and 157 (56.8%) of children were less than 5 years of age. Generalized tonic-clonic seizure was the most common seizure type (69.2%) followed by partial (19.2%), absence (2.8%), myoclonus (1.6%) and others (6.9%). Seizure disorder (33.7%), febrile seizures (30%), CNS infections (meningitis 6.1%, encephalitis 6.5% and Tubercular meningitis 1.8%) and neurocysticercosis were other common etiologies. Abnormal brain images were noted in 55 (45.45%) out of 121 patients and most common abnormality was neurocysticercosis 33(12%).Conclusions: Acute episode of seizure is one of the causes for hospitalization. It can be concluded from present study that most of seizures caused by febrile seizures and CNS infections (meningitis and encephalitis, neurocysticercosis) can be managed better with prompt interventions. Children presenting with unprovoked seizure need prolonged follow up with neurophysiologic studies and neuroimaging (CT or MRI) for better understanding of childhood seizure.

scholarly journals Clinicodemographic Profile of Children with Seizures in a Tertiary Care Hospital: A Cross-Sectional Observational Study

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Nagendra Chaudhary ◽  
Murli Manohar Gupta ◽  
Sandeep Shrestha ◽  
Santosh Pathak ◽  
Om Prakash Kurmi ◽  
...  
Keyword(s):  
Hospital Admissions ◽  
Tertiary Care Hospital ◽  
Statistical Significance ◽  
Tertiary Care ◽  
Age Groups ◽  
Idiopathic Epilepsy ◽  
Care Hospital ◽  
Partial Seizures ◽  
Cross Sectional ◽  
Mortality And Morbidity

Seizures are one of the common causes for hospital admissions in children with significant mortality and morbidity. This study was conducted to study the prevalence and clinicodemographic profile of children with seizures in a tertiary care hospital of western Nepal. This prospective cross-sectional study conducted over a period of 2 years included all admitted children (2 months–16 years) with seizures. Among 4962 admitted children, seizures were present in 3.4% (n=168) of children, with male preponderance. 138 (82.1%) children had generalized tonic-clonic seizures (GTCS) and 30 (17.9%) children had partial seizures. GTCS were more common than partial seizures in both sexes (male = 82.7%; female = 81.2%) and age groups. There was no statistical significance in the distribution of seizures (GTCS and partial seizures) with sexes (P=0.813) and age groups (P=0.955). Mean ages of children having GTCS and partial seizures were 8.2±4.6 years and 8.2±4.2 years, respectively. Loss of consciousness (55.4%), fever (39.9%), vomiting (35.1%), and headache (16.1%) were common complaints in seizure patients. Significant number of GTCS cases had fever (P=0.041) and neurocysticercosis (n=72; 43%) was the most common etiology in seizure patients. Idiopathic epilepsy (38 (22.6%)), meningoencephalitis (26 (15.5%)), and febrile convulsions (14 (8.33%)) were other leading disorders in children with seizures.

scholarly journals A clinical study to evaluate platelet count and serum albumin as independent prognostic factors in predicting the outcome in burn patients in a tertiary care hospital

2020 ◽  
Vol 7 (7) ◽  
pp. 2305
Author(s):  
Kavitha Jayanthi Balachandran ◽  
Serbin Mohammed
Keyword(s):  
Platelet Count ◽  
Serum Albumin ◽  
Tertiary Care ◽  
Survival Rates ◽  
Age Groups ◽  
Severity Index ◽  
Care Hospital ◽  
Burn Patients ◽  
Mortality And Morbidity ◽  
Reliable Marker

Background: Burns can affect the population of all age groups and regions. There has been a reduction in the mortality and morbidity of burn patients due to improvements in standards of medical care. Several laboratory values were proposed to indicate the prognosis of burns patients. Of these, the oldest is abbreviated burn severity index (ABSI), which includes variables such as sex, age, total burned body surface area (BSA), full-thickness injuries, and burns attributable to inhalation. Later the acute physiology and chronic health evaluation (APACHE) II and APACHE III scales which incorporates biochemical markers to improve predictive power evolved.Methods: In this study, in a tertiary care government institution, we attempt to assess platelet count and serum albumin independently in the prognosis of burns patient, in a background of sepsis.Results: For analysis, patients were divided into two groups- survivors and non-survivors as sepsis development and mortality was observed. There was a progressive decline in the platelet count in non-survivors, while the initial fall improved in those who survived. There was only a marginal difference between the two groups in serum albumin levels.Conclusions: A serial fall in platelet count is a predictor of sepsis and mortality in burn patients. It is an indicator of bone marrow depression and correlation with leucocyte count needs to be evaluated. In those patients where the initial fall in platelet count improved, survival rates were high. As a biochemical marker, serum albumin was not a reliable marker in predicting sepsis and mortality. 

DEMOGRAPHIC STUDY OF DEATHS DUE TO POISONING IN A TERTIARY CARE HOSPITAL IN MEWAT

2021 ◽  
pp. 14-15
Author(s):  
Rajeev Kumar ◽  
Kapil Yadav ◽  
Dara Sandeep ◽  
Sahil Sharma
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Age Groups ◽  
World Health ◽  
Hazardous Substance ◽  
Care Hospital ◽  
Mortality And Morbidity ◽  
Poisoning Deaths ◽  
Health Organization ◽  
Day By Day

According to World Health Organization, (WHO) poisoning occurs when people drink, eat, breathe, inject, or touch enough of a hazardous substance (poison) to cause illness or death. Deaths due to poisoning are most common and carry high rates of mortality and morbidity. The situation is the same all over the world involving individuals of all age groups, sex and all economic and ethnic groups. Poisoning deaths can be accidental or suicidal in manner. As the number of deaths by poisoning keeps on increasing day by day, this study was conducted to know the sociodemographic prole of such poisoning deaths which may help to implement strategies to reduce the burden of poisoning deaths in the society.

scholarly journals STATUS OF URINARY 15-F2t-ISOPROSTANE LEVELS IN GENERALIZED TONIC–CLONIC SEIZURE PATIENTS WITH LEVETIRACETAM IN A TERTIARY CARE HOSPITAL

2021 ◽  
pp. 98-100
Author(s):  
BHUVANESHWARI S ◽  
VIJAYA D
Keyword(s):  
Tertiary Care Hospital ◽  
Meta Analysis ◽  
Tertiary Care ◽  
Age Groups ◽  
Clonic Seizure ◽  
Care Hospital ◽  
Age Group ◽  
Epileptic Patients ◽  
The Mean ◽  
Pro Forma

Objectives: The objective of the study was to analyze urinary 15-2t-isoprostane levels in epileptic patients with levetiracetam (LEV) and to compare the urinary 15-2t-isoprostane levels between the different age groups, smokers, and alcoholics. Methodology: The study was conducted in a tertiary care hospital. Urinary 15-2t-isoprostane levels were assayed in epileptic patients taking LEV. Twenty patients were recruited. Urinary levels of 15-F2t-isoprostane determined by ELISA. The patient’s age, gender, height, weight, smoking, and alcoholic history were collected using pro forma. Statistical analysis of data was performed using SPSS version 23.0. Results: A total of 20 participants recruited for the study. Among these, 70% were male and 30% were female. The mean weight and height were more in males compared to females. The mean 15-F2t-isoprostane level was significantly higher in males compared to females. More than 40% of the participants were in the age group of >40 years. However, the mean urinary 15-F2t-isoprostane level is higher in the age group of 19–30 years. Only 20% of the participants were smokers and alcoholics. Non-smokers and non-alcoholics had higher urinary 15-F2t-isoprostane levels compared to smokers and alcoholics. Conclusion: The urinary 15-F2t-isoprostane levels were more in males, the age group of 19–30 years, non-smokers and non-alcoholics. However, the levels are lesser when compared to earlier meta-analysis study. This concludes that LEV may have antioxidant effect. There is a need for further studies with more sample size and correlation of LEV and urinary 15-F2t-isoprostane levels.

ETIOLOGICAL EVALUATION OF SEIZURE IN CHILDREN ADMITTED IN TERTIARY CARE HOSPITAL OF NORTHERN INDIA

2021 ◽  
pp. 39-41
Author(s):  
Nikki Kumari ◽  
Rajesh Kumar ◽  
Gopal Saran ◽  
A. K. Jaiswal
Keyword(s):  
Bacterial Infections ◽  
Tertiary Care ◽  
Disease Process ◽  
Febrile Seizures ◽  
Idiopathic Epilepsy ◽  
Cns Infection ◽  
Seizure Type ◽  
Care Hospital ◽  
Age Group ◽  
Northern India

Introduction: Convulsions are one of the most common paediatric neurological disorder worldwide. It could either be idiopathic or secondary to disease process of brain. Incidence of convulsion is highest among children younger than 3 yrs. Aims And Objectives: Current study was done to know the proportion of idiopathic epilepsy and secondary seizures. It further aimed to identify various aetiologies of convulsion in children between 1month to15years of age. Materials And Methods: It was a descriptive study conducted in patients admitted in emergency and indoor of department of paediatrics, Patna Medical College and Hospital, over a period of 2 years from October 2014 to September 2016. Children from 1 month to 15 years of age with seizures were studied to know the various aetiologies and proportion of idiopathic or secondary seizures. Results: During study period, 200 children between ages 1 month to 15 years, with convulsion, were enrolled. Seizures were found to be more common in males (67.5%). Secondary seizures were present in 90% cases and idiopathic epilepsy accounted only for 10%. GTCS was the commonest type of seizure both in idiopathic epilepsy (100%) as well as in secondary seizure group (87.77%). Family history of seizure disorders was present in 13% of cases. Developmental delay was found in 11.5% cases, whereas 88.5% children were developmentally normal. Infective aetiologies were the commonest cause followed by febrile seizures. Febrile seizures were commonly seen in age group between 1yr - 5yrs (23.75%). Hypocalcemic seizures were mostly seen in the age group of 1month to 1 year (17.5%). Japanese encephalitis virus and dengue virus as a cause of viral meningoencephalitis were found in 10% and 5% respectively. Conclusion: Incidence of idiopathic epilepsy was less common than secondary seizures. GTCS was the commonest seizure type. CNS infection and febrile seizures were common causes of convulsion in this age group. Bacterial infections were the commonest CNS infections. Serum electrolytes, lumbar puncture, neuroimaging, EEG were important tools in reaching diagnosis

scholarly journals Etiological profile of adult onset seizures: a hospital based prospective study from Kashmir, India

2017 ◽  
Vol 4 (3) ◽  
pp. 793
Author(s):  
Nawaz A. Sheikh ◽  
Nasreena Shabnum ◽  
Gulzar A. Bhat ◽  
Atif Kawoosa ◽  
Mudasir Mushtaq ◽  
...  
Keyword(s):  
Prospective Study ◽  
Sinus Thrombosis ◽  
Tertiary Care ◽  
Medical Science ◽  
Clonic Seizure ◽  
Cerebral Venous Sinus Thrombosis ◽  
Cerebrovascular Diseases ◽  
Seizure Type ◽  
Care Hospital ◽  
Adult Onset

Background: Adult onset seizure (AOS) is considered the epilepsy that start after the age of 18 years. It is a common neurological disorder with multiple etiologies. Objective was to study the etiologies, diagnosis and treatment of AOS in Kashmiri population and to compare its different clinical and etiological profiles in different age groups.Methods: All patients who developed seizure after the age of 18 years were recruited in the current prospective study. In total 144 subjects with AOS were included in this study. The study was done in the Neurology unit of Sher-i-Kashmir Institute of Medical Science, Srinagar- a tertiary care hospital in Kashmir, India from August 2014 to July 2016.Results: Among the 144 recruited subjects, the 25-34 years age group was more susceptible to onset seizures. Generalized tonic-clonic seizure with a percentage of 48.8% was the most common seizure type among the studied subjects. Gender wise males were more susceptible to intracerebral hemorrhage while as cerebral venous sinus thrombosis is more common among females. Among the infection group, encephalitis was a leading causal factor in 10 (6.9%) patients and age wise younger population is more susceptible to encephalitis and central nervous system, while prion disease was more frequent in subjects with age of ≥55. On comparing various cerebrovascular diseases and seizures, ICH was responsible in most number of subjects (12.5%). MRI and EEG (59.7% and 52.8% respectively) findings were abnormal in maximum number of subjects and both findings showed statistically a significant positive correlation (r=0.73; p=<0.01).Conclusions: Idiopathic factors are the main cause of AOS with EEG and MRI being the mainstay for identifying, classifying and localizing seizures among the study patients.

Seroprevalence of anti-SARS-CoV-2 IgG antibodies in hospitalized patients at a tertiary referral center in North India (Preprint)

2020 ◽  
Author(s):  
Dr. Animesh Ray ◽  
Dr. Komal Singh ◽  
Souvick Chattopadhyay ◽  
Farha Mehdi ◽  
Dr. Gaurav Batra ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Age Groups ◽  
Hospitalized Patients ◽  
North India ◽  
P Value ◽  
Care Hospital ◽  
Igg Antibodies ◽  
Igg Antibody ◽  
Increased Risk ◽  
Significant Difference

BACKGROUND Seroprevalence of IgG antibodies against SARS-CoV-2 is an important tool to estimate the true extent of infection in a population. However, seroprevalence studies have been scarce in South East Asia including India, which, as of now, carries the third largest burden of confirmed cases in the world. The present study aimed to estimate the seroprevalence of anti-SARS-CoV-2 IgG antibody among hospitalized patients at one of the largest government hospital in India OBJECTIVE The primary objective of this study is to estimate the seroprevalence of SARS-CoV-2 antibody among patients admitted to the Medicine ward and ICU METHODS This cross-sectional study, conducted at a tertiary care hospital in North India, recruited consecutive patients who were negative for SARS-CoV-2 by RT-PCR or CB-NAAT. Anti-SARS-CoV-2 IgG antibody levels targeting recombinant spike receptor-binding domain (RBD) protein of SARS CoV-2 were estimated in serum sample by the ELISA method RESULTS A total of 212 hospitalized patients were recruited in the study with mean age (±SD) of 41.2 (±15.4) years and 55% male population. Positive serology against SARS CoV-2 was detected in 19.8%patients(95% CI 14.7-25.8). Residency in Delhi conferred a higher frequency of seropositivity 26.5% (95% CI 19.3-34.7) as compared to that of other states 8% (95% CI 3.0-16.4) with p-value 0.001. No particular age groups or socio-economic strata showed a higher proportion of seropositivity CONCLUSIONS Around, one-fifth of hospitalized patients, who were not diagnosed with COVID-19 before, demonstrated seropositivity against SARS-CoV-2. While there was no significant difference in the different age groups and socio-economic classes; residence in Delhi was associated with increased risk (relative risk of 3.62, 95% CI 1.59-8.21)

scholarly journals Sociodemographic and Clinical Profile of Patients Presenting With Erectile Dysfunction: Experience From a Tertiary Care Centre of North India

2021 ◽  
pp. 263183182110311
Author(s):  
Adarsh Tripathi ◽  
Dhirendra Kumar ◽  
Sujita Kumar Kar ◽  
PK Dalal ◽  
Anil Nischal
Keyword(s):  
Erectile Dysfunction ◽  
Rating Scale ◽  
Nuclear Family ◽  
Sexual Experience ◽  
Tertiary Care ◽  
Clinical Profile ◽  
Sexual Disorders ◽  
Care Hospital ◽  
Tertiary Center ◽  
Hamilton Rating Scale

Background: Erectile dysfunction (ED) is one of the most common psychosexual disorders in clinical practice, and it results in significant distress, interpersonal impairments, poor quality of life, and marital disharmony. However, there is limited research on ED in India. Therefore, this study aimed to assess the sociodemographic and clinical profile of patients presenting with ED. Method: Cross-sectional evaluation of patients with ED presenting to the psychosexual outpatient department (OPD) of psychiatry department in a tertiary care hospital was done on structured clinical pro forma, Mini-International Neuropsychiatric Interview, International Index of Erectile Function-5, Arizona Sexual Experience, Hamilton rating scale for depression, and Hamilton rating scale for anxiety. Results: The sample included 102 patients. The mean age was 33.38 years. The majority of the patients were married (81.4%), Hindu (82.4%), residing in a rural area (60.8%), and belonging to a nuclear family (62.7%). The majority of the patients had a moderate level of ED (50%) followed by mild-to-moderate ED (26.5%) and severe ED (23.5%). Premature ejaculation (46.1%) and depression (28.4%) were the most common sexual and psychiatric comorbidities. Obesity was common (62.7%), and only a minority had other metabolic dysfunction, namely dyslipidemia (7.8%), diabetes (5.9%), and hypertension (4.9%). Tobacco dependence and alcohol dependence were present in 37.3% and 6.9% cases, respectively. Conclusion: Young adults with moderate-to-severe ED were present for treatment at a tertiary center. Comorbidities of other sexual disorders, psychiatric disorders, and substance use are commonly encountered in such patients. Promotion of early help-seeking should be encouraged. Clinicians should thoroughly assess even the young patients for other sexual, psychiatric, and medical comorbidities.

scholarly journals Epidemiology and Treatment Outcomes of Head Injury in Bangladesh: Perspective from the Largest Tertiary Care Hospital

2021 ◽  
Author(s):  
Sukriti Das ◽  
Bipin Chaurasia ◽  
Dipankar Ghosh ◽  
Asit Chandra Sarker
Keyword(s):  
Head Injury ◽  
Road Traffic ◽  
Head Injuries ◽  
Skull Fracture ◽  
Tertiary Care ◽  
Acute Subdural Hematoma ◽  
Care Hospital ◽  
Female Ratio ◽  
Mortality And Morbidity ◽  
The Government

Abstract Background Traumatic brain injury (TBI) is one of the leading causes of mortality and morbidity. Economic impact is much worse in developing countries like Bangladesh, as victims are frequently male, productive, and breadwinners of the families. Objectives The objective of our study was to highlight the etiological pattern and distribution of varieties of head injuries in Bangladesh and give recommendations regarding how this problem can be solved or reduce to some extent at least. Methods From January 2017 to December 2019, a total of 14,552 patients presenting with head injury at emergency got admitted in Neurosurgery department of Dhaka Medical College and Hospital and were included in this study. Results The most common age group was 21 to 30 years (36%: 5,239) with a male-to-female ratio of 2.6:1. Injury was mostly caused by road traffic accident (RTA [58.3%: 8,484]), followed by fall (25%: 3,638) and history of assault (15.3%: 2,226). The common varieties of head injury were: acute extradural hematoma (AEDH [42.30%: 1,987]), skull fracture either linear or depressed (28.86%: 1,347), acute subdural hematoma (ASDH [12.30%: 574]), brain contusion (10.2%: 476), and others (6.04%: 282). Conclusion RTA is the commonest cause of TBI, and among them motor bike accident is the severe most form of TBI. AEDH is the commonest variety of head injuries. Proper steps taken by the Government, vehicle owners, and drivers, and proper referral system and prompt management in the hospital can reduce the mortality and morbidity from TBI in Bangladesh.

scholarly journals Epidemiology and outcome of sepsis in a tertiary-care hospital in a developing country

2005 ◽  
Vol 134 (2) ◽  
pp. 315-322 ◽  
Author(s):  
M. D. TANRIOVER ◽  
G. S. GUVEN ◽  
D. SEN ◽  
S. UNAL ◽  
O. UZUN
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical Approach ◽  
Gram Negative Bacteria ◽  
Care Hospital ◽  
Gram Negative ◽  
Mortality And Morbidity ◽  
Underlying Diseases ◽  
Major Pathogens ◽  
Very High

Sepsis continues to have a substantial mortality and morbidity despite advances in the diagnosis and management of this condition. We retrospectively analysed hospital charts of patients diagnosed to have sepsis between January 2002 and June 2003. Demographic characteristics of patients, microbiological findings and predictors of survival were evaluated. Sixty-nine sepsis episodes that occurred in 63 patients were analysed. The most common underlying diseases were hypertension, malignancies and diabetes mellitus. Renal insufficiency, respiratory distress and disseminated intravascular coagulation developed in 52·2, 30·4 and 30·4% of the episodes respectively; 47·7% of the blood cultures yielded an organism. Gram-negative bacteria were the predominant microorganisms (65·9%). Fifty-five patients (87·3%) died. Mechanical ventilation and underlying renal disease were significant determinants of mortality. In conclusion, Gram-negative bacteria remain the major pathogens in sepsis. The mortality remains very high, and a change in the clinical approach to the septic patient should be employed to improve the outcome.

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