ETIOLOGICAL EVALUATION OF SEIZURE IN CHILDREN ADMITTED IN TERTIARY CARE HOSPITAL OF NORTHERN INDIA

2021 ◽  
pp. 39-41
Author(s):  
Nikki Kumari ◽  
Rajesh Kumar ◽  
Gopal Saran ◽  
A. K. Jaiswal
Keyword(s):  
Bacterial Infections ◽  
Tertiary Care ◽  
Disease Process ◽  
Febrile Seizures ◽  
Idiopathic Epilepsy ◽  
Cns Infection ◽  
Seizure Type ◽  
Care Hospital ◽  
Age Group ◽  
Northern India

Introduction: Convulsions are one of the most common paediatric neurological disorder worldwide. It could either be idiopathic or secondary to disease process of brain. Incidence of convulsion is highest among children younger than 3 yrs. Aims And Objectives: Current study was done to know the proportion of idiopathic epilepsy and secondary seizures. It further aimed to identify various aetiologies of convulsion in children between 1month to15years of age. Materials And Methods: It was a descriptive study conducted in patients admitted in emergency and indoor of department of paediatrics, Patna Medical College and Hospital, over a period of 2 years from October 2014 to September 2016. Children from 1 month to 15 years of age with seizures were studied to know the various aetiologies and proportion of idiopathic or secondary seizures. Results: During study period, 200 children between ages 1 month to 15 years, with convulsion, were enrolled. Seizures were found to be more common in males (67.5%). Secondary seizures were present in 90% cases and idiopathic epilepsy accounted only for 10%. GTCS was the commonest type of seizure both in idiopathic epilepsy (100%) as well as in secondary seizure group (87.77%). Family history of seizure disorders was present in 13% of cases. Developmental delay was found in 11.5% cases, whereas 88.5% children were developmentally normal. Infective aetiologies were the commonest cause followed by febrile seizures. Febrile seizures were commonly seen in age group between 1yr - 5yrs (23.75%). Hypocalcemic seizures were mostly seen in the age group of 1month to 1 year (17.5%). Japanese encephalitis virus and dengue virus as a cause of viral meningoencephalitis were found in 10% and 5% respectively. Conclusion: Incidence of idiopathic epilepsy was less common than secondary seizures. GTCS was the commonest seizure type. CNS infection and febrile seizures were common causes of convulsion in this age group. Bacterial infections were the commonest CNS infections. Serum electrolytes, lumbar puncture, neuroimaging, EEG were important tools in reaching diagnosis

scholarly journals Profile of children with seizures in a tertiary care hospital at VCSGGIMS and R Srinagar Pauri, Gharwal, Uttarakhand, India

2019 ◽  
Vol 6 (3) ◽  
pp. 1113
Author(s):  
Rohit Chib ◽  
Manju Devi
Keyword(s):  
Tertiary Care ◽  
Age Groups ◽  
Febrile Seizures ◽  
Clonic Seizure ◽  
Seizure Type ◽  
Care Hospital ◽  
Unprovoked Seizure ◽  
Mortality And Morbidity ◽  
Cns Infections ◽  
Tertiary Center

Background: Seizure is one of the common causes of childhood hospitalization with significant mortality and morbidity. Current study is to find the etiology of seizure and classify seizure into various types and age groups presenting to tertiary center in Department of pediatrics VCSGGIMS and R Srinagar Pauri, Gharwal, Uttrakhand, India.Methods: This was a hospital based prospective study carried out from 1st Jan. 2014 to 31st Dec 2014. Variables collected were demographics, clinical presentations, laboratory tests, brain imaging studies, electroencephalography, diagnosis and hospital course.Results: A total of 276 patients were admitted for seizures with 172 (62.3%) males and 104 (37.7%) females. Among these patients, 148 (53.5%) presented with fever and 157 (56.8%) of children were less than 5 years of age. Generalized tonic-clonic seizure was the most common seizure type (69.2%) followed by partial (19.2%), absence (2.8%), myoclonus (1.6%) and others (6.9%). Seizure disorder (33.7%), febrile seizures (30%), CNS infections (meningitis 6.1%, encephalitis 6.5% and Tubercular meningitis 1.8%) and neurocysticercosis were other common etiologies. Abnormal brain images were noted in 55 (45.45%) out of 121 patients and most common abnormality was neurocysticercosis 33(12%).Conclusions: Acute episode of seizure is one of the causes for hospitalization. It can be concluded from present study that most of seizures caused by febrile seizures and CNS infections (meningitis and encephalitis, neurocysticercosis) can be managed better with prompt interventions. Children presenting with unprovoked seizure need prolonged follow up with neurophysiologic studies and neuroimaging (CT or MRI) for better understanding of childhood seizure.

scholarly journals Iron deficiency and febrile seizures: a retrospective analysis

2019 ◽  
Vol 6 (4) ◽  
pp. 1725
Author(s):  
Bharat Gajare ◽  
Madhuri Engade ◽  
Anuj Khatri ◽  
Pooja Sharma
Keyword(s):  
Iron Deficiency ◽  
Binding Capacity ◽  
Tertiary Care ◽  
Febrile Seizures ◽  
First Episode ◽  
Healthy Children ◽  
Care Hospital ◽  
Age Group ◽  
Upper Respiratory Tract ◽  
Indian Children

Background: Febrile seizures (FS) are the commonest cause of seizures in children, with 2-5% of neurologically healthy children experiencing at least 1 episode. Iron deficiency is reported to be one of the most prevalent nutritional problems in the world today, especially in developing countries, with an estimated 46%-66% people affected. Our study is an attempt to clarify the relation between iron deficiency and first febrile seizure.Methods: The present study was a case control study carried from December 2016 till June 2018 in a tertiary care hospital at Aurangabad, Maharashtra, India. The study was done after obtaining approval from Institutional ethical Committee.Results: 77 cases and equal number of controls were included. Males were most commonly affected (>50%) as compared to females in both groups. Highest number of cases and controls were in the age group 0.5 to 1 year group, followed by 1-2 and 2-3 years group. Upper respiratory tract infection was most common etiological factor. Anemia (Hb<11 gm/dl) was seen in in 84% of the cases and 65% of the controls. Serum iron and total iron binding capacity (TIBC) was reduced in cases as compared to controls and this difference was highly statistically significant.Conclusions: Iron deficiency is a modifiable risk factor for first episode of febrile seizures in Indian children of age group 6 months to 5 years its early detection and timely correction may be an important determinant for prevention of febrile seizure in children.

Clinico - aetiological profile of new onset seizures among adult Egyptians

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A K Mohamed ◽  
M H Mahmoud ◽  
E M Awad ◽  
M A Shafik
Keyword(s):  
Tertiary Care ◽  
Cerebrovascular Diseases ◽  
Idiopathic Epilepsy ◽  
Etiologic Factor ◽  
Seizure Type ◽  
Epilepsy Syndrome ◽  
Care Hospital ◽  
Cross Sectional ◽  
Cluster Seizures ◽  
New Onset

Abstract Objectives We aimed to evaluate the clinical and etiological profile of new onset seizures in adults with the help of laboratory and neuroimaging studies in a tertiary care hospital in Cairo. Methods An observational hospital based cross sectional analytical study of 120 cases with new onset seizures were included in the study, who had their first seizure above the age of 18, and admitted to Neurology OPCs and ER of Ain Shams University and Nasr city Health Insurance Hospitals between March 2018 to September 2018. We determined the type of seizure and etiological factors. Results In the 120 patients, whose specific incidence of acute new onset seizures was found to be highest in males in the age group &gt; 55 years 48 (66.67 %), we found the most common seizure type was generalized seizure 56 (46.67%) and the most common etiologic factor was cerebrovascular diseases 58 (48.33 %). Patients presented with cluster seizures was 31 (25.83 %) and status epileptics was 14 (11.67 %). The most common metabolic insult was hypocalcemia 12 (10%) and hyponatremia 8 (6.76%). Conclusion Cerebrovascular disease was the most common etiology after 55 years of age whereas Idiopathic epilepsy syndrome and Metabolic insults were common in younger individuals (18-35) years of age. Patients presented with cluster seizures were mostly found to have SOL.

CLINICAL AND INVESTIGATIVE FEATURES OF SEIZURE IN CHILDREN ADMITTED IN TERTIARY CARE HOSPITAL OF NORTHERN INDIA

2021 ◽  
pp. 32-35
Author(s):  
Nikki Kumari ◽  
Rajesh Kumar ◽  
Gopal Saran ◽  
A. K. Jaiswal
Keyword(s):  
Ct Scan ◽  
Clinical Laboratory ◽  
Tertiary Care ◽  
Disease Process ◽  
Cerebral Atrophy ◽  
Idiopathic Epilepsy ◽  
Care Hospital ◽  
Neck Stiffness ◽  
Altered Sensorium ◽  
Organ Systems

Introduction: Convulsions are one of the most common paediatric neurological disorders worldwide, with its incidence being highest among children younger than 3 years of age. It is also one of the most frequent causes for visit to the pediatric emergency department and could either be idiopathic or secondary to disease process of brain. Seizures lead to alterat Aims and objectives: ions in the laboratory values and reect changes in different organ systems. This study was done to evaluate the clinical, laboratory, EEG and CT ndings in cases of seizure among children between 1month to15years of age. It was a descriptive study conducted in patients admitt Materials and methods: ed in emergency and indoor of department of paediatrics, Patna Medical College and Hospital, over a period of 2 years from October 2014 to September 2016. Children from 1 month to 15 years of age with seizures were studied to know the proportion of idiopathic or secondary seizures and to evaluate various laboratory, EEG and CT ndings in these cases. During study period, 200 children between ages Results: 1 month to 15 years, with convulsion, were enrolled. Seizures were found to be more common in males (67.5%). Secondary seizures were present in 90% cases and idiopathic epilepsy accounted only for 10%. GTCS was the commonest type of seizure both in idiopathic epilepsy (100%) as well as in secondary seizure group (87.77%). Family history of seizure disorders was present in 13% of cases. Developmental delay was found in 11.5% cases, whereas 88.5% children were developmentally normal. Commonest symptoms associated with secondary seizures were fever (86.11%), altered sensorium (77.22%), and cough (38.89%). Headache, vomiting, ear discharge, rashes were other symptoms. Altered sensorium (69.5%), neck stiffness (33%), cranial nerve involvement (16%) were commonest signs. Hypocalcemia, hyponatremia and hypoglycaemia were found in 4.5%, 1.67% and 1.11% cases respectively, in cases of secondary seizures. CSF analysis was done in all 200 cases and was found to be normal in all cases (100%) of idiopathic epilepsy, whereas it was abnormal in 81% cases of secondary seizures. Abnormal CSF ndings included low CSF glucose (24.69% cases), high CSF proteins (100%) and CSF pleocytosis in 82.71% cases. EEG was also done in all cases, and was found to be abnormal in 85% cases of idiopathic epilepsy, whereas 43.89% cases of secondary seizures had abnormal recordings. Abnormal EEG recordings were abnormal background activity in 60.41%, generalised interictal discharges (IED) in 77.08% and focal IED in 21.87%. Abnormal CT scan ndings were seen in 60(45.8%) cases. Out of these 60 cases, commonest CT scan abnormalities seen were cerebral oedema (45%), cerebral atrophy (20%), and hydrocephalus (16.7%). Other CT ndings were ring enhancing lesions, basal exudates, infarcts etc.

scholarly journals Sociodemographic Profile, Semiology, and Etiology of Patients with Status Epilepticus: A Study from a Tertiary Care Hospital in North India

2018 ◽  
Vol 09 (04) ◽  
pp. 487-491
Author(s):  
Wasim Qadir ◽  
Khurshid Ahmad Wani ◽  
Bilal Ahmad Bhat
Keyword(s):  
Intensive Care ◽  
Status Epilepticus ◽  
Tertiary Care ◽  
Pediatric Intensive Care ◽  
North India ◽  
Prior History ◽  
Seizure Type ◽  
Care Hospital ◽  
Age Group ◽  
Sociodemographic Profile

ABSTRACT Background and Objectives: Despite advance in treatment of status epilepticus (SE), a major neurological emergency, it is still associated with mortality and morbidity. The objective of our study was to estimate sociodemographic profile, semiology, and etiology in the children with SE admitted in pediatric intensive care. Materials and Methods: Children between 1 month and 18 years with continuous seizure activity of >5 min or two or more sequential seizures without full recovery of consciousness between seizures, admitted in the Pediatric Intensive Care Unit of the Department of Pediatrics, Government Medical College, Srinagar, were included in the study. A semi-structured tool was designed to record the sociodemographic details. Detailed history, clinical examination, and investigations (including neuroimaging as and when needed) were used to determine the type of seizure and etiology. Results: A total of 51 patients were included in our study. Most of the patients were <5 years with 47.10% in 1–5 years’ age group and 43.10% in >1-year age group. Males (60.80%) outnumbered females. Thirty-nine patients (76.47%) belonged to “known” or “symptomatic” group with 35 (68.60%) of them presenting with SE as their fresh seizure. Thirty-nine (76.47%) of our patients had generalized tonic–clonic seizure (GTCS) type of SE. Conclusion: Most of the children (90%) were below the age of 5 years with male predominance. Most of the patients had SE as their first seizure without prior history of seizures with GTCSs was the most frequent seizure type.

ANTIBIOTIC SUSCEPTIBILITY PATTERN OF MICROBIAL ISOLATES OBTAINED FROM OBSTETRICS PATIENTS IN TERTIARY CARE HOSPITAL IN NORTHERN INDIA

2021 ◽  
pp. 34-35
Author(s):  
Shruti Sharma ◽  
Aditya Rana ◽  
Subhash Chand Jaryal ◽  
Anuradha Sood ◽  
Daaman Thakur ◽  
...  
Keyword(s):  
Antimicrobial Susceptibility ◽  
Bacterial Infections ◽  
Tertiary Care ◽  
Empiric Therapy ◽  
Urine Samples ◽  
Care Hospital ◽  
E Coli ◽  
Northern India ◽  
Tract Infections ◽  
Susceptibility Patterns

BACKGROUND: Urinary tract infections (UTI) are one of the most frequent clinical bacterial infections in women. They are at higher risk to acquire UTI during pregnancy. The emergence and spread of antimicrobial resistance is a cause of increasing concern. Thus, knowledge of local antimicrobial susceptibility patterns of common uropathogens is essential for empiric therapy of UTIs. Retrospective study was conducted in the Department of Microbiology of DRPGM MATERIALS AND METHODS: C Kangra at Tanda. Study was conducted for the period of one years ie. from July 2020 to June 202. Urine samples were collected and sent to the laboratory for identication and antimicrobial susceptibility of bacterial isolates. RESULTS: During the 12-month study period, out of the 1266 samples screened, 977(77.2%) were sterile, 224(17.698%) samples showed signicant growth of >10฀CFU/ml and 65(5.1%) were contaminanst or insignicant growth, which were excluded from the study. E. coli alone accounted for 66.9% of the urinary isolates followed by Klebsiella spp 12.9%. Among the Gram-positive cocci, Enterococcus isolated from a single sample and Methicillin resistant staphylococcus aureus were seen in two urine samples. Signicantly high susceptibility was seen with fosfomycin(90%) and nitrofurantoin(84%). Resistance was quite high against the noroxacin(30.3%) and cefazolin(17.8%). The susceptibility patterns seen in our study see CONCLUSION: m to suggest that it is necessary to obtain sensitivity reports before initiation of antibiotic therapy in cases of suspected UTI

scholarly journals Profile of Children Presenting with Epilepsy in a Tertiary Health Care Centre in Bangladesh

2010 ◽  
Vol 23 (1) ◽  
pp. 46-50
Author(s):  
Md Belal Uddin ◽  
Md Mizanur Rahman ◽  
MA Mannan ◽  
MA Hossain ◽  
MS Hoq
Keyword(s):  
Initial Treatment ◽  
Age Of Onset ◽  
Tertiary Care ◽  
Febrile Seizures ◽  
Cns Infection ◽  
Care Hospital ◽  
Health Care Centre ◽  
Number Of Patients ◽  
Epileptic Children ◽  
History Of

Epilepsy is a common neurological problem in children. A retrospective study was carried out among the epileptic children attending in the child development and Neurology service center of the department of Pediatrics of Bangabandhu Sheikh Mujib Medical University, Dhaka over a period from September 1999 to September 2001. The aim of this study was to find out clinical profile of epilepsy in children attending in a tertiary care hospital. One hundred twenty children of 1 month to 15 years of age of both sexes were included. Febrile seizures and seizure due to acute CNS infection were excluded from the study. This study showed that epileptic children were mostly from urban area (58%) with M&F 3.14:1 and 50% of them between 1-5 years of age with mean age 2.67 years it was found that most of the children were term (86.55%); home delivered (67.80%), normal birth weight (86.55%), history of delayed crying (43.78%) and history of resuscitation (24.00%). Majority of the patients had perinatal history of irregular and no antenatal check up 51.25%. Common age of onset of seizures was found in the most cases (57.75%) before 1 year of age. GTCS (48.27%) was the commonest pattern of seizure. Epileptic children were mostly severe type (71.70%), which were associated with daily seizure discharged (66.67%). Some of the patients (39.53%) were associated with known provoking factors. Gross motors (58.62%) were the common associated impairment or disability of the epileptic patients. About one third of the patients (32.46%) were associated with cerebral palsy where quadriplegic type was common 48.65%). A significant number of patients (44.8%) were treated previously with AEDs. Among them 60% were treated with single drug. Fifty one percent of the epileptic children were treated inadequately. After attending in the neurology center 69.25% of the patients were getting mono therapy and polytherapy was given in 30.48% of the patients. Carbamazipine and Valproate were commonly used in initial treatment. After initial treatment, control of seizures occurred in 54.25% of cases at different duration. With poly therapy 22.22% of patients did not response with AEDs. During the study period total 26 patients were remain seizures free at different duration. TAJ 2010; 23(1): 46-50

Prescribing trends of antidiabetic drugs in diabetic and hypertensive diabetic patients in an urban tertiary care hospital of Bangladesh

2017 ◽  
Vol 3 (3) ◽  
pp. 338-343
Author(s):  
Mohammad Didar Khan ◽  
Md. Ibrahim ◽  
Md. Mizanur Rahman Moghal ◽  
Dipti debnath ◽  
Asma Kabir ◽  
...  
Keyword(s):  
Urban Areas ◽  
Tertiary Care ◽  
Diabetic Patients ◽  
Care Hospital ◽  
Age Group ◽  
Microsoft Excel ◽  
Patient Profile ◽  
Prescribing Trends ◽  
Medical University ◽  
Insight Into

Objective: The present epidemiological study was conducted with the objectives of providing an insight into the current use of antidiabetic medications to diabetics and hypertensive diabetics in urban areas and determining how the patient factors influence the prescribing of antidiabetic medications. Methodology: Data of patients of past two years were collected from Bangabandhu Sheikh Mujib Medical University (BSMMU) Hospital, Dhaka, Bangladesh. The details were entered in the structured patient profile form. Data were statistically analyzed using the Microsoft Excel 2007 software. Result: A total of 958 patient’s data were collected and analyzed of which 632 (65.97 %) were males and 326 (34.03 %) were females. These patients were further categorized based on their age. 330 patients (34.45 %) belonged to the age group 20 – 44 years, 504 (52.61 %) to the age group 45 – 65 years and 124 (12.94 %) to the age group 65 – 80 years. 684 (71.4%) patients out of the 958 patients studied were suffering from coexisting hypertension. Co-existing hypertension was found to be more prevalent in the age group 45 – 65 years (67.69%) and was found more in females (84.04%). Conclusion: Metformin was the oral hypoglycemic which was the highest prescribed. In hypertensive diabetics Metformin and Pioglitazone were most frequently prescribed drugs. Biguanides and Insulin were the most commonly prescribed antidiabetics. A combination of two or more drugs of different classes was prescribed to hypertensive diabetics. It is necessary to have an improved understanding of the etiology and pathophysiology of diabetes to focus on research efforts appropriately.

A Study on prescribing pattern of drugs in orthopaedic in-patient department at a tertiary care hospital in Guntur region

2020 ◽  
Vol 8 (2) ◽  
pp. 60-70
Author(s):  
Anjani Teja Ch ◽  
Ramesh babu K ◽  
Leela subramanyam S ◽  
Janani Y ◽  
Eswar Sai Kiran K ◽  
...  
Keyword(s):  
Tertiary Care Hospital ◽  
Care Delivery ◽  
Tertiary Care ◽  
Essential Medicine ◽  
Care Hospital ◽  
Age Group ◽  
Common Condition ◽  
Prescribing Pattern ◽  
Prescribing Indicators ◽  
Bed Days

The descriptive observational study was conducted over six months among inpatients of the orthopaedics department. The aim is to observe the prescribing pattern of drugs, to find out the percentage of analgesics given and most commonly prescribed analgesic, to compare the prescribed drugs whether they are in NLEM, WHO list and calculate DDD/100 Bed-days and to analyze the drugs for WHO prescribing drugs. A total of 250 patients were included in the study. Out of this, 168 were male, and 82 were female. Most of the patients were in the age group of 31-40[45 in number with 18%]. The most common condition was found to fracture [113 in number with 95.2%]. Commonly prescribed drugs were analgesics 447 with 26.76%. Among all the NSAID's, PCM was most commonly prescribed analgesic with 34.4%. The highest no, of drugs was found to be 4drugs/prescription with 24%. Monthly one analgesic was prescribed per prescription with 38.8%. Utilization of analgesics in term of DDD/100 Bed-days was 55.26; Drugs will be evaluated per prescription as per prescribing indicators of WHO was done, the average no. of drugs per prescription was found to be 0.45, percentage of drugs prescribed by generic name was found to be 13.3%, percentage of encounters with antibiotics prescribed were found to be 94.4%, In ratio percentage of drugs prescribed from the national list of essential medicine was found to be 92.6%. This study would help to facilitate better health care delivery.

Homelessness among an inpatient HIV-positive cohort at a tertiary care hospital in central London

2020 ◽  
Vol 31 (7) ◽  
pp. 705-707
Author(s):  
Venkateshwaran Sivaraj ◽  
Rudiger Pittrof ◽  
Olubanke Davies ◽  
Ranjababu Kulasegaram
Keyword(s):  
Bacterial Infections ◽  
Substance Misuse ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Hiv Positive ◽  
Care Hospital ◽  
Hiv Viral Load ◽  
Cd4 Cell Count ◽  
Cell Counts ◽  
Cd4 Cell

A cohort review was conducted at a central London tertiary care hospital trust on the prevalence of homelessness among human immunodeficiency virus (HIV)-positive inpatients over a year. Data were collected on the duration of inpatient stay, co-morbidities including acquired immune deficiency syndrome (AIDS)-defining illnesses, co-infections, initiation of antiretroviral therapy, CD4 cell count, HIV viral load and substance misuse. Homeless people were found to be at high risk for hepatitis C, mental health illness, substance misuse including injecting drug use, recurrent bacterial infections, AIDS-associated illnesses, lower CD4 cell counts and HIV viremia. They also had more missed HIV outpatient appointments. It was highlighted that a multidisciplinary approach in their care was necessary to address their needs and reduce the morbidity burden in this cohort.

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