Prevalence and risk factors of Helicobacter pylori infections in the patients suffering from acid-peptic disease at tertiary care center, Gujarat, India

Background: Helicobacter pylori (H. pylori) infection is a medical encumber especially in the developing countries, ranging from acute inflammation to malignancy. The study is intended to explore the prevalence of H. pylori infection and also to compute its associated risk factors.Methods: Sixty two (n=62) symptomatic patients attending the tertiary care hospital, were included in the study. Two antral biopsies collected from each patient were subjected to rapid urease test and Gram staining. IgG antibodies were detected by rapid test based on the principle of Immunochromatography. To evaluate the risk factors, various determinants were asked to each patient in the form of questionnaire. Statistical analysis was done using Fisher exact test. P value < 0.05 was considered significant.Results: Prevalence rate of H. pylori infection was 24.19 % (15/62). More than half (53%) of the infected patients had complained of persistent burning abdominal pain. Prevalence rate was found highest in the patients suffering from peptic ulcer disease (66.6%, P=0.0237). Consumption of unfiltered water (P=0.007, Odd Ratio (OR)-1.06), eating spicy food, meat, fish and chili pepper (P=0.052, OR-1.01) was found the major risk factors. Addictive habits of either smoking/alcohol/tobacco (P=0.904) were not associated with infection.Conclusions: Prevalence of H. pylori infection was found low comparatively and was mainly associated with symptom of persistent burning abdominal pain and peptic ulcer. Use of unfiltered water, spicy food, chili pepper and meat undoubtedly increase the risk of acquiring H. pylori infection. Addictive habits were not significantly associated with infection.

Download Full-text

Therapeutic efficacy of ranitidine bismuth citrate with clarithromycin for seven days in the eradication of Helicobacter pylori in Brazilian peptic ulcer patients

Sao Paulo Medical Journal ◽

10.1590/s1516-31802003000100004 ◽

2003 ◽

Vol 121 (1) ◽

pp. 15-18 ◽

Cited By ~ 2

Author(s):

Jaime Natan Eisig ◽

Fernando Marcuz Silva ◽

Cláudio Hashimoto ◽

Ethel Zimberg Chehter ◽

Antonio Atilio Laudanna

Keyword(s):

Helicobacter Pylori ◽

Peptic Ulcer ◽

Histological Examination ◽

Tertiary Care ◽

Therapeutic Regimen ◽

Care Hospital ◽

Peptic Ulcers ◽

Cross Sectional ◽

Bismuth Citrate ◽

Urease Test

CONTEXT: The curative treatment of peptic ulcer is made available nowadays through the eradication of the bacterium Helicobacter pylori, which is associated with it, but the best therapeutic regimen is yet to be determined. OBJECTIVE: To assess the efficacy of a therapeutic regimen with 400 mg ranitidine bismuth citrate associated with 500 mg clarithromycin given twice a day for seven days in a cohort of Brazilian patients with peptic ulcer. TYPE OF STUDY: Cross-sectional study. SETTING: Tertiary-care hospital. PATIENTS: One hundred and twenty nine outpatients, with active or healed peptic ulcers infected by Helicobacter pylori, diagnosed via endoscopy with confirmation via the urease test and histological examination, who had never undergone a regimen for the eradication of the bacterium. PROCEDURE: Administration of 400 mg ranitidine-bismuth and 500 mg clarithromycin twice a day, for seven days. MAIN MEASUREMENTS: Efficacy of the treatment, with a check on the cure done via another endoscopy eight weeks after drug administration. The eradication of the bacterium was determined via the urease test and histological examination. Patients who were negative for both were considered to be cured. RESULTS: Eight patients failed to complete the study. The eradication rate according to intention to treat was 81% (104/129) and per protocol was 86% (104/121). CONCLUSION: The bismuth ranitidine compound associated with clarithromycin used for one week was shown to be a simple, effective and well-tolerated therapeutic regimen for the eradication of Helicobacter pylori.

Download Full-text

Frequency of H. Pylori infection in children with recurrent abdominal pain at a Tertiary Care Hospital.

The Professional Medical Journal ◽

10.29309/tpmj/2020.27.03.3057 ◽

2020 ◽

Vol 27 (02) ◽

pp. 237-241

Author(s):

Asim Khurshid ◽

Shahid Ishaq ◽

Mushtaq Ahmad

Keyword(s):

Helicobacter Pylori ◽

Drinking Water ◽

Disease Duration ◽

Family Income ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Recurrent Abdominal Pain ◽

Male Gender ◽

Care Hospital ◽

H Pylori

Objectives: Recurrent abdominal pain (RAP) impacts quality of life of the children. RAP also hampers education and physical activity of the children. Current study was aimed to find out the frequency of Helicobacter pylori in children with RAP in our tertiary care hospital. Study Design: Descriptive, cross-sectional study. Setting: Department of Pediatric Medicine, Nishtar Hospital, Multan, Period: From 27-12-2017 to 26-06-2018. Material & Methods: A total of 185 patients suffering from RAP, aged 2-12 years, with a disease duration > 3 months, were enrolled. Age of the children, gender, duration of illness, number of episodes of pain, maternal literacy, family income, residential status, source of drinking water and h.pylori infection were calculated in these children. Post stratification chi-square test was applied to see its effect on H. Pylori infection. Results: Of these 185 study cases, 101 (54.6 %) were male patients while 84 (45.4%) were female. Mean age of our study cases was 7.57 ± 1.93 years. Of A total of 95 (51.4%) children belonged to rural areas and 90 (48.6 %) to urban areas. Helicobacter pylori infection was noted in 103 (55.7%) of our study cases. When helicobacter pylori was stratified with regards to study variables, male gender, age < 8 years, monthly family income <Rs. 35000, source of drinking water as Hand Pump and disease duration < 6 months turned out to be statistically significant (P value < 0.05). Conclusion: Frequency of H.pylori was high in children with RAP. Helicobacter pylori was significantly associated with male gender, younger age, poor socioeconomic status, source of drinking water and disease duration.

Download Full-text

Association of toll-like receptor 4, 5 and 10 polymorphisms with Helicobacter pylori -positive peptic ulcer disease in a center in Jordan

Annals of Saudi Medicine ◽

10.5144/0256-4947.2021.206 ◽

2021 ◽

Vol 41 (4) ◽

pp. 206-215

Author(s):

Laith AL-Eitan ◽

Fouad Abdelaziz Almomani ◽

Sohaib Mahmoud Al-Khatib ◽

Hanan Abdulraheem Aljamal ◽

Mohammed Nayef Al-Qusami ◽

...

Keyword(s):

Helicobacter Pylori ◽

Peptic Ulcer ◽

Conflicts Of Interest ◽

Care Center ◽

Treatment Success ◽

Tertiary Care ◽

Genotype Distribution ◽

Toll Like Receptor ◽

Toll Like Receptor 4 ◽

H Pylori

BACKGROUND: Helicobacter pylori infection is widespread, affecting about 50% of the global population. Polymorphisms in host genes such as the toll-like receptor 4 ( TLR4 ) might affect the susceptibility and severity of infection and treatment success. OBJECTIVE: Investigate the susceptibility and severity of H pylori infection with host TLR4 (rs11536889, rs4986790, rs200109652, rs10759932), TLR5 (rs5744174, rs2072493, rs746250566), TLR10 (rs559182335, rs10004195) polymorphisms. DESIGN: Analytical, cross-sectional. SETTING: Endoscopy clinic at tertiary care center. PATIENTS AND METHODS: Genomic DNA was extracted from formalin-fixed paraffin-embedded tissues collected from H pylori -infected patients and healthy individuals. The single nucleotide polymorphisms (SNPs) within the targeted TLR genes were genotyped to assess the genetic association of various SNPs with disease severity. MAIN OUTCOME MEASURES: Effect of genotype distribution on H pylori infection. SAMPLE SIZE: 250 peptic ulcer patients and 217 controls. RESULTS: The TLR10 genotype showed no significant association with H pylori infection except for rs10004195 (T>A) ( P =.002). The genotype frequency of Rs5744174 in TLR5 had a significant association with the presence of H pylori infection ( P =.046, OR=0.52). Except for gender (P=.022), there were no significant associations between clinical and demographic variables and SNPs relating to the severity of the H pylori infections. CONCLUSIONS: Our findings are consistent with differences in severity of H pylori infection due to TLR SNPs in different ethnic groups. Understanding differences in genetic susceptibility could help in classifying patients and matching patients with various treatment options on a genetic basis. LIMITATIONS: Lack of H pylori pathogenicity features assessment. CONFLICTS OF INTEREST: None.

Download Full-text

Association of Helicobacter Pylori with Peptic Ulcer Perforation

Journal of BP Koirala Institute of Health Sciences ◽

10.3126/jbpkihs.v2i1.24960 ◽

2019 ◽

Vol 2 (1) ◽

pp. 4-10

Author(s):

Sunit Agrawal ◽

D Thakur ◽

P Kafle ◽

A Koirala ◽

R K Sanjana ◽

...

Keyword(s):

Risk Factors ◽

Helicobacter Pylori ◽

Peptic Ulcer ◽

Peptic Ulcer Disease ◽

Perforated Peptic Ulcer ◽

Patch Repair ◽

Peptic Ulcer Perforation ◽

Ulcer Disease ◽

Ulcer Perforation ◽

H Pylori

Background: Helicobacter pylori is found in more than 90% cases of peptic ulcer. This study examines the possibility of association of Helicobacter pylori in perforated peptic ulcer disease and its relation to persisting ulcer as well as the influence of other risk factors; namely: smoking, alcohol, current non-steroidal anti inflammatory drugs (NSAIDs) and steroid use. Materials and Methods: In this prospective study, total of 50 cases of peptic ulcer perforation admitted in College of Medical Sciences and Teaching Hospital, Bharatpur, Nepal were selected on the basis of the non-probability (purposive) sampling method. All patients who presented with suspected peptic ulcer perforation were included in the study and the perforations were repaired by Modified Graham’s Patch and were given triple therapy postoperatively. The age, sex, incidence, mode of presentation, precipitating factors, association with the risk factors and postoperative complications were all evaluated and compared. Results: Of 50 patients studied, the age ranged from 17 to 75 years, mean age being 40.1 years with the peak incidence in the 3rd and 5th decades of life showing a male dominance (92%). H. pylori was seen in ulcer edge biopsy in 29 patients (58%). Most common clinical presentation was pain abdomen, the most common signs of perforation were tenderness, rebound tenderness and absent bowel sounds. The mean duration of stay in hospital in H. pylori positive patients was 12.07±8.15 days as compared with 11.1±5.12 days in H. pylori negative patients. The incidence of peptic ulcer perforation was higher in the patients consuming alcohol (64%) than smokers (48%), followed by NSAIDs user(22%). 20% of the patients with delayed presentation developed complications postoperatively. Perforated peptic ulcer was repaired by Modified Graham’s Patch Repair, followed by anti H. pylori therapy in all of them. Conclusion: Peptic ulcer perforation is quite common among the patients with peptic ulcer disease with history of chronic smoking, alcoholism and analgesic intake, more commonly in males. There is association of H. pylori in 58% of patients with peptic ulcer perforation.

Download Full-text

Frequency of Helicobacter Pylori Infection in the Local Population Presenting with Dyspeptic Symptom

10.53350/pjmhs211561692 ◽

2021 ◽

Vol 15 (6) ◽

pp. 1692-1694

Author(s):

Muhammad Zarrar ◽

Shahzad Memon ◽

Kashif Ali ◽

Arsalan Badar ◽

Yar Muhammad ◽

...

Keyword(s):

Helicobacter Pylori ◽

Tertiary Care Hospital ◽

Local Population ◽

Tertiary Care ◽

Antibody Test ◽

Helicobacter Pylori Infection ◽

Dyspeptic Symptom ◽

Care Hospital ◽

Iga Antibody ◽

H Pylori

Objectives: To determine the frequency of Helicobacter pylori infection in the local population presenting with dyspeptic symptom report to a tertiary care hospital of Nawabshah. Methodology: This cross-sectional study took place at department of medicine, Peoples Medical College and Hospital Nawabshah; during six months, form August 2015 to February 2016. A total of 115 patients with dyspeptic symptoms with upper abdominal disorders such as discomfort and pain, nausea, fullness, bloating, heartburn, anorexia, belching and regurgitation were included. After conducting detailed clinical examination and history, patients were subjected to relevant examinations, i.e. Blood antibody test (IgA antibody test), for H. pylori and venous blood was drawn. All the information was collected in the proforma. Results: The patients’ average age was 30.92±6.10 years. There were 66(57.4%) male cases and 49(42.6%) female cases. Helicobacter pylori (H. pylori) infection was observed to be frequent (60% cases) among both genders. Conclusion: In conclusion, the present results confirm that the frequency of patients suffering from helicobacter pylori infection was quite high in local population at tertiary care hospital, Nawabshah. Strategies could be developed at an earlier stage and prompt treatment may reduce the morbidity. Key Words: Dyspepsia, Helicobacter pylori, IgA antibody test

Download Full-text

Risk Factors For Recurrence of Peptic Ulcer Disease: A Retrospective Study In Tertiary Care Referral Center

10.21203/rs.3.rs-1184031/v1 ◽

2022 ◽

Author(s):

Yaser Alsinnari ◽

Mohammed S. Alqarni ◽

Meshari Attar ◽

Ziad M. Bukhari ◽

Faisal Baabbad ◽

...

Keyword(s):

Risk Factors ◽

Peptic Ulcer ◽

Peptic Ulcer Disease ◽

Recurrence Rate ◽

Univariate Analysis ◽

Tertiary Care ◽

Ulcer Disease ◽

Significant Difference ◽

Risk Factors For Recurrence ◽

H Pylori

Abstract Backgrounds: Peptic ulcer disease (PUD) is a common gastrointestinal tract disease characterized by mucosal damage secondary to pepsin and gastric acid secretion. The aim of this study was to evaluate the five-year recurrence rate for treated patients with PUD and risk factors contributing to PUD relapses.Methods: From 2016 through 2021, all patients with endoscopy-proved PUD were identified by reviewing medical records (Best-Care system). Possible risk factors including smoking, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, alcohol, caffeine, and steroid were analyzed by univariate analysis. Treatment outcomes, 5-year recurrence rate, and mortality rate were assessed.Results: Among 223 patients, there were 187 (83.8%), who diagnosed endoscopy-proved PUD and 36 (16.2%), who diagnosed clinical PUD. Among them, 126 (56.5%) patients were males and the mean age was 62±2 years. The five years recurrence rate of PUD was 30.9%. There was no significant difference in the recurrence rate between the duodenal ulcer (33.3%) and the gastric ulcer (28.8%). By univariate analysis, the use of steroid and NSAID and H. pylori infection were potential risk factors for PUD (P < 0.005). The common complication of PUD was gastrointestinal bleeding (34.1%). Patients who had a complicated PUD were associated with a higher rate of recurrence (45.9%) compared to the uncomplicated PUD (19.2%) (P > 0.05). Conclusion: Our findings demonstrated that the five years recurrence rate of PUD was 30.9%. The use of steroid and NSAID and H. pylori infection were risk factors for recurrence of PUD. PUD places a significant burden on health care systems. Therefore, a multicenter prospective study is needed for effective management to prevent recurrence and complications of PUD.

Download Full-text

ROLE OF HELICOBACTER PYLORI INFECTION AND LIFESTYLE HABITS IN THE DEVELOPMENT OF GASTRODUODENAL DISEASES IN A POPULATION FROM THE BRAZILIAN AMAZON

Arquivos de Gastroenterologia ◽

10.1590/s0004-28032013000200030 ◽

2013 ◽

Vol 50 (3) ◽

pp. 170-174 ◽

Cited By ~ 5

Author(s):

Ruth Maria Dias Ferreira VINAGRE ◽

Adenielson VILAR-e-SILVA ◽

Amanda Alves FECURY ◽

Luisa Caricio MARTINS

Keyword(s):

Risk Factors ◽

Helicobacter Pylori ◽

Peptic Ulcer ◽

Alcohol Consumption ◽

Eating Habits ◽

Severe Disease ◽

Lifestyle Habits ◽

Excessive Alcohol Consumption ◽

Excessive Alcohol ◽

H Pylori

Context Although more than half of the world's population is colonized with Helicobacter pylori, it remains unknown why this organism is able to produce severe disease in some hosts and be innocuous in others. The clinical outcome of infection is determined by several factors, including differences in the host response to bacterial stimulation, specific virulence factors of the organism and environmental influences, or a combination of these factors. Objectives This study compared the prevalence of H. pylori infection and risk factors (infection with CagA+ strains, excessive alcohol consumption, smoking, and inadequate eating habits) between patients with different gastrointestinal disorders and associated these risk factors with the histopathological findings. Methods In a prospective study, samples were collected from 442 patients and a standardized questionnaire regarding lifestyle habits (excessive alcohol consumption, smoking, and eating habits) was applied. The presence of H. pylori and of the cagA gene was investigated by polymerase chain reaction (PCR). Gastric biopsies were obtained for histological assessment. Results The frequency of alcohol consumption, smoking, inadequate diet and infection with CagA+ H. pylori was higher among patients with peptic ulcer and adenocarcinoma when compared to those with gastritis. Gastric inflammation was more pronounced in patients infected with CagA+ strains. Conclusion We conclude that infection with CagA+ H. pylori strains, excessive alcohol consumption, smoking and inadequate eating habits increase the risk of developing peptic ulcer and gastric carcinoma.

Download Full-text

Prevalence of Helicobacter pylori infection among dyspepsia patients with mucosal lesion in tertiary care hospital

International Surgery Journal ◽

10.18203/2349-2902.isj20182234 ◽

2018 ◽

Vol 5 (6) ◽

pp. 2264

Author(s):

Amit S. Yadav ◽

Umesh B. Kulkarni ◽

Bharat C. Kumar ◽

Unmesh V. Takalkar

Keyword(s):

Helicobacter Pylori ◽

Biopsy Specimen ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Exclusion Criteria ◽

Mucosal Lesions ◽

Non Ulcer Dyspepsia ◽

H Pylori ◽

Curved Rod

Background: Helicobacter pylori (H. pylori), a curved rod shaped bacteria, is found to be associated with acid peptic disease patients, more in ulcer than non-ulcer, leading to a belief that H. pylori plays a role in its etiopathogenesis. In this study we examine the prevalence of H. pylori infection among dyspepsia patients with mucosal lesion.Methods: 300 patients of dyspepsia were enrolled in the study as per inclusion/exclusion criteria for a period of eight months. Enrolled patients were subjected to upper gastro-intestinal endoscopy and findings were recorded. Biopsy specimen taken from mucosal lesions were immediately inoculated on ‘RUT dry kit’ to test for H. pylori infection.Results: 234 out of 300 patients (78%) were found to be positive for H. pylori infection. The incidence of H. pylori infection was higher in patients with ulcer dyspepsia (88.46%) when compared to the patients with non-ulcer dyspepsia (72.44%).Conclusions: Prevalence of H. pylori infection was high and was found to have an association with ulcer dyspepsia allowing us to conclude that H. pylori may have a role in its etiopathogenesis.

Download Full-text

Frequency of H. Pylori infection in children with recurrent abdominal pain at a Tertiary Care Hospital.

The Professional Medical Journal ◽

10.29309/tpmj/2020.27.02.3057 ◽

2020 ◽

Vol 27 (02) ◽

pp. 237-241

Author(s):

Asim Khurshid ◽

Shahid Ishaq ◽

Mushtaq Ahmad

Keyword(s):

Helicobacter Pylori ◽

Drinking Water ◽

Disease Duration ◽

Family Income ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Recurrent Abdominal Pain ◽

Male Gender ◽

Care Hospital ◽

H Pylori

Download Full-text

Frequency of Seropositivity of Helicobacter Pylori Among Patients Presented with Dyspepsia

10.53350/pjmhs2115103134 ◽

2021 ◽

Vol 15 (10) ◽

pp. 3134-3136

Author(s):

Nasrullah Aamer ◽

Muhammad Khalid Nizamani ◽

Narindar Kumar ◽

Muneer Sadiq ◽

Shaista Zeb ◽

...

Keyword(s):

Socioeconomic Status ◽

Helicobacter Pylori ◽

Tertiary Care ◽

Study Participant ◽

Abdominal Distension ◽

Care Hospital ◽

Duration Of Symptoms ◽

Medicine Department ◽

Seropositivity Rate ◽

H Pylori

Objective: To determine the frequency of seropositive helicobacter pylori (H. pylori) among patients presented at outpatient department (OPD) with dyspepsia at tertiary care Hospital. Methodology: This descriptive case-control study was conducted at medicine department of Peoples University of Medical and Health Sciences for women Nawabshah (SBA). Study duration was six months from October 2018 to March 2019. All the patients of age 18-70 years, presented with complaint of dyspepsia, either of gender were included in the study. After taking informed consent all the patients underwent serological assessment for H. pylori. From each study participant a 5ml blood sample was taken and sent to the laboratory for the diagnosis of H. pylori. After collection of the laboratory reports, all the data was collected via self-made study proforma. Data analysis was done by using SPSS version 20. Results: Total 78 patients of dyspepsia were enrolled, their mean age was34.23+6.22 years and average duration of symptoms was 15.23+7.14 months. Males were 43(55.1%) and females were 35(44.9%). Feeling of abdominal distension after meal was among 21(26.9%) cases, epigastrium pain was in 14(17.9%) cases, heart burn was among 32(41.0%) patients, 07(09.0%) had belching and 19(24.4%) had multiple complaints. Seropositivity rate of H. pylori was 33.30% among patients of dyspepsia and it was statistically insignificant according to gender and socioeconomic status (p->0.05). Conclusion: As per study conclusion the seropositivity of H. pylori was observed to be higher among patients of dyspepsia and seropositivity of H. pylori was insignificantly linked to gender and socioeconomic status. Keywords: Dyspepsia, H. pylori, seropositive

Download Full-text