scholarly journals ROLE OF HELICOBACTER PYLORI INFECTION AND LIFESTYLE HABITS IN THE DEVELOPMENT OF GASTRODUODENAL DISEASES IN A POPULATION FROM THE BRAZILIAN AMAZON

2013 ◽  
Vol 50 (3) ◽  
pp. 170-174 ◽  
Author(s):  
Ruth Maria Dias Ferreira VINAGRE ◽  
Adenielson VILAR-e-SILVA ◽  
Amanda Alves FECURY ◽  
Luisa Caricio MARTINS
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Alcohol Consumption ◽  
Eating Habits ◽  
Severe Disease ◽  
Lifestyle Habits ◽  
Excessive Alcohol Consumption ◽  
Excessive Alcohol ◽  
H Pylori

Context Although more than half of the world's population is colonized with Helicobacter pylori, it remains unknown why this organism is able to produce severe disease in some hosts and be innocuous in others. The clinical outcome of infection is determined by several factors, including differences in the host response to bacterial stimulation, specific virulence factors of the organism and environmental influences, or a combination of these factors. Objectives This study compared the prevalence of H. pylori infection and risk factors (infection with CagA+ strains, excessive alcohol consumption, smoking, and inadequate eating habits) between patients with different gastrointestinal disorders and associated these risk factors with the histopathological findings. Methods In a prospective study, samples were collected from 442 patients and a standardized questionnaire regarding lifestyle habits (excessive alcohol consumption, smoking, and eating habits) was applied. The presence of H. pylori and of the cagA gene was investigated by polymerase chain reaction (PCR). Gastric biopsies were obtained for histological assessment. Results The frequency of alcohol consumption, smoking, inadequate diet and infection with CagA+ H. pylori was higher among patients with peptic ulcer and adenocarcinoma when compared to those with gastritis. Gastric inflammation was more pronounced in patients infected with CagA+ strains. Conclusion We conclude that infection with CagA+ H. pylori strains, excessive alcohol consumption, smoking and inadequate eating habits increase the risk of developing peptic ulcer and gastric carcinoma.

scholarly journals Association of Helicobacter Pylori with Peptic Ulcer Perforation

2019 ◽  
Vol 2 (1) ◽  
pp. 4-10
Author(s):  
Sunit Agrawal ◽  
D Thakur ◽  
P Kafle ◽  
A Koirala ◽  
R K Sanjana ◽  
...  
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Perforated Peptic Ulcer ◽  
Patch Repair ◽  
Peptic Ulcer Perforation ◽  
Ulcer Disease ◽  
Ulcer Perforation ◽  
H Pylori

Background: Helicobacter pylori is found in more than 90% cases of peptic ulcer. This study examines the possibility of association of Helicobacter pylori in perforated peptic ulcer disease and its relation to persisting ulcer as well as the influence of other risk factors; namely: smoking, alcohol, current non-steroidal anti inflammatory drugs (NSAIDs) and steroid use. Materials and Methods: In this prospective study, total of 50 cases of peptic ulcer perforation admitted in College of Medical Sciences and Teaching Hospital, Bharatpur, Nepal were selected on the basis of the non-probability (purposive) sampling method. All patients who presented with suspected peptic ulcer perforation were included in the study and the perforations were repaired by Modified Graham’s Patch and were given triple therapy postoperatively. The age, sex, incidence, mode of presentation, precipitating factors, association with the risk factors and postoperative complications were all evaluated and compared. Results: Of 50 patients studied, the age ranged from 17 to 75 years, mean age being 40.1 years with the peak incidence in the 3rd and 5th decades of life showing a male dominance (92%). H. pylori was seen in ulcer edge biopsy in 29 patients (58%). Most common clinical presentation was pain abdomen, the most common signs of perforation were tenderness, rebound tenderness and absent bowel sounds. The mean duration of stay in hospital in H. pylori positive patients was 12.07±8.15 days as compared with 11.1±5.12 days in H. pylori negative patients. The incidence of peptic ulcer perforation was higher in the patients consuming alcohol (64%) than smokers (48%), followed by NSAIDs user(22%). 20% of the patients with delayed presentation developed complications postoperatively. Perforated peptic ulcer was repaired by Modified Graham’s Patch Repair, followed by anti H. pylori therapy in all of them. Conclusion: Peptic ulcer perforation is quite common among the patients with peptic ulcer disease with history of chronic smoking, alcoholism and analgesic intake, more commonly in males. There is association of H. pylori in 58% of patients with peptic ulcer perforation.

scholarly journals Prevalence and risk factors of Helicobacter pylori infections in the patients suffering from acid-peptic disease at tertiary care center, Gujarat, India

2018 ◽  
Vol 5 (5) ◽  
pp. 1250
Author(s):  
Anjali K. Kukreja ◽  
Himani B. Pandya ◽  
Santosh Kumar
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Abdominal Pain ◽  
Prevalence Rate ◽  
Tertiary Care ◽  
Chili Pepper ◽  
Care Hospital ◽  
Spicy Food ◽  
H Pylori

Background: Helicobacter pylori (H. pylori) infection is a medical encumber especially in the developing countries, ranging from acute inflammation to malignancy. The study is intended to explore the prevalence of H. pylori infection and also to compute its associated risk factors.Methods: Sixty two (n=62) symptomatic patients attending the tertiary care hospital, were included in the study. Two antral biopsies collected from each patient were subjected to rapid urease test and Gram staining. IgG antibodies were detected by rapid test based on the principle of Immunochromatography. To evaluate the risk factors, various determinants were asked to each patient in the form of questionnaire. Statistical analysis was done using Fisher exact test. P value < 0.05 was considered significant.Results: Prevalence rate of H. pylori infection was 24.19 % (15/62). More than half (53%) of the infected patients had complained of persistent burning abdominal pain. Prevalence rate was found highest in the patients suffering from peptic ulcer disease (66.6%, P=0.0237). Consumption of unfiltered water (P=0.007, Odd Ratio (OR)-1.06), eating spicy food, meat, fish and chili pepper (P=0.052, OR-1.01) was found the major risk factors. Addictive habits of either smoking/alcohol/tobacco (P=0.904) were not associated with infection.Conclusions: Prevalence of H. pylori infection was found low comparatively and was mainly associated with symptom of persistent burning abdominal pain and peptic ulcer. Use of unfiltered water, spicy food, chili pepper and meat undoubtedly increase the risk of acquiring H. pylori infection. Addictive habits were not significantly associated with infection.

scholarly journals Helicobacter pylori Infection and Predictors Risk Factors among Patients undergoing Gastro-duodenal Fibroscopy in Yaoundé, Cameroon

2021 ◽  
Vol 3 (4) ◽  
pp. 28-32
Author(s):  
Abel Fils Nkoth ◽  
Christian Ngounouh Taheu ◽  
Angele Clarisse Okono Kabeyene ◽  
Sandra Germaine Gueuma Tchoumbou ◽  
Jean Paul Chedjou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Alcohol Consumption ◽  
Cross Sectional Study ◽  
P Value ◽  
African Countries ◽  
Cross Sectional ◽  
Level Of Education ◽  
Regional Group ◽  
H Pylori

Background: Helicobacter pylori (H. pylori) infection affects more than half people worldwide particularly in African countries such as Cameroon. This study aimed to investigate the prevalence of H. pylori infection and predictors risk factors among patients undergoing gastro-duodenal fibroscopy at the Centre Medical, la Cathédrale of Yaoundé. Methods: A facility-based descriptive cross-sectional study involving 147 patients was conducted from October 2015 to April 2016. A structured questionnaire was used to collect information on socio-demographic factors and predictors of H. pylori infection. Gastric biopsies specimens were collected from the antrum and corpus using an Olympus GIF – Q30 fully immersible gastroscope respectively. The biopsies were screened for the presence of H. pylori by targeting the glmM gene using polymerase chain reaction (PCR). Statistical analysis was performed using SPSS v. 20 with p-value<0.05 considered statistically significant. Results: The mean age was 47.19 ±16.64 years and female were more represented with 88/147 (59.8%) versus (vs.) 59/147(40.1%) for male. The overall prevalence of H. pylori infection was 50/147 (34.01%; 95% CI: 26.41% - 42.28%). The prevalence of H. pylori infection was 22/59 (37.29%) in male vs. 28/88 (31.82%) in female and this prevalence increased with age and peaked among 30-50 years. Bivariate logistic regression analysis identified that, the regional group, particularly the Centre region (OR 2.55, p= 0.007) and West region (OR 2.67, p=0.005), the level of education (OR 1.18, p=0.001), source of income (OR 0.95, p=0.004), and alcohol consumption (OR 1.41, p=0.0001) were predictors risk factors of H. pylori infection. Conclusions: Our findings indicate a relatively high prevalence of H. pylori infection in Yaoundé. Factors such as regional group, level of education, source of income, and alcohol consumption predisposed the subjects to H. pylori infection.

scholarly journals Pola makan suku asli Papua dan non-Papua sebagai faktor risiko kejadian hipertensi

2014 ◽  
Vol 10 (4) ◽  
pp. 198
Author(s):  
Sarni Rante Allo Bela ◽  
Bambang Djarwoto ◽  
I Made Alit Gunawan
Keyword(s):  
Risk Factors ◽  
Alcohol Consumption ◽  
Sodium Intake ◽  
Health Sector ◽  
Fat Intake ◽  
Chi Square ◽  
Excessive Alcohol Consumption ◽  
High Sodium ◽  
Potassium Intake ◽  
Excessive Alcohol

Background: Hypertension is one of the problems in the medical and public health sector. The prevalence of hypertension in Jayapura City is 23,8%. Hypertensive disease was ranked 6th among the top 10 diseases in Abepura Hospital. The risk factors, a diet containing high fat, high sodium, low potassium and excessive alcohol consumption has contributed to the increasing of blood pressure.Objective: To determine the degree of hypertension difference between Papuans and non-Papuans, and the effect of intake of fat, sodium, potassium and alcohol consumption as risk factors for hypertension in each tribe.Method: The study was an observational analytic with a case-control design. Samples are 248 which is divided in 62 cases and 62 controls on each tribe. Data analysis using the statistical independent t-test, Chi-Square, Mantel Haenzel, Multiple Regression Logistic.Results: Non-Papuan tribes had 1.9 times higher risk of hypertension stage 2. The fat intake of indigenous Papuans (OR=3.250) and non-Papuans (OR=3.275) correlated significantly. Sodium intake significantly associated in indigenous Papuans, but the non-Papuans, have a significant relation (OR=2.531). There was a correlation between potassium intake in indigenous Papuans (OR=2.348), but the non-Papuans, was not. Consumption of alcohol in indigenous Papuans was significantly associated (OR=2.343), but the non-Papuans, was not. Multivariate analysis showed that psychosocial stress, consumption of alcohol, family history of hypertension, and potassium intake were contributing in indigenous Papuans. Intake of fat, sodium intake, and obesity was contributed in non-Papuan tribes. Conclusion: Non-Papuan tribes prone to has hypertension stage 2. In Papuans, fat intake (> 30%), potassium intake (<2000 mg) and excessive alcohol (≥ 2 glasses/day) are risk factors. In the non-Papuan, fat intake (> 30%) and sodium intake (≥ 2300 mg) are risk factors for hypertension.

scholarly journals Risk factors and clinical features of recurrent stroke in the Tyva Republic

2014 ◽  
Vol 95 (2) ◽  
pp. 199-202
Author(s):  
Kh D Mongush ◽  
A B Ondar ◽  
R Ch Chylbak-ool ◽  
M B Balchir ◽  
Ch O Mongush
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Alcohol Consumption ◽  
Arterial Hypertension ◽  
Recurrent Stroke ◽  
Excessive Alcohol Consumption ◽  
Stroke Group ◽  
History Of ◽  
Excessive Alcohol ◽  
Male Patients

Aim. To determine risk factors and clinical features of the recurrent stroke. Methods. A prospective 3-year cohort study was conducted including 120 patients with stroke admitted to the neurological department of the Republican Hospital №1 of Kyzyl at 2010-2012, 60 of whom had recurrent stroke (group 1), and 60 had primary stroke (group 2). Results. Recurrent stroke was by 16.66% more common in men. The mean age of males having recurrent stroke was younger compared to females (р 0.05). Patients with family history of arterial hypertension in closest relatives were significantly more prevalent among those with recurrent stroke (70 versus 35%, p 0.05). The rate of excessive alcohol consumption was also significantly higher in patients with recurrent stroke (18.33 versus 6.67%, p 0.05). Mortality associated with the recurrent stroke was higher in males of all age groups, difference was statistically significant in male patients over 70 years of age (p 0.05). Combined first 28-day mortality was 26.67% (32 cases), and was higher in patients with primary stroke (p 0.05). Only 21.67% of patients took antihypertensives regularly prior to the primary stroke, among patients with recurrent stroke this share reached 70%. Antiplatelet drugs were taken by 5% of patients prior to the primary stroke, in patients who suffered the stroke the share was higher and reached 53.33%. Conclusion. Family history of arterial hypertension was the most important risk factor for recurrent stroke. Male patients had higher risks of recurrent stroke and fatal outcome, which may be associated with lower drug compliance (including antiplatelet drugs and anticoagulants, antihypertensives) and higher exposure to other risk factors (smoking, excessive alcohol consumption).

scholarly journals Absence of Helicobacter pylori is not protective against peptic ulcer bleeding in elderly on offending agents: lessons from an exceptionally low prevalence population

2013 ◽  
Author(s):  
Yeong Yeh Lee ◽  
Nordin Noridah ◽  
Syed Abdul Aziz Syed Hassan ◽  
Jayaram Menon
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Hospital Mortality ◽  
Ulcer Bleeding ◽  
Recurrent Bleeding ◽  
Gi Bleeding ◽  
Peptic Ulcer Bleeding ◽  
H Pylori ◽  
Risk For Bleeding

Aim Helicobacter pylori (H. pylori) infection is exceptionally rare in population from the north-eastern region of Peninsular Malaysia. This provides us an opportunity to contemplate the future without H. pylori in acute non-variceal upper gastrointestinal (GI) bleeding.Methods All prospective cases in the GI database registry with GI bleeding between 2003 and 2006 were reviewed. Cases with confirmed non-variceal aetiology were analysed. Rockall score > 5 was considered high risk for bleeding and primary outcomes studied were in-hospital mortality, recurrent bleeding and need for surgery. Results The incidence of non-variceal upper GI bleeding was 2.2/100,000 person-years. Peptic ulcer bleeding was the most common aetiology (1.8/100,000 person-years). In-hospital mortality (3.6%), recurrent bleeding (9.6%) and need for surgery (4.0%) were uncommon in this population with a largely low risk score (85.2% with score ≤ 5). Elderly were at greater risk for bleeding (mean 68.5 years, P = 0.01) especially in the presence of duodenal ulcers (P = 0.04) despite gastric ulcers being more common. NSAIDs (34%) and aspirin (22.8%) were the main risk factors. Conclusions The absence of H. pylori infection may not reduce the risk of peptic ulcer bleeding in the presence of risk factors especially offending drugs in the elderly.

scholarly journals Absence of Helicobacter pylori is not protective against peptic ulcer bleeding in elderly on offending agents: lessons from an exceptionally low prevalence population

2013 ◽  
Author(s):  
Yeong Yeh Lee ◽  
Nordin Noridah ◽  
Syed Abdul Aziz Syed Hassan ◽  
Jayaram Menon
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Hospital Mortality ◽  
Ulcer Bleeding ◽  
Recurrent Bleeding ◽  
Gi Bleeding ◽  
Peptic Ulcer Bleeding ◽  
H Pylori ◽  
Risk For Bleeding

Aim Helicobacter pylori (H. pylori) infection is exceptionally rare in population from the north-eastern region of Peninsular Malaysia. This provides us an opportunity to contemplate the future without H. pylori in acute non-variceal upper gastrointestinal (GI) bleeding.Methods All prospective cases in the GI database registry with GI bleeding between 2003 and 2006 were reviewed. Cases with confirmed non-variceal aetiology were analysed. Rockall score > 5 was considered high risk for bleeding and primary outcomes studied were in-hospital mortality, recurrent bleeding and need for surgery. Results The incidence of non-variceal upper GI bleeding was 2.2/100,000 person-years. Peptic ulcer bleeding was the most common aetiology (1.8/100,000 person-years). In-hospital mortality (3.6%), recurrent bleeding (9.6%) and need for surgery (4.0%) were uncommon in this population with a largely low risk score (85.2% with score ≤ 5). Elderly were at greater risk for bleeding (mean 68.5 years, P = 0.01) especially in the presence of duodenal ulcers (P = 0.04) despite gastric ulcers being more common. NSAIDs (34%) and aspirin (22.8%) were the main risk factors. Conclusions The absence of H. pylori infection may not reduce the risk of peptic ulcer bleeding in the presence of risk factors especially offending drugs in the elderly.

scholarly journals 378. Seroprevalence of Helicobacter pylori among HIV-Infected Patients in a Tertiary Care Hospital in Busan, South Korea

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S197-S197
Author(s):  
Jeong Eun Lee ◽  
Sun Hee Lee ◽  
Shinwon Lee ◽  
Kye-Hyung Kim ◽  
Soon Ok Lee
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Alcohol Consumption ◽  
South Korea ◽  
Cell Count ◽  
Care Hospital ◽  
Cd4 Cell Count ◽  
H Pylori ◽  
Cd4 Cell

Abstract Background As human immunodeficiency virus (HIV) management has become more successful during the past years, the importance of non-AIDS-defining cancer such as gastric cancer has increased. Gastric cancer is the second most common cancer, and the third leading cause of cancer-related deaths in South Korea. Chronic inflammation of the gastric mucosa with Helicobacter pylori (H. pylori) is associated with gastric cancer, the highest incidence of which is observed in South Korea. The objective of this study was to evaluate the seroprevalence and risk factors of H. pylori infection in Korean HIV-infected patients. Methods In a hospital-based survey, HIV-infected patients attending Outpatient Department of Pusan National University Hospital were enrolled between October 2018 and January 2019. Socio-demographic information was evaluated using questionnaires, serological status of H. pylori infection was tested with commercial H. pylori serology kits (Helicobacter pylori IgG ELISA, IBL, Germany). Results A total of 302 patients were included in the study. Two hundred and Sixty-one patients (86.4%) were males and 41 (13.6%) were females. Their median age was 54 years (range, 23–81 years), median CD4+ count was 667 /μL (7–1,699 /μL). The overall seropositivity of H. pylori in HIV-infected patients was 30.1%. Age-specific seroprevalence was as follows: 20–29 years, 12.5%; 30–39 years, 15.6%; 40–49 years, 38.6%; 50–59 years, 36.2%; 60–69 years, 27.9%; and ≥70 years, 18.2%. A lower seroprevalence of H. pylori was observed among patients younger than 40 years; however, it was not significant (P = 0.063). The risk factors associated with H. pylori seropositivity were alcohol consumption [adjusted odds ratio (OR): 1.99, 95% confidence interval (CI): 1.17 to 3.39; P = 0.011] and CD4 cell count ≥350/μL (OR = 4.32; 95% CI 1.51–12.36; P = 0.006). Conclusion HIV-infected patients had a lower seroprevalence of H. pylori compared with general population (30.1% vs. 49.1%). Alcohol consumption and CD4 cell count ≥350/μL were significantly associated with H. pylori seropositivity. Disclosures All authors: No reported disclosures.

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