scholarly journals Utilization pattern of blood and its components in a tertiary care super speciality hospital

2020 ◽  
Vol 7 (11) ◽  
pp. 4526
Author(s):  
Anjali Handa ◽  
Sunita Bundas ◽  
Ashok Pal
Keyword(s):  
Blood Transfusion ◽  
Whole Blood ◽  
Health Care Services ◽  
Blood Donation ◽  
Human Life ◽  
Tertiary Care ◽  
Blood Component ◽  
Blood Components ◽  
Periodic Review ◽  
Utilization Pattern

Background: Blood is the most precious gift for human life. Blood transfusion services play a vital role in managing health care services. There is no substitute for blood and its components till date, therefore blood donation drive is very crucial. The primary responsibility of blood transfusion services is to provide safe, sufficient and timely supply of blood and blood products. There has been shift for usage of blood and blood components from the use of whole blood so that maximum utilization of this precious resource could be done. Aim and objectives was to study pattern of utilization of blood and blood components in a super speciality hospital with the indications for transfusions for different components during the study period.Methods: This retrospective study for 12 months (January 2019- December 2 019) on pattern of utilization of blood components was carried out in the department of immunohaematology and transfusion medicine in a super speciality hospital.Results: There were total of 90237 transfusions which were carried out during the study period of 12 months. During the study period, 366 stored whole blood units, 55300 Packed RBC units, 19111 FFP units, 14298 Random Donor Platelet units, 1119 single donor platelets and 43 cryoprecipitate units were issued for use in patients admitted to our hospital.Conclusions: Periodic review and audit of blood component usage becomes essential to assess the blood utilization pattern in any hospital.  

scholarly journals Pattern of blood component cross-matching and their utilization in a tertiary care hospital of Jammu region

2018 ◽  
Vol 6 (4) ◽  
pp. 1337 ◽  
Author(s):  
Irm Yasmeen ◽  
Ibrar Ahmed ◽  
Meena Sidhu
Keyword(s):  
Whole Blood ◽  
Tertiary Care ◽  
Blood Component ◽  
Care Hospital ◽  
Blood Components ◽  
Cross Sectional ◽  
Inappropriate Use ◽  
Wide Range ◽  
Surgical Conditions ◽  
Cross Matching

Background: Transfusion of donated blood remains the mainstay of treatment for a wide range of medical and surgical conditions. Although it can save life, but transfusion of blood is not without risk. Clinicians should cautiously assess the appropriateness of indications before requesting various blood components thereby preventing misuse of blood and unnecessary exposure of patient to various transfusion transmitted infections and antibodies production. This study was conducted to determine the pattern of whole blood (WB) and blood component cross-matching and their utilization and to minimize the inappropriate use of blood and its components.Methods: This cross-sectional prospective study was performed at SMGS Hospital Blood Bank, Jammu from April 2016 to September 2016. The requisition forms were analysed at the reception counter and inside the pre-transfusion testing laboratory for any error. The department wise utilization of blood and its components, Crossmatching to transfusion (C/T) ratio, transfusion probability (T%) and transfusion index (TI) were calculated.Results: A total of 14376 requests for cross-matching of blood and its components were received. All the units were cross-matched. Out of these, 12766(88.8%) units of blood and its components were issued to various departments. The most common indication for using packed red cells and whole blood was anemia and bleeding (APH/PPH/Trauma). The total C/T Ratio, transfusion probability (T%) and Transfusion index(TI)  of various blood components were 1.12:1, 88.8% and 0.88 respectively.Conclusions: Our study indicates efficient usage of blood and its component. However, awareness is still needed amongst the clinicians and residents to ensure the appropriate use of blood and its components in the future as well. Hospital transfusion committee has to develop transfusion guidelines and subsequent implementation of such guidelines to assure effective blood utilization. MSBOS (maximum surgical blood ordering schedule) should be formulated for elective procedures with regular auditing, feedback, and modifications to improve blood ordering and utilization.

scholarly journals A study to assess the knowledge regarding blood donation among general population attending primary health centre of Dhawa, Jodhpur, Rajasthan

2021 ◽  
Vol 8 (8) ◽  
pp. 3909
Author(s):  
Vandna Pandey ◽  
Nancy Kurien ◽  
Krishna Kumari ◽  
Lata Garg ◽  
Manisha Yadav ◽  
...  
Keyword(s):  
General Population ◽  
Blood Transfusion ◽  
Blood Donation ◽  
Care Delivery ◽  
Human Life ◽  
Health Centre ◽  
Essential Element ◽  
Blood Component ◽  
Research Approach ◽  
Primary Health

Background: Human blood is an essential element of the human life and there is no substitute for it. Blood donation save lives during critical situation but several thousands of patients who need blood transfusion do not receive timely access to safe blood. Today, blood transfusion services constitute a crucial part of any health care delivery system. Adequate and safe supply of blood and blood component is essential.Methods: Present study has been carried out among general population of community attending primary health center. Quantitative research approach was used to assess the knowledge regarding blood donation. Data was collected through self-structured knowledge questionnaire. Sixty samples were selected by non-probability convenient sampling technique.Results: In the study there were 60 subjects, in which male were 33(55%) and female were 27(45%). Ten subjects had excellent knowledge, 21 subjects had good knowledge, 20 subjects had average knowledge and 9 subjects had poor knowledge. Statistically significant association was found between knowledge score and selected demographic variables (i.e., gender and occupation) at p<0.05 level of significance.Conclusions: The study indicates that awareness session on blood donation should be held regularly to improve the knowledge and create positive attitude and remove the misconception among general population about blood donation. 

scholarly journals Donor Hemovigilance Programme in managing Blood Transfusion Needs: Complications of Whole Blood Donation

2013 ◽  
Vol 3 (6) ◽  
pp. 459-463 ◽  
Author(s):  
S Mangwana
Keyword(s):  
Blood Transfusion ◽  
Adverse Effects ◽  
Adverse Events ◽  
Whole Blood ◽  
Blood Donors ◽  
Blood Donation ◽  
Tertiary Care ◽  
Care Hospital ◽  
Blood Donations ◽  
Vasovagal Reactions

Background: Hemovigilance like quality systems and audits have become an integral part of Blood Transfusion Services in the developed countries and has contributed greatly to its development. Hemovigilance begins with donors and must enable the collection of information on reactions occurring during the donation of blood, selections of donors and to prevent such incidents. The aim of study was to help identify the trends of adverse events , occurring in blood donors at a tertiary-care hospital, to recommend best practices to improve donor care and safety Materials and Methods: This record-based study was conducted on all adverse events related to allogenic whole blood donations performed over 24 months. All whole blood donations were analyzed. All adverse events occurring during or at the end of the donation were noted using a standardized format and analyzed determining significance at p<0.05. Results: Overall rate was 0.3% with vasovagal reactions constituting 82%, and 18% mild syncopal reactions (p<0.001). Immediate vasovagal reaction with injury was very rare (0.007%). Vasovagal reactions showed a significant association with young age, female gender, first time donation status. Mean age of persons recording adverse effects was 30.23 ± 7.49 years as compared to those without adverse effects, 31.14 ± 8.56 years. Conclusion: Donor safety is an essential perquisite to increase voluntary blood donation. AE analysis helps in identifying the blood donors at risk of AE, applying appropriate motivational strategies, predonation counseling, care during and after donation, developing guidelines and hemovigilance programme in countries with limited resources. DOI: http://dx.doi.org/10.3126/jpn.v3i6.8993   Journal of Pathology of Nepal (2013) Vol. 3, 459-463

scholarly journals Blood Transfusion Requests: An Audit in a Blood Transfusion Wing of a Referral Laboratory

2019 ◽  
Vol 11 (2) ◽  
pp. 3-6 ◽  
Author(s):  
Md Mizanur Rahman ◽  
Debashish Saha ◽  
Susitra Saha ◽  
SM Mahbubul Alam ◽  
Susane Giti
Keyword(s):  
Blood Transfusion ◽  
Whole Blood ◽  
Platelet Rich Plasma ◽  
Demographic Data ◽  
Supportive Therapy ◽  
Armed Forces ◽  
Fresh Frozen Plasma ◽  
Blood Component ◽  
Blood Components ◽  
Cross Match

Introduction: Transfusion of blood and its components such as Packed Red Cell (PRC), Platelet Rich Plasma (PRP) and Fresh Frozen Plasma (FFP) play an important role as a supportive therapy in patients admitted to a hospital. Objective: To conduct an audit of blood transfusion requests regarding demographic data of the recipients, the component therapy, blood groups of the issued units, cross-match transfusion ratio, expiry of the transfusion units, pattern of blood components usage and transfusion reaction for which blood was returned back to blood bank. Materials and Methods: This retrospective crosssectional study was conducted at the transfusion wing of a referral laboratory over a period of three months from January 2013 to March 2013 upon 3015 episodes of transfusion units of whole blood and different blood components. Results: Out of total 3015 episodes of transfusion unit in 1926 recipients, 930 were male and 996 female. About 41.0% requests of transfusion units received from the department of Obstetrics and Gynaecology (OBG) followed by the department of Surgery of about 28.7%. The most commonly used transfusion units was whole blood (55.3%) followed by platelet rich plasma (27.2%). Most of the recipients (62.3%) received single transfusion units and 37.7% recipients of ≥2 units. Out of 3769 cross-match, 3015 transfusion units were issued. In 12 (0.4%) cases, there were minor febrile and allergic reactions. During the study period, shelf life of six transfusion units had expired. Conclusion: This study suggests that either systems audit or medical practice audit of blood and blood component orders can help to reduce the inappropriate or indiscriminate transfusions and may be an important educational tool for the ordering physicians as well as for residents in training Journal of Armed Forces Medical College Bangladesh Vol.11(2) 2015: 3-6

The physiology of blood in anaesthetic practice

2017 ◽  
Author(s):  
Hanane El Kenz ◽  
Philippe Van der Linden
Keyword(s):  
Blood Transfusion ◽  
Whole Blood ◽  
Fresh Frozen Plasma ◽  
Blood Component ◽  
Blood Components ◽  
Pathogen Inactivation ◽  
Septic Complications ◽  
Packed Red Blood Cells ◽  
Blood Component Therapy ◽  
Fresh Frozen

Following the discovery of the ABO blood groups by Landsteiner in 1901, Albert Hustin described the first transfusion of a whole blood unit in 1914. The modern transfusion era really begins in 1916 with the discovery of sodium citrate as an anticoagulant by the same physician, allowing blood conservation in dedicated packs. Since that time, many advances have been made especially over the past two decades in the storage, the conservation, and the laboratory testing of blood components and in transfusion medicine practice. Transfusion of whole blood has been replaced by blood component therapy, which consists of the administration of packed red blood cells, fresh frozen plasma, or platelets. Although blood transfusion is safer than ever, the risk of complications will never reach zero. The risk of infectious transfusion-transmitted diseases has been markedly reduced by the implementation of extensive infectious disease testing, donor selection, and pathogen-inactivation procedures. In countries with a high human development index, the leading causes of allogeneic blood transfusion-related deaths actually resulted from immunological and septic complications. The first section of this chapter describes the structure, function, and immunological aspects of the different blood components that are routinely transfused today. The second section details the composition of the different blood components, their indications, the pre-transfusion compatibility tests, and the main adverse effects associated with their transfusion.

scholarly journals Analysis of blood transfusion request and utilization pattern at teaching hospital in Eastern Nepal

2018 ◽  
Vol 8 (2) ◽  
pp. 1374-1377 ◽  
Author(s):  
Santosh Upadhyaya Kafle ◽  
Krishna Kumar Jha ◽  
Mrinalini Singh ◽  
Shilpi Shaukin
Keyword(s):  
Blood Transfusion ◽  
Blood Group ◽  
Teaching Hospital ◽  
Whole Blood ◽  
Age Group ◽  
Utilization Pattern ◽  
Total Blood ◽  
Cross Sectional ◽  
Male And Female ◽  
Gynecology And Obstetrics

Background: Blood transfusion unit collection, storage and dispatching on Birat Medical College and Teaching Hospital began from 19 June 2016 via blood bank. After which, many blood distribution were made accessible via this service. This study analyzes the blood transfusion request and utilization pattern and also to monitor for managing the bloodstocks meeting present and future demand in hospital. Materials and Methods: This is descriptive cross-sectional study conducted for all the requests of whole blood dispatched from 19th June, 2016 to 04th July, 2018. Whole blood requisitions from various departments were reviewed regarding the number of requisition, total blood unit replaced, blood group and socio-demographic profile of patients.Results: Of 648 transfusion units dispatched, 131 and 324 patients were male and female respectively, B positive blood group were most common, followed by A positive, O positive, AB positive, A negative, O negative and AB negative respectively. The largest numbers of requisitions were from Gynecology and Obstetric department in the hospital of 258 requisitions followed by internal medicine, surgery department, postoperative ward and orthopaedic department. Majority of the requisitions were for 20-29 years age group from the local district Morang. The total blood units replaced were 75, of which 29 and 46 of male and female respectively. Conclusions: B Positive was the predominant requested blood group with Gynecology and Obstetrics department making the most requests, among 20-29 years age group from Morang district. The total replaced blood units were less in number with some requisition forms even lacked essential details.

scholarly journals 1792. Viral DNA Loads in Various Blood Components of Patients with EBV-Positive T/NK Cell Lymphoproliferative Diseases

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S660-S661
Author(s):  
Jun-ichi Kawada ◽  
Yasuko Kamiya ◽  
Akihisa Sawada ◽  
Keiji Iwatsuki ◽  
Koji Izustu ◽  
...  
Keyword(s):  
Disease Activity ◽  
Infectious Mononucleosis ◽  
Whole Blood ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Nk Cell ◽  
Inactive Disease ◽  
Blood Component ◽  
Blood Components ◽  
Ebv Dna

Abstract Background Epstein–Barr virus (EBV) is associated with T- and NK-cell lymphoproliferative disorders (EBV T/NK-LPD). For diagnosis of EBV T/NK-LPD, quantification of EBV DNA loads in peripheral blood by real-time PCR has been widely used. However, optimal blood components and cut-off values for diagnosis were not fully evaluated. Methods Fifty-nine patients with EBV T/NK-LPD including chronic active EBV infection (CAEBV), severe mosquito bite allergy, hydroa vacciniforme-like lymphoproliferative disorder (HV), and EBV- hemophagocytic lymphohistiocytosis (EBV-HLH) were enrolled. EBV DNA loads were compared among disease categories in each blood component from the same whole blood sample. The association between EBV DNA loads and disease activity were evaluated in CAEBV patients. Furthermore, the diagnostic cut-off value for EBV DNA loads in whole blood from CAEBV patients as compared with infectious mononucleosis patients was determined. Results EBV DNA loads in whole blood and peripheral blood mononuclear cells (PBMCs) were not significantly different among disease categories, whereas EBV DNA loads in plasma were significantly higher in EBV- HLH patients than in HV patients. EBV DNA loads in whole blood and PBMCs showed strong correlation (Figure 1). EBV DNA loads in plasma were significantly higher in CAEBV patients with active disease than in those with inactive disease (median: 104.5 IU/mL vs. 100.8 IU/mL, P < 0.001) (Figure 2). Diagnostic cut-off values for whole blood EBV DNA loads of CAEBV patients as compared with those of infectious mononucleosis was 104.2 ( = 15,800) IU/mL (Figure 3). Conclusion Measuring EBV DNA loads in whole blood can be considered as initial evaluation for diagnosis of EBV T/NK-LPD. EBV DNA loads in plasma are more closely related to disease activity of CAEBV than EBV DNA loads in whole blood and PBMCs. Disclosures All authors: No reported disclosures.

scholarly journals Pattern of utilization of blood and blood components in obstetrics at tertiary care hospital

2017 ◽  
Vol 6 (10) ◽  
pp. 4671
Author(s):  
Vidyadhar Bangal Bangal ◽  
Satyajit P. Gavhane ◽  
Kunal H. Aher ◽  
Dhruval K. Bhavsar ◽  
Priyanka R. Verma ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Blood Donation ◽  
Tertiary Care ◽  
Severe Anaemia ◽  
Blood Bank ◽  
Care Hospital ◽  
Obstetric Haemorrhage ◽  
Obstetric Emergencies ◽  
The Common ◽  
Health Institutions

Background: Obstetric emergencies occur suddenly and unexpectedly. Blood transfusion becomes one of the live saving measures in such situations. Severe anaemia due to nutritional deficiency, obstetric haemorrhage either during pregnancy, labour or in postpartum period are the commonest indications for blood transfusion worldwide. Blood bank services play important role in saving lives in obstetric emergencies. Health institutions must carry out internal blood transfusion audits to reassure optimal and judicious use of blood and blood components.Methods: Analysis of 755 Obstetric patients requiring blood transfusion in eighteen months period was done to find out the incidence and indications for blood transfusion at tertiary care hospital.Results: Overall, 5.33% of obstetric admissions required transfusion of blood or its components. Severe anaemia (36.55%), accidental haemorrhage (20.92%), postpartum haemorrhage (8.34%), placenta praevia (5.03%) and caesarean section (10.33%) were the common indications for blood transfusion. In more than 65% cases, two or three unit of blood were transfused. In majority of cases (96%) components were used.Conclusions: Blood transfusion helped to save many lives in the present study. Severe anaemia and obstetric haemorrhage of varied aetiology were the common indications for blood transfusion. Component therapy helped to correct specific deficiency. Voluntary blood donation should be encouraged in the younger generation to keep adequate stock of blood in blood bank for emergency use. Preventive measures like improving dietary iron intake and prophylactic iron therapy will go a long way in reducing the need for blood transfusion in Obstetrics.

scholarly journals Analysis of Reasons for Discard of Blood and Blood Components in a Tertiary Care Hospital in South India

2020 ◽  
Vol 7 (9) ◽  
pp. A478-482
Author(s):  
Deepika Mani ◽  
Megala C ◽  
Thamil Selvi R
Keyword(s):  
Blood Transfusion ◽  
Care Delivery ◽  
Tertiary Care ◽  
Health Care Delivery System ◽  
Fresh Frozen Plasma ◽  
Care Hospital ◽  
Blood Components ◽  
Expiry Date ◽  
Emergency Situations ◽  
Safe Blood

Background: Blood transfusion is an important and essential constituent of present health-care delivery system. Millions of lives are saved every year in regular and emergency situations by the accessibility of safe blood transfusion services. This emphasizes the need for proper utilization of blood and its components with preferably “NO” or minimal wastage. The aim of this study was to find out causes for discarding blood and blood components.   Methods: Retrospective analysis was carried out at Vinayaka Missions Medical College and Hospital Blood Bank from October 1st, 2018 to October 31st, 2019.   Results: The total number of donors from whom blood was collected during this study period was 2522. Out of which 2507 units of components were prepared. The overall discard rate of blood and its components was 5.95%. Among those 5 (33.33%) whole blood, 28 (1.25%) packed red blood cell concentrate, 93 (4.16%) fresh frozen plasma, 157 (57.51%) platelet concentrate were discarded. The common causes of discarding blood components were due to expiry date 211 (74.56%), 30 (10.60%) were due to sero-reactivity for transfusion transmitted infections, 23 (8.13%) due to leakage of components, 13 (4.59%) due to low volume and other causes were 6 (2.12%).   Conclusion: Blood being irreplaceable source, discard rate can be reduced by proper counselling of blood donors, conducting donor screening, adhering to strict donor deferral criteria, notification and counselling of permanently deferred donors. Properly implementing blood transfusion policies will help to utilize the blood components in a proper way, thus resulting in discarding a smaller number of blood bags due to expiry. Continued medical education for technicians with regards to maintenance of proper stock, quality indicators, review of blood management system will further help in reducing discard rate.

scholarly journals Whole blood transfusion improves vascular integrity and increases survival in artemether-treated experimental cerebral malaria

2021 ◽  
Author(s):  
Saba Gul ◽  
Flavia L. Ribeiro-Gomes ◽  
Aline S. Moreira ◽  
Guilherme S. Sanches ◽  
Fabiana G. Conceição ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Cerebral Malaria ◽  
Whole Blood ◽  
Plasmodium Berghei ◽  
Severe Thrombocytopenia ◽  
Blood Components ◽  
Vascular Integrity ◽  
Experimental Cerebral Malaria ◽  
Angiopoietin 2 ◽  
Lymphocyte Populations

Abstract Pathological features observed in both human and experimental cerebral malaria (ECM) are endothelial dysfunction and changes in blood components. Blood transfusion has been routinely used in patients with severe malarial anemia and can also benefit comatose and acidotic malaria patients. In present study Plasmodium berghei-infected mice were transfused intraperitoneally with 200 µL of whole blood along with 20 mg/kg of artemether. ECM mice showed severe thrombocytopenia and decreases in hematocrit. Artemether treatment markedly aggravated anemia within 24 hours. Whole blood administration significantly prevented further drop in hematocrit and partially restored the platelet count. Increased levels of plasma angiopoietin-2 (Ang-2) remained high 24 hours after artemether treatment but returned to normal levels 24 hours after blood transfusion, indicating reversal to quiescence. Ang-1 was depleted in ECM mice and levels were not restored by any treatment. Blood transfusion prevented the aggravation of the breakdown of blood brain barrier after artemether treatment and decreased spleen congestion without affecting splenic lymphocyte populations. Critically, blood transfusion resulted in markedly improved survival of mice with ECM (75.9% compared to 50.9% receiving artemether only). These findings indicate that whole blood transfusion can be an effective adjuvant therapy for cerebral malaria.

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