scholarly journals Sero prevalence of SARS-CoV-2 in general population of Nagpur district

2021 ◽  
Vol 8 (8) ◽  
pp. 3952
Author(s):  
Sarita K. Sharma ◽  
Pragati G. Rathod ◽  
Ujwala U. Ukey ◽  
Uday W. Narlawar ◽  
Sanjay Zodpey
Keyword(s):  
Venous Blood ◽  
Population Level ◽  
Epidemiological Studies ◽  
Population Based ◽  
Cross Sectional Study ◽  
Mitigation Measures ◽  
Cross Sectional ◽  
Background Population ◽  
Nagpur District ◽  
Spread Of Infection

Background: Population based sero-epidemiological studies help us to determine the burden of COVID-19 infection at the community level and to monitor the trends in transmission of SARS-CoV-2 infection. Antibody based sero-positivity indicates the extent of spread of infection in the given population and forms the basis for strengthening public health mitigation measures. The present study was carried out with the objective of conducting population level serosurvey in Nagpur district to understand the spread of SARS-CoV-2 and to help the designing and implementation of appropriate health system and policy level interventions. This cross-sectional study was carried out in Nagpur District over two weeks in October and November 2020. For the purpose of this survey the Nagpur district was divided into NMC area and Non NMC area.Methods: House to house survey was carried out and data was collected using Google form. For detection of SARS-CoV-2 specific antibodies venous blood was collected from each participant and electrochemiluminescence immunoassay was performed. The data was cleaned, coded and analysed using EPI INFO.Results: The total seroprevalence in Nagpur district was found to be 35.17 %. The seroprevalance in NMC area was 49.7% which was more than twice from that of Non NMC area (20.7%).Conclusions: Considerably large numbers of infections are asymptomatic, however a sizeable proportion of population is still susceptible to the infection and thus there is no time for complacency.

scholarly journals Very high relative seroprevalence of anti-SARS-CoV-2 antibodies among communities in Bangui, Central African Republic

2021 ◽  
Author(s):  
Alexandre Manirakiza ◽  
Christian Malaka ◽  
Brice Martial Yambiyo ◽  
Saint Calver Henri Diemer ◽  
Jean de Dieu Longo ◽  
...  
Keyword(s):  
Large Scale ◽  
Central African Republic ◽  
Venous Blood ◽  
Population Level ◽  
Significant Degree ◽  
Population Based ◽  
Cross Sectional Study ◽  
Individual Characteristics ◽  
Cross Sectional ◽  
High Level

Background: Large-scale population-based seroprevalence studies of SARS-CoV-2 are essential to characterize the cumulative incidence of SARS-CoV-2 infection and to extrapolate the prevalence of presumptive immunity at the population level. Objective: The objective of our survey was to estimate the cumulative population immunity for COVID-19 and to identify individual characteristics associated with a positive serostatus. Method: This was a clustered cross-sectional study conducted from July 12 to August 20, 2021, in households in the city of Bangui, the capital of the Central African Republic. Information regarding demographic characteristics (age, gender, and place of residence), comorbidities (chronic diseases) was collected. A venous blood sample was obtained for each participant to determine the level of total anti-SARS-CoV-2 antibodies using a WANTAI SARS-CoV-2 Ab ELISA kit. Results: All up, 799 participants were surveyed. The average age was 27 years, and 45.8% of the respondents were male (sex ratio: 0.8). The overall proportion of respondents with a positive serostatus was 74.1%. Participants over 20 years of age were twice as likely to have a positive serostatus, with an OR of 2.2 (95% CI: [1.6, 3.1]). Interpretation: The results of this survey revealed a high cumulative level of immunity in Bangui, thus indicating a significant degree of spread of SARS-CoV-2 in the population. The public health implications of this high level of immunity to SARS-CoV-2, particularly on its variants burden, remain to be determined.

scholarly journals Prevalence of systemic lupus erythematosus in Spain: higher than previously reported in other countries?

Rheumatology ◽  
2020 ◽  
Vol 59 (9) ◽  
pp. 2556-2562 ◽  
Author(s):  
Raúl Cortés Verdú ◽  
José M Pego-Reigosa ◽  
Daniel Seoane-Mato ◽  
Mercedes Morcillo Valle ◽  
Deseada Palma Sánchez ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Adult Population ◽  
Geographical Area ◽  
Geographic Origin ◽  
The United States ◽  
Epidemiological Studies ◽  
Population Based ◽  
Cross Sectional Study ◽  
Medical Visit ◽  
Cross Sectional

Abstract Objectives Prevalence of SLE varies among studies, being influenced by study design, geographical area and ethnicity. Data about the prevalence of SLE in Spain are scarce. In the EPISER2016 study, promoted by the Spanish Society of Rheumatology, the prevalence estimate of SLE in the general adult population in Spain has been updated and its association with sociodemographic, anthropometric and lifestyle variables has been explored. Methods Population-based multicentre cross-sectional study, with multistage stratified and cluster random sampling. Participants were contacted by telephone to carry out a questionnaire for the screening of SLE. Investigating rheumatologists evaluated positive results (review of medical records and/or telephone interview, with medical visit if needed) to confirm the diagnosis. To calculate the prevalence and its 95% CI, the sample design was taken into account and weighing was calculated considering age, sex and geographic origin. Multivariate logistic regression models were defined to analyse which sociodemographic, anthropometric and lifestyle variables included in the telephone questionnaire were associated with the presence of SLE. Results 4916 subjects aged 20 years or over were included. 16.52% (812/4916) had a positive screening result for SLE. 12 cases of SLE were detected. The estimated prevalence was 0.21% (95% CI: 0.11, 0.40). SLE was more prevalent in the rural municipalities, with an odds ratio (OR) = 4.041 (95% CI: 1.216, 13.424). Conclusion The estimated prevalence of SLE in Spain is higher than that described in most international epidemiological studies, but lower than that observed in ethnic minorities in the United States or the United Kingdom.

Edinburgh Vein Study: Methods and Response in a Survey of Venous Disease in the General Population

1997 ◽  
Vol 12 (4) ◽  
pp. 127-135 ◽  
Author(s):  
C J. Evans ◽  
F. G. R. Fowkes ◽  
C. V. Ruckley ◽  
P. L. Allan ◽  
M. N. Carson ◽  
...  
Keyword(s):  
General Population ◽  
Response Rate ◽  
Venous Blood ◽  
Disease Status ◽  
Epidemiological Studies ◽  
Ethnic Origin ◽  
Cross Sectional Study ◽  
Venous Disease ◽  
Cross Sectional ◽  
Study Participants

Objective: To describe the methods required to conduct a large epidemiological study of venous disease in the general population, and the resulting response. Design: Cross-sectional study. Setting: University of Edinburgh. Participants: Men and women aged 18–64 years, randomly selected from general practice registers. Methods: Subjects were invited for the following procedures: questionnaire, height and weight measurement, classification of varices and chronic venous insufficiency, duplex measurement of duration of venous reflux and venous blood sampling. A questionnaire survey of non-responders was carried out. Results of response: A total of 1566 subjects attended, a final response rate of 53.8%. The response rate increased with age. The distribution of ethnic origin and social class of attenders was similar to that of the general Edinburgh population. Study participants were generally older, from more affluent areas and more often female than non-responders ( p ≤ 0.001). Conclusions: Large epidemiological studies of venous disease in the community are feasible but the level of response illustrates the importance of obtaining information on the disease status of non-responders.

scholarly journals EFFECT OF PREANALYTICAL VARIABLES ON SERUM THYROID STIMULATING HORMONE ANALYSIS BY CHEMILUMINESCENCE METHOD

2021 ◽  
Vol 71 (Suppl-1) ◽  
pp. S102-05
Author(s):  
Ambreen Rehman ◽  
Naveed Asif ◽  
Saima Shakeel Malik ◽  
Waqas Sheikh ◽  
Quratulain . ◽  
...  
Keyword(s):  
Venous Blood ◽  
Armed Forces ◽  
Epidemiological Studies ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
P Value ◽  
Cross Sectional ◽  
Specimen Handling ◽  
Tsh Levels ◽  
Stimulating Hormone

Objective: To identify effect of pre-analytical variables on serum thyroid stimulating hormone. Study Design: Cross sectional study. Place and Duration of Study: Armed Forces Institute of Pathology (AFIP) Rawalpindi, Department of Chemical Pathology & Endocrinology, from Mar 2018 to Aug 2018. Methodology: Hundred subjects with ages ranging from 18 to 34 years, irrespective of gender, were randomly selected for this study. Five milliliters venous blood sample was collected from each subject in a serum separator and divided into two aliquots. First aliquot was centrifuged and analyzed immediately for TSH, while second aliquot was stored for 24 hours and was then analyzed. TSH was measured by third generation assay usingchemiluminescence technique on ADVIA Centaur® XP. Serum TSH levels were also analyzed twice daily; in the morning (0800 to 0900 hours) and afternoon (1400 to 1600 hours). Data was analyzed using SPSS version 24. Frequency and percentages were calculated for qualitative variables like gender and pre-analytical variables. Test of significance Mann-Whitney U-test was applied and p-value <0.05 was taken as significant. Results: Mean age of subjects was 23 ± 3.4 years. Change in circadian rhythm was observed in 17 (28%) males and 14 (36%) females. Statistically significant association was found between morning and evening TSH levels, while no change was observed in TSH level by early and late centrifugation of samples. Conclusion: TSH levels vary significantly between blood samples collected at different timings of the day from the same person. TSH is resistant to degradation, immunologically stable, and reasonably insensitive to potential problems associated with routine specimen handling, when measured by immunoassay technique. Therefore, it is helpful in large epidemiological studies and small size laboratory, which require long transportation time and storage.

scholarly journals Prevalence of intermittent claudication in rural and urban Vellore, Tamil Nadu, India: a population-based study

2018 ◽  
Vol 5 (7) ◽  
pp. 2620
Author(s):  
Manjunath Krishna ◽  
Anu M. Oommen ◽  
Jackwin Sam Paul G. ◽  
Vinod J. Abraham ◽  
Kuryan George
Keyword(s):  
Intermittent Claudication ◽  
Tobacco Use ◽  
Tamil Nadu ◽  
Population Level ◽  
Sociodemographic Factors ◽  
Population Based ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Rural And Urban ◽  
Background Population

Background: Population based estimates from India on the prevalence of Peripheral Artery Disease (PAD) are scarce. This study aimed to assess the population-based prevalence of PAD in rural and urban Vellore, Tamil Nadu, South India.Methods: A cross sectional survey was conducted using the WHO STEPS methodology and the WHO/Rose questionnaire for intermittent claudication for identifying symptomatic PAD among adults aged 30-64 years. The study was done in nine villages of one rural block and in 48 urban wards of Vellore, between 2011-12. Risk factors for PAD such as sociodemographic factors, tobacco use, anthropometry, known medical conditions, Fasting Plasma Glucose and lipid profile were also assessed and association with PAD estimated using odds ratios, chi-square tests and logistic regression.Results: Among 5429 adults aged 30-64 years, the prevalence of PAD (intermittent claudication) was 4.9/1000 (95% Confidence Interval CI: 3.0/1000 - 6.8/1000). The prevalence in urban Vellore was higher than in the rural area (6.9/1000 vs. 3.8/1000).  After adjusting for sociodemographic factors and other confounding factors, current tobacco use was found to be significantly associated with the presence of PAD (adjusted Odds Ratio: 2.89, 95% CI: 1.10-7.54).Conclusions: This study provides estimates of the burden of PAD in rural and urban adults in Vellore, Tamil Nadu. The trend of this condition needs to be monitored in various locations to assess the public health significance and the need for population level measures for diagnosis, treatment and screening. Education regarding harmful effects of tobacco use should also involve education regarding risk of PAD.

scholarly journals Are normoglycaemic individuals at risk of depression? The depression-dysglycaemic phenotype from a European population-based cross-sectional study

2019 ◽  
Author(s):  
Sarah Cuschieri ◽  
Julian Mamo
Keyword(s):  
Communicable Disease ◽  
Population Level ◽  
Female Gender ◽  
Educational Status ◽  
Population Based ◽  
Cross Sectional Study ◽  
Health Concern ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of

Abstract Background Depression is an ever more common chronic non communicable disease and its control constitutes a growing public health concern given its links with a number of co-morbidities, including diabetes mellitus. The study aimed to estimate the prevalence of depression at a population level across groups of different glycaemic status, whilst establishing its socioeconomic phenotypic characteristics.Methods A nationally representative cross-sectional study was conducted in Malta between 2014 and 2016. Participants were categorized into different sub-populations according to their glycaemic status. Depression prevalence rates and socio-economic characteristics for each sub-population were established. Multiple regression analysis was performed to identify links with depression.Results Depression was prevalent in 17.15% (CI 95%: 16.01 – 18.36) with a female predominance. The normoglycaemic sub-population had the highest depression rates. However, persons with known diabetes had a higher probability of having a history of depression (OR:2.36 CI 95%:1.12 – 4.96), as well as with being of the female gender, having lower educational status, having a history of smoking tobacco and having established cardiovascular disease.Conclusions Depression was highly prevalent among the normoglycaemic population especially as age progress. Physicians in primary care should implement a depression screening tool as part of their routine health check-ups, with special attention to those with cardiovascular co-morbidities and any signs of psycho-socio-economic burden.

scholarly journals Impact of Two Different Recruitment Procedures (Random versus Volunteer Selection) on the Results of Seroepidemiological Study (SARS-CoV-2)

2021 ◽  
Vol 18 (18) ◽  
pp. 9928
Author(s):  
Maksymilian Gajda ◽  
Małgorzata Kowalska ◽  
Jan Eugeniusz Zejda
Keyword(s):  
Selection Bias ◽  
Epidemiological Studies ◽  
Population Based ◽  
Cross Sectional Study ◽  
National Registry ◽  
Effective Control ◽  
Nasopharyngeal Swab ◽  
Willingness To Participate ◽  
Cross Sectional ◽  
Small Component

The proper recruitment of subjects for population-based epidemiological studies is critical to the external validity of the studies and, above all, to the sound and correct interpretation of the findings. Since 2020, the novel coronavirus SARS-CoV-2 pandemic has been a new factor that has been, additionally, hindering studies. Therefore, the aim of our study is to compare demographic, socio-economic, health-related characteristics and the frequency of SARS-CoV-2 infection occurrence among the randomly selected group and the group composed of volunteers. We compare two groups of participants from the cross-sectional study assessing the seroprevalence of SARS-CoV-2 coronavirus, which was conducted in autumn 2020, in three cities of the Silesian Voivodeship in Poland. The first group consisted of a randomly selected, nationally representative, age-stratified sample of subjects (1167 participants, “RG” group) and was recruited using personal invitation letters and postal addresses obtained from a national registry. The second group (4321 volunteers, “VG” group) included those who expressed their willingness to participate in response to an advertisement published in the media. Compared with RG subjects, volunteers were more often females, younger and professionally active, more often had a history of contact with a COVID-19 patient, post-contact nasopharyngeal swab, fewer comorbidities, as well as declared the occurrence of symptoms that might suggest infection with SARS-CoV-2. Additionally, in the VG group the percentage of positive IgG results and tuberculosis vaccination were higher. The findings of the study confirm that surveys limited to volunteers are biased. The presence of the bias may seriously affect and distort inference and make the generalizability of the results more than questionable. Although effective control over selection bias in surveys, including volunteers, is virtually impossible, its impact on the survey results is impossible to predict. However, whenever possible, such surveys could include a small component of a random sample to assess the presence and potential effects of selection bias.

scholarly journals Multimorbidity Patterns in the General Population: Results from the EpiChron Cohort Study

2020 ◽  
Vol 17 (12) ◽  
pp. 4242
Author(s):  
Ignatios Ioakeim-Skoufa ◽  
Beatriz Poblador-Plou ◽  
Jonás Carmona-Pírez ◽  
Jesús Díez-Manglano ◽  
Rokas Navickas ◽  
...  
Keyword(s):  
General Population ◽  
Large Scale ◽  
Musculoskeletal Diseases ◽  
Epidemiological Studies ◽  
Population Based ◽  
Cross Sectional Study ◽  
Real World Data ◽  
Cross Sectional ◽  
Complex Interactions ◽  
And Gender

The correct management of patients with multimorbidity remains one of the main challenges for healthcare systems worldwide. In this study, we analyze the existence of multimorbidity patterns in the general population based on gender and age. We conducted a cross-sectional study of individuals of all ages from the EpiChron Cohort, Spain (1,253,292 subjects), and analyzed the presence of systematic associations among chronic disease diagnoses using exploratory factor analysis. We identified and clinically described a total of 14 different multimorbidity patterns (12 in women and 12 in men), with some relevant differences in the functions of age and gender. The number and complexity of the patterns was shown to increase with age in both genders. We identified associations of circulatory diseases with respiratory disorders, chronic musculoskeletal diseases with depression and anxiety, and a very consistent pattern of conditions whose co-occurrence is known as metabolic syndrome (hypertension, diabetes, obesity, and dyslipidaemia), among others. Our results demonstrate the potential of using real-world data to conduct large-scale epidemiological studies to assess the complex interactions among chronic conditions. This could be useful in designing clinical interventions for patients with multimorbidity, as well as recommendations for healthcare professionals on how to handle these types of patients in clinical practice.

EXPRESS: What is the Median Volume of Intracerebral Hemorrhage and is it Changing?

2021 ◽  
pp. 174749302110325
Author(s):  
David Robinson ◽  
Carson Van Sanford ◽  
Soo Young Kwon ◽  
Elisheva Coleman ◽  
Padmini Sekar ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Intracerebral Hemorrhage ◽  
Temporal Trends ◽  
Clinical Trial Design ◽  
Population Level ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Risk Factor Management ◽  
Median Volume

Abstract: Objectives: Population-level estimates of the median intracerebral hemorrhage (ICH) volume would allow for the evaluation of clinical trial external validity and determination of temporal trends. We previously reported the median ICH volume in 1988. However, differences in risk factor management, neuroimaging and demographics may have affected ICH volumes. The goal of this study was to determine the median volume of ICH within a population-based cross-sectional study, including whether it has changed over time. Methods: The Genetic and Environmental Risk Factors for Hemorrhagic Stroke study was a population-based study of ICH among residents of the Greater Cincinnati/Northern Kentucky region from 2008 through 2012. The current study utilizes those data and compares with ICH cases from the same region in 1988. Initial CT images of the head were reviewed, and ICH volumes were calculated using consistent methodology. Results: From 2008 through 2012, we identified 1117 cases of ICH. The median volume of ICH was 14.0 mL and was lower in black (11.6) than in white (15.5) patients. Median volumes of lobar and deep ICH were 28·8 mL and 9.8 mL, respectively. Median ICH volume changed significantly from 1988 to 2008-2012, with age-and-race adjusted volume decreasing from 18.3 mL to 13.76 mL (p=0.025). Conclusions: Median volume of ICH was 13.76 mL, and this should be considered in clinical trial design. Median ICH volume has apparently decreased from 1988 to 2008-2012.

Physical Activity Levels According to Physical and Social Environmental Factors in a Sample of Adults Living in South Brazil

2010 ◽  
Vol 7 (s2) ◽  
pp. S204-S212 ◽  
Author(s):  
Tales C. Amorim ◽  
Mario R. Azevedo ◽  
Pedro C. Hallal
Keyword(s):  
Physical Activity ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Population Level ◽  
Population Based ◽  
Cross Sectional Study ◽  
Neighborhood Environment ◽  
Activity Levels ◽  
Cross Sectional ◽  
Social Environmental

Objective:To evaluate the association between the physical and social environment and physical activity (leisure-time and transport-related) in a population-based sample of adults.Methods:Cross-sectional study including 972 adults (20−69 years) living in the urban area of Pelotas, Brazil. Physical activity was measured using the long International Physical Activity Questionnaire. Environmental variables were assessed using a modified version of the Neighborhood Environment Walkability Scale.Results:69.8% (95% CI = 66.9−72.7) and 51.9% (95% CI = 48.8−55.1) of the subjects did not reach 150 min/wk on leisure-time and transport-related physical activity, respectively. Subjects living near green areas were more likely to be active in leisure-time, as well as those who reported to live in safe neighborhoods. Transport-related physical activity was higher among individuals living in areas with garbage accumulation, and was lower among those living in neighborhoods which are difficult to walk or cycle due to traffic. Social support was strongly associated with leisure-time physical activity.Conclusions:Safety investments, which are urgently required in Brazil, are likely to have a desirable side effect at increasing physical activity at the population level. Building enjoyable and safe public spaces for physical activity practice must be prioritized.

Sign in / Sign up

Export Citation Format

Share Document