scholarly journals A retrospective study on clinical and demographic features of autoimmune vesiculobullous disorders from a rural tertiary care institute in Tamil Nadu

2019 ◽  
Vol 5 (3) ◽  
pp. 486
Author(s):  
Rajalakshmi Ramalingam ◽  
Vikram Kumar Adaikalam Ganapathy ◽  
Seethalakshmi Rajanga Chandrasekar ◽  
Balasubramanian Narasiman ◽  
Deivam Subbaraya Gounder
Keyword(s):  
Retrospective Study ◽  
Bullous Pemphigoid ◽  
Medical Records ◽  
Tamil Nadu ◽  
Skin Diseases ◽  
Tertiary Care ◽  
Pemphigus Vulgaris ◽  
Age Group ◽  
Care Institute ◽  
Heterogenous Group

<p class="abstract"><strong>Background:</strong> Autoimmune vesiculobullous disorders are a heterogenous group of skin diseases in which autoantibodies are directed against cell adhesion molecules which are essential for the integrity of skin and oral mucosa. They are clinically characterized by the presence of vesicles, bullae or erosions over the skin and/ or mucosa depending on the antibodies involved. They are divided into intraepidermal and subepidermal based on the location of the bulla. Among intraepidermal bullous disorders, pemphigus vulgaris (PV) is most common. Bullous pemphigoid (BP) is the most common among the subepidermal bullous disorders. Although they occur worldwide, the incidence shows geographical variation. A retrospective study was carried out with the objective to analyse the clinical and demographic profile of patients with autoimmune vesiculobullous disorders among patients attending a tertiary care teaching hospital in a rural setup.</p><p class="abstract"><strong>Methods:</strong> A total of 137 case sheets were audited from the Medical Records Department of our institute. Details were collected and tabulated, compiled and analysed.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of the 137 cases studied, intraepidermal autoimmune vesiculobullous disorders accounted for 63.4% of cases, and subepidermal autoimmune vesiculobullous disorders accounted for 36.6% of cases. Out of the 137 cases, 74 patients (54%) were females, and 63 patients (46%) were males. Majority of the patients were in the age group of 51-60 years (29.9%), followed by 41-50 years (24.1%) and 61-70 years (17.5%).</p><p class="abstract"><strong>Conclusions:</strong> Pemphigus vulgaris was the most common among the intraepidermal autoimmune vesiculobullous disorders, and bullous pemphigoid was the most common among the subepidermal autoimmune vesiculobullous disorders.</p>

scholarly journals POLA PENYAKIT KULIT NON-INFEKSI PADA ANAK DI POLIKLINIK KULIT DAN KELAMIN RSUP PROF. DR. R. D. KANDOU MANADO PERIODE 2009-2011

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Ananias Malak
Keyword(s):  
Retrospective Study ◽  
General Hospital ◽  
Skin Disease ◽  
Medical Records ◽  
Pathogenic Bacteria ◽  
Skin Diseases ◽  
Study Data ◽  
Age Group ◽  
Infectious Skin Diseases ◽  
In Infants And Children

Abstract: Non-infectious skin disease is a skin disease that is not caused by pathogenic bacteria or by transmission. Many non-infectious skin diseases showed different manifestations in infants and children. This study aimed to obtain the patterns of non-infectious skin diseases in children at Dermatovenorology Department Prof. Dr. R. D. Kandou General Hospital period 2009-2011. This was a retrospective study. Data of the annual cases, gender, and ages were obtained from the medical records. From a total of 595 patients in 2009-2011 there were 323 (54.29%) children with non-infectious skin diseases, females (167 patients, 51.70%) were more frequent than males, and most commonly in the age group of 5 to 14 years (59.13%). Conclusion: Non-infectious skin diseases were still common in Dermatovenorology Department Prof. Dr. R. D. Kandou General Hospital period 2009-2011.Keywords: non-infectious skin diseases, childrenAbstrak: Penyakit kulit non-infeksi adalah penyakit kulit yang tidak disebabkan oleh kuman patogen ataupun ditularkan. Banyak penyakit kulit non-infeksi memperlihatkan manifestasi yang berbeda pada bayi dan anak-anak. Penelitian ini bertujuan untuk mengetahui pola penyakit kulit non-infeksi pada anak di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode 2009-2011.Metode Penelitian dilakukan secara retrospektif pada pasien anak dengan penyakit kulit non-infeksi yang datang ke Poliklinik Kulit dan Kelamin pada tahun 2009-2011. Data diperoleh dari rekam medik mengenai jumlah kasus pertahun, jenis kelamin, dan umur. Hasil penelitian memperlihatkan dari sejumlah 595 kunjungan pada tahun 2009-2011 terdapat 323 (54,29%) pasien anak dengan penyakit kulit non-infeksi, distribusi jenis kelamin memperlihatkan perempuan yang terbanyak 167 (51,70%), dan ter banyak pada kelompok umur 5-14 tahun (59,13%). Simpulan: Penyakit kulit non-infeksi masih sering dijumpai pada pasien anak di RSUP Prof. Dr. R. D. Kandou Manado.Kata kunci: penyakit kulit non-infeksi, anak

scholarly journals Seasonal variation of pediatric dermatoses: a retrospective study conducted in tertiary care centre Ujjain

2018 ◽  
Vol 4 (2) ◽  
pp. 168
Author(s):  
Ujjwal Kumar ◽  
Krishnendra Varma ◽  
Pawan Kumar Khairwar
Keyword(s):  
Seasonal Variation ◽  
Retrospective Study ◽  
Skin Disease ◽  
Skin Diseases ◽  
Climatic Factors ◽  
Pediatric Population ◽  
Tertiary Care ◽  
Age Group ◽  
Pediatric Age ◽  
Tertiary Care Centre

<p class="abstract"><strong>Background:</strong> Skin diseases in pediatric age are common health problem with wide variation in the presentation in various regions. Association of seasonal variation in skin disease has been studied for centuries. Environmental factors plays significant role in skin disease. Different climatic factors that may decide the incidence of skin diseases. Cold, warmth, light and humidity play direct or indirect role in occurrence of various dermatosis. Many studies have been done to study pattern of skin disease in pediatric population but only few studies are done for its clinical correlation of seasonal variation. Hence we decided to study seasonal variation in pediatric dermatoses. The objective of the study was to study the seasonal variation, age-wise variation and distribution of common dermatoses in pediatric population in 0-15 years.</p><p class="abstract"><strong>Methods:</strong> This was a retrospective study done in R.D. Gardi Medical College, Ujjain over a period of one year. A total of 1110 cases of age 0-15 years, who presented in out-patient clinic of dermatology deparment were included in this study. Demographic profile and clinical details were recorded. Data were collected and patient’s details were categorized according to four seasons summer, autumn, winter and spring. Microsoft excel was used for data entry and analysis was done using SPSS version 22.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of all the subjects recruited, 55.7% were males and 44.3% were females with M:F ratio1.25:1. The maximum numbers of patients were in the age group of 10-15 years (43.3%). Majority of visits were in summer (n=360, 32.43%) followed by winter and spring season. Most common dermatosis seen during summer was bacterial infection (n=93, 8.37%) and during winter was eczema (n=62, 5.58%).</p><p><strong>Conclusions:</strong> Dermatoses in children are wide spread problem responsible for significant morbidity in them. In the present study there is seasonal variation of dermatological diseases in pediatric age group. </p>

AI-Provided Instant Differential Diagnosis of Pemphigus Vulgaris and Bullous Pemphigoid: Qualitative Study (Preprint)

2020 ◽  
Author(s):  
Xiaoyu He ◽  
Juan Su ◽  
Guangyu Wang ◽  
Kang Zhang ◽  
Navarini Alexander ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Early Diagnosis ◽  
Image Classification ◽  
Bullous Pemphigoid ◽  
Skin Diseases ◽  
Pemphigus Vulgaris ◽  
Classification Model ◽  
Clinical Image ◽  
Clinical Images ◽  
Multimodal Classification

BACKGROUND Pemphigus vulgaris (PV) and bullous pemphigoid (BP) are two rare but severe inflammatory dermatoses. Due to the regional lack of trained dermatologists, many patients with these two diseases are misdiagnosed and therefore incorrectly treated. An artificial intelligence diagnosis framework would be highly adaptable for the early diagnosis of these two diseases. OBJECTIVE Design and evaluate an artificial intelligence diagnosis framework for PV and BP. METHODS The work was conducted on a dermatological dataset consisting of 17,735 clinical images and 346 patient metadata of bullous dermatoses. A two-stage diagnosis framework was designed, where the first stage trained a clinical image classification model to classify bullous dermatoses from five common skin diseases and normal skin and the second stage developed a multimodal classification model of clinical images and patient metadata to further differentiate PV and BP. RESULTS The clinical image classification model and the multimodal classification model achieved an area under the receiver operating characteristic curve (AUROC) of 0.998 and 0.942, respectively. On the independent test set of 20 PV and 20 BP cases, our multimodal classification model (sensitivity: 0.85, specificity: 0.95) performed better than the average of 27 junior dermatologists (sensitivity: 0.68, specificity: 0.78) and comparable to the average of 69 senior dermatologists (sensitivity: 0.80, specificity: 0.87). CONCLUSIONS Our diagnosis framework based on clinical images and patient metadata achieved expert-level identification of PV and BP, and is potential to be an effective tool for dermatologists in remote areas in the early diagnosis of these two diseases.

scholarly journals Epidemiological study of burn injury with special reference to its prevention- A Nine-year retrospective study from a tertiary care hospital of West Bengal, India

2015 ◽  
Vol 7 (1) ◽  
pp. 70-75 ◽  
Author(s):  
Shib Shankar Kuiri ◽  
Bikash Chandra Ghosh ◽  
Nilay Mandal ◽  
Mintu Mohan Nandi ◽  
Tusar Kanti Saradar ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Injury Risk ◽  
West Bengal ◽  
Burn Injury ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Burn Injuries ◽  
Care Hospital ◽  
Burn Patients ◽  
Age Group

Aims and Objectives: We conducted a retrospective analysis among 1984 burn patients to study the incidence, prevalence of burn injury, its various types and modes (actual event behind the burn injury), risk factors and to find out the preventive measures.Materials and Methods: The retrospective study was carried out among 1984 patients having burn injuries, admitted in a tertiary care hospital of West Bengal, India over a period of nine years. The sources of information were the admission registers and the patients' folders from the medical records department. The Ethical clearance was taken from the Institutional Ethical Committee. The information obtained included age, sex, whether accidental or suicidal, etiology of burn injury and particularly the mechanism of injury. Results: Females were mostly affected (83%) in comparison to males. Among the study population, most of the burn patients were in the age group of 21-30yrs i.e. 35.3%. The number of burn patients were less in number in the age group of 11-20yrs i.e. 7.3%. Most of the burn injuries (87%) were accidental. Suicidal burns occurred in 10% cases. Of which about 1/3rd of the cases were due to dowry related issues.  A significant number of teenagers also attempted suicides due to trivial reasons (e.g. failure in examination, quarrelling with parents). Gas oven related injuries occurred in 2.7% cases. Oil lamps (‘kupi’), candles and hurricane-lanterns, diyas were also responsible to some extent in rural India for flame burns(5%). Smoking related burn injuries occurred in 1.7% cases. Scald injuries occurred in 14% cases. Chemical injuries (0.3%) were due to spillage of unlabelled bottles of acid/alkali. Electrical burn injury occurred in 4.9% cases. Conclusion: Burn injury prevention is not easy, but to avoid the significant morbidity and mortality following injury we have to prevent it by any means. A coordinated and dedicated approach among social workers , medical and paramedical personnel, administrators can only minimize the incidence of burn.Asian Journal of Medical Sciences Vol.7(1) 2015 70-75

scholarly journals Efficacy and Safety of Rituximab in Immunobullous Diseases: A Retrospective Study from a Tertiary Care Centre of Nepal

2020 ◽  
Author(s):  
Sudip Parajuli ◽  
Jyoti Vidhan ◽  
Dinesh Binod Pokhrel ◽  
Upama Paudel
Keyword(s):  
Retrospective Study ◽  
Adverse Effects ◽  
Tertiary Care ◽  
Data Entry ◽  
Pemphigus Vulgaris ◽  
University Teaching ◽  
Efficacy And Safety ◽  
Tertiary Care Centre ◽  
Cutaneous Lesions

Introduction: Rituximab is effective and safe treatment of immunobullous disorders. There are variations in doses of drugs used in different studies and uncertainties on when to use it along with use of adjuvant therapies. Efficacy and safety of this drug has not been described in Nepalese population till date. Dermatologists have hesitation in starting this drug in immunobullous diseases because of lack of data on efficacy and safety. Aim: To assess the efficacy and side effects of Rituximab therapy in treating immunobullous disorders in Nepalese patients. Materials and Methods: This was a retrospective study of patients with immunobullous diseases treated with Rituximab in Dermatological ward of Tribhuvan University Teaching Hospital, Kathmandu, Nepal from May 2018 to August 2019. Data were analysed for duration of disease and treatment received before Rituximab therapy, duration of steroid used before Rituximab, adverse effects due to prolonged steroid use, time to remission from 1st Rituximab pulse, duration of remission, relapse, duration of steroid and adjuvant drug used post 1st pulse and adverse effects associated with Rituximab. SPSS version 20 was used for data entry and descriptive statistics was used for analysis of the data. Results: Nine patients (Pemphigus Vulgaris-8 (PV-8), Bullous Pemphigoid-1 (BP-1) were treated with Rituximab. Seven were treated for refractory disease not controlled by conventional therapy and two received Rituximab as first-line therapy. The patients were under follow-up for 15-60 weeks (mean 31.89±15.62 weeks). Out of these nine patients, eight were free of lesions in one to eight weeks (mean 5.125±2 weeks) of first pulse. One patient with Oral Pemphigus had persistence of old lesions, however there were no new cutaneous lesions after first pulse. Adverse effects were seen in four patients that included infusion reaction in one and infection in three. There was relapse in one patient at last follow-up. Conclusion: Rituximab is efficacious and is safe in treating immunobullous disorders in Nepalese Population.

scholarly journals Clinico-epidemiological profile of hepatitis A virus and hepatitis E virus co-infection in pediatric age group: a hospital based retrospective study

2019 ◽  
Vol 6 (2) ◽  
pp. 588 ◽  
Author(s):  
Shikha Handa ◽  
Sanober Wasim ◽  
B. P. Kalra ◽  
Anil Rawat ◽  
Vipan Chandar ◽  
...  
Keyword(s):  
Developing Countries ◽  
Retrospective Study ◽  
Hepatitis E Virus ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Tertiary Care ◽  
Hepatitis E ◽  
Age Group ◽  
Pediatric Age ◽  
Pediatric Age Group

Background: Hepatitis-A virus (HAV) and Hepatitis E virus (HEV) are two major hepatotropic viruses of great public health importance in the developing countries like India. Both HAV and HEV are enterically transmitted and there are speculations that their co-infection might be associated with a more severe clinical course and increased rate of mortality. The objective of this study is to determine the prevalence, clinical features and biochemical parameters of Hepatitis A and Hepatitis E co-infection in hospitalized patients at a tertiary care centre in Uttarakhand.Methods: It is a retrospective study, covering a period of 4years and conducted in Himalayan Institute of Medical Sciences, SRHU Jolly Grant, Dehradun. Records of the patients with Hepatitis A and Hepatitis E co-infection were retrieved and analyzed.Results: Out of total 125 patients of acute viral hepatitis, 13 patients had HAV and HEV co-infection. 100% of the patients with co-infection presented with complaints of fever and jaundice, followed by 76.92% with vomiting, 69.23% with pruritis, 61.53% with pain in abdomen and 23.07% with altered sensorium. Mean Bilirubin, ALT, AST were 8.69±7.27 mg/dl, 2030.69±1726.93IU/L and 1880.07±1881.11IU/L respectively. Average duration of stay was 8.2 days. Encephalopathy was seen in 2 patients. However, no mortality was reported.Conclusions: Co-infection of HAV and HEV is not rare in pediatric age group. Knowledge about this will be of immense help for planning of future vaccination strategies and for better sanitation program in developing countries like India.

scholarly journals Prevalence of paediatric dermatoses among patients attending Dermatology outpatient department in a tertiary care hospital in Puducherry

2018 ◽  
Vol 4 (3) ◽  
pp. 368
Author(s):  
Varsha Medasani ◽  
Paquirissamy Oudeacoumar ◽  
Rao Chitralekhya ◽  
Saurabh Krishna Misra
Keyword(s):  
Dietary Habits ◽  
Skin Diseases ◽  
Tertiary Care Hospital ◽  
Fungal Infections ◽  
Tertiary Care ◽  
Outpatient Department ◽  
Care Hospital ◽  
Age Group ◽  
Major Health Problem ◽  
Pigmentary Disorders

<p class="abstract"><strong>Background:</strong> Skin diseases are a major health problem in the paediatric age group and are associated with significant morbidity. Dermatoses in children are more influenced by socioeconomic status, dietary habits, climatic exposure and external environment as compared to adults. The present study was undertaken to know the prevalence of paediatric dermatoses among patients attending Dermatology outpatient department in a tertiary care hospital in Puducherry.</p><p class="abstract"><strong>Methods:</strong> All newly diagnosed, untreated male and female paediatric patients (from neonates to adolescents ≤19 years of age) attending Dermatology OPD, from October 2015 to September 2017 were evaluated to study the prevalence and patterns of paediatric dermatoses. The skin disorders were classified into groups like infections, infestations, eczemas, acne, hypersensitivity disorders, sweat gland disorders, pigmentary disorders, nevi, keratinisation disorders, hair and scalp disorders, papulosquamous disorders, bullous disorders, nail disorders, drug reactions, other dermatoses.<strong></strong></p><p class="abstract"><strong>Results:</strong> The prevalence of pediatric dermatoses in our OPD is 25.21%. Incidence of pediatric dermatoses was found to be more in males 237 (59.39%) than in females 162 (40.60%) and the majority of the patients were in adolescent age group (217; 54.38%). Present study showed that majority of cases belonged to the lower socioeconomic group 186(46.6 %). In our study, majority (58.98%) of dermatoses belonged to infections and infestations group. Of the infective dermatoses, fungal infections (27.88%) were the most common.</p><p><strong>Conclusions:</strong> Infectious dermatoses were commonly seen in this study that may be due to poverty, overcrowding, poor hygiene. There is an increasing trend of fungal infections which might be related to hygiene and environment. </p>

scholarly journals Characteristics of childhood allergic diseases in outpatient and emergency departments in Shanghai, China, 2016–2018: a multicenter, retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yuanyuan Qi ◽  
Peng Shi ◽  
Renjie Chen ◽  
Yufeng Zhou ◽  
Lijuan Liu ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Emergency Departments ◽  
Outpatient Care ◽  
Skin Diseases ◽  
Allergic Diseases ◽  
Age Group ◽  
Allergic Skin

Abstract Background The prevalence of allergic diseases (ADs), such as asthma and allergic rhinitis (AR), is increasing worldwide in both adults and children. Although ADs are common and frequently coexist in outpatient care, city-level data regarding the characteristics of childhood AD remain limited in China. This study aimed to assess the profile and characteristics of ADs in the city of Shanghai. Methods A multicenter retrospective study was designed to collect routine administrative data from outpatient and emergency departments from 66 hospitals in Shanghai, China, from 2016 to 2018. Children with asthma, AR, allergic conjunctivitis (AC), and allergic skin diseases were investigated. Demographic characteristics, patients visit pattern, spectrum of diagnosis, and comorbidities were analyzed. Results A total of 2,376,150 outpatient and emergency visits for ADs were included in the period from 2016 to 2018. Allergic skin diseases accounted for 38.9%, followed by asthma (34.8%), AR (22.9%), and AC (3.3%), with a male predominance in all four diseases. Asthma and allergic skin diseases were most frequent in the 1 to < 4 years of age group, while AR and AC were more common in the 4 to < 7 years of age group. Asthma accounted for the greatest number of annual and emergency visits. The most frequent comorbidity of asthma was lower respiratory tract infection (LRTI) (49.3%), followed by AR (20.5%) and upper respiratory tract infection (14.1%). The most common comorbidities of AR were otitis media (23.4%), adenoid hypertrophy/obstructive sleep apnea (22.1%), followed by LRTI (12.1%), asthma (9.4%) and chronic pharyngitis (8.9%). Conclusions Asthma and allergic skin diseases were the most common ADs in outpatient and emergency departments in the study period. Respiratory tract infection was the most common comorbidity of asthma in children. More attention should be devoted to the treatment of comorbidities to improve childhood AD outcomes with a better understanding of the characteristics of ADs in outpatient care.

scholarly journals Profil pioderma pada orang dewasa di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode tahun 2013-2015

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Cindy E. Gama ◽  
Ferra O. Mawu ◽  
Renate T. Kandou
Keyword(s):  
Retrospective Study ◽  
Combination Therapy ◽  
Fusidic Acid ◽  
Medical Records ◽  
Skin Infection ◽  
Age Group ◽  
Topical Antibiotic ◽  
Gram Positive Bacteria ◽  
Common Skin ◽  
Using Data

Abstract: Pyoderma is one of the most common skin infection caused mainly by Gram-positive bacteria, Staphylococcus, Streptococcus, or both. It is closely associated with low-sosioeconomic, malnutrition, high density of population, and bad hygiene. This study was aimed to figure out the profile of pyoderma infection in adults at Department of Dermato-venereology, Prof. Dr. R. D. Kandou General Hospital Manado in the period of 2013-2015. This was a descriptive retrospective study using data of register books and medical records. The results showed that there were 164 new cases (4.59%) of pyoderma in adults, predominantly males (51,8%), age group of 45-64 years (44.5%), and folliculitis as the most clinical diagnosis. Most infections were treated with combination therapy of systemic antibiotic and topical antibiotic, clindamicyn (48.2%) and fusidic acid (59.8%) respectively.Keywords: pyoderma, adult Abstrak: Pioderma merupakan salah satu penyakit infeksi kulit yang paling sering ditemui. Penyakit ini paling banyak disebabkan oleh kuman Gram-positif, yakni Staphylococcus dan Streptococcus, atau keduanya. Pioderma erat hubungannya dengan keadaan sosial ekonomi yang rendah, malnutrisi, kepadatan penduduk, dan sanitasi yang buruk. Penelitian ini bertujuan untuk mengetahui profil pioderma pada orang dewasa di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode tahun 2013-2015. Jenis penelitian ialah deskriptif retrospektif menggunakan data dari buku register dan catatan rekam medik. Hasil penelitian menunjukkan insidensi pioderma pada orang dewasa periode tahun 2013-2015 sebanyak 164 kasus baru (4,59%). Distribusi terbanyak pada laki-laki (51,8%), usia 45-64 tahun (44,5%), dengan bentuk klinis folikulitis (38,4%). Sebanyak 95 pasien (57,9%) menggunakan terapi kombinasi antibiotik sistemik dan antibiotik topikal. Terapi antibiotik sistemik yang terbanyak digunakan ialah klindamisin (48,2%) dan antibiotik topikal yang paling banyak digunakan ialah asam fusidat (59,8%). Kata kunci: pioderma, dewasa

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