Consensus on management of acne-induced post-inflammatory hyperpigmentation: an Indian perspective

2021 ◽  
Author(s):  
Jayakar Thomas ◽  
Krupa Shankar ◽  
Sudhir Pujara ◽  
Rajeev Sharma ◽  
David Pudukadan ◽  
...  
Keyword(s):  
Panel Discussion ◽  
Treatment Strategies ◽  
Skin Condition ◽  
Clinical Settings ◽  
Patient Counselling ◽  
Expert Opinions ◽  
Indian Patients ◽  
Wide Range ◽  
Chemical Peels ◽  
Group A

<p class="abstract">Post-inflammatory hyperpigmentation (PIH) is a multifactorial disorder linked to alterations in melanin pigment because of inflammatory skin condition or any injury. Acne-induced PIH is one of the common presentations observed in dermatological consultations in India, especially in females of younger age group. A wide range of topical depigmenting agents are available for effective clearance of hyperpigmentation in patients affected with acne. Besides, chemical peels and cosmetic procedures like lasers and light therapies are commonly employed. However, treatment of acne-induced PIH is challenging in Indian clinical settings for multiple reasons such as relapsing of the condition and long-standing nature of the disease; the tendency of treatment to cause pigmentation; insufficient clinical data on natural ingredients; and lack of clinical practice guidelines, exclusively for the management of PIH in Indian patients. An experts’ panel discussion involving dermatologists all over India was conducted to review the evidence-based concept of acne-induced hyperpigmentation, and to obtain expert opinions on effective and practical management of acne-induced PIH in Indian settings. This article outlines consensus expert opinions aimed at identifying, diagnosing, and managing acne-induced PIH using topical depigmenting agents in Indian patients. It also highlights effective preventive strategies, the role of patient counselling and education regarding awareness about the disease and its treatment strategies.  </p>

scholarly journals Thoracic Aortic Emergencies: Presenting Pathologies and Treatment Strategies

2020 ◽  
Vol 37 (01) ◽  
pp. 085-096
Author(s):  
Daniel P. Sheeran ◽  
Adam M. Zelickson ◽  
Luke R. Wilkins ◽  
J. Fritz Angle ◽  
David M. Williams ◽  
...  
Keyword(s):  
Treatment Algorithm ◽  
Treatment Strategies ◽  
Clinical Settings ◽  
Accurate Identification ◽  
Treatment Techniques ◽  
Appropriate Treatment ◽  
Clinical Presentations ◽  
Wide Range ◽  
Pathologic Processes ◽  
Thoracic Stent Graft

AbstractThoracic aortic emergencies reflect a wide range of etiologies, pathologic processes, and clinical presentations. Accurate identification with an appropriate treatment algorithm is best accomplished in a multidisciplinary setting with interventional radiologists, vascular surgeons, and cardiothoracic surgeons. While knowledge of thoracic stent graft equipment and technique is essential in the treatment of thoracic aortic emergencies, many clinical settings may employ alternative treatment techniques. This article will review the most common thoracic aortic emergencies and treatment strategies.

Age related volume of cadaver-prostates in Bangladesh

1970 ◽  
Vol 4 (2) ◽  
pp. 74-77
Author(s):  
Rukshana Ahmed ◽  
Shamim Ara
Keyword(s):  
Prostate Gland ◽  
Age Groups ◽  
Clinical Settings ◽  
Cross Sectional ◽  
Medical College ◽  
Age Related ◽  
Group A ◽  
Key Words Prostate ◽  
The Mean ◽  
Group B

Pathological changes in the prostate gland occur commonly with advancing age including inflammation, atrophy, hyperplasia and carcinoma and a change in volume is also evident. Estimation of volume of prostate may be useful in a variety of clinical settings. A cross-sectional descriptive study was designed to see the changes in volume of the prostate with advancing age and done in the Department of Anatomy, Dhaka Medical College, Dhaka from August 2006 to June 2007. The study was performed on 70 post-mortem human prostates collected from the unclaimed dead bodies that were under examination in the Department of Forensic Medicine, Dhaka Medical College, Dhaka. The samples were divided into three age groups; group A (10-20 years), group B (21-40 years) and group C (41-70 years). Volume of the sample was measured by using the ellipsoid formula. The mean ± SD volume of prostate was 7.68 ± 3.64 cm3 in group A, 10.61 ± 3.99 cm3 in group B and 15.40 ± 6.31 cm3 in group C. Mean difference in volume between group A and group C, group B and group C were statistically significant (p<0.001). Statistically significant positive correlation was found between age and volume of prostate (r = + 0.579, p < 0.001). Key Words: Prostate; volume; Bangladeshi. DOI: 10.3329/imcj.v4i2.6501Ibrahim Med. Coll. J. 2010; 4(2): 74-77

scholarly journals Advances and Applications of Water Phytoremediation: A Potential Biotechnological Approach for the Treatment of Heavy Metals from Contaminated Water

2021 ◽  
Vol 18 (10) ◽  
pp. 5215
Author(s):  
Cristián Raziel Delgado-González ◽  
Alfredo Madariaga-Navarrete ◽  
José Miguel Fernández-Cortés ◽  
Margarita Islas-Pelcastre ◽  
Goldie Oza ◽  
...  
Keyword(s):  
Water Quality ◽  
Plant Species ◽  
Treatment Strategies ◽  
Pollution Sources ◽  
Water Contaminants ◽  
Biotechnological Approach ◽  
Wide Range ◽  
Great Relevance ◽  
Multidisciplinary Perspective ◽  
Viable Method

Potable and good-quality drinking water availability is a serious global concern, since several pollution sources significantly contribute to low water quality. Amongst these pollution sources, several are releasing an array of hazardous agents into various environmental and water matrices. Unfortunately, there are not very many ecologically friendly systems available to treat the contaminated environment exclusively. Consequently, heavy metal water contamination leads to many diseases in humans, such as cardiopulmonary diseases and cytotoxicity, among others. To solve this problem, there are a plethora of emerging technologies that play an important role in defining treatment strategies. Phytoremediation, the usage of plants to remove contaminants, is a technology that has been widely used to remediate pollution in soils, with particular reference to toxic elements. Thus, hydroponic systems coupled with bioremediation for the removal of water contaminants have shown great relevance. In this review, we addressed several studies that support the development of phytoremediation systems in water. We cover the importance of applied science and environmental engineering to generate sustainable strategies to improve water quality. In this context, the phytoremediation capabilities of different plant species and possible obstacles that phytoremediation systems may encounter are discussed with suitable examples by comparing different mechanistic processes. According to the presented data, there are a wide range of plant species with water phytoremediation potential that need to be studied from a multidisciplinary perspective to make water phytoremediation a viable method.

scholarly journals An Evaluation of Morphological Changes and Deformability of Suspended Red Blood Cells Prepared Using Whole Blood with Different Hemoglobin Levels of Tibetans

2021 ◽  
pp. 1-10
Author(s):  
Rui Zhong ◽  
Dingding Han ◽  
Xiaodong Wu ◽  
Hong Wang ◽  
Wanjing Li ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Whole Blood ◽  
Blood Cells ◽  
Morphological Changes ◽  
Osmotic Fragility ◽  
Spherical Shape ◽  
Hypoxic Environment ◽  
Wide Range ◽  
Group A ◽  
Cell Membrane Protein

Background: The hypoxic environment stimulates the human body to increase the levels of hemoglobin (HGB) and hematocrit and the number of red blood cells. Such enhancements have individual differences, leading to a wide range of HGB in Tibetans’ whole blood (WB). Study Design: WB of male Tibetans was divided into 3 groups according to different HGB (i.e., A: >120 but ≤185 g/L, B: >185 but ≤210 g/L, and C: >210 g/L). Suspended red blood cells (SRBC) processed by collected WB and stored in standard conditions were examined aseptically on days 1, 14, 21, and 35 after storage. The routine biochemical indexes, deformability, cell morphology, and membrane proteins were tested. Results: Mean corpuscular volume, adenosine triphosphate, pH, and deformability were not different in group A vs. those in storage (p > 0.05). The increased rate of irreversible morphology of red blood cells was different among the 3 groups, but there was no difference in the percentage of red blood cells with an irreversible morphology after 35 days of storage. Group C performed better in terms of osmotic fragility and showed a lower rigid index than group A. Furthermore, SDS-PAGE revealed similar cross-linking degrees of cell membrane protein but the band 3 protein of group C seemed to experience weaker clustering than that of group A as detected by Western Blot analysis after 35 days of storage. Conclusions: There was no difference in deformability or morphological changes in the 3 groups over the 35 days of storage. High HGB levels of plateau SRBC did not accelerate the RBC change from a biconcave disc into a spherical shape and it did not cause a reduction in deformability during 35 days of preservation in bank conditions.

Age-Dependency of Total Tau in the Cerebrospinal Fluid Is Corrected by Amyloid-β 1–40: A Correlational Study in Healthy Adults

2021 ◽  
pp. 1-8
Author(s):  
Paul Theo Zebhauser ◽  
Achim Berthele ◽  
Marie-Sophie Franz ◽  
Oliver Goldhardt ◽  
Janine Diehl-Schmid ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Amyloid Β ◽  
Healthy Adults ◽  
Tau Proteins ◽  
Clinical Settings ◽  
Inclusion Criteria ◽  
Total Tau ◽  
Potential Marker ◽  
Wide Range ◽  
The Relationship

Background: Tau proteins are established biomarkers of neuroaxonal damage in a wide range of neurodegenerative conditions. Although measurement of total-Tau in the cerebrospinal fluid is widely used in research and clinical settings, the relationship between age and total-Tau in the cerebrospinal fluid is yet to be fully understood. While past studies reported a correlation between age and total-Tau in the cerebrospinal fluid of healthy adults, in clinical practice the same cut-off value is used independently of patient’s age. Objective: To further explore the relationship between age and total-Tau and to disentangle neurodegenerative from drainage-dependent effects. Methods: We analyzed cerebrospinal fluid samples of 76 carefully selected cognitively healthy adults and included amyloid-β 1–40 as a potential marker of drainage from the brain’s interstitial system. Results: We found a significant correlation of total-Tau and age, which was no longer present when correcting total-Tau for amyloid-β 1–40 concentrations. These findings were replicated under varied inclusion criteria. Conclusion: Results call into question the association of age and total-Tau in the cerebrospinal fluid. Furthermore, they suggest diagnostic utility of amyloid-β 1–40 as a possible proxy for drainage-mechanisms into the cerebrospinal fluid when interpreting biomarker concentrations for neurodegenerative diseases.

Prevalence of Hand Malformations in Patients With Moebius Syndrome and Their Management

Hand ◽  
2021 ◽  
pp. 155894472199426
Author(s):  
Jose E. Telich-Tarriba ◽  
David F. Navarro-Barquin ◽  
Karol Verdezoto-Gaibor ◽  
Alexander Cardenas-Mejia
Keyword(s):  
Upper Extremity ◽  
Treatment Strategies ◽  
Abducens Nerve ◽  
Poland Syndrome ◽  
Statistical Association ◽  
Moebius Syndrome ◽  
Cross Sectional ◽  
Reconstructive Procedures ◽  
Nerve Paralysis ◽  
Wide Range

Background: Moebius syndrome is a disorder characterized by facial and abducens nerve paralysis. Patients can present a wide range of upper extremity malformations. Literature focused on orthopedic manifestations of Moebius syndrome shows variability in the prevalence and clinical presentation of upper extremity anomalies. The aim of this work is to evaluate the prevalence of upper extremity malformations in patients with Moebius syndrome, clarify its various clinical presentations, and present treatment strategies for their management. Methods: This is a retrospective, cross-sectional study including patients with Moebius syndrome and upper extremity malformations between 2012 and 2019. Data include demographic characteristics, Moebius syndrome subtype, type of malformation, affected extremity, and surgical procedures underwent. Quantitative data were recorded as mean (standard deviation [SD]), and qualitative data were expressed in terms of totals and percentages. Statistical association between Moebius syndrome subtype and development of upper extremity anomalies was evaluated using binary logistic regression. Results: Twenty-five out of 153 patients (16.3%) presented upper extremity malformations (48% male). Mean age of presentation was 9.08 ± 9.43 years. Sixty-eight percent of the malformations were unilateral. The most common presentations included Poland syndrome and simple syndactyly with 8 cases each (32%), followed by 5 cases of brachysyndactyly (20%), 3 cases of amniotic band syndrome (12%), and 1 case of cleft hand (4%). No statistical association was found between Moebius syndrome subtype and odds ratio for development of upper extremity anomalies. Thirteen patients (52%) underwent reconstructive procedures. Conclusion: Poland syndrome and syndactyly are the most common anomalies in patients with Moebius syndrome. Patients may present with a wide range of hand malformations, each patient should be carefully evaluated in order to determine whether surgical treatment is needed and to optimize rehabilitation protocols.

scholarly journals The Interned Soldiers of UРR Army at the Camp Stshalkovo in Poland (the Second Half of 1921 – the Beginning of 1922): the Moral and Life Conditions

2017 ◽  
pp. 182-195
Author(s):  
I. Sribnyak
Keyword(s):  
Armed Forces ◽  
Educational Work ◽  
Material Resources ◽  
Life Conditions ◽  
Wide Range ◽  
Red Army ◽  
Group A ◽  
Moral Condition ◽  
The Government ◽  
Destructive Processes

The article analyzes the moral condition and conditions of staying of interned Ukrainian soldiers in the camp of Stshalkovo (Poland) in the second half of 1921 – early 1922. Based on the use of a wide range of archival sources, the author concludes that the camp everyday life of the wartime period was marked by significant difficulties due to its extraordinary crowding and presence in the camp of interned and captured soldiers of other formations (Balahovtsy and Red Army soldiers). The lack of any material resources, the lack of adequate and high-quality food, the lack of fuel for heating booths, anti-Ukrainian agitation, led to the fact that a part of Ukrainian soldiers lost national moral values. In order to prevent the demoralization of Ukrainian warfare, the command of the group tried to intensify cultural and educational work in the camp, but due to lack of premises and lack of resources, it slowly collapsed. Some of the interned ones did not withstand the burden of hopeless and burdensome camping munitions, and left the camp in search of better living conditions. Obviously, this was a dangerous trend, and the command of the interned troops in various ways tried to prevent it from further spreading. The leader of the group A. Pиzitsky was particularly opposed to the destructive processes in the camp. His measures were fully understood and supported by the higher military leadership of the Armed Forces and the Government of the UPR.

scholarly journals Global trends and growth dynamics in media industry

2021 ◽  
Vol 29 (2) ◽  
pp. 324-337
Author(s):  
Elena S. Pinchuk
Keyword(s):  
Growth Dynamics ◽  
Media Industry ◽  
Global Media ◽  
Global Trends ◽  
Expert Opinions ◽  
Current Period ◽  
Wide Range ◽  
Rapid Transition ◽  
The Media ◽  
Key Aspects

The article reviews the trends in the media industry landscape formation based on content as a source of economic processes taking place in the industry. A wide range of expert opinions, reflecting the current changes was collected and analyzed. The life cycle of content is examined and the key trends in its production, packaging, distribution and consumption are highlighted. The attention is focused on the economic and technological factors that determine each of the trends, for instance, a change in the model of media consumption, the development and distribution of OTT platforms as a new way of delivering content, as well as a rapid transition to a new technological level. The latest statistical data from Russian and foreign sources support the reviewed trends. There is a separate description of the coronavirus pandemic impact consequences on the global media and the Russian industry in particular, and the key aspects of the development of the industry are identified in the current period on its basis.

scholarly journals Analysis of virulence factors and emm typing of Streptococcus pyogenes clinical isolates.

2019 ◽  
Author(s):  
Gustavo Enck Sambrano ◽  
Gustavo P Riboldi ◽  
Keli C Reiter ◽  
Thiago Galvão da Silva Paim ◽  
Neidmar Correa Tolfo ◽  
...  
Keyword(s):  
Virulence Factors ◽  
Streptococcus Pyogenes ◽  
Virulence Genes ◽  
Clinical Isolates ◽  
Pcr Analysis ◽  
Tissue Tropism ◽  
Factors Analysis ◽  
Wide Range ◽  
Group A ◽  
Micro Organisms

Background: Streptococcus pyogenes, a Group A streptococci (GAS), is an important human pathogen that causes a wide range of infections. Methods: Twenty five clinical isolates of S. pyogenes were submitted to an emm typing and to a Real-time PCR analysis for 23 important virulence factors. Results: Fourteen emm types were found and the emm1 type was the most prevalent. The majority of the isolates were classified as emm pattern E, followed by A-C3. No pattern D was found. Among the virulence factors, the most prevalent were SpeG, Slo, C5a-peptidase and SPNA. Phage encoded virulence genes were also found among the strains, such as mf-2, SpeJ and SpeL. Discussion: The emm1 type was the most prevalent while the 13 others M types were distributed along the strains. No tissue tropism was found on the isolates. The virulence factors analysis demonstrated that chromosomally and phage-encoded genes were found, which confers a potential for high virulent micro-organisms.

scholarly journals Analysis of virulence factors and emm typing of Streptococcus pyogenes clinical isolates.

2019 ◽  
Author(s):  
Gustavo Enck Sambrano ◽  
Gustavo P Riboldi ◽  
Keli C Reiter ◽  
Thiago Galvão da Silva Paim ◽  
Neidmar Correa Tolfo ◽  
...  
Keyword(s):  
Virulence Factors ◽  
Streptococcus Pyogenes ◽  
Virulence Genes ◽  
Clinical Isolates ◽  
Pcr Analysis ◽  
Tissue Tropism ◽  
Factors Analysis ◽  
Wide Range ◽  
Group A ◽  
Micro Organisms

Background: Streptococcus pyogenes, a Group A streptococci (GAS), is an important human pathogen that causes a wide range of infections. Methods: Twenty five clinical isolates of S. pyogenes were submitted to an emm typing and to a Real-time PCR analysis for 23 important virulence factors. Results: Fourteen emm types were found and the emm1 type was the most prevalent. The majority of the isolates were classified as emm pattern E, followed by A-C3. No pattern D was found. Among the virulence factors, the most prevalent were SpeG, Slo, C5a-peptidase and SPNA. Phage encoded virulence genes were also found among the strains, such as mf-2, SpeJ and SpeL. Discussion: The emm1 type was the most prevalent while the 13 others M types were distributed along the strains. No tissue tropism was found on the isolates. The virulence factors analysis demonstrated that chromosomally and phage-encoded genes were found, which confers a potential for high virulent micro-organisms.

Sign in / Sign up

Export Citation Format

Share Document