scholarly journals A retrospective study of pap smear and cervical biopsy correlation in abnormal cervical cytology cases

2021 ◽  
Vol 6 (2) ◽  
pp. 87-90
Author(s):  
K Rajeswari ◽  
Dinesh Kumar S ◽  
Ramya Krishna ◽  
Meenakshisundaram K
Keyword(s):  
Pap Smear ◽  
Screening Tool ◽  
Cervical Cytology ◽  
Histopathological Diagnosis ◽  
Pap Smear Test ◽  
Cervical Biopsy ◽  
Abnormal Cervical Cytology ◽  
Intraepithelial Lesions ◽  
Smear Testing ◽  
Global Health Problem

Cancer cervix is a global health problem and Pap smear is an important screening tool, which has proven to be highly effective in reducing the number of cases and the mortality from cervical carcinoma. Any abnormality detected in Pap smear has to be confirmed with cervical biopsy, which is the gold standard for diagnosing the lesions of the cervix. To study the prevalence of abnormal cervical cytology cases detected by Pap smear testing in our setting, to find the distribution of cytologically abnormal cases and also the concordance and discordance between Pap smear and cervix biopsy in cytologically abnormal cases to assess the sensitivity of Pap smear in detecting the intraepithelial lesions / malignancy of cervix. The study included all the abnormal cervical cytology cases and their cervix biopsies, for five years. The cytologically abnormal cases were listed and a thorough search was made for their cervix biopsy. The histopathological diagnosis of the corresponding cervix biopsies (if done) were also listed and compared for concordance. There were totally 12600 cases of Pap smear done during the study period and there were 146 cytologically abnormal cases. Histopathology reports of the cervix biopsy were available for 44 cases. Out of the 44 cases, 40 cases were concordant. The sensitivity of Pap smear test in our setting was found to be 90.9%. Our study revealed a good correlation between Pap smear and cervix biopsy.

scholarly journals Correlation of colposcopy with biopsy in cases of abnormal cervical cytology

2019 ◽  
Vol 14 (1) ◽  
pp. 36-39
Author(s):  
Kirtipal Subedi
Keyword(s):  
Predictive Value ◽  
Prospective Observational Study ◽  
Accurate Diagnosis ◽  
Cervical Cytology ◽  
Histopathological Diagnosis ◽  
Cervical Biopsy ◽  
Abnormal Cervical Cytology ◽  
Disease Threshold ◽  
Sensitivity Specificity

Aims: This study aims to find out the role of colposcopy and its correlation with cervical biopsy in detection of pre malignant cervical lesion. Methodology: This is hospital based prospective observational study on 60 cases with abnormal cervical cytology reports conducted in the Department of Obstetrics and Gynecology, PMWH, Thapathali, Kathmandu. Colposcopy guided biopsies were done and findings noted. Results: Among 60 cases enrolled in the study the most common cervical cytology finding was ASCUS, LSIL, HSIL and ASC-H present in 46.6%, 31.6%, 15% and 6.6% respectively.  The colposcopy finding among these cases was normal, CIN1, CIN 2 and CIN 3 in 45%, 23.3%, 16.7% and 9% respectively. Among these cases the most common biopsy finding was normal, CIN 1, CIN 2, CIN 3 and squamous cell carcinoma in 55%, 18.3%, 8.3%, 15% and 3.3% respectively. The sensitivity, specificity, positive predictive value and negative predictive value of colposcopy with CIN 1 as disease threshold was calculated to be 80.6%, 93.1%, 81.8% and 92.6% respectively. While evaluating the validity of colposcopy with histopathology, colposcopy seems to make an accurate diagnosis in 75% of cases, overestimating in 15% and underestimating in 8% of cases. Conclusions: There is a good correlation of colposcopy with histopathological diagnosis of cervical cancer. Keywords: colposcopy, cytology, diagnosis, premalignant  

scholarly journals TO STUDY LIQUID BASED CYTOLOGY AS A SCREENING TOOL FOR ABNORMAL CERVICAL CYTOLOGY

2020 ◽  
pp. 1-3
Author(s):  
Jyothivishnu J L ◽  
Sushil Chawla ◽  
K G Vivek
Keyword(s):  
Diagnostic Accuracy ◽  
Sample Size ◽  
Sensitivity And Specificity ◽  
Pap Smear ◽  
Screening Tool ◽  
Evaluation Study ◽  
Cervical Cytology ◽  
High Diagnostic Accuracy ◽  
Abnormal Cervical Cytology ◽  
Liquid Based Cytology

Aim – To determine sensitivity and specificity of liquid base cytology for detection of abnormal cervical cytology Methodology- diagnostic evaluation study Sample size- 370 Result – Sensitivity – 96.9% Specificity – 91.7% Conclusion – LBC has high diagnostic accuracy in detecting abnormal cervical cytology compared to pap smear

scholarly journals Frequency of abnormal cervical cytology in symptomatic women.

2021 ◽  
Vol 28 (08) ◽  
pp. 1156-1160
Author(s):  
Hafiza Khatoon ◽  
◽  
Nousheen Mushtaq ◽  
Safia - ◽  
Fiza Ali Khan ◽  
...  
Keyword(s):  
Pap Smear ◽  
Cross Sectional Study ◽  
Cervical Cytology ◽  
Medical Sciences ◽  
Cross Sectional ◽  
Abnormal Cervical Cytology ◽  
Large Numbers ◽  
Cervical Diseases ◽  
Study Setting ◽  
Smear Testing

Objective: To estimate the frequency of abnormal cervical cytology detected by Pap smear. Study Design: Cross Sectional Study. Setting: Department of Obstetrics and Gynaecology Gambat Institute of Medical Sciences Gambat, Khairpur Sindh. Period: November 2018 to June 2019. Material & Methods: A total of 160 women with the complaint of heavy vaginal discharge and moderate to servere lowere abdominal pain more than 6 weeks were included in this study. Per speculum examination of cervix was carried out with the help of cuscos speculum before PAP smear and finding were noted, After labeling the sample was sent to histopathology for cytological examination. Results: The average age of the patient’s was 37.68±7.46 years. Percentage of normal smears 10%, advance disease 1.3% and percentage of inflammatory smear is 63.8% while frequency of abnormal cervical cytology was observed in 25% in which CIN-1 was 12.5%, CIN-2 was 11.3% and CIN-3 was 1.3%. Conclusion: Our population have large numbers of undiagnosed cervical diseases. Therefore, Pap smear testing should be widely used throughout Pakistan to reduce the incidence of cervical cancer.

scholarly journals Factors associated with the intention to undergo Pap smear testing in the rural areas of Indonesia: a health belief model

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Sumarmi Sumarmi ◽  
Yu-Yun Hsu ◽  
Ya-Min Cheng ◽  
Shu-Hsin Lee
Keyword(s):  
Cervical Cancer ◽  
Health Beliefs ◽  
Rural Women ◽  
Rural Areas ◽  
Pap Smear ◽  
Statistical Significance ◽  
Health Belief ◽  
Pap Smear Test ◽  
Smear Test ◽  
Smear Testing

Abstract Purposes This study aimed to understand the influence of health beliefs, demographic factors, and health characteristics on the intention to undergo Pap smear testing among women in rural areas of Indonesia. Methods A descriptive cross-sectional study was conducted and 687 married women participated in the study. A convenience sampling was applied to recruit the participants from community health centres in a rural region in Indonesia. Self-reported data using the Health Beliefs Model Scale for Cervical Cancer and Pap Smear Test was collected to assess the health beliefs. Independent t-tests, simple logistic regressions, and a hierarchical logistic regression with 3 steps were run. Statistical significance for analysis was set at p < 0.05. Results The mean age of the participants was 42 years (SD = 8.4). Among the participants, 81% of the women had never undergone a Pap smear test, and 61% (n = 422) of the women reported a high intention of receiving a Pap smear test. Income and education Health beliefs regarding Pap smear testing were different between women who had low and high intentions to undergo Pap smear testing. Health beliefs, such as perceived benefits, severity, barriers to Pap smear testing, and health motivation for a Pap smear test were associated with the intention to undergo Pap smear testing among rural Indonesian women. Overall, the hierarchical multiple regression with 3 steps containing demographic, health characteristics, and health belief variables accounted for 31% variance of the intention to undergo Pap smear test among the Indonesian rural women. Conclusions Low screening rates of cervical cancer and high intentions to do the screening exist among rural Indonesian women. Health beliefs significantly affect the rural women’s intention of Pap smear testing in Indonesia.

Cervical cytologic abnormalities and negative colposcopy: histologic assessment

1994 ◽  
Vol 4 (5) ◽  
pp. 348-351 ◽  
Author(s):  
R. Chenoy ◽  
S. Manohar ◽  
C. W.E. Redman ◽  
D. M. Luesley
Keyword(s):  
Cervical Cytology ◽  
Histologic Diagnosis ◽  
Abnormal Cervical Cytology ◽  
Accurate Definition ◽  
Cone Biopsy ◽  
Histologic Evaluation ◽  
Simple Regression Analysis ◽  
Definition Of ◽  
Cytologic Abnormalities ◽  
Intraepithelial Lesions

Colposcopic assessment may be normal in the presence of severe or persistent minor cytologic abnormality. To assess the significance of negative satisfactory colposcopy in patients with abnormal cervical smears, a retrospective review was carried out on 1170 patients who had undergone out-patient loop diathermy excision for abnormal cervical cytology. Of these, 69 patients were treated for abnormal cervical cytology, despite normal colposcopic findings. Cytologic abnormalities ranged from persistent borderline changes to severe dyskariosis. Histologic assessment of the excision specimens revealed cervical intraepithalial neoplasia (CIN) in 43 (62.3%) cases, of which high-grade CIN accounted for 24 (34.8%) cases. There was good correlation between cytologic and histologic diagnosis. Simple regression analysis showedr= 0.46,P< 0.0001. The cytologic abnormality was highly predictive of the corresponding histologic diagnosis. This analysis has shown that significant intraepithelial lesions may exist despite negative colposcopic examination and highlights the need for histologic evaluation in such cases. In these circumstances, loop cone biopsy permits accurate definition of lesion severity, avoids potential undertreatment of significant lesions and causes less morbidity than conventional cone biopsy.

scholarly journals Cytohistological correlation of conventional Papanicolaou smears in cervical neoplasia at a tertiary care hospital of Nepal

2019 ◽  
Vol 9 (1) ◽  
pp. 1475-1479
Author(s):  
Anuj Poudel ◽  
Prahar Dahal
Keyword(s):  
Uterine Cervix ◽  
Pap Smear ◽  
Cervical Screening ◽  
Tertiary Care ◽  
Cost Effective ◽  
Cervical Cytology ◽  
Pap Smears ◽  
Care Hospital ◽  
Cervical Lesions ◽  
Cervical Biopsy

Background: Conventional Cervical Cytology is the most widely used cervical cancer screening test. The incidence of cervical carcinoma is incredibly high in developing countries due to lack of proper knowledge. The extensive use of cervical screening with Papanicolau smears had considerably increased the detection of precancerous and cancerous lesion of uterine cervix. Study was conducted to evaluate cytohistological correlation and to calculate concordance and discordance of Pap smear in detection of precancerous and cancerous lesions of uterine cervix. Materials and Methods: A total of 54 samples reported in Pap smear as cervical intraepithelial lesions and suspicious for invasive malignancies were selected and correlated with corresponding histopathological findings. It was an observational study done for a period of 18 months from November 2016 to May 2018 at UCMS-TH. All the statistical evaluation was done by using SPSS version 20. Results: During the study period 54 cases were evaluated. Atypical Squamous Cell of Undetermined Significance was the common abnormal findings in the Pap smear with frequency of 26 (48.1%). Out of total 54 cases of Pap smears, 30 (55.55%) were concordant while discrepancies occurred in 24(44.44%) cases with cervical biopsy. Conclusions: The study revealed a good correlation between cervical cytology and cervical biopsy. We also concluded that conventional Pap smear is a cost effective test for the early detection of precancerous and cancerous cervical lesions.

The prevalence of abnormal cervical cytology among postnatal clinic attendees at the University of Calabar Teaching Hospital, Calabar, Nigeria.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e12568-e12568
Author(s):  
Boniface Uji Ago
Keyword(s):  
Cervical Cancer ◽  
Pap Smear ◽  
Gynecologic Oncology ◽  
Cross Sectional Study ◽  
Cervical Cytology ◽  
Screening Methods ◽  
Low Grade ◽  
Cross Sectional ◽  
Preventable Disease ◽  
Abnormal Cervical Cytology

e12568 Background: Carcinoma of the uterine cervix is a deadly but preventable disease. It is still a major gynecologic problem in our subregion. Cervical cytology remains the key to its early detection and prompt treatment. Methods: This was a prospective cross sectional study of postnatal women to determine the prevalence of abnormal cervical cytology and their socio-demographic characteristics. Institutional ethical clearance and informed consent of participants were obtained. Aye's spatula and endocervical brush were used to collect specimen from the ectocervix and endocervix respectively and smeared on individually labelled glass slides. The samples were treated using the conventional Papanicolaou staining method and reported using the Bethesda system. Researcher-administered questionnaire generated data as well as results of cytology were analyzed using Epi-Info version 3.5.1.0 (CDC Atlanta USA 2008). Results: There were 100 women screened. Three percent had low grade squamous intraepithelial lesion. Colposcopy done, however, did not reveal abnormal findings. Ninety-five percent of the women had no prior knowledge of cervical cancer and Pap smear. Two percent of the women had a family history of cervical cancer and both patients died of the disease due to lack of facilities for treatment. Conclusions: Cervical cancer is a preventable disease. Women in our subregion are under-screened. Effective screening methods are the mainstay in its prevention. Availability of well equipped gynecologic oncology centers with personnel training are a necessary end to this carnage.

scholarly journals Correlation of pap smear and colposcopic finding of cervix with histopatholgiocal report in a group of patient attending in a tertiary hospital

2013 ◽  
Vol 22 (1) ◽  
pp. 39-44
Author(s):  
Suraiya Parvin ◽  
Nazneen Kabir ◽  
Yeasmin Samad Lipe ◽  
Khaleda Nasreen ◽  
KM Nurul Alam
Keyword(s):  
Pap Smear ◽  
Diagnostic Value ◽  
Tertiary Hospital ◽  
Cervical Cytology ◽  
Inclusion Criteria ◽  
Cross Sectional ◽  
Medical College ◽  
Abnormal Cervical Cytology ◽  
One Year ◽  
Colposcopy Clinic

Objective: To correlate Pap’s smear and colposcopic finding of cervix with histopathological report of abnormal area of cervix in a group of patient attending a tertiary hospital. Methods: It was a cross-sectional prospective study done in one year period from January to December 2007 in Colposcopy Clinic of Institute of Child and Maternal Health (ICMH) Hospital, Dhaka. The study carried out including fifty two female patients having clinically unhealthy cervices as in the form of hypertrophy, erosion, congestion or bleeds on touch or having positive pap smear found during P/V or P/S examination, attending gynaecology out patient department of ICMH Hospital after fulfilling all the inclusion criteria. Result: The present study showed a correlation between cervical cytology and colposcopically directed biopsy, the correlation was accurate within one grade in 39 of 51 cases (76.16%) (as cytology was not done in one case). Other studies showed cytologic accuracy (within one level of histologic finding) to about 83% and 88% cases. Conclusion: The study done here shows excellent correlation between findings of colposcopy with that of histopathology of guided biopsy. It also confirms the diagnostic value of colposcopy in the management of women with abnormal cervical cytology with squamous atypia. DOI: http://dx.doi.org/10.3329/jdmc.v22i1.15604 J Dhaka Medical College, Vol. 22, No. 1, April, 2013, Page 39-44

scholarly journals Evaluation of a real-time optoelectronic method in the diagnostics of CIN over four years of observations

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247702
Author(s):  
Barbara Suchońska ◽  
Wanda Gajzlerska-Majewska ◽  
Mirosław Wielgoś
Keyword(s):  
Cervical Cancer ◽  
Developing Countries ◽  
Real Time ◽  
Pap Smear ◽  
Histopathological Diagnosis ◽  
Primary Screening ◽  
Cervical Squamous Intraepithelial Lesions ◽  
Optoelectronic Method ◽  
The Moment ◽  
Intraepithelial Lesions

Cervical cancer is considered to be particularly amenable to prevention and highly treatable in its early stages. The real-time optoelectronic method of cervix examination seemed to be very promising in the detection of cervical squamous intraepithelial lesions and demonstrated relatively good efficacy. Although this method was introduced into clinics almost 10 years ago, it has not found its place in diagnostic schemes. At the moment, cytological smears and HPV detection with genotyping are still essential. TruScreen seems to be a slightly forgotten test. The aim of the study was to evaluate the efficacy and accuracy of TruScreen in detecting cervical pathology: CIN and cervical cancer confirmed with a histopathological diagnosis in comparison with other methods–cytology and colposcopy over four years of observations. The study was conducted on 130 women with abnormal Pap smear results. We can conclude that a real-time optoelectronic method like TruScreen can be useful as an effective initial cervical cancer screening in developing countries, possibly in combination with other methods. The combination of cytology and TruScreen examination may help clinicians to take decision about the next diagnostics steps (e.g. colposcopy) and contribute to better primary screening for cervical cancer.

scholarly journals Human papillomavirus (HPV) prevalence in relation with cervical cytology in Bengali population of India

2020 ◽  
Author(s):  
Puja Banerjee ◽  
Arghya Bondhopadhyay ◽  
Bibek Mohan Rakshit ◽  
Amitava Pal ◽  
Anupam Basu
Keyword(s):  
Human Papillomavirus ◽  
Pap Smear ◽  
Hpv Infection ◽  
Cervical Cytology ◽  
Infectious Agents ◽  
Normal Cytology ◽  
Pap Smear Test ◽  
Specific Pcr ◽  
Hpv Prevalence ◽  
Different Types

AbstractBackgroundHuman papillomavirus (HPV) is one of the major infectious agents of cervical cancer. Papanicolaou (pap) smear study is generally carried out to screen the initial cervical condition and consequently specific PCR based study is carried out to recognize the different types of HPV. In the present study, we would like to screen the frequency of HPV infection in the women with normal and abnormal cervical discharges.MethodsIn our study, 216 subjects were recruited. Cervical cytology was done by Pap smear test. Nested PCR was carried out using MY09/11 and GP 5+/6+ primers to screen HPV infection.Result and conclusionA significant co-relation between HPV infection and early sexual intercourse was observed. We found a higher HPV prevalence in the age group below 29 years(35.48%). 85.71% SCC patients were positive for HPV infection, 80% HSIL patients were positive for HPV infection, 75% LSIL patients were positive for HPV infection; 66.7% ASCUS patients were positive for HPV infection. 50% ASC-H patients were positive for HPV infection. HPV positive was found in 22.22% of the subjects, among them 16.75% show normal cytology (NILM).

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