To study and analyze hematological parameters in anaemia in males

Hematological parameters like Hb (haemoglobin), TC (total count), DC (differential count), PCV (packed cell volume), MCV (mean red cell corpuscular volume) done in the automated cell counter and peripheral smear findings were studied. Observational study.Out of 250 cases, 192 i.e. 76.8% cases showed microcytic hypochromic anaemia, 30 cases i.e. 12% had normocytic hypochromic anaemia, 27 cases i.e. 10.6% had normocytic normochromic anaemia and dimorphic anaemia was seen in 02 cases i.e. 0.6% cases.Out of 250 cases, 193 i.e. 77.2% cases showed microcytosis maximally in 0-5 years age group and 57 cases i.e. 22.8% had normocytic picture. The distribution of peripheral smear (RBC size) finding with age varied significantly (p value <0.05). Iron deficiency is almost universal when dealing with this magnitude of anaemia. However, clinically speaking, many technical experts believe that to differentiate severe anaemia, a screening for other causes is desirable, all males are recommended to be screened. In the present study of pediatric cases 0-5 years age group males were most affected and prevalence was more in males as compared to females and the predominant morphological pattern was microcytic hypochromic anaemia.

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COMPARATIVE STUDY OF ANAEMIA CASES BASED ON PERIPHERAL BLOOD SMEARS AND CELL COUNTER GENERATED RED CELL INDICES

10.36106/ijsr/5024100 ◽

2020 ◽

pp. 32-34

Author(s):

Durga Nand Jha ◽

Ajit Kumar Chaudhary ◽

Debarshi Jana

Keyword(s):

Peripheral Blood ◽

Red Cell ◽

Peripheral Smear ◽

Microcytic Hypochromic Anaemia ◽

Hypochromic Anaemia ◽

Blood Smears ◽

Normocytic Normochromic Anaemia ◽

Red Cell Indices ◽

Peripheral Blood Smears ◽

Cell Counter

Background: Analyzing peripheral blood smears routinely has facilitated interpretation of various hematological disorders and has been a major diagnostic tool. The advent of automated hematology cell counter has improved accuracy, precision and safety. There is still a need to depend on manual techniques for primary calibration. This highlights the importance of maintaining the manual technical skills, Thus, the present study was undertaken to compare anaemia cases based on peripheral blood smears and cell counter generated Red blood cell (RBC) Indices. Material and Methods: The peripheral blood smears in anaemia were evaluated and compared it with cell counter generated red cell indices of 500 anemic patients. The automated analyzer SYSMEX XP-100 was used.Simultaneously, a peripheral smear was prepared according to standard operating procedures and stained by Leishman stain. Results: The cases consisted of normocytic normochromic anaemia (14%), microcytic hypochromic anaemia (76.2%), macrocytic anaemia (0.4%) and dimorphic anaemia (13.4%). In normocytic normochromic anaemia on peripheral smears 65.7% showed normal curve. In microcytic hypochromic anaemia 81.1% showed left shift. In cases of macrocytic anaemia 100% histogram showed right shift. Majority of the curves in dimorphic anaemia showed broad based curve (46.26%). Discussion: The relationship between histogram patterns and peripheral smear diagnosis in dimorphic anaemia posed queries regarding the validity of histocytograms. Hence, peripheral smear examination along with clinical history is an important diagnostic tool while handling the patients with hematological conditions.

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Evaluation of anaemia

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20174581 ◽

2017 ◽

Vol 5 (10) ◽

pp. 4481 ◽

Cited By ~ 1

Author(s):

Suchita V. Ingale ◽

Milind P. Ullewar ◽

Vikas C. Ingale ◽

Jayshree J. Upadhye

Keyword(s):

Red Blood Cells ◽

Blood Cells ◽

Complete Blood Count ◽

Severe Anaemia ◽

Peripheral Smear ◽

Pathology Laboratory ◽

Mild Anemia ◽

Normocytic Normochromic Anaemia ◽

Moderate Anemia ◽

Mild Anaemia

Background: Often, the first test used to diagnose anemia is a complete blood count (CBC). It determines the number, size, volume, and hemoglobin content of red blood cells. Peripheral smear is done for typing of anaemia. Such evaluation is necessary for proper treatment.Methods: A retrospective study was done in 300 anaemic patients at Shakuntala pathology laboratory, Nagpur. Patients were randomly selected including males and females. CBC and peripheral smear were analyzed.Results: Out of total 300 patients evaluated, the prevalence of anaemia was quite significant in females 225 (75%) than males 75 (25%). 66 females (22%) had mild anemia while 129 females (43%) had moderate anemia and 30 females (10%) had severe anaemia 36 males (12%) had mild anaemia, 30 males (10%) had moderate anaemia while 9 males (3%) had severe anaemia. In morphology of red blood cells, normocytic normochromic anaemia was seen in 132 (44%) females and in 45 (15%) of males. Microcytic hypochromic anaemia was seen in 90 (30%) females and 27 (9%) males. Macrocytic anaemia was seen in 3 (1%) females and 3 (1%) males.Conclusions: Prevalence of anaemia is quite high in females than males. Also, the severity of anaemia is more in females than males. So, heath programmes should be directed more towards females since adolescent age.

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MORPHOLOGICAL EVALUATION OF ANAEMIA CASES IN DIFFERENT AGE GROUPS IN A TERTIARY CARE HOSPITAL IN CENTRAL INDIA

10.36106/gjra/9001856 ◽

2020 ◽

pp. 59-60

Author(s):

Arti Gupta ◽

Pankaj Kumar Gupta ◽

Pushpendra Kumar Gupta ◽

Abhishree Geda

Keyword(s):

Tertiary Care ◽

Age Groups ◽

Developed Countries ◽

Reproductive Age ◽

Care Hospital ◽

Age Group ◽

Adult Females ◽

Microcytic Hypochromic Anaemia ◽

Hypochromic Anaemia ◽

Developing And Developed Countries

Introduction: Anaemia is prevalent clinical condition in both developing and developed countries so it needs constant evaluation. As morphological study of red blood cell is initial and cheep tool for approach to causative factors here is an attempt to evaluate morphological distribution of anaemia. Aims and objectives: 1-To study distribution of anaemia in different age and sex category. 2-To determine morphological pattern of anaemia in all age groups. Material and Methods: A total of 752 anaemic samples were studied by peripheral smear examination, Samples were also run in automated cell counter to nd red cell parameters WHO Criteria were used as cut off for haemoglobin concentration Results: Among Seven hundred fty two cases , paediatric age group include 92 cases (12.23%), adult male aged 12 to 65 years include 160 patients (21.27%) , adult female aged 12 to 65 years was 476 ( 63.29%) and elderly patients more than 65 years was 24 (3.19%).Among all 752 cases 311 patients (41.3%) were having microcytic hypochromic anaemia Conclusion: To conclude in our study maximum numbers of cases are observed in adult females in reproductive age group. In both adult females and children maximum number of cases is having microcytic hypochromic anaemia due to iron deciency. So it is important to focus on screening, early dietary modication and supplemental therapy to reduce anaemia prevalence in the developing and developed countries.

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Haematological Profile in Microcytic Hypochromic Anaemia in Children

Journal of Universal College of Medical Sciences ◽

10.3126/jucms.v9i02.41941 ◽

2021 ◽

Vol 9 (02) ◽

pp. 3-7

Author(s):

Raju Kafle ◽

Anupama Bastola ◽

Ashok P Samdurkar ◽

Narayan Gautam ◽

Anuj Poudel ◽

...

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anaemia ◽

Cross Sectional Study ◽

Severe Anaemia ◽

Cross Sectional ◽

Deficiency Anaemia ◽

Microcytic Hypochromic Anaemia ◽

Hypochromic Anaemia ◽

Haematological Profile ◽

Rbc Count

INTRODUCTION: The most common disorders presenting with microcytic hypochromic anaemia are iron deficiency anaemia (IDA) and β-Thalassemia trait (β-TT), and each of them has different pathogenesis and treatment modality. Here we intend to see the haematological profile in microcytic hypochromic anaemia in children apart from IDA and Thalassemia with respect to age and gender. MATERIAL AND METHODS: A total of 95 pediatric patients between the ages of 2 to 12 years with microcytic hypochromic anaemia were included in the study. Blood samples obtained from each patient were evaluated for various haematological and biochemical profiles along with haemoglobin electrophoresis. It was a hospital based observational cross-sectional study done for a period of 18 months from January 2019 to July 2020. RESULTS: Severe anaemia was seen in 55 (57.89%) cases, followed by 38 (40.00%) cases with moderate anaemia and 2 (2.11%) cases with mild anaemia. Majority of the cases showed IDA, which were 85 (89.5%) cases, followed by 6 (6.3%) cases with β-TT and 4 (4.2%) cases with β-TM. RBC count, hematocrit and RDW showed significant variation between IDA, β-TM and β-TT. Most number of correctly diagnosed cases were shown by Ricerca Index with 90 (94.74 %). CONCLUSION: Our study concludes RBC count and RDW, along with Srivasthava Index, Ricerca Index and RDW Index could be used as reliable indices to differentiate between iron deficiency anaemia and β-Thalassemia. Red cell indices, serum iron profile and haemoglobin electrophoresis complement each other for the precise diagnosis of underlying cause of microcytic hypochromic anaemia.

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Anaemia Types and Severity in Patients Aged 1 to 14 Years at the Children’s Hospital of the University Teaching Hospitals in Zambia

Journal of Preventive and Rehabilitative Medicine ◽

10.21617/jprm2021.323 ◽

2021 ◽

Vol 3 (1) ◽

pp. 79-84

Author(s):

Panji Nkhoma ◽

◽

Patrick Loti ◽

Musalula Sinkala ◽

Hamakwa Mantina ◽

...

Keyword(s):

Vitamin A Deficiency ◽

Age Groups ◽

Haemoglobin Concentration ◽

Public Health Problem ◽

University Teaching ◽

Teaching Hospitals ◽

P Value ◽

Microcytic Hypochromic Anaemia ◽

Hypochromic Anaemia ◽

University Teaching Hospitals

Anaemia is a condition in which either the number of red blood cells or their oxygen-carrying capacity is insufficient to meet physiologic needs, which vary by age, sex, altitude, smoking and pregnancy status. The global estimate of childhood anaemia indicates that 293.1 million children are anaemic, and 28.5% of these children reside in sub-Sahara Africa. Also,anaemia is a significant public health problem with a high age-standardised death rate of 11.18 per 100,000 in Zambia. We conducted a cross-sectional study involving 392 anaemic children aged one year to 14 years. The study was conducted at the Children Hospital, University Teaching Hospitals, which is a third-level referral Hospital in Lusaka, Zambia. The aim was to determine the most common type of anaemia, it’s severity, and the most affected age groups among children aged 1–14 years.Out of392 participants, 219 (56%) were female. Maximum haemoglobinrecorded was 10.9g/dl, a minimum of 2.0 g/dl, a mean of 7.8g/dl and a standard deviation of 1.86g/dl. 200 (51%) participants had severe anaemia, and 192 (49%) had moderate anaemia with none having mild anaemia. Microcytic hypochromic anaemia was the commonest (60%), followed by normochromic normocytic anaemia (26%) and the least was macrocytic anaemia in 14% of the participants. An analysis of variance showed that the difference in mean haemoglobin concentration between age groups was not significant, F (7.94) = 0.83, p > 0.57. A Chi-squared test was used to determine the relationship between anaemia types (microcytic, hypochromic) and age groups.The interaction was not significant (Chi-Square (1) = 1.28, p-value = 0.73. Microcytic hypochromic anaemia was the most prevalent and all age groups were equally affected.We recommend the country’s National Food and Nutrition Commission to revisit the Zambian National Strategy and Plan of Action for the Prevention and Control of Vitamin A Deficiency and Anaemia of1999 to 2004 and implement the measures stated in the strategic plan

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Hematological Profile of Children With Malaria in Sorong, West Papua, Indonesia

10.21203/rs.3.rs-98603/v1 ◽

2020 ◽

Author(s):

Syilvia Jiero ◽

Ayodhia Pitaloka Pasaribu

Keyword(s):

Malaria Infection ◽

Hematological Parameters ◽

Public Health Problem ◽

Malaria Diagnosis ◽

White Blood Count ◽

P Value ◽

Major Public Health Problem ◽

Age Group ◽

Hematological Profile ◽

West Papua

Abstract Background: Malaria remains a major public health problem in Indonesian Papua, with children under five years of age being the most affected group. Hematological changes such as cytopenia that occur during malaria infection have been suggested as potential predictors and can aid in the diagnosis of malaria. This study aimed to assess the hematological alterations associated with malaria infection in children presenting with signs and symptoms of malaria. Methods: A retrospective study was performed by collecting data from the medical records of malaria patients at Sorong Regional General Hospital, Sorong, West Papua, Indonesia, both from outpatient and inpatient clinics, from January 2014 until December 2017. The laboratory profile of children suffering from malaria was evaluated. Results: One hundred and eighty-two children aged 1 month to 18 years old were enrolled. The subjects were mostly male (112, 61.5%) with a mean age of 6.45 years (SD = 4.3 years). Children <5 years suffering from malaria had the highest number at 77 (42.3%). One hundred two subjects (56%) were infected with Plasmodium falciparum. Half of the enrolled subjects (50%) had hemoglobin level (Hb) between 5.1 and 10 gr/dL. A total of 41 children (53.2%) less than 5 years old suffered from P. falciparum infection. In the age group of 5-10 years, there were 34 children (57.6%) who suffered from P. falciparum, and in the age group >10 years, 27 children (58.7%) suffered from P. falciparum infection. Only 4 subjects (5.2%) in the less than 5 years old age group had mixed malaria infection. Of the eight parameters of the hematological profile, there were five parameters that were significantly associated with the diagnostic criteria, namely hemoglobin, hematocrit, leukocytes, platelets and monocytes (p <0.05). Generally, clinical symptoms are not significantly associated with a malaria diagnosis, and only one variable showed a significant relationship, pale, with a p value of 0.001. Conclusions: Children with malaria had changes in some hematological parameters, with anemia, low platelet count, white blood count, and lymphocyte count being the most important predictors of malaria infection in our study area. These parameters could improve malaria diagnosis when used in combination with other clinical diagnoses and microscopy.

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Beta Thalassemia Trait among Antenatal Mothers and Those with Microcytic Anaemia

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/463 ◽

2021 ◽

Vol 8 (28) ◽

pp. 2503-2508

Author(s):

Mohan D. Kashinkunti ◽

Radhika Acharya

Keyword(s):

Iron Deficiency ◽

Complete Blood Count ◽

Gene Mutations ◽

Beta Thalassemia ◽

P Value ◽

Microcytic Hypochromic Anaemia ◽

Hypochromic Anaemia ◽

Thalassemia Minor ◽

Thalassemia Trait ◽

Patient Department

BACKGROUND Among microcytic hypochromic anaemias, the most common disorders are iron deficiency anaemia (IDA) and co-pathological conditions such as α- or βthalassemia (α- or β- thalassemia) traits. Thalassemia minor is often an asymptomatic carrier state but exhibit marked microcytosis that can be mistaken for iron deficiency. About 1.5 % of the global population (80 to 90 million people) are carriers of thalassemia and more than 200 mutations are described in thalassemia, the only effective way to reduce burden of thalassemia is to prevent birth of homozygotes. The purpose of this study was to estimate the prevalence of beta thalassemia trait (BTT) in adult individuals with microcytic hypochromic anaemia and among antenatal mothers visiting the Obstetric Department of SDMCMSH. METHODS In this prospective descriptive study, 101 adult patients between 18 and 40 years who were in in-patient department (IPD) or attending out-patient department (OPD) from department of general medicine and department of haematology were studied during a period of one year from October 2018 to October 2019 and their blood sample was sent for complete blood count (CBC), iron studies and haemoglobin electrophoresis. All the data was entered in Microsoft Excel software and analysis was done using Minitab software. P value of less than 0.05 was considered statistically significant. RESULTS Out of the 101 microcytic hypochromic anaemia patients analysed, 7 patients have beta thalassemia trait. 4 of the 7 are females. Their haemoglobin electrophoresis report showed high HBA2 value of > 3.8. There were no carriers among the pregnant individuals tested. A regression model was fitted for predicting HBA2 based on values of serum iron, serum ferritin, and mean corpuscular volume (MCV). CONCLUSIONS In conclusion, identification of thalassemia gene mutations in our population is necessary because of the country’s multiracial population. This will prevent unnecessary treatment with iron supplements in thalassaemic patients and also helps in pregnant women to prevent thalassemia major children. Molecular genotyping provides a rapid and reliable method for identification of common, and unknown α - and β - gene mutations, which help to diagnose unexplained microcytosis and thus prevent unnecessary iron supplementation. We conclude that microcytosis due to thalassemia is common in north Karnataka. This illustrates the importance of adequate prenatal and laboratory investigation for these abnormalities. KEYWORDS Beta Thalassemia Trait, Microcytosis, Haemoglobin Electrophoresis, Antenatal Screening, Thalassemia

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To Establish A Normal Range of Inter-Incisal Opening - A Study of 756 Subjects of Age Group 20-50 Years in Yamunanagar City, Haryana.

Dental Journal of Advance Studies ◽

10.1055/s-0038-1670583 ◽

2013 ◽

Vol 01 (01) ◽

pp. 001-003

Author(s):

Aruna Singh ◽

Nymphea Pandit ◽

Monica Sharma

Keyword(s):

Pearson Correlation ◽

Mouth Opening ◽

Clinical History ◽

P Value ◽

Age Group ◽

Male Population ◽

Female Population ◽

Odontogenic Infections ◽

Anterior Teeth ◽

Average Maximum

Abstract Aim- 1. The aim of this study was to investigate the average maximum range of inter-incisal mouth opening in a representative sample of the adult subjects of Haryana. 2. To see any correlation between maximal inter-incisal opening with age. Methods- Maximum mouth opening was studied in 756 adult subjects with age range of 20-50 years in Yamunanagar, Haryana. Age limit was further divided into three groups (20-30, 31-40, 41-50). Those with clinical history of TMJ involvement, OSMF, any trauma, odontogenic and non-odontogenic infections, dental prosthesis on the anterior teeth, congenital anomalies in the maxillofacial region were excluded from this study. The measurements were recorded twice and mean of the two values were taken. Statistical Analysis- Independent sample t-test was calculated to compare age and mouth opening in both male and females respectively. Bivariate pearson correlation was used to see any relationship between age and mouth opening. P-value ≤ 0.05 and CI (confidence interval) at 95% were considered statistically significant. The Results- The average mouth opening of males (45.36±6.70 mm) subjects was higher as compared to female (41.27 ± 6.75 mm) with significant, p-value 0.000. The mean mouth opening ± SD for both sexes combined was 43.39 ± 7.02 mm. The corresponding values for mean inter-incisal opening in male population aged 20-30, 31-40, 41-50 were 45.52 ± 7.15, 46.16 ± 5.47, 42.96 ± 6.82 mm and in female population aged 20-30, 31-40, 41-50 were 41.40 ± 7.08, 41.60 ± 6.29 and 40.03 ± 6.38 mm respectively. Conclusion- Maximal mouth opening differ significantly with gender. There is a decrease in MMO with older age group.

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Haematological profile of children with malaria in Sorong, West Papua, Indonesia

Malaria Journal ◽

10.1186/s12936-021-03638-w ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Syilvia Jiero ◽

Ayodhia Pitaloka Pasaribu

Keyword(s):

Malaria Infection ◽

Clinical Symptoms ◽

Public Health Problem ◽

Malaria Diagnosis ◽

White Blood Count ◽

P Value ◽

Major Public Health Problem ◽

Age Group ◽

Haematological Profile ◽

West Papua

Abstract Background Malaria remains a major public health problem in Indonesian Papua, with children under five years of age being the most affected group. Haematological changes, such as cytopenia that occur during malaria infection have been suggested as potential predictors and can aid in the diagnosis of malaria. This study aimed to assess the haematological alterations associated with malaria infection in children presenting with signs and symptoms of malaria. Methods A retrospective study was performed by collecting data from the medical records of malaria patients at Sorong Regional General Hospital, Sorong, West Papua, Indonesia, both from outpatient and inpatient clinics, from January 2014 until December 2017. The laboratory profile of children suffering from malaria was evaluated. Results One hundred and eighty-two children aged 1 month to 18 years old were enrolled. The subjects were mostly male (112, 61.5%) with a mean age of 6.45 years (SD = 4.3 years). Children below 5 years of age suffered the most from malaria in this study (77, 42.3%). One hundred two subjects (56%) were infected with Plasmodium falciparum. Half of the enrolled subjects (50%) had haemoglobin level (Hb) between 5.1 and 10 gr/dL. A total of 41 children (53.2%) less than 5 years old suffered from P. falciparum infection. In the age group of 5–10 years, there were 34 children (57.6%) who suffered from P. falciparum, and in the age group > 10 years, 27 children (58.7%) suffered from P. falciparum infection. Only 4 subjects (5.2%) in the less than 5 years old age group had mixed malaria infection. Among eight predictors of the haematological profile, there were five predictors that were significantly associated with the diagnostic criteria, namely haemoglobin, haematocrit, leukocytes, platelets and monocytes (p < 0.05). Generally, clinical symptoms are not significantly associated with a malaria diagnosis, and only one variable showed a significant relationship, pale, with a P value of 0.001. Conclusions Children with malaria had changes in some haematological markers, with anaemia, low platelet count, white blood count, and lymphocyte count being the most important predictors of malaria infection in the study area. These markers could be used to raise suspicion of malaria in children living in high endemic areas, such as West Papua.

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Trends of Stomach Cancer in Central Serbia

Medicina ◽

10.3390/medicina57070665 ◽

2021 ◽

Vol 57 (7) ◽

pp. 665

Author(s):

Miodrag M. Stojanovic ◽

Natasa K. Rancic ◽

Marija R. Andjelkovic Apostolovic ◽

Aleksandra M. Ignjatovic ◽

Mirko V. Ilic

Keyword(s):

Stomach Cancer ◽

Preventive Measures ◽

Age Groups ◽

Optimal Number ◽

P Value ◽

Age Group ◽

Joinpoint Regression ◽

Mortality Trends ◽

Incidence Trend ◽

Incidence And Mortality

Somach cancer is the third most common cause of cancer-related deaths worldwide. The objective of the paper was to analyze the incidence and mortality trends of stomach cancer in Central Serbia in the period between 1999–2017. Materials and Methods: trends and annual percentage change (APC) of the incidence and mortality rate with corresponding 95% confidence intervals (CI) were calculated by joinpoint regression analyses. The optimal number of Joinpoints was identified using the Monte Carlo permutation method. The trend was considered to be significantly increasing (positive change) or decreasing (negative change) when the p-value was below 0.05 (p < 0.05). Results: the total number of new cases was 16,914 (10,873 males and 6041 females) and the total number of mortality cases was 14,790 (9348 in and 5442 in females). Almost one third (30.8%) of new cases were registered in the 60–69-year age group, and new cases were significantly more frequent in males than in females (30.8% vs. 29.02%, p < 0.001). Joinpoint regression analysis showed a significant decrease of incidence trend in females during the 2000–2015 period with APC of −2.13% (95% CI: −3.8 to −0.5, p < 0.001). An insignificant decrease in incidence trend was in males with APC of −0.72% (95% CI: −2.3 to 0.9, p = 0.30). According to the joinpoint analysis, a significant decrease of mortality trends both in males during 2000–2015 with APC of −2.21% (95% CI: −1.6 to −7.5, p ≤ 0.001 and in females, during the same period, with APC of −1.75% (95% CI: −2.9 to −0.6, p < 0.001) was registered. From 2015 to 2017, a significant increase of mortality was registered with APC of 44.5% (95% CI: from 24.2 to −68.1, p ≤ 0.001) in females and in males with APC of 53.15% (95% CI: 13.5 to −106.6, p ≤ 0.001). Conclusion: a significant decrease of stomach cancer incidence trend in females and insignificant decrease of incidence trend in males were determined in Central Serbia. Based on presented results, the mortality trend decreased significantly both in males and in females during 2000–2015, and from 2015 to 2017 we recorded a significant increase in mortality in both sexes. We found significantly more new cases in women than in men in the age group of 40–49, and the mortality of stomach cancer was significantly more frequent among females compared to males in the age groups 30–39, as well as in the 50–59 age group. There is a need for improving recording and registration of new cases of stomach cancer, especially in females. Urgent primary and secondary preventive measures are needed—introducing stomach cancer screening and early detection of premalignant changes. Urgent primary and secondary preventive measures are needed.

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