scholarly journals Analysis ofmulticomponent mixture on the example of the drug ”Pentalgin” bythe methods of TLC and IR-Fourier spectrometry

2017 ◽  
Vol 21 (3) ◽  
pp. 164-173
Author(s):  
A.L. Lobachev ◽  
N.A. Red’kin ◽  
Yu.V. Trifonova

The definition of a qualitative composition of multicomponent drugs ”Pen- talgin” and ”Pentalgin ICN” by TLC and IR-spectrometry is carried out. It is shown that using just TLC or just FT-IR spectrometry does not allow us to identify all the major components. It has been proposed an authentication scheme, which includes the steps of isolating of the test components, their sep- aration by TLC, followed by extraction of components and definition by FTIR spectrometry. The combination of these two techniques allows to separate and identify almost all the most important components of the mixture.

Author(s):  
Anna Mahtani

Abstract The ex ante Pareto principle has an intuitive pull, and it has been a principle of central importance since Harsanyi’s defence of utilitarianism (to be found in e.g. Harsanyi, Rational behaviour and bargaining equilibrium in games and social situations. CUP, Cambridge, 1977). The principle has been used to criticize and refine a range of positions in welfare economics, including egalitarianism and prioritarianism. But this principle faces a serious problem. I have argued elsewhere (Mahtani, J Philos 114(6):303-323 2017) that the concept of ex ante Pareto superiority is not well defined, because its application in a choice situation concerning a fixed population can depend on how the members of that population are designated. I show in this paper that in almost all cases of policy choice, there will be numerous sets of rival designators for the same fixed population. I explore two ways that we might complete the definition of ex ante Pareto superiority. I call these the ‘supervaluationist’ reading and the ‘subvaluationist’ reading. I reject the subvaluationist reading as uncharitable, and argue that the supervaluationist reading is the most promising interpretation of the ex ante Pareto principle. I end by exploring some of the implications of this principle for prioritarianism and egalitarianism.


2021 ◽  
Vol 66 ◽  
pp. 96-102
Author(s):  
V.M. Logoida

The article is devoted to the study of the experience of legal regulation of the legal status of cryptocurrencies and transactions with them in Asian countries (except for the People's Republic of China and Asian countries - members of the Commonwealth of Independent States, as the author examined them in separate publications). In the article the author, based on the study of regulations, administrative and judicial practice of all major countries in this part of the world, emphasizes the divergent trends in cryptocurrency transactions regulation in the region, when some countries move from a liberal approach to the use of cryptocurrencies to their total ban and vice versa. It is noted that almost all countries in the region give a legal assessment of the payment function of cryptocurrencies, using regulatory or prohibitive approaches, depending on the chosen policy, which indirectly confirms their understanding of the legal nature of cryptocurrencies primarily as a means of payment. At the same time, these countries not only categorically distinguish cryptocurrencies from fiat money issued by central banks, but also mostly avoid the official definition of cryptocurrency as private (decentralized) cash, preferring to qualify them as an intangible asset, virtual asset, digital asset, financial value and even a good or service, which is currently a kind of compromise between political expediency and economic realities. The author also notes that the Asian region is characterized by very active attempts to resolve the legal status of cryptocurrencies at the legislative level, and not just administrative or judicial response to the actual legal relationship, although the progress of different countries in this matter is different. As a result, the author concludes that in the Asian countries considered in the article, there is no same view on the legal nature of cryptocurrency, its qualification as an object of civil rights, and ways to regulate transactions with it (libertarian approach, positive-cryptocurrency approach but with detailed government regulation and control or a completely restrictive policy in relation to the cryptocurrency market).


Author(s):  
Deborah Combs ◽  
Brian Nichols

This paper explores how the tax cuts and jobs act of 2017 impacts middle-class taxpayers by calculating the tax liability at different levels of income and deductions in 2017 versus 2018. The results confirm the statements supporting the positive effect of the tax change for the middle class. The tax cut and jobs act eliminates personal exemptions, changes the standard deductions at various incomes and family sizes, and lowers marginal tax rates. After providing details of the act, this research examines the definition of the U.S. middle class by using prior research from the Pew Research Center, the United States Census Bureau, and the federal reserve to determine which income levels are attributable to the middle class. Then the tax liability for these income classes is calculated for single and married filing jointly taxpayers in both 2017 and 2018 to determine if the tax cuts and jobs act reduces the tax liability for the middle class. The results show that in almost all scenarios the tax liability in 2018 will be lower than in 2017, regardless of whether standard or itemized deductions are taken. The marriage penalty is no longer applicable, and the new tax act provides a substantial benefit to large families


1988 ◽  
Vol 42 (8) ◽  
pp. 1365-1368 ◽  
Author(s):  
R. M. Robertson ◽  
J. A. De Haseth ◽  
J. D. Kirk ◽  
R. F. Browner

A new solvent elimination interface based on the Monodisperse Aerosol Generation Interface for Combining Liquid Chromatography with Fourier transform infrared (MAGIC-LC/FT-IR) spectrometry is described. The solvent elimination efficiency of MAGIC-LC/FT-IR was studied by varying the mobile-phase composition from 100% methanol to 100% water. As the mobile-phase composition was varied, erythrosin B was injected into the interface and deposited on a KBr window after the solvent removal. Spectra were obtained which compared favorably with reference spectra, even as the mobile-phase water content was increased. A reverse-phase separation was completed to demonstrate that readily identifiable spectra can be obtained from mobile phases containing high percentages of water, without heating of the effluent stream.


1998 ◽  
Vol 25 ◽  
pp. 93-110 ◽  
Author(s):  
Quentin Gausset

Traditional accounts of the nineteenth-century Fulbe conquest in northern Cameroon tell roughly the same story: following the example of Usman Dan Fodio in Nigeria, the Fulbe of Cameroon organized in the beginning of the nineteenth century a “jihad” or a “holy war” against the local pagan populations to convert them to Islam and create an Islamic state. The divisions among the local populations and the military superiority of the Fulbe allowed them to conquer almost all northern Cameroon. They forced those who submitted to give an annual tribute of goods and servants, and they raided the other groups. In these traditional accounts the Fulbe are presented as unchallenged masters, while the local populations are depicted as slaves who were powerless over their fate; their role in the conquest of the region and in the administration of the new political order is supposed to have been insignificant.I will show that, on the contrary, in the area of Banyo the Wawa and Bute played a crucial role in the conquest of the sultanate and in its administration. I will then re-examine the cliche that all members of the local populations were the slaves of the Fulbe by distinguishing the fate of the Wawa and Bute on one side from that of the Kwanja and Mambila on the other, and by showing the importance of the Fulbe's identity in shaping the definition of slavery. Finally I will argue that, if the historical accounts found in the scientific literature invariably insist on Fulbe hegemony and minimize the role played by the local populations, it is because those accounts are often based on Fulbe traditions, and because these traditions are remodeled by the Fulbe in order to correspond to their discourse on identity.


2002 ◽  
Vol 56 (10) ◽  
pp. 1259-1267 ◽  
Author(s):  
Cyril Petibois ◽  
Georges Cazorla ◽  
André Cassaigne ◽  
Gérard Déléris

Global metabolic adaptations to physical conditioning were described in 15 subjects by FT-IR spectrometry as the method allowed determination of glucose (Glc), lactate (La), glycerol, triglycerides (TG), fatty acyl moieties (FAM), and total amino acids plasma concentrations. Subtraction of plasma FT-IR spectra obtained at resting state from the exercise spectra also allowed determination of the biomolecular response to exercise. On week 1, exercise induced a transient hypoglycemia, a lactatemia increase of 153%, a FAM depletion of 27%, and a TG concentration decrease of 28%. Protein contents increased by 2%, but these were partly catabolized for amino acid supply (+27%), suggesting an important metabolic stress during exercise. On week 3, exercise hypoglycemia had disappeared, lactate increase was diminished by 91%, TG contents were decreased by 14%, and proteins and amino acids exhibited higher absorption increases. On week 5, TG and FAM concentrations were markedly increased during exercise, protein absorption was still increased (+9%), but amino acid blood release was diminished by 81%. These results described positive adaptations to training. Furthermore, FAM concentration could be determined from plasma FT-IR spectra by using the 2996–2819 cm−1 spectral area [ νas(CH3), νas(CH2), νs(CH3), and νs(CH2) absorbance; 0.82 mMol·L−1, a.u. cm−1], as well as for amino acid concentration by using the ν(COO−) spectral area (1430–1360 cm−1; 0.062 g·L−1, a.u. × cm−1). FT-IR spectrometry was useful to determine simultaneously various plasma concentrations and most of the biomolecular changes through successive samples.


2021 ◽  
pp. 9-13
Author(s):  
I. V. Izhdeneva

The article actualizes the possibilities of mobile learning based on the use of mobile devices and technologies available to almost all students. Various approaches to the definition of the concept of "mobile learning" are analyzed, including techno-centric and information-centric approaches. The concept of mobility as one of the attributes of learning tools is revealed. The importance of mobile learning in the current difficult situation of distance learning during the pandemic is substantiated. The characteristic features of mobile learning are highlighted, affecting its main functions, learning tools and independence from the time and place of learning. Possible directions for the implementation of mobile learning are characterized, from simple transfer of educational content to compliance with basic educational theories. From the point of view of the functioning and directions of development of mobile learning, its basic principles in teaching informatics are formulated. The types of students' activities are briefly characterized; some advantages of mobile learning are highlighted and its features as visualization, interactivity, efficiency of use in teaching children with disabilities are characterized. Some popular educational apps for mobile devices are considered, their characteristics are given, and their educational potential is revealed. Examples of mobile applications are given, the use of which in informatics lessons will help to activate the educational and cognitive activity of students and stimulate them to engage in informatics, coding and robotics.


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