scholarly journals Disseminated Tuberculosis in a Postpartum Young Women Presenting as Isolated Optic Neuritis

2018 ◽  
Vol 1 (1) ◽  
pp. 46-48
Author(s):  
Priya Sivakumar
Keyword(s):  
Optic Neuritis ◽  
Post Partum ◽  
World Health ◽  
Diagnostic Challenge ◽  
Extra Pulmonary Tuberculosis ◽  
Disseminated Tuberculosis ◽  
Competent Person ◽  
The World ◽  
Health Organization ◽  
Hiv 1

Tuberculosis (TB) is the first infectious disease declared by the World Health Organization as a global health mergency. It remains the leading cause of death among infectious diseases causing more deaths worldwide than uman immune deficiency virus (HIV) [1]. The following case report highlights the occult and non specific  resentations of the disease which makes it a diagnostic challenge. We report a case of extensively disseminated tuberculosis in an immune competent post partum young woman presenting as isolated optic neuritis. Extra pulmonary tuberculosis is commoner among immune compromised patients. Co-existence of military and intracranial tuberculosis in an immune competent person is extremely rare.

scholarly journals Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine

2019 ◽  
Author(s):  
Petter I. Andersen ◽  
Klara Krpina ◽  
Aleksandr Ianevski ◽  
Nastassia Shtaida ◽  
Eunji Jo ◽  
...  
Keyword(s):  
Influenza A ◽  
Rift Valley Fever Virus ◽  
Antiviral Agents ◽  
Viral Disease ◽  
World Health ◽  
Valley Fever ◽  
The World ◽  
Health Organization ◽  
Hiv 1

Viruses are the major causes of acute and chronic infectious diseases in the world. According to the World Health Organization, there is an urgent need for better control of viral diseases. Re-purposing existing antiviral agents from one viral disease to another could play a pivotal role in this process. Here we identified novel activities of obatoclax and emetine against herpes simplex virus type 2 (HSV-2), human immunodeficiency virus 1 (HIV-1), echovirus 1 (EV1), human metapneumovirus (HMPV) and Rift Valley fever virus (RVFV) in cell cultures. Moreover, we demonstrated novel activities of emetine against influenza A virus (FluAV), niclosamide against HSV-2, brequinar against HIV-1, and homoharringtonine against EV1. Our findings may expand the spectrum of indications of these safe-in-man agents and reinforce the arsenal of available antiviral therapeutics pending the results of further in vivo tests.

scholarly journals "CHRONIC SORROW THEORY APPLICATION" TO OVERCOME THE FEELING OF LOSS DUE TO INFANT MORTALITY IN POST-PARTUM WOMEN

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Dedeh Sri Rahayu
Keyword(s):  
Mortality Rate ◽  
Infant Mortality ◽  
Assessment Tool ◽  
Post Partum ◽  
Infant Mortality Rate ◽  
World Health ◽  
Chronic Sorrow ◽  
The World ◽  
Theory Application ◽  
Health Organization

Data from the World Health Organization (WHO) in 2012 stated that 44% of infant deaths in the world occurred in the first 28 days of life (neonatal period). The research results of the Central Statistics Agency (CSA) in 2016 noted that the infant mortality rate (IMR) reached 25.5%, West Java Province was one of the contributors to the highest maternal mortality rate (MMR) and infant mortality rate (IMR). Infant mortality inside the womb or outside the womb triggers grief and deep sorrow that is at risk of progressive, repetitive and permanent in women. Nurses in the maternity area play an important role in overcoming the problem of loss through various approaches to either theory or intervention. The purpose of this study was to determine the application of chronic sorrow theory in post-partum women whose babies were dead at Sariningsih Hospital Bandung. Method: This research was qualitative research. Participants were 5 people selected using purposive sampling techniques. Data collection was done by interviewing using a guide from the Burke / Eakes Chronic Sorrow Assessment Tool. Results: It was identified that women's opinions about the causes of infant mortalities were planned (abortion) and unplanned. Participants had effective coping strategies in dealing with their loss such as social support, and spiritual beliefs for comfort. Conclusion: participants felt the effectiveness of the chronic sorrow theory to overcome infant loss.Keywords: chronic sorrow theory application, loss, post-partum women, Qualitative.

scholarly journals Mixed phenotype acute leukaemia: a case report of an unusual presentation

2017 ◽  
Vol 5 (7) ◽  
pp. 3247
Author(s):  
Veeraraghavan Gurusamy ◽  
Ramya Panneerselvam ◽  
Bharathi Vidhya Jayanthi
Keyword(s):  
Case Report ◽  
Acute Leukaemia ◽  
World Health ◽  
Lymphoid Tissues ◽  
Diagnostic Challenge ◽  
The World ◽  
B Lymphoid ◽  
Health Organization ◽  
Mixed Phenotype

Mixed phenotype acute leukaemias (MPALs), a varied group of disorders pose a diagnostic challenge to the physicians and pathologists alike. This rare subset of acute leukaemias are characterised by the presence of blasts which express markers of more than one lineage (B-lymphoid / T-lymphoid / Myeloid lineage), making the essentiality of immunophenotyping more pertinent. MPALs are included in the acute leukaemias of ambiguous lineage under the World health organization (WHO) classification of tumours of haematopoietic and lymphoid tissues. We describe here a case report of mixed phenotype acute leukaemia (T-Lymphoid/Myeloid). 

Short Communication: Population-Based Surveillance of HIV-1 Drug Resistance in Cameroonian Adults Initiating Antiretroviral Therapy According to the World Health Organization Guidelines

2016 ◽  
Vol 32 (4) ◽  
pp. 329-333 ◽  
Author(s):  
Joseph Fokam ◽  
Désiré Takou ◽  
Maria Mercedes Santoro ◽  
Haniel Ze Akonie ◽  
Charles Kouanfack ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
World Health Organization ◽  
Short Communication ◽  
Population Based ◽  
World Health ◽  
The World ◽  
Health Organization ◽  
Hiv 1

In Silico Studies of Potentially Active 2-Amino-Thiophenic Derivatives Against HIV-1

2020 ◽  
Vol 5 (2) ◽  
pp. 100-119
Author(s):  
Alex France Messias Monteiro ◽  
Marcus Tullius Scotti ◽  
Luciana Scotti
Keyword(s):  
Life Cycle ◽  
World Health ◽  
Computational Tools ◽  
Toxicological Effects ◽  
Rational Drug ◽  
In Silico Studies ◽  
The World ◽  
Potential Activity ◽  
Health Organization ◽  
Hiv 1

HIV is a virus that affects more than 37 million people worldwide, where only 23.3 million were receiving retroviral treatment by 2018, according to the World Health Organization (WHO). Three important enzymatic targets in the life cycle of HIV are: reverse transcriptase, protease and integrase; disease progression causes a decrease in CD4 + T lymphocytes, makes the infected organism vulnerable to opportunistic diseases. Therefore, much research aims to inhibit these enzymes to try to fight AIDS. This research aims to verify the use of silico techniques for an inhibitory activity of a set of 2-aminothiophenic drugs against these three enzymes, based on rational drug planning, virtual screening, and molecular modeling. To this end, many computational tools were used to generate data that improve the expectation of potential activity of these compounds. After all analyses, it was concluded that 12 of the 180 compounds tested may have potential activity against HIV-1 with low toxicological effects.

scholarly journals MATERNAL COMPLIANCE IN POSTPARTUM VISITS IN PULAU BULUH VILLAGE BULANG DISTRICT, BATAM CITY

2021 ◽  
Vol 10 (3) ◽  
pp. 1
Author(s):  
Efilona Setri ◽  
Mohd. Faisyal Reza
Keyword(s):  
Mortality Rate ◽  
Maternal Mortality ◽  
World Health Organization ◽  
Frequency Distribution ◽  
Post Partum ◽  
World Health ◽  
Maternal Deaths ◽  
Live Births ◽  
The World ◽  
Health Organization

Background : According to the World Health Organization (WHO), maternal mortality is still quite high, every day around the world around 800 women die from complications during pregnancy, childbirth and the puerperium. In 2013, 289,000 women died during and after pregnancy, childbirth and the puerperium. Between 1990 and 2013, the global maternal mortality rate (i.e. the number of maternal deaths per 100,000 live births) decreased by only 2.6% per year. This figure is still far from the target of reducing the annual MMR (5.5%) needed to achieve the 5th MDG target (Andiani, and Retno, 2014). Method : The research objective was to determine the compliance of mothers in conducting postpartum visits. Result : Results of the Research on Maternal Compliance in Postpartum Visits Postpartum Visits in Pulau Buluh Village, Bulang District, Batam City It was found that maternal post-partum visits in Pulau Buluh Village consisted of 35 respondents, namely 19 respondents (54%) postnatal visits were obedient, and 16 respondents (46 %) postpartum visits are non-compliant Conclusion : It is known that 19 (54%) of the respondent's frequency distribution of Compliance Postpartum visits are complete and 16 (46%) respondents who are incomplete during postpartum visits

scholarly journals Renal ischemic adverse drug events related to tranexamic acid in women of child-bearing age: an analysis of pharmacovigilance data

2020 ◽  
Author(s):  
Dominik Stämpfli ◽  
Stefan Weiler ◽  
Carolyn F. Weiniger ◽  
Andrea M. Burden ◽  
Michael Heesen
Keyword(s):  
Tranexamic Acid ◽  
World Health Organization ◽  
Adverse Drug Events ◽  
Post Partum ◽  
World Health ◽  
Child Bearing ◽  
Embolism And Thrombosis ◽  
The World ◽  
Health Organization ◽  
Renal Vascular

Abstract Purpose In response to a large trial, the World Health Organization broadened their recommendation on tranexamic acid to be used for post-partum hemorrhage. A 2013 French periodic safety update report warned of an abnormally high rate of renal cortical necrosis associated with tranexamic acid and other drugs for severe post-partum hemorrhage. We aimed to identify the reporting incidence of adverse thrombo-embolic events among women in child-bearing age who received tranexamic acid, with a focus on renal vascular and ischemic conditions. Methods We analyzed individual case safety reports (ICSRs) on renal vascular and ischemic conditions, pulmonary thrombotic and embolic conditions, and peripheral embolism and thrombosis from the database of the World Health Organization – Uppsala Monitoring Centre (WHO-UMC). ICSRs were restricted to reports including tranexamic acid as a suspected drug, sex reported as female, and reported age between 18 and 44 years. Reporting odds ratios (RORs) and 95% confidence intervals (95% CIs) were calculated by comparing ICSRs on tranexamic acid to all other drugs in VigiBase. Results Within 2245 included ICSRs on tranexamic acid, we identified 29 reports of adverse renal vascular and ischemic conditions, 42 reports of pulmonary thrombotic and embolic conditions, and 41 reports of peripheral embolism and thrombosis. RORs were statistically significant by 32.6-fold (32.62, 95% CI: 22.50–47.29), 2.5-fold (2.52, 95% CI: 1.85–3.42), and 2.7-fold (2.67, 95% CI: 1.96–3.64), respectively, when compared to any other drug within VigiBase. Conclusion Tranexamic acid might bear an increased risk for renal ischemic adverse drug events in women of child-bearing age.

scholarly journals Oxytocyn Massage Using Innovative Massage Tool and Conventional Effleurage Techniques to Increase Breastmilk Production in Post Partum Mothers

2020 ◽  
Author(s):  
Nining Istighosah ◽  
◽  
Aprilia Nurtika Sari ◽  
Keyword(s):  
Treatment Group ◽  
Breast Milk ◽  
Milk Production ◽  
Exclusive Breastfeeding ◽  
Post Partum ◽  
World Health ◽  
Breast Milk Production ◽  
The World ◽  
Massage Treatment ◽  
Health Organization

ABSTRACT Background: Exclusive breastfeeding for the first six months of life is recommended by the World Health Organization and United Nations Children’s Fund. The World Health Organization (WHO) recommends exclusive breastfeeding for up to 6 months and continuous breastfeeding for up to 2 months. Exclusive breastfeeding is the most effective intervention to reduce infant mortality. It is estimated that it can prevent 13% of under-five mortality in low-income countries. This study aimed to analyze the difference in breastmilk volume before and after the mother received the oxytocin massage using innovative massage tool and conventional effleurage techniques. Subjects and Methods: This was a quasi-experiment study with a non-randomized control trial pretest-posttest design was conducted in Kediri from August to September 2020. The sample used was post-partum women on days 4 to 10 using purposive sampling technique. The dependent variable was amount of breast milk production. The independent variables were oxytocin massage treatment with effleurage technique, and the combination of oxytocin massage, effleurage technique and innovation massage tool. The data was analyzed by T-Test. Results: In the oxytocin massage treatment group used the conventional Effleurage method (Mean = 42; SD = 29) while in the massage treatment group using an innovative massage tool (Mean = 60; SD = 51) this was very different in the control group (Mean = 3.4; SD = 8.8) and it was statistically significant (p= 0.005). Conclusion: Giving oxytocin massage using an innovative massage device were higher than oxytocin massage using the conventional Effleurage method and massage using this innovative massage device had a statistical impact on increasing breast milk production Keywords: oxytocin massage, breast milk production, innovative massage tool Correspondence: Nining Istighosah. School of Midwifery Dharma Husada Kediri. Jl. Penanggungan No. 41-A Kediri. E-mail: [email protected]. Mobile: +6281231352032. DOI: https://doi.org/10.26911/the7thicph.03.48

scholarly journals Post Partum Hemorrhage – Mini Review

2019 ◽  
Vol 18 (4) ◽  
pp. 141-146
Author(s):  
Charalampos Voros ◽  
Kalliopi Pappa
Keyword(s):  
Postpartum Hemorrhage ◽  
Post Partum ◽  
Medical Intervention ◽  
World Health ◽  
International Guidelines ◽  
The World ◽  
Health Organization ◽  
Effective Component ◽  
Current Guidelines ◽  
Prompt Diagnosis

Background: Postpartum hemorrhage (PPH) remains a common cause of maternal mortality worldwide, mainly caused by uterine atony. Medical intervention plays an important part in prevention and therapies of PPH. Prophylactic interventions include the use of uterotonic drugs. We elaborated the consistency of national and international guidelines on those medical approaches. Materials and methods: Medical approaches in PPH were extracted from recent publications. Furthermore, the current guidelines of the World Health Organization, the FIGO and of the American, British,and Canadian of Obstetricians and Gynecologists on PPH were analyzed. Results: Use of oxytocin after delivery of the anterior shoulder is the most important and effective component of this practice. However, the examined guidelines fail to give unequivocal recommendations on further uterotonics in PPH, which may partially be attributed to differing publication dates of the guidelines. Conclusion: Appropriate management of postpartum hemorrhage requires prompt diagnosis and treatment . International guidelines on PPH are characterized by differing recommendations. However, recent publications suggest that adhering to local guidelines significantly reduces the prevalence of severe PPH.

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