scholarly journals Clinical and Laboratory Findings among Patients with Toxocaria-sis in Medic Medical Center, Ho Chi Minh City, Vietnam in 2017-2019

2021 ◽  
Author(s):  
Le Dinh Vinh Phuc ◽  
Cao Ba Loi ◽  
Huynh Hong Quang ◽  
Le Duc Vinh ◽  
Cao Truong Sinh ◽  
...  
Keyword(s):  
Significant Relationship ◽  
Eosinophil Count ◽  
Clinical Laboratory ◽  
Clinical Symptoms ◽  
Medical Center ◽  
Elisa Test ◽  
Clinical Findings ◽  
Ho Chi Minh City ◽  
Laboratory Findings ◽  
Wide Range

Background: Human toxocariasis is prevalent in many countries but this disease has been rarely reported from Vietnam. We aimed to investigate the clinical and laboratory findings and assess possible association between these findings in patients with toxocariasis in Vietnam. Methods: A prospectively study, between October 2017 and June 2019 was performed involving 120 toxocariasis patients at Medic Medical Center, Ho Chi Minh City, Vietnam. The diagnosis of toxocariasis was established based on clinical, laboratory (eosinophilia, raised IgE concentration) and serological (positive Toxocara IgG ELISA test) evaluation as well as the exclusion of other helminthic coinfection.   Results: The most frequently reported manifestation was of skin (n = 93, 77.5%), including urticarial (n= 69, 57.5%) followed by neurologic, gastrointestinal and pulmonary signs/symptoms. Hepatic involvement occurred in 8.3% of the patients. No significant relationship between clinical findings and laboratory parameters was found except the higher values of eosinophil count and IgE concentration among patients with liver involvement. There was a significant relationship between eosinophil count and IgE concentration (r=0.389, P<0.001). Serological findings did not show a correlation with clinical and other laboratory findings. Conclusion: Our data revealed a wide range of clinical symptoms/signs and a high incidence of skin manifestations in patients with toxocariasis. Eosinophil count and IgE concentration are valuable markers for the evaluation of the disease.

scholarly journals Clinicoepidemiological Profile and Short term Outcome of Abdominal Tuberculosis in Western Region of Bangladesh

2018 ◽  
Vol 37 (1) ◽  
pp. 25-29
Author(s):  
Madhusudan Saha ◽  
SAHM Mesbahul Islam ◽  
Irin Perveen ◽  
Nasrin Aktar ◽  
Kabir Ahmed ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Clinical Symptoms ◽  
Intestinal Tuberculosis ◽  
Abdominal Tuberculosis ◽  
Clinical Findings ◽  
Response To Therapy ◽  
Laboratory Findings ◽  
Term Outcome ◽  
Gold Standard Method

Introduction: Abdominal tuberculosis is not uncommon in daily medical practice. This study was done focusing variable presentations of abdominal tuberculosis Material and methods: Data of consecutive patients diagnosed as abdominal tuberculosis were analyzed. Their epidemiological features, presentations, laboratory findings, and response to therapy were analysed. Result: Total 69 cases (male 43, 62.3%,and female 26, 37.7%), age ranging from 15 to 85 years (mean 36.23) were enrolled. Rural (55, 79.7%), poor (49,71%) and housewives (24, 34.8%) and people of 21-30 years age group (27, 39.1%) were more affected. Diagnosis was based on combinations of clinical, laboratory findings and therapeutic response. In this series 30 (43.5%), 23 (33.4%) and 12 (17.3%) were diagnosed as intestinal, peritoneal and disseminated tuberculosis respectively. Of them68 patients recovered with treatment. Five patients developed intestinal obstruction and one developed hepatitis and lost from follow up. Conclusion: Diagnosis of abdominal tuberculosis is by combinations of clinical findings, without gold standard method. In our series intestinal tuberculosis and peritoneal tuberculosis were common clinical types with weight loss and abdominal pain as common clinical symptoms. And outcome of Treatment of TB was excellent J Bangladesh Coll Phys Surg 2019; 37(1): 25-29  

scholarly journals The mRNA Distribution of Cancer Stem Cell Marker CD90/Thy-1 Is Comparable in Hepatocellular Carcinoma of Eastern and Western Populations

Cells ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 2672
Author(s):  
An B. Luong ◽  
Huy Q. Do ◽  
Paola Tarchi ◽  
Deborah Bonazza ◽  
Cristina Bottin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Demographic Data ◽  
Clinical Findings ◽  
Stem Cell Marker ◽  
Ho Chi Minh City ◽  
Tumor Diameter ◽  
Laboratory Findings ◽  
Tissue Samples ◽  
Single Laboratory ◽  
Pcr Conditions

Epidemiology of hepatocellular carcinoma (HCC) showed a correlation between incidence and geographical-relevant risk factors. This study aims to compare the distributions of cancer stem cells (CSC) in two distant populations in Asia and Europe. We analyzed 52 and 43 selected HCC patients undergoing hepatectomy in Ho Chi Minh City (Vietnam) and Trieste (Italy). Each patient sample consisted of HCC, peri-HCC, and non-tumoral (distal) tissue. Demographic data were recorded together with clinical findings. The protocol for the collection of tissue samples and RNA was standardized in both laboratories and gene expression analysis was performed in a single laboratory with identical PCR conditions. Baseline data showed comparable laboratory findings between the two cohorts. mRNA distribution showed a comparable pattern of all CSC markers analyzed with the expression of CD90 progressively increasing from distal and peri-HCC to be highest in HCC (p < 0.001), confirmed by immunofluorescence data. CD90 mRNA distribution was related to HBV-related HCC and a tumor diameter less than 5 cm. Patients with high tumoral CD90 mRNA had a shorter time (p < 0.05) to tumor recurrence compared to patients with lower CD90. This comparative study showed that CD90 mRNA expressions are comparable between Eastern and Western HCC cases.

A Team-Based Approach to Autopsy Education: Integrating Anatomic and Clinical Pathology at the Rotation Level

2014 ◽  
Vol 138 (3) ◽  
pp. 322-327 ◽  
Author(s):  
Tiffany Michele Hébert ◽  
Sara Maleki ◽  
Ljiljana V. Vasovic ◽  
Jeffrey L. Arnold ◽  
Jacob J. Steinberg ◽  
...  
Keyword(s):  
New York ◽  
Clinical Laboratory ◽  
Medical Center ◽  
Clinical Pathology ◽  
Holistic Approach ◽  
Final Diagnosis ◽  
Perceived Usefulness ◽  
Final Report ◽  
Laboratory Findings ◽  
Depth Analysis

Context.—Pathology residency training programs should aim to teach residents to think beyond the compartmentalized data of specific rotations and synthesize data in order to understand the whole clinical picture when interacting with clinicians. Objective.—To test a collaborative autopsy procedure at Montefiore Medical Center (Bronx, New York), linking residents and attending physicians from anatomic and clinical pathology in the autopsy process from the initial chart review to the final report. Residents consult with clinical pathology colleagues regarding key clinical laboratory findings during the autopsy. This new procedure serves multiple functions: creating a team-based, mutually beneficial educational experience; actively teaching consultative skills; and facilitating more in-depth analysis of the clinical laboratory findings in autopsies. Design.—An initial trial of the team-based autopsy system was done from November 2010 to December 2012. Residents were then surveyed via questionnaire to evaluate the frequency and perceived usefulness of clinical pathology autopsy consultations. Results.—Senior residents were the most frequent users of clinical pathology autopsy consultation. The most frequently consulted services were microbiology and chemistry. Eighty-nine percent of the residents found the clinical pathology consultation to be useful in arriving at a final diagnosis and clinicopathologic correlation. Conclusion.—The team-based autopsy is a novel approach to integration of anatomic and clinical pathology curricula at the rotation level. Residents using this approach develop a more holistic approach to pathology, better preparing them for meaningful consultative interaction with clinicians. This paradigm shift in training positions us to better serve in our increasing role as arbiters of outcomes measures in accountable care organizations.

scholarly journals Diagnostic Tests and Clinical, Laboratory and Radiological Charactersitics of COVID-19 in Pregnant Women: A Review

2020 ◽  
Vol 24 (2) ◽  
pp. 146-157
Author(s):  
Sedigheh Hasani Moghadam ◽  
◽  
Abbas Alipour ◽  
Saeid Abedian Kenari ◽  
Soghra Khani ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Clinical Laboratory ◽  
Ground Glass Opacity ◽  
Clinical Findings ◽  
Diagnostic Methods ◽  
Laboratory Findings ◽  
Radiographic Findings ◽  
Controllable Factors ◽  
Second Category ◽  
Do So

The emerging Coronavirus (COVID-19) is a new infectious disease and the definitive gold standard for its diagnosis in pregnancy has not yet been established. Therefore, this study was conducted with the aim of reviewing the diagnostic methods and clinical, laboratory and radiological symptoms of COVID-19 disease in pregnant women. The present study is a Narrative review. To do so, the keywords were searched in the Scopus, Google scholar, PubMed, Embase, Science Direct, WHO databases from April 1, 2020 to May 9, 2020. 34 articles were obtained and finally 6 articles were used to write this study. Evidence related to the purpose of this study was identified in three categories. The first category examines clinical findings (fever and cough), the second category examines laboratory findings (leukocytosis and lymphopenia), and a third category examines chest radiographic findings (Pure ground-glass opacity). Since infection is one of the most important causes of death in pregnant women and is one of the preventable and controllable factors, so by identifying the correct diagnostic methods of this infection, at-risk pregnant women will be identified and Prevent the consequences of this infection.

scholarly journals Factors contributing to diagnostic delay of Caroli syndrome: a single-center, retrospective study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wen Shi ◽  
Xiao-ming Huang ◽  
Yun-lu Feng ◽  
Feng-dan Wang ◽  
Xiao-xing Gao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Symptoms ◽  
Medical Center ◽  
Diagnostic Delay ◽  
Mainland China ◽  
Magnetic Resonance Cholangiopancreatography ◽  
Laboratory Findings ◽  
Hepatic Cysts ◽  
Initial Symptoms ◽  
Caroli Syndrome

Abstract Background Caroli syndrome (CS) is a rare congenital disorder without pathognomonic clinical symptoms or laboratory findings; therefore, the diagnosis is often delayed. The objective of this study was to investigate the diagnostic delay and associated risk factors in CS patients. Methods This was a retrospective analysis of 16 CS patients admitted to a single tertiary medical center on mainland China. The diagnostic timelines of CS patients were reviewed to demonstrate the initial findings of CS at diagnosis, the risk factors associated with diagnostic delay, and potential clues leading to early diagnosis. Results The median diagnostic delay was 1.75 years (range: 1 month to 29 years, interquartile range: 6.2 years) in 16 enrolled CS patients. Sex, age, and initial symptoms were not associated with diagnostic delay. 87.5% of CS patients were diagnosed by imaging, and the accuracies of ultrasonography, computed tomography (CT), and magnetic resonance cholangiopancreatography were 25, 69.2, and 83.3%, respectively. The median diagnostic delays for patients with or without CT performed at the first hospital visited according to physician and radiologist suspicion of the diagnosis were 7.4 months and 6 years, respectively (p = 0.021). Hepatic cysts with splenomegaly were detected by ultrasound in over half of CS patients. Conclusions The majority of CS patients were not diagnosed until complications of portal hypertension had already developed. Recognition and early suspicion of the disease were important factors influencing diagnostic delay of CS. Hepatic cysts plus splenomegaly detected by US might raise the clinical suspicion to include CS in the differential diagnosis.

scholarly journals A A Multicentre ICET-A Study of Confirmed SARS-CoV-2 Infection in Patients with Hemoglobinopathies: Preliminary Data from 10 Countries

2020 ◽  
Vol 12 (1) ◽  
pp. e2020046 ◽  
Author(s):  
Vincenzo De Sanctis
Keyword(s):  
Clinical Laboratory ◽  
Clinical Symptoms ◽  
Respiratory Infections ◽  
Gastrointestinal Symptoms ◽  
Thalassemia Major ◽  
Absolute Number ◽  
Laboratory Findings ◽  
Radiologic Findings ◽  
Novel Coronavirus ◽  
Viral Respiratory Infections

Objectives: This study aims to investigate, retrospectively, the epidemiological and clinical characteristics, laboratory results, radiologic findings and outcomes of novel coronavirus disease-19 (COVID-19) in patients with transfusion dependent β thalassemia (β-thalassemia major-TM), non-transfusion dependent β thalassemia (β-thalassemia intermedia -TI) and sickle cell disease (SCD). Design, setting: A total of 17 Centers, from 10 countries, following 9,499 patients with hemoglobinopathies participated in the survey. Main outcome measures: Clinical, laboratory and radiologic findings and outcomes of patients with COVID-19 were collected from medical records and summarized. Results: A total of 13 patients, 7 with TM, 3 with TI and 3 with SCD, with confirmed COVID-19, were identified from 6 Centers from different countries. The overall mean age of patients was 33.7±12.3 years (range:13-66); 9/13 (69.2%) patients were females. The commonest symptoms in the 10 symptomatic patients were: fever (80%), cough (70%), headache (60%), fatigue (60%), gastrointestinal symptoms (diarrhea /vomiting/abdominal pain; 50%), tachypnea/dyspnea (40%), and sore throat (40%). Six patients had pneumonia (unilateral, bilateral or multiple opacity) and 4 needed oxygen therapy. An oxygen saturation ≤ 93% was documented in 3 patients at diagnosis. 6/10 patients had an exacerbation of anemia (2 with SCD, associated with back and chest pain in 1 patient), and 3 (<30%) had a decreased absolute number of lymphocytes. Increased C-reactive protein and D-dimers were the most common laboratory findings (66.6 %). Conclusions: The clinical presentation for COVID-19 in patients with β-thalassemia and SCD varies. Patients with mild/ordinary COVID-19 infection appear to have clinical symptoms and laboratory findings common to other viral respiratory infections. One 30 year old TM female patient with diabetes and chronic kidney disease. For a better understanding of COVID-19 in patients with hemoglobinopathies, further epidemiologic and clinical studies in a larger cohort of patients are required.

Clinical and Epidemiologic Features of Visceral Leishmaniasis in Children: A 6-year Study from an Iranian Referral Hospital

2020 ◽  
Vol 20 (4) ◽  
pp. 461-466 ◽  
Author(s):  
Mohamadreza Abdolsalehi ◽  
Babak Pourakbari ◽  
Shima Mahmoudi ◽  
Mina Moradzadeh ◽  
Hossein Keshavarz ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Clinical Laboratory ◽  
Medical Center ◽  
Final Diagnosis ◽  
Laboratory Findings ◽  
Center Hospital ◽  
Regional Disease ◽  
Loss Of Appetite ◽  
And Control ◽  
Epidemiologic Features

Background:: Visceral leishmaniasis (VL) is an emerging zoonosis disease that is endemic in the northwestern and southern part of Iran. This study aimed to evaluate the clinical characteristics and laboratory findings of the children with VL hospitalized at Children Medical Center Hospital (CMC), Tehran, Iran. Methods:: A retrospective study was performed based on studied medical records of children with a final diagnosis of VL from 2011 to 2016. For each patient’s demographics, clinical laboratory findings and treatment were examined. Results:: The clinical features of 17 children were examined and the most frequent symptoms were fever (94.1%, n=16), pallor, loss of appetite (76.5%, n=13), splenomegaly (82.4%, n=14) and hepatomegaly (58.8%, n=10). The most frequent laboratory abnormalities were hematological including anemia (94.1%, n=16), leukopenia (52.9%, n=9) and thrombocytopenia (70.5%, n=12). In order to detect anti-Leishmania antibodies, DAT was performed in 11 patients and 82% of them were positive (titers ≥ 1: 3200). In addition, rK39 was used in 9 cases and 7 children (78%) had positive results. Direct parasitology revealed the presence of amastigotes of Leishmania in bone marrow aspirate (BMA) stained by Giemsa stain in 9 patients (69%, among 13 children). Conclusion:: Leishmaniasis is a regional disease therefore management and control of disease, particularly in an endemic area, as well as detection of new emerging foci are recommended.

scholarly journals Clinical Features of Patients with Probable 2019 Novel Coronavirus Infected Pneumonia in Rasht, Iran: A Retrospective Case Series

2020 ◽  
Vol 8 (T1) ◽  
pp. 16-22
Author(s):  
Samad Karkhah ◽  
Mohammad Javad Ghazanfari ◽  
Amir Shamshirian ◽  
Latif Panahi ◽  
Meysam Molai ◽  
...  
Keyword(s):  
Clinical Features ◽  
Clinical Laboratory ◽  
Clinical Symptoms ◽  
Case Series ◽  
Symptomatic Treatment ◽  
Retrospective Case ◽  
Laboratory Findings ◽  
Retrospective Case Series ◽  
Case Series Study ◽  
Novel Coronavirus

BACKGROUND: Coronavirus disease-19 (COVID-19) is the first pandemic infectious disease caused by a novel coronavirus. Viral pneumonia is a severe complication of COVID-19. AIM: Due to the high prevalence of this disease globally, especially in Iran, the aim of this study was to determine the clinical features of seven patients with probable COVID-19 infected pneumonia in Rasht, North Iran. MATERIALS AND METHODS: In this retrospective case series study, we described the clinical, laboratory, and radiological features of seven patients with probable COVID-19 infected pneumonia at Razi Hospital, Rasht, north of Iran, from February 27 to March 16, 2020. RESULTS: In this study, the most common clinical symptoms during hospitalization in patients with COVID-19 were poor appetite (seven cases), dehydration (seven cases), cough (six cases), dyspnea (six cases), fatigue (six cases), fever above 38°C (five cases), myalgia (five cases), Chills (five cases), feeling fever (five cases), sore throat (five cases), and nausea (five cases), respectively. The average body temperature in these patients was 39.32°C. In laboratory findings, erythrocyte sedimentation rate was elevated in three patients. Contrary to most of the evidence, C-reactive protein was not elevated in five patients. All patients received antibiotic and antiviral medications and received symptomatic treatment. Finally, four patients responded to the treatments and were discharged from the hospital; two patients were still hospitalized and only one patient died. CONCLUSION: Patients with COVID-19 associated pneumonia can be treated by evaluating and implementing appropriate therapeutic management. However, at the moment the disease progression for patients with COVID-19 cannot be accurately predicted.

scholarly journals Clinical, laboratory and ultrasonographic findings in 38 calves with type-4 abomasal ulcer

2021 ◽  
Vol 63 (1) ◽  
Author(s):  
Ueli Braun ◽  
Christina Widmer ◽  
Karl Nuss ◽  
Monika Hilbe ◽  
Christian Gerspach
Keyword(s):  
Clinical Laboratory ◽  
Clinical Findings ◽  
Pathological Examination ◽  
Severe Illness ◽  
Diffuse Peritonitis ◽  
Laboratory Findings ◽  
Poor General Health ◽  
Abdominal Examination ◽  
The Right ◽  
Tentative Diagnosis

Abstract Background Type-4 abomasal ulcers (U4) are perforated ulcers causing diffuse peritonitis. This retrospective study describes the clinical, laboratory and ultrasonographic findings in 38 calves with U4. The medical records of 38 calves aged three days to 20 weeks with U4 were scrutinised. Results The most common clinical findings were poor general health (95%), reduced skin elasticity (95%), rumen atony (91%), abdominal guarding (76%) and positive percussion auscultation and/or swinging auscultation on the right side of the abdomen (75%). The most frequent laboratory findings were increased numbers of segmented neutrophils (87%), eosinopenia (87%), acidosis (84%), azotaemia (79%) and hyponatraemia (79%). The most frequent abdominal ultrasonographic findings were intestinal atony (68%), fluid (67%) and fibrin deposits (58%) in the abdomen. Thirty-five calves were euthanased and three calves died spontaneously. All calves underwent pathological examination. Diffuse peritonitis caused by a transmural abomasal ulcer was the principal diagnosis in all calves. Conclusions Perforated abomasal ulcers cause severe illness, and a thorough clinical examination combined with ultrasonographic abdominal examination should lead to a tentative diagnosis.

scholarly journals Movement Disorders in Oncology: From Clinical Features to Biomarkers

Biomedicines ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 26
Author(s):  
Luca Marsili ◽  
Alberto Vogrig ◽  
Carlo Colosimo
Keyword(s):  
Brain Tumors ◽  
Movement Disorders ◽  
Clinical Laboratory ◽  
Checkpoint Inhibitors ◽  
Diagnostic Testing ◽  
Response To Treatment ◽  
Immune Checkpoints ◽  
Laboratory Findings ◽  
Antineuronal Antibodies ◽  
Wide Range

Background: the study of movement disorders associated with oncological diseases and anticancer treatments highlights the wide range of differential diagnoses that need to be considered. In this context, the role of immune-mediated conditions is increasingly recognized and relevant, as they represent treatable disorders. Methods: we reappraise the phenomenology, pathophysiology, diagnostic testing, and treatment of movement disorders observed in the context of brain tumors, paraneoplastic conditions, and cancer immunotherapy, such as immune-checkpoint inhibitors (ICIs). Results: movement disorders secondary to brain tumors are rare and may manifest with both hyper-/hypokinetic conditions. Paraneoplastic movement disorders are caused by antineuronal antibodies targeting intracellular or neuronal surface antigens, with variable prognosis and response to treatment. ICIs promote antitumor response by the inhibition of the immune checkpoints. They are effective treatments for several malignancies, but they may cause movement disorders through an unchecked immune response. Conclusions: movement disorders due to focal neoplastic brain lesions are rare but should not be missed. Paraneoplastic movement disorders are even rarer, and their clinical-laboratory findings require focused expertise. In addition to their desired effects in cancer treatment, ICIs can induce specific neurological adverse events, sometimes manifesting with movement disorders, which often require a case-by-case, multidisciplinary, approach.

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