scholarly journals Factor Analysis of Metabolic Syndrome Components in a Popu-lation-Based Study in the South of Iran (PERSIAN Kharameh Cohort Study)

2021 ◽  
Author(s):  
Hossein-Ali Nikbakht ◽  
Abbas Rezaianzadeh ◽  
Mozhgan Seif ◽  
Haleh Ghaem
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Factor Analysis ◽  
Cohort Study ◽  
Age Groups ◽  
Population Based ◽  
Large Sample Size ◽  
The Metabolic Syndrome ◽  
Screening Parameter ◽  
Metabolic Syndrome Components

Background: We aimed to estimate the exploratory factor analysis (EFA) of metabolic syndrome components based on variables including gender, BMI, and age groups in a population-based study with large sample size. Methods: This study was conducted on 10663 individuals 40-70 yr old in Phase 1 of the Persian Kharameh cohort study conducted in 2014-2017. EFA of the metabolic syndrome components, including waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), high-density lipoprotein (HDL) and fasting blood sugar (FBS), was performed on all participants by gender, BMI (Body Mass Index), and age groups. Results: EFA results in the whole population based on eigenvalues ​​greater than one showed two factors explaining 56.06% of the total variance. Considering factor loadings higher than 0.3, the first factor included: DBP, SBP, and WC, named as hypertension factor. The second factor also included TG, negative-loaded HDL, FBS, and WC, named as lipid factor. Almost similar patterns were extracted based on subgroups.  Conclusion: MetS is a multi-factorial syndrome. Both blood pressure and lipid had a central role in this study and obesity was an important factor in both ones. Hypertension, having the highest factor loading, can generally be a valuable screening parameter for cardiovascular and metabolic risk assessment.

scholarly journals Poor breakfast habits in adolescence predict the metabolic syndrome in adulthood

2014 ◽  
Vol 18 (1) ◽  
pp. 122-129 ◽  
Author(s):  
Maria Wennberg ◽  
Per E Gustafsson ◽  
Patrik Wennberg ◽  
Anne Hammarström
Keyword(s):  
Metabolic Syndrome ◽  
Central Obesity ◽  
Fasting Glucose ◽  
International Diabetes Federation ◽  
Population Based ◽  
The Metabolic Syndrome ◽  
High Fasting Glucose ◽  
The Relationship ◽  
Metabolic Syndrome Components

AbstractObjectiveTo analyse whether poor breakfast habits in adolescence predict the metabolic syndrome and its components in adulthood. Previous studies suggest that regular breakfast consumption improves metabolic parameters.DesignProspective. Breakfast habits and other lifestyle variables at age 16 years were assessed from questionnaires. Poor breakfast habits were defined as skipping breakfast or only drinking or eating something sweet. At age 43 years, the effective sample consisted of 889 participants defined as having the metabolic syndrome or not, using the International Diabetes Federation criteria. Logistic regression was used to calculate odds ratios and confidence intervals.SettingThe Northern Swedish Cohort, a longitudinal population-based cohort with 27-year follow-up.SubjectsAdolescents (age 16 years).ResultsPrevalence of the metabolic syndrome at age 43 years was 27·0 %. Of the participants, 9·9 % were classified with poor breakfast habits at age 16 years. Adjusted odds for the metabolic syndrome at age 43 years was OR = 1·68 (95 % CI 1·01, 2·78) for those with poor breakfast habits at age 16 years compared with breakfast eaters. Looking at the metabolic syndrome components, poor breakfast habits at age 16 years were associated with central obesity (OR = 1·71; 95 % CI 1·00, 2·92) and high fasting glucose (OR = 1·75; 95 % CI 1·01, 3·02) at age 43 years, even after multivariate adjustments.ConclusionsPoor breakfast habits in adolescence predicted the metabolic syndrome in adulthood. Of the metabolic syndrome components, poor breakfast habits in adolescence predicted central obesity and high fasting glucose in adulthood. Further research is needed to fully understand the relationship between early breakfast habits and adult metabolic syndrome.

scholarly journals Serum Omega-6 Polyunsaturated Fatty Acids and the Metabolic Syndrome: A Longitudinal Population-based Cohort Study

2012 ◽  
Vol 176 (3) ◽  
pp. 253-260 ◽  
Author(s):  
M. Vanhala ◽  
J. Saltevo ◽  
P. Soininen ◽  
H. Kautiainen ◽  
A. J. Kangas ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acids ◽  
Cohort Study ◽  
Polyunsaturated Fatty Acids ◽  
Population Based ◽  
The Metabolic Syndrome ◽  
Omega 6

What components drive the metabolic syndrome? Results from the population-based LifeLines Cohort Study

2015 ◽  
Author(s):  
Sandra N Slagter ◽  
Robert P van Waateringe ◽  
Marjolein Wendker ◽  
Jana V van Vliet-Ostaptchouk ◽  
Helen L Lutgers ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Population Based ◽  
The Metabolic Syndrome

scholarly journals The Prevalence of the Metabolic Syndrome and Its Risk Factors in a Middle-Aged Swedish Population — Mainly a Function of Overweight?

2008 ◽  
Vol 7 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Gunilla Hollman ◽  
Margareta Kristenson
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Risk Factor ◽  
Waist Circumference ◽  
Hdl Cholesterol ◽  
Population Based ◽  
Middle Aged ◽  
Swedish Population ◽  
The Metabolic Syndrome

Background: The prevalence of obesity, one risk factor for developing the metabolic syndrome (MS), has increased during the last decades. It has therefore been assumed that the prevalence of MS would also increase. Aims: The aim was to analyse the prevalence of MS and its risk factors in a middle-aged Swedish population. Methods: Data were obtained between 2003 and 2004 from a random population based sample of 502 men and 505 women, 45–69 years old. Measures of plasma glucose, serum lipids, blood pressure, weight, height, waist circumference and self-reported data concerning presence of disease, medication and lifestyle were obtained. Results: The prevalence of MS was 14.8% among men and 15.3% among women, with an increase by age among women only, 10% to 25% ( p = 0.029). Among individuals with MS the most frequent risk factor was large waist circumference, present in 85% of men and 99% of women, followed by high blood pressure, high triglycerides, high glucose and HDL cholesterol (38% and 47% respectively). Conclusion: The prevalence of MS was 15%, increasing with age only among women. Overweight was a dominant characteristic, and only half of the individuals with MS had glucose/HDL cholesterol levels beyond defined cut points of the syndrome.

scholarly journals Higher breakfast glycaemic load is associated with increased metabolic syndrome risk, including lower HDL-cholesterol concentrations and increased TAG concentrations, in adolescent girls

2014 ◽  
Vol 112 (12) ◽  
pp. 1974-1983 ◽  
Author(s):  
Analise Nicholl ◽  
Mary du Heaume ◽  
Trevor A. Mori ◽  
Lawrence J. Beilin ◽  
Wendy H. Oddy ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adolescent Girls ◽  
Hdl Cholesterol ◽  
Population Based ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Glycaemic Load ◽  
The Metabolic Syndrome ◽  
Almost All ◽  
Metabolic Syndrome Components

Almost all previous studies examining the associations between glycaemic load (GL) and metabolic syndrome risk have used a daily GL value. The daily value does not distinguish between peaks of GL intake over the day, which may be more closely associated with the risk of the metabolic syndrome. The aim of the present study was to investigate the cross-sectional associations between daily and mealtime measures of GL and metabolic syndrome risk, including metabolic syndrome components, in adolescents. Adolescents participating in the 14-year follow-up of the Western Australian Pregnancy Cohort (Raine) Study completed 3 d food records and metabolic assessments. Breakfast GL, lunch GL, dinner GL and a score representing meal GL peaks over the day were determined in 516 adolescents. Logistic regression models were used to investigate whether GL variables were independent predictors of the metabolic syndrome in this population-based cohort (3·5 % prevalence of the metabolic syndrome). Breakfast GL was found to be predictive of the metabolic syndrome in girls (OR 1·15, 95 % CI 1·04, 1·27; P <0·01), but not in boys. Other meal GL values and daily GL were found to be not significant predictors of the metabolic syndrome. When breakfast GL was examined in relation to each of the components of the metabolic syndrome in girls, it was found to be negatively associated with fasting HDL-cholesterol concentrations (P= 0·037; β = − 0·004; 95 % CI − 0·008, − 0·002) and positively associated with fasting TAG concentrations (P= 0·008; exp(β) = 1·002; 95 % CI 1·001, 1·004). The results of the present study suggest that there may be an association between breakfast composition and metabolic syndrome components in adolescent girls. These findings support further investigation into including lower-GL foods as part of a healthy breakfast in adolescence, particularly for girls.

scholarly journals Assessment of risk factors and clinical effectiveness in the treatment of arterial hypertension in patients with the metabolic syndrome

2021 ◽  
Author(s):  
Э.И. Полозова ◽  
В.В. Скворцов ◽  
Е.В. Пузанова ◽  
А.А. Сеськина ◽  
Н.С. Нефедов
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Arterial Hypertension ◽  
Inpatient Treatment ◽  
Blood Pressure Reduction ◽  
Age Groups ◽  
Excess Body Weight ◽  
The Metabolic Syndrome ◽  
Target Values

Высокая распространенность метаболического синдрома во всем мире, неуклонный рост заболеваемости у людей разных возрастных групп делают его одной из самых серьезных проблем в клинике внутренних болезней и позволяют по праву считать неинфекционной эпидемией XXI века. Учитывая, что одним из основных компонентов метаболического синдрома является артериальная гипертензия, целью работы явилось изучение и оценка факторов риска и эффективности лечения артериальной гипертонии у больных метаболическим синдромом. В исследовании приняли участие 110 пациентов с верифицированным диагнозом артериальной гипертонии II стадии и метаболическим синдромом. Все пациенты из группы исследования находились на стационарном лечении в ГБУЗ РМ «Республиканская клиническая больница № 5» г. Саранска с 2018 по 2020 гг. Проведена оценка факторов риска и проанализировано лечение артериальной гипертонии у больных метаболическим синдромом. Клиническое исследование показало, что наиболее распространенными факторами риска неблагоприятного прогноза у пациентов с метаболическим синдромом и артериальной гипертензией выступают психоэмоциональный стресс, избыточная масса тела, гиподинамия и наследственная отягощенность по артериальной гипертензии и метаболическому синдрому. Назначаемая в стационаре пациентам с метаболическим синдромом для лечения артериальной гипертонии комбинированная гипотензивная терапия была рациональной в 100% случаев. Стационарное лечение больных метаболическим синдромом было эффективным, что определялось снижением артериального давления до уровня целевых значений в средние сроки 5,86 ± 0,94 дня. The high prevalence of metabolic syndrome worldwide, the steady growth of morbidity in people of different age groups makes it one of the most serious problems in the clinic of internal diseases, rightfully considering it an epidemic of the 21st century. Taking into account that one of the main components of the metabolic syndrome is arterial hypertension, we studied and assessed the risk factors and effectiveness of the treatment of arterial hypertension in patients with metabolic syndrome. Purpose of the paper: To assess the risk factors and effectiveness of the treatment of arterial hypertension in patients with the metabolic syndrome. The study involved 110 patients with a verified diagnosis of Stage II arterial hypertension and metabolic syndrome. All patients in the study group were treated as inpatients at Saransk Republican Clinical Hospital № 5 during the period 2018-2020. Risk factors were assessed and the treatment of arterial hypertension in patients with metabolic syndrome was analysed. The clinical study showed that the most common risk factors for adverse prognosis in patients with metabolic syndrome and arterial hypertension are psycho-emotional stress, excess body weight, hypodynamia and hereditary burden of arterial hypertension and metabolic syndrome. Inpatient treatment of arterial hypertension in patients with the metabolic syndrome with combined hypotensive therapy was rational in 100% of cases. Inpatient treatment of patients with metabolic syndrome was effective, which was determined by a reduction in blood pressure to the level of target values. The average time of blood pressure reduction in the patients of the analyzed group was 5,86 ± 0,94 days.

scholarly journals GCKR Common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults

2021 ◽  
Author(s):  
Asiyeh Sadat Zahedi ◽  
Mahdi Akbarzadeh ◽  
Bahareh Sedaghati-khayat ◽  
Atefeh Seyedhamzehzadeh ◽  
Maryam S Daneshpour
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Blood Sugar ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Fasting Blood Sugar ◽  
The Metabolic Syndrome ◽  
Functional Variants ◽  
Sugar Levels ◽  
Metabolic Syndrome Components

Abstract Background: Previous studies reported that common functional variants (rs780093, rs780094, and rs1260326) in the glucokinase regulator gene (GCKR) were associated with metabolic syndrome despite the simultaneous association with the favorable and unfavorable metabolic syndrome components. We decided to evaluate these findings in a cohort study with a large sample size of Iranian adult subjects, to our knowledge for the first time. We investigated the association of the GCKR variants with incident MetS in mean follow-up times for nearly ten years.Methods: Analysis of this retrospective cohort study was performed among 5666 participants of the Tehran Cardiometabolic Genetics Study (TCGS) at 19-88 years at baseline. Linear and logistic regression analyses were used to investigate the metabolic syndrome (JIS criteria) association and its components with rs780093, rs780094, and rs1260326 in an additive genetic model. Cox regression was carried out to peruse variants' association with the incidence of metabolic syndrome in the TCGS cohort study.Results: In the current study, we have consistently replicated the association of the GCKR SNPs with higher triglyceride and lower fasting blood sugar levels (p<0.05) in Iranian adults. The CT genotype of the variants was associated with lower HDL-C levels. The proportional Cox adjusted model regression resulted that TT carriers of rs780094, rs780093, and rs1260326 were associated with 20%, 23%, and 21% excess risk metabolic syndrome incidence, respectively (p<0.05).Conclusions: Elevated triglyceride levels had the strongest association with GCKR selected variants among the metabolic syndrome components. Despite the association of these variants with decreased fasting blood sugar levels, T alleles of the variants were associated with metabolic syndrome incidence; so whether individuals are T allele carriers of the common functional variants, they have a risk factor for the future incidence of metabolic syndrome.

scholarly journals Predictor of Metabolic Syndrome: A community study from Urban Delhi, India

2015 ◽  
Vol 12 (1) ◽  
pp. 1451
Author(s):  
Astha Bansal ◽  
P.C. Joshi
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Area Under Curve ◽  
Fasting Blood Glucose ◽  
Youden Index ◽  
Large Sample Size ◽  
Operating Characteristics ◽  
Likelihood Ratios ◽  
Serum Triglycerides ◽  
The Metabolic Syndrome

<p>The aim of the present study is to assess and compare the presence of metabolic syndrome using IDF and Modified NCEP ATPIII criteria among Sunni Muslim of Delhi and to determine the optimal cut off values of different parameters for the detection of metabolic syndrome. A total of, 406 individuals (125 men, 281women) aged 35-65 years were recruited. Anthropometric, blood pressure and laboratory investigations were performed following the standard protocols. Receiver operating characteristics (ROC) curves of waist circumference, serum triglycerides, High density lipoprotein cholesterol, systolic and diastolic blood pressure and fasting blood glucose were created for the determination of the metabolic syndrome and the area under curve (AUC) was evaluated to determine the predictive efficiency of each variable of metabolic syndrome. The cut off values of each parameter with corresponding sensitivity, specificity, Youden index and likelihood ratios were estimated.  </p><p>The overall metabolic syndrome assessed through Modified NCEP ATP III was 75.12% while through IDF criterion it was 75.36%. Majority of the participants were equally identified by both definitions. The metabolic syndrome was higher in women as compare to men using both the criteria. The area under curve (AUC) shows that serum triglycerides have highest predictive ability for metabolic syndrome in modified NCEP ATP III and IDF. The population specific cut off values of different variable to detect metabolic syndrome was formed. Although these result may not apply to rest of Indian population due to multi ethnicity but similar studies with large sample size to find the cut off values of parameter for metabolic syndrome is needed for better detection and prevention. </p><p align="left"><strong> </strong></p>

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