scholarly journals EFFECT OF Aloe vera GEL ON SUPEROXIDE DISMUTASE (SOD) LEVEL IN STREPTOZOTOCIN (STZ)-INDUCED DIABETIC WISTAR Rattus novergicus LIVER

2015 ◽  
Vol 2 (1) ◽  
pp. 51
Author(s):  
Nia Lukita Ariani ◽  
Abdul Gofur ◽  
Dwi Listyorini ◽  
Hendra Susanto ◽  
Yuda Handaya
Keyword(s):  
Diabetes Mellitus ◽  
Superoxide Dismutase ◽  
Aloe Vera ◽  
Wistar Rat ◽  
Positive Control ◽  
Negative Control ◽  
Diabetic Rats ◽  
Wistar Strain ◽  
Aloe Vera Gel ◽  
One Way Anova

Diabetes mellitus is a metabolic disorder characterized by the increasing levels of blood glucose as a result of either impaired of insulin secretion, insulin action, or both. Persistent hyperglycemia causes oxidative stress. Aloe vera is known of having an antioxidant activity. One of intrinsic antioxidant enzyme is superoxide dismutase (SOD) which eliminates superoxide radical. This research aims to determine the effect of Aloe vera gel on SOD level in STZ-induced diabetic Wistar rat liver. Wistar strain of Rattus novergicus used in this research were grouped into eight groups, consist of negative control (K-), non diabetic groups (NDM) consist of NDM 1 (dose of 30 mg/day), NDM 2 (dose of 60 mg/day), NDM 3 (dose of 120 mg/day), positive control (DM), and the DM group consists of DM 1 (dose of 30 mg/day), DM 2 (dose of 60 mg/day), and DM 3 (dose of 120 mg/day), with three replications each. Diabetic rats were induced using an intra-peritoneal injection of 60 mg/kg BW STZ. Three milliliters of Aloe vera gel were given intragastrointestinally for 14 days started from three days after injection of STZ. The level of liver SOD was measured with spectrophotometer.The results of One-Way Anova showed that Aloe vera gel has a significant effect on SOD levels (p< 0.05). Further analysis using LSD showed that only the treatment of NDM with 60 mg/day of Aloe vera gel giving a significant decreasing of SOD level compared to (K-). The conclusion is that Aloe vera has potency as a natural antioxidant. Keywords: Aloe vera, diabetes mellitus, superoxide dismutase (SOD), liver, streptozotocin (STZ) 

scholarly journals The Comparison of Bay Leaf and Celery Leaf Infusion Effect on Decreasing LDL Level in Dyslipidemic Wistar Rats Model

1970 ◽  
Vol 1 (1) ◽  
pp. 21
Author(s):  
Anjani Putri Retnaninggalih ◽  
Erfan Efendi ◽  
Hairrudin Hairrudin
Keyword(s):  
Cholesterol Level ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Ldl Cholesterol ◽  
Wistar Rat ◽  
Positive Control ◽  
Negative Control ◽  
High Fat ◽  
Leaf P ◽  
One Way Anova

Coronary heart disease (CHD) is the cause of 7,3 million death globally in 2008. The main pathophysiology process that leads to CHD is atherosclerosis which is caused by high LDL cholesterol level. The aim of this study was to explore bay leaf and celery leaf infusion effect on reducing LDL cholesterol level in dyslipidemic rat model. The type of this study was true experimental research using wistar rat (Rattus novergicus) as the sample. The rats were induced by high fat diet and PTU for two weeks then each of the group were given either bay leaf infusion, celery leaf infusion, simvastatin (positive control), or aquadest (negative control) for a week. The measurement of LDL level used Friedewald formulation. Data was analyzed using paired sample t test and one way ANOVA. As the result there was a significance reduction on LDL level after treatment with bay leaf (p=0,013) and celery leaf infusion (p=0,035) but there was no significance difference between groups (p=0,293). It was concluded that bay leaf and celery leaf infusion could reduce the LDL level in dyslipidemic wistar rat but there was no difference on the capability of the two different leafs on reducing LDL level. Keywords: dyslipidemia, LDL, bay leaf, celery leaf, wistar rats

scholarly journals ANTINEPHROPATHY EFFECT OF Aloe vera GEL TO PKC-β LEVEL ON WISTAR RAT KIDNEY IN DIABETES MELLITUS

2015 ◽  
Vol 2 (1) ◽  
pp. 45
Author(s):  
Juliyatin Putir Utami ◽  
Umie Lestari ◽  
Nuning Wulandari ◽  
Hendra Susanto ◽  
Yuda Handaya
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Rat Kidney ◽  
Research Result ◽  
Aloe Vera ◽  
Wistar Rat ◽  
Potential Candidate ◽  
Aloe Vera Gel ◽  
Pkc Β ◽  
Negative Controls

Aloe veragelhas a large vitamins which has become potential candidate to supressed vascular damaged oforganwhich potentially lead to complications such as diabetic nephropathy. This process through down regulation of PKC-β level as a cascade activator of gene transcription such as contraction and permeability of cell. The research goal was to determinethe effect of Aloe vera gel on PKC-β level in the kidneys of diabetes mellitus (DM) wistar rats. Twenty four rats divided into eight treatments (negative controls, positive controls, Non DM with A.vera gel dosage 30, 60, and 120 mg/day, DM with A.vera gel dosage 30, 60 and 120 mg/day) with three replications each. All of the data was analyzed using one way Anova with Statistical Product and Service Solution 16 software. The research result showed that the A. vera gelhas significant effectto decrease PKC-β level significantly (p < 0,000) in diabetes mellitus (DM) wistar rat kidney. In conclusion A.vera gel supressed diabetic nephropathy process via PKC-β and ROS activity in optimum dosage 30 mg/ day. Keywords: Aloe vera Gel, PKC-β level, Diabetes mellitus. 

scholarly journals Effects of Extracts of Plathymenia Reticulata Benth and Azadirachta Indica (Neem) in Glycated Hemoglobin in Diabetic Rats

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A438-A439
Author(s):  
Ezio De Martino Neto ◽  
Joyce Satil Chaves da Silva ◽  
Eliane Cristina Lourenço ◽  
Arthur Cesário de Castro Neto ◽  
Isabella Cecilio Resende Ferreira ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Azadirachta Indica ◽  
Insulin Treatment ◽  
Glycated Hemoglobin ◽  
Positive Control ◽  
Negative Control ◽  
Diabetic Rats ◽  
Male Adult ◽  
Significant Difference

Abstract Introduction: The Plathymenia reticulata benth is a herbal medicine that has properties of pancreatic islet hyperplasia and glycemic control in diabetic rats. Neem (Azadirachta indica A. Juss, Meliaceae) is a tree native to India that has several medicinal effects. Goal: To verify the effect of glycated hemoglobin levels in rats with type 1 and non-diabetic diabetes mellitus, in treatment with Plathymenia Reticulata Benth, Neem and the association between them. compared to insulin. Methodology: Diabetes was induced by intraperitoneal streptozotocin (65mg/kg) administration after a 24-hour fast. The diagnosis was made using a blood glucose value above 200mg/dl. The study was conducted in 60 male adult Wistar rats, weighing between 180 and 220 grams, divided into 9 groups, between diabetics (DM) and non-diabetic controls (NdM), and treated with Neem (300 mg/kg), cold aqueous extract of Plathymenia (100 mg/kg), water (negative control) and insulin (3 IU/day) - positive control; and association between plants. The treatment was performed by orogastric gavage for a period of 28 consecutive days, and weekly weight and daily feed intake were performed. Data were analyzed using ANOVA and Tukey-Kramer’s pos-hoc test, with a significance level of 5% using the SPSS25.0 software. The results are expressed on average ± EPM. Results: There was a significant difference in glycated hemoglobin levels in rats submitted to insulin treatment (6.18 ± 0.36) compared to those submitted to treatment with Neem (10.12 ± 1.29, p=0.047), Plathymenia+Neem (12.09 ± 0.38, p=0.006) and water (10.86 ± 1.26, p=0.015). However, no significant difference was observed between the reduction in glycated hemoglobin levels in the groups submitted to insulin treatment compared to the group treated with Plathymenia (7.30 ± 0.68, p=0.911). Conclusion: The results allow us to evaluate a non-inferiority condition in relation to the use of the Plathymenia when compared to treatment with insulin therapy, positive control in the treatment of type 1 diabetes mellitus. The Plathymeniamay present as a herbal option in the treatment of the disease and prevention of complications. Further studies are necessary to evaluate the effect of the extract on other aspects related to the pathology.

scholarly journals ALOE VERA ETHANOL EXTRACT AS A THERAPY FOR ALVEOLAR MANDIBLE REGENERATION IN LIPOPOLYSACCHARIDE-EXPOSED RATS

2018 ◽  
Vol 10 (1) ◽  
pp. 11
Author(s):  
Latifah Fitriani Rakhman ◽  
Octaviana Widya Pangestika ◽  
Delvi Fitriani ◽  
Rudhanton Rudhanton ◽  
Nur Permatasari
Keyword(s):  
Alveolar Bone ◽  
Aloe Vera ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Alveolar Tissue ◽  
Hematoxylin Eosin ◽  
One Way Anova

Objective: The study examined the effects of Aloe vera ethanol extract on alveolar mandible regeneration in rats (Rattus norvegicus).Methods: Rats were divided into five groups as follows: Negative control group received no treatment, positive control group received Escherichiacoli lipopolysaccharide (LPS) alone for 5 days, and Groups P1, P2, and P3 received LPS for 5 days followed by 40, 80, and 160 mg/kg BW A. veraethanol extract, respectively, orally on days 6–12. Alveolar bone tissues were taken and histologically processed through hematoxylin-eosin staining.Osteoblast and osteoclast numbers in alveolar tissue were also examined.Results: One-way ANOVA revealed strong relationships between the A. vera ethanol extract dosage and the numbers of osteoblasts (r=0.921, p<0.05)and osteoclasts (r=−0.631, p<0.05) in rats.Conclusion: A. vera ethanol extract appears capable of stimulating alveolar bone regeneration following LPS exposure.

scholarly journals ACTIVITY NANOKIRINYUH (CHROMOLAENA ODORATA) LEAVES EXTRACT IN ALLOXAN INDUCED DIABETIC RATS

2021 ◽  
pp. 220-222
Author(s):  
KENI IDACAHYATI ◽  
WINDA TRISNA WULANDARI ◽  
FIRMAN GUSTAMAN ◽  
INDRA LUSI NURDIANTI
Keyword(s):  
Diabetes Mellitus ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Test Results ◽  
Heart Attacks ◽  
The One ◽  
Histopathological Investigation

Objective: Diabetes Mellitus is a type of degenerative disease that is increasing every year in countries around the world. Diabetes Mellitus is a major cause of blindness, kidney failure, heart attacks, and stroke. Nanokirinyuh leaves have potential as an antidiabetic because they contains chemical compounds that have antioxidant activity. The purpose of this study was to determine activity of nanokirinyuh leaves as an antidiabetic. Methods: Wistar rats as many as 24 animals were divided into 6 groups, namely the normal control group, positive control (glibenclamide 0.5 mg/Kg BW), negative control (alloxan 600 mg/BW rat), and nanochitosan kirinyuh leaves at a dose of 225 mg/Kg BW rat, 450 mg/Kg BW rat and 675 mg/Kg BW treatment was carried out for 10 d. Percent decrease of level glucose was evaluated along with histopathological investigation in various experimental groups of rats. Data analysis using the One Way Anova test and continued LSD test. Results: Level of Glucose at a dose of 675 mg/Kg BW rats showed the highest levels of the negative group and other dose groups. Pancreas histopathology test results showed that the group with a dose of 450 mg/Kg BW of rats had the lowest necrosis rate compared to the negative control group and other dose groups. Conclusion: Nanokirinyuh leaves can reduce of level plasma glucose and necrosis in a histopathology test.

The Effect of Herbal Infusion on Fasting Blood Glucose (FBS) and Malondyaldehyde (MDA) Levels in Diabetic Rats

2020 ◽  
Vol 1009 ◽  
pp. 9-14
Author(s):  
Apriliani Ismi Fauziah ◽  
Lintang Dian Saraswati ◽  
Ari Udiyono ◽  
Beti Safitri
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Aloe Vera ◽  
Control Sample ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Albino Rats

Aloe vera, ginger, and sappan wood have recently gained attention as a potent antioxidant. This study was undertaken to analyze the possible effects of oral administration of herbal infusion (the combination of Aloe vera, ginger, and sapang wood) on fasting blood glucose (FBS) and malondialdehyde (MDA) levels in diabetic rats. Forty male albino rats (150-250 gm) were divided into five groups (n=8 in each group): alloxan-induced diabetic (negative control group/K-), acarbose treated (positive control group/K+), diabetic rats treated with herbal infusion dose 6.75 mg/150 gmbw (P1), diabetic rats treated with herbal infusion dose 13.5 mg/150 gmbw (P2), and diabetic rats treated with herbal infusion dose 20.25 mg/150 gmbw (P3). Male albino rats induced with a dose of alloxan 120 mg/kgbw and also 5% glucose after 6 hours of alloxan induction. FBS and MDA levels of each rat were measured before induction of alloxan was performed as a control sample. After seven days and 14 days of herbal infusion administration, FBS parameters was investigated with a glucometer. In the last week, the concentration of MDA in serum blood was determined using a UV-VIS spectrophotometer with a wavelength of 545 nm. Diabetic rats exhibited a significant decrease in FBS and MDA. Administration of herbal infusion was reduced FBS significantly between groups (ANOVA, Bonferroni, p<0.05). The concentration of MDA in serum blood was decreased significantly on K-, K+, P1, P2, P3 compared to the control group (ANOVA, LSD, P<0.05). It could be postulated herbal infusion has anti-hyperglycemic and anti-diabetic effects of FBS and MDA in male albino rats Wistar strain.

scholarly journals MDA levels in the pancreas, testes, liver, and plasma of diabetic rats: The effect of snakehead (Channa striata) extract

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
NURLITA ABDULGANI ◽  
DEWI HIDAYATI ◽  
RESSY ADINOVITASARY ◽  
VARAH OLIVIATIE ◽  
AYU DIAH SEKARTAJI
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Low Dose ◽  
Positive Control ◽  
Negative Control ◽  
Diabetic Rats ◽  
High Dose ◽  
Channa Striata ◽  
Negative Controls ◽  
Biomarkers Of Oxidative Stress

Abstract. Abdulgani N, Hidayati D, Adinovitasary R, Oliviatie V, Sekartaji AD. 2020. MDA levels in the pancreas, testes, liver, and plasma of diabetic rats: The effect of snakehead (Channa striata) extract. Nusantara Bioscience 12: 50-54. There are several biomarkers of oxidative stress in diabetes mellitus; one of those biomarkers is Malondialdehyde (MDA). Increasing oxidative stress will cause increased tissue damage. This study was conducted to determine the effect of snakehead extract (SHE) on MDA level of pancreas, testes, liver, and plasma of alloxan-induced diabetic rats. There were 5 groups of treatments: non-diabetic rats/negative control (C-), diabetic rats/positive control (C+), and 3 SHE level of administration: 1 mL/day (low dose/LD), 1.6 mL/day (middle dose/MD) and 2.1 mL/day (high dose/HD). Alloxan-induced diabetic rats were administered with SHE extract orally every day for two weeks. The results showed that MDA levels in the testes, liver, pancreas, and plasma of diabetic rats administered with SHE and non-diabetic rats/negative controls (C-) were significantly lower (p <0.05) compared to MDA levels in the testes, liver, pancreas, and plasma of diabetic rats without SHE administration (positive control/ C +). The highest dose of SHE treatment (2.1 mL/day) results in decreasing MDA levels were not significantly different (p> 0.05) with the group of non-diabetic rats / negative controls (C-). The conclusion of this study was increasing SHE administration up to 2.1 mL/day result in reducing more of MDA levels in plasma, pancreas, liver, and testes of diabetic rats.

scholarly journals Hot Oil Exposure on Styrofoam and Black Crackle Bag Effect on Malondialdehyde MDA Level of White Rat (Rattus norvegicus) Wistar Strain

2019 ◽  
Vol 1 (2) ◽  
pp. 9
Author(s):  
Marcella ◽  
Kristina Simanjuntak ◽  
Yuni Setyaningsih
Keyword(s):  
Oxidative Stress ◽  
Positive Control ◽  
Negative Control ◽  
Wistar Strain ◽  
Plastic Bag ◽  
Black Plastic ◽  
Mixed Oil ◽  
Post Hoc ◽  
Oil Exposure ◽  
One Way Anova

ABSTRACT This study purposed to determine the effect of hot oil exposure on styrofoam and black plastic bag on MDA levels in rats. The study was purely experimental, a sample of 28 Wistar rats, weight ±200gram, age 3 months, divided into 4 groups, treatment was given for 28 days. Negative control was given feed and drink; styrofoam group was given feed, drink, oil on styrofoam; the black plastic group was given feed, drink, oil on black plastic; positive control was given feed, drink, toluene mixed oil. On 14th and 28th-day blood was taken from the tail and examined for plasma MDA by spectrophotometer λ=532nm. One-way ANOVA shows there is an effect of hot oil exposure on styrofoam and black plastic on MDA levels on the 14th and 28th days (p=0.000). Post hoc showed the styrofoam group had a significant increase in MDA levels on 14th (p=0.003) and 28th (p=0.043) compared to negative controls, the black plastic group as well on 14th (p=0.000) and 28th (p=0.000). MDA levels between styrofoam and black plastic groups significantly different on 14th (p=0.012), but not on 28th (p=0.340). There was a significant MDA increase in the styrofoam group between 14th and 28th days (p=0.009), and in the black plastic group (p=0.031). This shows that hot oil exposure on styrofoam and black plastic cause cell oxidative stress. Keyword: Black Plastic Bag, MDA, Oxidative Stress, Styrofoam     ABSTRAK Penelitian bertujuan mengetahui pengaruh paparan minyak panas pada stirofoam dan kresek hitam terhadap kadar MDA. Penelitian merupakan eksperimental murni, sampel 28 ekor tikus putih galur Wistar, berat badan ±200gram, usia 3 bulan, dibagi menjadi 4 kelompok, perlakuan selama 28 hari. Kontrol negatif diberi pakan biasa dan air minum; kelompok stirofoam diberi pakan, minum, dan minyak pada stirofoam; kelompok kresek hitam diberi pakan, minum, dan minyak pada kresek hitam; kontrol positif diberi pakan, minum, dan minyak dicampur toluene. Mengambil darah dari vena ekor pada hari ke-14 dan ke-28 lalu memeriksa MDA plasma dengan spektrofotometer λ=532 nm. Hasil One-way Anova menunjukkan peningkatan MDA kelompok stirofoam dan kresek hitam hari ke-14 dan ke-28 (p=0.000). Uji post hoc menunjukkan MDA kelompok stirofoam meningkat signifikan pada hari ke-14 (p=0.003) dan ke-28 (p=0.043) dibanding kontrol negatif, begitu juga kelompok kresek hitam hari ke-14 (p=0.000) dan ke-28 (p=0.000). Kadar MDA antara kelompok stirofoam dan kresek hitam berbeda signifikan pada hari ke-14 (p=0.012), tetapi tidak pada hari ke-28 (p=0.340). MDA berbeda bermakna antara hari ke-14 dan ke-28 pada kelompok stirofoam (p=0.009) dan kelompok kresek hitam (p=0.031). Hal ini menunjukkan paparan minyak panas pada stirofoam dan kresek hitam dapat menimbulkan stres oksidatif sel. Kata Kunci: Kresek Hitam, MDA, Stirofoam, Stres Oksidatif

scholarly journals AKTIVITAS ANALGESIK EKSTRAK ETANOL DAUN SOYOGIK (Saurauia bracteosa DC) PADA TIKUS PUTIH JANTAN GALUR WISTAR

PHARMACON ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 868
Author(s):  
Dina Imorina Legoh ◽  
Max R.J. Runtuwene ◽  
Paulina V.Y. Yamlean
Keyword(s):  
Analgesic Activity ◽  
Rattus Norvegicus ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
White Rats ◽  
Wistar Strain ◽  
Before And After ◽  
Thermal Induction ◽  
One Way Anova

ABSTRACT  Soyogik leaves (Saurauia bracteosa DC) are plants that have flavonoid compounds that act as analgesics. This study aims to test the analgesic activity of soyogic leaf extract on male white rats Wistar strain using the thermic pain induction method. This research method is laboratory experimental, using male white rats (Rattus novergicus). The results obtained from the number of responses of mice between before and after giving the test solution. The treatment was initiated by thermal induction of pain in rats. Furthermore, the rat response was calculated, then given negative control (CMC), positive control (paracetamol), and soyogic leaf extract with a dose of 0.375 g / KgBB, 0.75 g / KgBB and 1.5 g / KgBB. The response of the mice after being given the treatment was seen from the 30th, 60th, 90th, and 120th minutes. Data were analyzed using the SPSS program, the real differences between the treatments were tested by one way ANOVA. The results showed that soyogic leaf extract with a dose of 0.375 g / KgBB, a dose of 0.75 g / KgBB and a dose of 1.5 g / KgBB have analgesic activity. Keywords: analgesics, Saurauia bracteosa DC, Rattus norvegicus  ABSTRAK Daun soyogik (Saurauia bracteosa DC) merupakan tanaman yang memiliki senyawa flavonoid yang berperan sebagai analgesik. Penelitian ini bertujuan untuk menguji aktivitas analgesik dari ekstrak daun soyogik pada tikus putih jantan galur wistar dengan metode induksi nyeri cara termik. Metode penelitian ini adalah eksperimental laboratorium, menggunakan tikus putih jantan (Rattus novergicus). Hasil penelitian diperoleh dari jumlah respon tikus antara sebelum dan sesudah pemberian larutan uji. Perlakuan diawali dengan induksi nyeri cara termik pada tikus. Selanjutnya dihitung jumlah respon tikus, kemudian diberikan kontrol negatif (CMC), kontrol positif (paracetamol), dan ekstrak daun soyogik dosis  0,375 g/KgBB, 0,75 g/KgBB dan 1,5 g/KgBB. Respon tikus setelah diberikan perlakuan dilihat mulai dari menit ke 30, 60, 90, dan 120. Data dianalisis menggunakan program SPSS, beda nyata antar perlakuan diuji dengan one way ANOVA. Hasil yang didapat menunukkan ekstrak daun soyogik dosis 0,375 g/KgBB, dosis 0,75 g/KgBB dan dosis 1,5 g/KgBB memiliki aktivitas analgesik.  Kata Kunci: analgesik, Saurauia bracteosa DC, Rattus norvegicus

Effect of a Polyphenol-Rich Extract from Aloe vera Gel on Experimentally Induced Insulin Resistance in Mice

2007 ◽  
Vol 35 (06) ◽  
pp. 1037-1046 ◽  
Author(s):  
Yolanda Y. Pérez ◽  
Enrique Jiménez-Ferrer ◽  
Alejandro Zamilpa ◽  
Marcelino Hernández-Valencia ◽  
Francisco J. Alarcón-Aguilar ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Aloe Vera ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Glucose Levels ◽  
Insulin Tolerance ◽  
Aloe Vera Gel ◽  
Experimentally Induced

Insulin resistance, which precedes type 2 diabetes mellitus (T2DM), is a widespread pathology associated with the metabolic syndrome, myocardial ischemia, and hypertension. Finding an adequate treatment for this pathology is an important goal in medicine. The purpose of the present research was to investigate the effect of an extract from Aloe vera gel containing a high concentration of polyphenols on experimentally induced insulin resistance in mice. A polyphenol-rich Aloe vera extract (350 mg/kg) with known concentrations of aloin (181.7 mg/g) and aloe-emodin (3.6 mg/g) was administered orally for a period of 4 weeks to insulin resistant ICR mice. Pioglitazone (50 mg/kg) and bi-distilled water were used as positive and negative controls respectively. Body weight, food intake, and plasma concentrations of insulin and glucose were measured and insulin tolerance tests were performed. The insulin resistance value was calculated using the homeostasis model assessment for insulin resistance (HOMA-IR) formula. Results showed that the polyphenol-rich extract from Aloe vera was able to decrease significantly both body weight ( p < 0.008) and blood glucose levels ( p < 0.005) and to protect animals against unfavorable results on HOMA-IR, which was observed in the negative control group. The highest glucose levels during the insulin tolerance curve test were in the negative control group when compared to the Aloe vera extract and pioglitazone treated mice ( p < 0.05). In conclusion, Aloe vera gel could be effective for the control of insulin resistance.

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