scholarly journals Remdesivir and Favipiravir Changes Hepato-Renal Profile in COVID-19 patients: A Cross Sectional Observation in Bangladesh

2021 ◽  
Vol 8 (01) ◽  
pp. 5196-5201
Author(s):  
Rawshan Ara Perveen ◽  
Morshed Nasir ◽  
Mohammad Murshed M ◽  
Rumana Naznin ◽  
Sonia Nasreen Ahmed
Keyword(s):  
Average Duration ◽  
The Other ◽  
Health Concern ◽  
Global Public Health ◽  
Public Health Concern ◽  
Cross Sectional ◽  
Hospital Records ◽  
Duration Of Hospital Stay ◽  
Renal Markers ◽  
Renal Safety

Background: Coronavirus disease (COVID-19) is the current global public health concern. Till date no specific, effective, and approved treatment available. With the rapid increase in rate of infection, repurposing use of anti- viral like remdesivir and favipiravir were considered as an option to find the promising anti-COVID therapeutics. In this study, we aim to observe hepato-renal safety concerns related to these drugs. Method: A retrospective study done from May 17 to September 9, 2020 on total 1348 hospital records. 182 patients were included in the study, devided into two groups who recieved remdesivir only (RO) and favipiravir only (FO). Result: Mean age of respective groups are 59.42 (RO) and 54.64 (FO). Average duration of hospital stay was 11 to 12 days. Mortality rate (28.39%) was higher in RO group. Mean± SD of both ALT (70.65± 50.25) and AST (62.25± 25.46) level was increased in RO group than FO group. On the other hand, Blood urea (56.67± 38.40) and serum creatinine (01.70± 02.41) level was higher in FO group. Hematuria was absent in both group, proteinuria was also unremarkable. Conclusion: In patients with Covid-19 receive remdesivir and favipiravir, showed elevation in the level of hepato- renal markers.

scholarly journals Optimized and Non-Optimized Personal Protective Equipment Use during the COVID-19 Pandemic in Thailand: A National Cross-Sectional Survey in a Resource-Limited Setting

2021 ◽  
Vol 15 ◽  
pp. 117863022110135
Author(s):  
Visal Moolasart ◽  
Weerawat Manosuthi ◽  
Varaporn Thienthong ◽  
Uajai Jaemsak ◽  
Winnada Kongdejsakda ◽  
...  
Keyword(s):  
Personal Protective Equipment ◽  
Negative Pressure ◽  
Symptom Severity ◽  
Univariate Analysis ◽  
Education Level ◽  
Health Concern ◽  
Protective Equipment ◽  
Global Public Health ◽  
Cross Sectional ◽  
Infection Control Program

Introduction: Coronavirus disease (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-COV2). COVID-19 is highly contagious, potentially fatal, and a global public health concern. Combining optimized personal protective equipment (PPE) use and hand hygiene is the best strategy for preventing COVID-19 in health care workers (HCWs). Methods: We conducted a national cross-sectional web-based survey of HCWs in the infection control program (IPC) in Thailand between May 5, 2020 and May 15, 2020. The primary objective was the prevalence of optimized PPE use amongst HCWs. The secondary objective was identification of the independent predictors of optimized PPE use. Results: We received a response from 46% of HCWs (756/1650), and all those who responded were nurse or HCWs who were registered in the IPC network. Five HCWs were excluded because of missing data, and 751 were included in the final analysis. The prevalences of PPE use were 22% (168/751) for optimized PPE use, 78% (583/751) for non-optimized PPE use, 35% (263/751) for PPE overuse, and 43% (320/751) for PPE underused. In univariate analysis, optimized PPE use was significantly associated with age, education level, knowledge of appropriate negative pressure room selection, and knowledge of apparently milder symptom severity in children than adults. In multivariate analysis, independent predictors of optimized PPE use were knowledge of appropriate negative pressure room selection (aOR = 1.95, 95% CI = 1.18-3.22), the difference in symptom severity between children and adults (aOR = 0.55, 95% CI = 0.37-0.81), and education level (aOR = 1.54, 95% CI = 1.04-2.27). Conclusion: The prevalence of optimized PPE use amongst HCWs was 22%. Independent predictors of optimized PPE use were COVID-19 knowledge-based factors and education level. Therefore, the continued education training program should be implemented to ensure maintenance of appropriate practices during the COVID-19 pandemic.

scholarly journals Probiotics as a Possible Strategy for the Prevention and Treatment of Allergies. A Narrative Review

Foods ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 701
Author(s):  
Aroa Lopez-Santamarina ◽  
Esther Gonzalez Gonzalez ◽  
Alexandre Lamas ◽  
Alicia del Carmen Mondragon ◽  
Patricia Regal ◽  
...  
Keyword(s):  
Allergic Diseases ◽  
Urban Environments ◽  
Probiotic Bacteria ◽  
Health Concern ◽  
Global Public Health ◽  
Cytokine Release ◽  
Public Health Concern ◽  
Beneficial Effects ◽  
Opportunistic Bacteria

Allergies are an increasing global public health concern, especially for children and people living in urban environments. Allergies impair the quality of life of those who suffer from them, and for this reason, alternatives for the treatment of allergic diseases or reduction in their symptoms are being sought. The main objective of this study was to compile the studies carried out on probiotics as a possible therapy for allergies. The most studied allergies on which probiotics have been shown to have a beneficial effect are rhinitis, asthma, and atopic dermatitis. Most studies have studied the administration of Lactobacillus and Bifidobacterium spp. in children and have shown beneficial effects, such as a reduction in hyperreactivity and inflammation caused by allergens and a decrease in cytokine release, among other beneficial effects. In the case of children, no clear beneficial effects were found in several studies, and the potential risk from the use of some opportunistic bacteria, such as probiotics, seems controversial. In the studies that reported beneficial results, these effects were found to make allergy symptoms less aggressive, thus reducing morbidity in allergy sufferers. The different effects of the same probiotic bacteria on different patients seem to reinforce the idea that the efficacy of probiotics is dependent on the microbial species or strain, its derived metabolites and byproducts, and the gut microbiota eubiosis of the patient. This study is relevant in the context of allergic diseases, as it provides a broader understanding of new alternatives for the treatment of allergies, both in children, who are the main sufferers, and adults, showing that probiotics, in some cases, reduce the symptoms and severity of such diseases.

scholarly journals Perception of mucormycosis infection among Bangladeshi healthcare workers: an exploratory cross-sectional study in the year following the COVID-19 pandemic

2022 ◽  
Vol 46 (1) ◽  
Author(s):  
Humayun Kabir ◽  
Md. Kamrul Hasan ◽  
Mamunur Rahman ◽  
Shimpi Akter ◽  
Golam Ishraque Chowdhury ◽  
...  
Keyword(s):  
Public Health ◽  
Fungal Infection ◽  
Healthcare Workers ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Health Concern ◽  
Sectional Study ◽  
Monthly Income ◽  
Public Health Concern ◽  
Cross Sectional

Abstract Background Mucormycosis, a severe fungal infection, is an emerging public health concern during the COVID-19 pandemic. This study aimed to investigate the perception of mucormycosis among Bangladeshi healthcare workers. Results An exploratory cross-sectional study was carried out among the Bangladeshi healthcare workers from May 25, 2021, to June 5, 2021. The study found 422 responses from the healthcare workers of Bangladesh. Among the respondents, nearly half of them (45.26%) were doctors (n = 191). This study explored that the healthcare workers’ mucormycosis perception scores were significantly associated with their age, gender, profession, monthly income, marital status, job type, and death of friends and family members due to COVID-19. Conclusions This study emphasized the healthcare workers’ mucormycosis perception along with other associated factors. The findings could help policymakers to mitigate mucormycosis and related infectious diseases emergencies in the post-COVID-19 situation.

scholarly journals The association of socio-demographic and environmental factors on childhood diarrhea in Cambodia

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 303
Author(s):  
Vong Pisey ◽  
Pannee Banchonhattakit
Keyword(s):  
Maternal Age ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Secondary Data ◽  
Cross Sectional Study ◽  
Health Concern ◽  
Childhood Diarrhea ◽  
Public Health Concern ◽  
Cross Sectional ◽  
One Year

Background: Diarrhea is still the leading cause of childhood death worldwide, as well as a major cause for concern in developing countries. This study was conducted to investigate the factors related to childhood diarrhea in Cambodia. Methods: A cross-sectional study of the secondary data from the Cambodia Demographic and Health Survey 2014 was conducted using the combination of household data and children’s data. A generalized linear mixed model was used to analyze the determinant factors of childhood diarrhea. Results: The surveys included 2,828 children, aged 12 to 35 months. The prevalence of diarrhea in the last 2 weeks was 16.44% (95% CI: 14.72%-18.31%). Factors with statistically significant associations with childhood diarrhea in Cambodia were: maternal  unemployment, compared with being in employment (AOR = 1.43; 95% CI: 1.14-1.78); the child being male (AOR = 1.25; 95%CI: 1.02-1.53); the presence of unimproved toilet facilities (AOR = 1.17; 95%CI: 1.05-1.31) compared with improved toilet facilities; and unhygienic disposal of children’s stools (AOR = 1.32; 95%CI: 1.06-1.64) compared with hygienic disposal of children’s stools when controlling for other covariates. Both maternal age (one year older; AOR = 0.85; 95%CI: 0.78– 0.93) and child age (one month older; AOR = 0.86; 95%CI: 0.78-0.94) had significant negative associations with the occurrence of childhood diarrhea. Conclusion: Childhood diarrhea remains a public health concern in Cambodia. The probability of diarrhea occurring is shown to be increased by maternal unemployment, the sex of the child being male, lack of provision of improved toilet facilities, and the unhygienic disposal of children’s stools; whereas increasing maternal age and child’s age were associated with a reduced chance of diarrhea occurring. On the basis of these results, we recommend provision of programs focusing on reducing diarrhea through the construction of improved toilet facilities and the promotion of behavior to improve hygiene, specifically targeting younger mothers.

scholarly journals Factors Affecting Tramadol-Associated Seizure

2020 ◽  
Vol 10 (4) ◽  
pp. 26674.1-26674.5
Author(s):  
Maryam Zaare Nahandi ◽  
◽  
Sayna Abbaszadeh ◽  
Mostafa Mansouri ◽  
Haniyeh Elahifard ◽  
...  
Keyword(s):  
Previous History ◽  
Health Concern ◽  
Affecting Factors ◽  
Public Health Concern ◽  
Cross Sectional ◽  
Factors Affecting ◽  
Study Results ◽  
History Of ◽  
The Mean ◽  
Higher Doses

Background: Tramadol is a widely prescribed analgesic and due to its opioid-like effects, the potential for abuse of tramadol is noticeable. Besides, the complications of tramadol abuse have become a public health concern. This study aimed to investigate the affecting factors on the seizure, as one of the most common complications of tramadol consumption. Methods: A total number of 64 patients from 315 patients who were referred to Sina Hospital, Tabriz, Iran because of tramadol toxicity were included in this 9 months cross-sectional retrospective study. Results: There were 52 males and 12 females in the study. The seizure happened in 53.1% of the subjects and the Mean±SD time between tramadol consumption and seizure was 5.9±7.36 hours. There was no significant association between seizure and sex, age, the dose of tramadol, and previous tramadol consumption history. A significant association was seen between the dose of tramadol and the time of seizure. Conclusion: Seizure that happens due to tramadol overdose is not dependent on sex, age, and previous history of tramadol consumption. As the dose of tramadol is higher, the seizure happens later. More research is needed to understand why the seizure occurs later in higher doses.

scholarly journals Profile of Hand Surgery Cases at Kirtipur Hospital

2018 ◽  
Vol 14 (2) ◽  
pp. 41-43
Author(s):  
Bikash Karki ◽  
Kiran Nakarmi ◽  
Mangal Gharti Magar ◽  
Krishna Nagarkoti ◽  
Shankar Man Rai
Keyword(s):  
Birth Defects ◽  
Reconstructive Surgery ◽  
Hand Surgery ◽  
Health Concern ◽  
Age Group ◽  
Hand Trauma ◽  
Public Health Concern ◽  
Cross Sectional ◽  
Common Cause ◽  
Male Preponderance

Background: There can be multiple hand problems with which patients can present. Such hand problems can be because of any kind of trauma, birth defects, tumours, infection or other conditions. Hand surgery is a special field of plastic surgery, which deals with these hand problems. The Department of Burns, Plastic & Reconstructive Surgery of Kirtipur Hospital run by Public Health Concern Trust-Nepal has been providing hand surgery service to the patients with these hand problems.Aim of Study: To analyse the various types of surgical hand problems in patients attending Kirtipur Hospital.Material and Methods: It is a cross sectional retrospective  observational study of the patients with different hand problems done at the Department of Burns, Plastic & Reconstructive surgery of Kirtipur Hospital from January to December 2016.Results: There were 124 patients who presented with various hand problems. There was male preponderance and the most common age group affected was between 15-60 years. Hand trauma was the most common cause of hand problems followed by post burn contractures.Conclusion: Hand is a complicated organ which can give rise to various problems. Hand surgery is an essential component of reconstructive surgery to deal with these problems. JNGMC,  Vol. 14 No. 2 December 2016, Page: 41-43

scholarly journals Antibodies and Vaccines Against Botulinum Toxins: Available Measures and Novel Approaches

Toxins ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 528 ◽  
Author(s):  
Rasetti-Escargueil ◽  
Popoff
Keyword(s):  
Clostridium Botulinum ◽  
Botulinum Neurotoxin ◽  
Health Concern ◽  
Global Public Health ◽  
Public Health Concern ◽  
Positive Bacterium ◽  
Pathological Conditions ◽  
Future Challenges ◽  
Clostridial Species ◽  
Potential Use

Botulinum neurotoxin (BoNT) is produced by the anaerobic, Gram-positive bacterium Clostridium botulinum. As one of the most poisonous toxins known and a potential bioterrosism agent, BoNT is characterized by a complex mode of action comprising: internalization, translocation and proteolytic cleavage of a substrate, which inhibits synaptic exocytotic transmitter release at neuro-muscular nerve endings leading to peripheral neuroparalysis of the skeletal and autonomic nervous systems. There are seven major serologically distinct toxinotypes (A–G) of BoNT which act on different substrates. Human botulism is generally caused by BoNT/A, B and E. Due to its extreme lethality and potential use as biological weapon, botulism remains a global public health concern. Vaccination against BoNT, although an effective strategy, remains undesirable due to the growing expectation around therapeutic use of BoNTs in various pathological conditions. This review focuses on the current approaches for botulism control by immunotherapy, highlighting the future challenges while the molecular underpinnings among subtypes variants and BoNT sequences found in non-clostridial species remain to be elucidated.

scholarly journals Gambling Harm as a Global Public Health Concern: A Mixed Method Investigation of Trends in Wales

2020 ◽  
Vol 8 ◽  
Author(s):  
Bev John ◽  
Katy Holloway ◽  
Nyle Davies ◽  
Tom May ◽  
Marian Buhociu ◽  
...  
Keyword(s):  
Public Health ◽  
Mixed Method ◽  
Health Concern ◽  
Global Public Health ◽  
Public Health Concern ◽  
Gambling Harm
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