scholarly journals The Correlation of L-citrulline Levels with Blood Pressure in Severe Preeclampsia

2020 ◽  
Vol 12 (1) ◽  
pp. 15-8
Author(s):  
Hudila Rifa Karmia ◽  
Afriwardi Afriwardi ◽  
Hirowati Ali ◽  
Johanes Cornelius Mose ◽  
Yusrawati Yusrawati

BACKGROUND: Based on 'vascular disorder of pregnancy' terminology, preeclampsia primarily was not a hypertensive disorder, but a vascular disorder (general vasospasm) in pregnancy due to idiopathic etiology. The overall incidence of preeclampsia was 5-14% of all pregnancies. One of the substances responsible for regulating vascular tone is nitric oxide (NO), which produced in endothelial blood vessels. NO and L-citrulline are produced altogether by the reaction between L-arginine and oxygen. L-citrulline levels reflected NO production. This study was aimed to assess the correlation between the L-citrulline level and blood pressure in severe preeclampsia.METHODS: This cross-sectional study was done in Dr. M. Djamil Central General Hospital, Padang, Indonesia The sample size was 36 samples of pregnant women with severe preeclampsia and had yet been given antihypertensive therapy. Sampling was done by consecutive sampling from Obstetrics and Gynecology Division. After maternal examination and measurements L-citrulline levels of cubital venous blood by using enzyme-linked immunosorbent assay (ELISA) method, Pearson correlation was performed to assess the relationship between variables for normally distributed data and Spearman's correlation for abnormal distribution data with significance level p<0.05.RESULTS: Means of L-citrulline levels, systolic blood pressure, diastolic blood pressure, and arterial pressure (MAP) were 87.21 nmol/mL, 179.4 mmHg, 108.3mmHg, and 132.1 mmHg, respectively. Correlation of the L-citrulline level with systolic blood pressure, diastolic blood pressure, and MAP were -0.08, -0.175, and -0.136 (p>0.05), respectively.CONCLUSION: L-citrulline levels had no correlation with blood pressure in severe preeclampsia.KEYWORDS: L-citrulline levels, blood pressure, severe preeclampsia

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Joseph Thomas III ◽  
Mindy Paulet ◽  
Jigar R. Rajpura

Objectives. This study evaluated consistency between self-reported values for clinical measures and recorded clinical measures.Methods. Self-reported values were collected for the clinical measures: systolic blood pressure, diastolic blood pressure, glucose level, height, weight, and cholesterol from health risk assessments completed by enrollees in a privately insured cohort. Body mass index (BMI) was computed from reported height and weight. Practitioner recorded values for the clinical measures were obtained from health screenings. We used bivariate Pearson correlation analysis and descriptive statistics to evaluate consistency between self-reported data and recorded clinic measurements.Results. There was high correlation between self-reported clinical values and recorded clinical measures for diastolic blood pressure (r=0.91,P=<0.0001), systolic blood pressure (r=0.93,P=<0.0001), cholesterol (r=0.97,P=<0.0001), body mass index (r=0.96,P=<0.0001), glucose (r=0.96,P=<0.0001), weight (r=0.98,P=<0.0001), and height (r=0.89,P=<0.0001).Conclusions. Self-reported clinical values for each of the eight clinical measures examined had good consistency with practitioner recorded data.


2020 ◽  
Vol 56 (1) ◽  
pp. 67
Author(s):  
Susilowati Andajani

The purpose of this study was to analyze the influence of age, sex, Body Mass Index (BMI), and nutritional status on blood pressure in class X and XI students, SMAK St. Hendrikus, Surabaya, Indonesia. The sample of students in class X and XI of SMAK St. Hendrikus Surabaya in 2013. The sample size was 150 students. The sampling technique was consecutive sampling. The independent variables were age, sex, BMI, and nutritional status, while the dependent variable was blood pressure. Data were analyzed by Pearson correlation test, Spearman, and Chi Square statistical test with ?=0.05. The level of risk was calculated by epi info program. Most students (40.7%) were 16 years old, those with pre-hypertension (systolic) 26.7%, grade 1 systolic hypertension by 1.3%, diastolic pre-hypertension 25.3% and grade 1 diastolic hypertension by 6.7%. Age did not have significant influence (p=0.623) on systolic blood pressure, but had a significant influence (p=0.002) on diastolic blood pressure. Male sex significantly influenced systolic (p=0.002, RR 5.36 95% CI 2.2320-12.8649) and diastolic (p <0.001, RR 1.95 95% CI 1.1272-3 , 3719) blood pressure. BMI had significant influence (p <0.001) on blood pressure. Nutritional status had significant influence on systolic blood pressure (p=0.002), with overnutrition status with RR 2.28, 95% CI 1.3983-3.7104. Nutritional status had significant influence on diastolic blood pressure (p <0.001), and with overnutrition status with RR 2.73, 95% CI 1.8143-4.1179. In conclusion, the trend for pre-hypertension to grade 1 diastolic hypertension increases with age and age has an influence on diastolic blood pressure. The risk of males to have pre-hypertension to grade 1 systolic hypertension is 5.36 times that of females, and the risk to have pre-hypertension to grade 1 diastolic hypertension is 1.95 times that of women. The higher the BMI, the higher the systolic and/or diastolic blood pressure.


2021 ◽  
Vol 56 (1) ◽  
pp. 67
Author(s):  
Susilowati Andajani

The purpose of this study was to analyze the influence of age, sex, Body Mass Index (BMI), and nutritional status on blood pressure in class X and XI students, SMAK St. Hendrikus, Surabaya, Indonesia. The sample of students in class X and XI of SMAK St. Hendrikus Surabaya in 2013. The sample size was 150 students. The sampling technique was consecutive sampling. The independent variables were age, sex, BMI, and nutritional status, while the dependent variable was blood pressure. Data were analyzed by Pearson correlation test, Spearman, and Chi Square statistical test with ?=0.05. The level of risk was calculated by epi info program. Most students (40.7%) were 16 years old, those with pre-hypertension (systolic) 26.7%, grade 1 systolic hypertension by 1.3%, diastolic pre-hypertension 25.3% and grade 1 diastolic hypertension by 6.7%. Age did not have significant influence (p=0.623) on systolic blood pressure, but had a significant influence (p=0.002) on diastolic blood pressure. Male sex significantly influenced systolic (p=0.002, RR 5.36 95% CI 2.2320-12.8649) and diastolic (p <0.001, RR 1.95 95% CI 1.1272-3 , 3719) blood pressure. BMI had significant influence (p <0.001) on blood pressure. Nutritional status had significant influence on systolic blood pressure (p=0.002), with overnutrition status with RR 2.28, 95% CI 1.3983-3.7104. Nutritional status had significant influence on diastolic blood pressure (p <0.001), and with overnutrition status with RR 2.73, 95% CI 1.8143-4.1179. In conclusion, the trend for pre-hypertension to grade 1 diastolic hypertension increases with age and age has an influence on diastolic blood pressure. The risk of males to have pre-hypertension to grade 1 systolic hypertension is 5.36 times that of females, and the risk to have pre-hypertension to grade 1 diastolic hypertension is 1.95 times that of women. The higher the BMI, the higher the systolic and/or diastolic blood pressure.


e-CliniC ◽  
2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Siti N. Mansur ◽  
Frans E. Wantania ◽  
Eko Surachmanto

Abstract: Inflammation plays an important role in hypertension process and central obesity. Recent studies found that hyperuricemia was also related to inflammation. This study aimed to find out the relation between uric acid level with blood pressure among central-obese-male students in the Faculty of Medicine Unsrat. Methods: This was an analytical study with a cross section design. There were 37 people as samples. Data were obtained by measuring the waist size, blood pressure, and uric acid. The data were analyzed with the Statistical Product and Service Solution (SPSS) and Pearson correlation test. The results showed that most respondents were 19 years old (12 respondents, 32.4%) and the lowest were 17, 22 and 23 years old, each of them was 1 person (2.7%). The mean systolic blood pressure was 130.54 mmHg (SD ± 10.259). The mean diastolic blood pressure was 88.11 mmHg (SD ± 7.760). The mean level of uric acid was 7.514 mg/dL (SD ± 1.65). This study showed that there was some significant relation between the systolic blood pressure and uric acid level (p=0.019), as well as between the diastolic blood pressure and uric acid level (p=0.022). Conclusion: There was a significant correlation between the uric acid level and blood pressure in male students with central obesity.Keywords: obesity, uric acid, blood pressureAbstrak: Inflamasi berperan penting dalam proses terjadinya hipertensi dan obesitas sentral. Pada penelitian terkini ditemukan bahwa hiperurisemia juga berhubungan dengan proses inflamasi. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar asam urat dengan tekanan darah pada mahasiswa pria obesitas sentral Fakultas Kedokteran Unsrat. Penelitian ini bersifat analitik menggunakan rancangan potong lintang dengan sampel berjumlah 37 orang. Data diperoleh melalui pemeriksaan lingkar perut, tekanan darah, dan asam urat. Data dianalisis dengan menggunakan Statistical Product and Service Solution (SPSS) dan uji Pearson correlation. Hasil penelitian memperlihatkan bahwa sebagian besar responden berada pada kategori umur 19 tahun (12 responden, 32,4%) dan terendah umur 17, 22, dan 23 tahun masing-masing sejumlah 1 orang (2,7%). Berdasarkan nilai mean dapat dilihat bahwa rerata tekanan darah sistol 130,54 mmHg (SD ± 10,259). Rerata tekanan darah diastol 88,11 mmHg (SD ± 7,760). Rerata kadar asam urat responden 7,514 mg/dL (SD ± 1,65). Hasil penelitian menunjukkan secara statistik terdapat hubungan yang bermakna, baik antara tekanan darah sistol dan asam urat (p=0,019) maupun antara tekanan darah diastol dan kadar asam urat (p=0,022). Simpulan: Terdapat hubungan bermakna antara kadar asam urat dan tekanan darah pada mahasiswa pria obesitas sentral.Kata kunci: obesitas, asam urat, tekanan darah


Author(s):  
Meice Fitrina ◽  
Sofie R. Krisnadi ◽  
Hartanto Bayuaji

Abstract Objective: To determine differences in serum nephrin levels in severe preeclampsia compared to normal pregnancy and also its correlation with systolic and diastolic blood pressure and proteinuria.Methods: This study is an analytical observational with cross sectional study. The observation group consisted of severe preeclampsia (n= 30) and normal pregnancy group as a control (n= 30). Both groups measured systolic and diastolic blood pressure, proteinuria and serum nephrin using the Human NPHN (Nephrin) ELISA Kit. Statistical test were performed with Mann-Whitney test and the Spearman’s rank test. A value of p<0.05 was considered significant. The study was conducted in the Obstetric Clinic Inward and Laboratorium Department of Clinical Pathology Dr. Hasan Sadikin General Hospital/Faculty of Medicine Universitas Padjadjaran on March–May 2019.Results: Levels of serum nephrin in the severe preeclampsia group were significantly higher than in normal pregnancies (6.4 ng/mL vs 4.2 ng/mL; p= 0.014). There is a positive weak correlation but statistically significant between serum nephrin with systolic blood pressure (r= 0.36; p= 0.02) but not significant to diastolic blood pressure (r= 0.3; p= 0.05). There is no significant correlation was found between serum nephrin levels and proteinuria (r= 0.18; p= 0.54).Conlusions:  Levels of serum nephrin in the severe preeclampsia group were significantly higher than in normal pregnancies and there is a correlation between serum nephrin with systolic blood pressure. Keywords: blood pressure, proteinuria, serum nephrin, podocyte, severe preeclampsia. Abstrak Tujuan: Untuk mengetahui perbedaan kadar nephrin serum pada preeklamsia berat dibandingkan dengan kehamilan normal dan juga hubungannya dengan tekanan darah sistolik dan diastolik serta proteinuria.Metode: Penelitian ini bersifat analitik observasional dengan pendekatan potong silang. Kelompok pengamatan terdiri dari kelompok preeklamsia berat (n= 30) dan kelompok kehamilan normal sebagai kontrol (n= 30). Pada kedua kelompok dilakukan pengukuran tekanan darah sistolik dan diastolik, proteinuria serta pengukuran kadar nephrin serum menggunakan Human NPHN (Nephrin) ELISA Kit. Uji statistik dilakukan dengan uji Mann-Whitney dan uji rank Spearman. Nilai p<0,05 dianggap bermakna. Penelitian dilakukan di ruang perawatan obstetri FKUP/RSHS dan Laboratorium Patologi Klinik FKUP/RSHS pada bulan Maret-Mei 2019.Hasil: Rerata kadar nephrin serum pada kelompok preeklamsia berat lebih tinggi secara bermakna dibandingkan kehamilan normal (6,4 ng/mL vs 4,2 ng/mL; p= 0,014). Terdapat korelasi positif dengan derajat lemah namun bermakna secara statistik antara nephrin serum dengan tekanan darah sistolik (r= 0,36; p= 0,02) namun tidak signifikan terhadap tekanan darah diastolik (r= 0,3; p= 0,05). Tidak ditemukan korelasi yang bermakna antara kadar nephrin serum dengan proteinuria (r= 0,18; p= 0,54). Kesimpulan: Kadar nephrin serum pada kelompok preeklamsia berat lebih tinggi dibandingkan kehamilan normal dan terdapat korelasi antara nephrin serum dengan tekanan darah sistolik. Kata kunci: nephrin serum, podosit, preeklamsia berat, proteinuria, tekanan darah


2021 ◽  
Vol 29 (01) ◽  
pp. 57-61
Author(s):  
Fozia Mohammad Bakhsh ◽  
Khanda Gul ◽  
Safia Bibi ◽  
Palwasha Gul

Objective: To compare maternal morbidity in planned induction of labour versus expectant management in women with gestational hypertension at term. Study Design: Randomized Clinical Trial. Setting: Department of Obstetrics and Gynecology, Bolan Medical Complex Hospital Quetta. Period: January 2017 to December 2017. Material & Methods: 240 pregnant women with the diagnosis of gestational hypertension with systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg without proteinuria were included. Patients were equally divided into two groups; group A (the intervention group) and group B (the expectant group). In group A, cervical ripening was stimulated with use of intravaginal prostaglandins. In group B, patients were monitored until the onset of spontaneous Labour. In both groups intervention was recommended in case of non-optimal FHR, the diastolic blood pressure ≥110mmHg or the systolic blood pressure ≥170 mmHg and eclampsia. Results: Out of 120 deliveries, 87 (72.5%) delivered by vaginal and 33 (27.5%) by caesarean section in group A. While in group B, out of 120 deliveries, 66 (55%) delivered by vaginal and 54 (45%) by caesarean section. The frequency of maternal outcome like mild preeclampsia present in 15% and 40% of women in group A and in group B respectively. Severe preeclampsia was noted 7.5% and 22.5% in group A and in group B respectively. Seizures were found in 2.5% of women in group A and 10% of women in group B. Conclusion: Complications like mild and severe preeclampsia and eclampsia could be prevented by induction of labour at term and also by widespread use of prenatal care education, prompt diagnosis and treatment of gestational hypertension.


e-CliniC ◽  
2018 ◽  
Vol 6 (2) ◽  
Author(s):  
Angelica Talumepa ◽  
Frans E.N. Wantania ◽  
Bisuk Parnigotan

Abstract: Central obesity is one of the multifactorial diseases which occurs due to accumulation of excessive fat in the intraabdominal adipose tissue contributed toward the main causes of mortality and morbidity, including heart attack, stroke and hypertension. Hypertension is the independent risk factor of cardiovascular diseases meanwhile the independent risk factor of hypertension is obesity. This study was aimed to determine the correlation between waist circumference and blood pressure among students of Faculty of Medicine, Sam Ratulangi University Manado. This was an observational analytical study with a cross-sectional design. Data of physical examination were waist circumference and blood pressure. There were 70 subjects in this study. The results of the Pearson correlation and simple linier regression test showed a significant correlation of waist circumference and systolic blood pressure (P=0.000) as well as waist circumference and diastolic blood pressure (P=0.000). Furthermore, the study obtained that waist circumference affected systolic blood pressure by 29.70% and diastolic blood pressure by 18.50%. Conclusion: There was a significant correlation between waist circumference and blood pressure among students of Faculty of Medicine, Sam Ratulangi University Manado.Keywords: waist circumference, systolic blood pressure, diastolic blood pressure. Abstrak: Obesitas sentral merupakan suatu penyakit multifaktor yang terjadi akibat akumulasi lemak yang berlebihan di jaringan adiposa intra-abdomen. Akumulasi lemak tersebut berkontribusi terhadap penyebab utama kematian dan kecacatan, termasuk serangan jantung, stroke dan tekanan darah tinggi. Hipertensi merupakan faktor risiko independen terhadap penyakit kardiovaskular, dan salah satu faktor risiko independen hipertensi ialah obesitas. Penelitian ini bertujuan untuk mengetahui hubungan antara ukuran lingkar pinggang dengan tekanan darah pada mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi. Jenis penelitian ialah analitik obeservasional dengan desain potong lintang. Data diperoleh melalui pemeriksaan fisik yaitu pengukuran lingkar pinggang dan tekanan darah. Penelitian ini menggunakan uji korelatif Pearson serta analisis regresi linier sederhana. Hasil penelitian mendapatkan subyek berjumlah 70 orang mahasiswa. Uji korelatif Pearson menunjukkan adanya hubungan bermakna, baik antara lingkar pinggang dengan tekanan darah sistolik (P=0,000) maupun antara lingkar pinggang dengan tekanan darah diastolik (P=0,000). Pengaruh lingkar pinggang terhadap tekanan darah sistolik sebesar 29,70% dan terhadap tekanan darah diastolik sebesar 18,50%. Simpulan: Terdapat hubungan bermakna antara lingkar pinggang dengan tekanan darah pada mahasiswa Fakultas kedokteran Universitas Sam Ratulangi.Kata kunci: lingkar pinggang, tekanan darah sistolik, tekanan darah diastolik


2019 ◽  
Vol 10 (01) ◽  
pp. 33-44
Author(s):  
N.L.G. Sudaryati ◽  
I P. Sudiartawan ◽  
Dwi Mertha Adnyana

The aim of the study was to determine the effectiveness of giving hydrotherapi foot soak in hypertensive patients. The study was conducted with one group pretestposttest design without a control group by measuring blood pressure (pretest) before being given an intervention in the form of foot soak hydrotherm against 15 people with hypertension in Banjar Sri Mandala, Dauhwaru Village, Jembrana Subregency. Then do the blood pressure measurement again (posttest) after finishing the intervention. After the study was completed, the results showed that before the hydrotherapi foot bath intervention, there were 0% of patients classified as normal, 13.32% in prehypertension category, 60.08% in hypertension category I and 26.60% in hypertension category II. After the intervention was given, there were 13.32% of the patients classified as normal, 66.68% in the prehypertension category, 20.00% in the first category of hypertension and no patients belonging to the second grade hypertension category. There is a decrease of 20-30 mmHg for systolic blood pressure and 0-10 mmHg for diastolic blood pressure after intervention. Based on the results of the study it can be concluded that the hydrotherapi foot bath is effectively used to reduce blood pressure in hypertensive patients in the Banjar Sri Mandala, Dauhwaru Village, Jembrana District.


2016 ◽  
pp. 31-40
Author(s):  
Long Nhon Phan ◽  
Van Minh Huynh ◽  
Thi Kim Nhung Hoang ◽  
Van Nham Truong

Objective: To evaluate the results of treatment achieved blood pressure goal (BP goal) and results of hypertensive patient management. Subjects and methods: A study of 400 hypertensive patient intervention, treatment and management after 2 year. To assess the results of BP target, monitor the use of medicines, the situation of hospitalization and complications of stroke. Results: Treatment: -100% of patients using diuretics and angiotensin-converting enzyme inhibitors (ACEIs), 33% of patients using angiotensin receptor blockers (ARBs), 46.25% of patients using calcium channel blockers (CCBs) and 19.5% of patients using beta-blocker. After 24 months of treatment: 50.5% of patients using 1 antihypertensive drug, 22% of patients using 2 drugs, 20.5% of patients using 3 drugs and 7% of patients taking more than 3 drugs. After 24 months of treatment: 91.75% achieved BP target and 8.25% fail. -Average risk stratification: 97.32% achieved BP target, hight risk stratification: 95.91% and very hight risk stratification: 73.03%. After 24 months of treatment. -Stage 1: 88.48% achieved BP target, stage 2: 92.85% achieved BP target and stage 3: 71.08% achieved BP target. After 24 months of treatment. -Hypertesive results before treatment were: 159.80 ± 20,22mmHg average systolic blood pressure and 82.97 ± 5,82mmHg average diastolic blood pressure. After treatment: average systolic blood pressure 125.38 ± 6,88mmHg and average diastolic blood pressure 79.83 ± 1,79mmHg. No adverse change in the index of tests about lipidemia, liver, kidney, glucomia and no recorded cases of drug side effects. Management of patients: -There were 89% non-medical examinational patients 1 month, 5.25% non-medical examinational patients 2 months, 4.25% non-medical examinational patients 3 months and 1.5% non-medical examinational patients 4 months. There were 93.5% drop pill 1 month, 3.25% drop pill 2 months, 4.25% drop pill 3 months and no patient drop pill over 3 months. In 24 months follow-up, 47% hospitalized inpatients <5 times, 44.5% hospitalized inpatients 5-10 times, 3% hospitalized inpatients 11-15 times, 4.75% hospitalized inpatients from 16-20 times and 0.75% hospitalized inpatients > 20 times. -There were 32.75% hospitalized inpatients for reasons of hypertension and 63.75% hospitalized inpatients for other common diseases. -There were a total of 11592 contacts directly by phone for medical advice, medical reminders and examinational reminders during 24 months of management. -There were 0.5% of patients stroked during 24 months of treatment and management. Conclusion: Treatment by protocol and management by phone directly for medical taking and re-examinational reminders is the best resulted method of achieving blood pressure target and reducing complications of stroke for hypertensive patients. Key word: : blood pressure target; risk stratification; treatment; management; stage; phone.


2017 ◽  
pp. 88-92
Author(s):  
Van Hien Pham ◽  
Huu Vu Quang Nguyen ◽  
Tam Vo

Background: Cardiovascular diseases are the leading cause of death in patients with chronic renal failure. When a patient undergoes dialysis, making AVF or AVG causes cardiovascular events. Understanding the relationship between complications: hypertension, heart failure, AVF or AVG (formation time, position, diameter) helps us monitor, detect, prevent and treatment of complications to limit the risk of death in patients with dialysis. Objective: Relationship between cardiovascular diseases and anatomosis of arteriovenous fistular in patients with regularly hemodialysis at Cho Ray Hospital. Methods: A cross-sectional study was conducted at Cho Ray Hospital from 2015 to 2016. The survey some cardiovascular diseases are done by clinical examination, tests for diagnostic imaging such as X-ray, electrocardiogram and echocardiogram: heart and diameter of anastomosis AVF, AVG. Results: The study population included 303 patients with chronic renal failure who were dialysis. Of which, patients aged 25-45 accounted for the highest proportion (43.9%). The proportion of male and female patients was similar (48.5% and 51.5% respectively). The mean value of systolic blood pressure on patients made AVF, AVG less than 12 months is higher than patients made AVF, AVG over 12 months, and there is negative correlation (r = -0.43) between AVF, AVG and systolic blood pressure (p <0.05). The mean value of diastolic blood pressure on patients made AVF, AVG less than 12 months is lower than patients made AVF, AVG over 12 months, and and there is positive correlation (r = -0.43) between AVF, AVG and diastolic blood pressure (p <0.05) (p <0.05). The prevalence of patients with heart failure made AVF, AVG over 12 months is higher than that of the under 12 months group, there is a negative correlation (r = - 0.43) between AVF, AVG diameter and EF index (p <0.05). Conclusion: It is important to note the diameter of anastomosis AVF, AVG in patients with chronic renal failure dialysis to limit cardiovascular complications, especially heart failure. Key words: Chronic kidney disease, hemodialysis.


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