scholarly journals ON THE ROLE OF THE THIOLDISULPHYDE SYSTEM IN PROTECTION THE HUMAN BODY FROM AEROSOL AIR POLLUTION

2019 ◽  
Vol 96 (8) ◽  
pp. 701-706
Author(s):  
Tatyana I. Vitkina ◽  
T. A. Gvozdenko ◽  
V. N. Rakitskiy ◽  
V. P. Kolosov ◽  
V. I. Yankova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Main Role ◽  
Oxidative Damages ◽  
Thioredoxin System ◽  
Oxidative Processes ◽  
Essential Contribution ◽  
The City ◽  
Favorable Area

In this paper results of research of quantitative distribution and qualitative characteristics of microdispersed particles of atmospheric air in the city of Vladivostok are presented. The chronic impact of aerosols of a microsize range on inhabitants of the urbanized territory led to the development of a condition of an oxidative stress giving rise in the increase of the level of oxidative damages of cellular macromolecules and the expansion in the number of cells with the lowered power status in comparison with residents of the favorable area. The induction of oxidative processes caused the enlargement in the content of key antioxidant enzymes (thireodoxin, glutathione, superoxide dismutase) and the gain of antioxidant activity in general. The main role in reparation of proteins and DNA in the oxidizing influence of microdispersed particles belongs to thioredoxin system due to restoration of thiol-disulfide communications and restoration of reparating enzymes. Thiol-disulfide-depended antioxidant processes make an essential contribution to the protection of an organism, preventing the development of the oxidative stress and the cell apoptosis. Long-term stress - induced influence of microdispersed particles can lead to exhaustion of adaptation and reparation opportunities of an organism and to promote еру development of pathology.

scholarly journals Mitochondria, Oxidative Stress, cAMP Signalling and Apoptosis: A Crossroads in Lymphocytes of Multiple Sclerosis, a Possible Role of Nutraceutics

Antioxidants ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 21
Author(s):  
Anna Signorile ◽  
Anna Ferretta ◽  
Maddalena Ruggieri ◽  
Damiano Paolicelli ◽  
Paolo Lattanzio ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
T Lymphocytes ◽  
Main Role ◽  
Apoptosis Resistance ◽  
Nutraceutical Compounds ◽  
Camp Pathway ◽  
Central Nervous Systems ◽  
Genetic And Environmental Factors

Multiple sclerosis (MS) is a complex inflammatory and neurodegenerative chronic disease that involves the immune and central nervous systems (CNS). The pathogenesis involves the loss of blood–brain barrier integrity, resulting in the invasion of lymphocytes into the CNS with consequent tissue damage. The MS etiology is probably a combination of immunological, genetic, and environmental factors. It has been proposed that T lymphocytes have a main role in the onset and propagation of MS, leading to the inflammation of white matter and myelin sheath destruction. Cyclic AMP (cAMP), mitochondrial dysfunction, and oxidative stress exert a role in the alteration of T lymphocytes homeostasis and are involved in the apoptosis resistance of immune cells with the consequent development of autoimmune diseases. The defective apoptosis of autoreactive lymphocytes in patients with MS, allows these cells to perpetuate, within the CNS, a continuous cycle of inflammation. In this review, we discuss the involvement in MS of cAMP pathway, mitochondria, reactive oxygen species (ROS), apoptosis, and their interaction in the alteration of T lymphocytes homeostasis. In addition, we discuss a series of nutraceutical compounds that could influence these aspects.

Introgression between non-sister species of honeyeaters (Aves: Meliphagidae) several million years after speciation

2019 ◽  
Vol 128 (3) ◽  
pp. 583-591
Author(s):  
Leo Joseph ◽  
Alex Drew ◽  
Ian J Mason ◽  
Jeffrey L Peters
Keyword(s):  
Gene Flow ◽  
Reproductive Isolation ◽  
Sex Chromosomes ◽  
Common Ancestor ◽  
Sister Species ◽  
Species Boundaries ◽  
North Eastern ◽  
The City

Abstract We reassessed whether two parapatric non-sister Australian honeyeater species (Aves: Meliphagidae), varied and mangrove honeyeaters (Gavicalis versicolor and G. fasciogularis, respectively), that diverged from a common ancestor c. 2.5 Mya intergrade in the Townsville area of north-eastern Queensland. Consistent with a previous specimen-based study, by using genomics methods we show one-way gene flow for autosomal but not Z-linked markers from varied into mangrove honeyeaters. Introgression barely extends south of the area of parapatry in and around the city of Townsville. While demonstrating the long-term porosity of species boundaries over several million years, our data also suggest a clear role of sex chromosomes in maintaining reproductive isolation.

scholarly journals The Spaces of Nostalgia(s) and the Politics of Belonging in Contemporary Chernivtsi, Western Ukraine

2018 ◽  
Vol 33 (1) ◽  
pp. 218-237 ◽  
Author(s):  
Karolina Koziura
Keyword(s):  
Cultural Practices ◽  
Second World War ◽  
City Center ◽  
Symbolic Resources ◽  
The Social ◽  
Western Ukraine ◽  
The City ◽  
Second World

This article is part of the special cluster titled Bukovina and Bukovinians after the Second World War: (Re)shaping and (re)thinking a region after genocide and ‘ethnic unmixing’, guest edited by Gaëlle Fisher and Maren Röger. This article explores ways in which Habsburg nostalgia has become an important factor in contemporary place-making strategies in the city of Chernivtsi, Western Ukraine. Through the analysis of diasporic homecomings, city center revitalization, and nationalist rhetoric surrounding the politics of monuments, I explore hybrid and diverse ways in which Habsburg nostalgia operates in a given setting. Rather than a static and homogenous form of place attachment, in Chernivtsi different cultural practices associated with Habsburg nostalgia coexist with each other and depending on the political context as well as the social position of the “nostalgic agents” manifest themselves differently. Drawing from my long-term ethnographic fieldwork, I argue that in order to fully understand individuals’ attachment to space, it is necessary to grasp both the subtle emotional ways in which the city is experienced by individuals as well as problematize the role of the built environment in the visualization of collective memory and emotions of particular groups. The focus on changing manifestations of the Habsburg nostalgia can bring then a better understanding of the range and scope of the city’s symbolic resources that might be mobilized for various purposes.

scholarly journals Could Pushkin Have Repaid His Debts?

2019 ◽  
pp. 176-191
Keyword(s):  
Literary Work ◽  
The State ◽  
Economic Life ◽  
Accurate Data ◽  
Publishing Activity ◽  
Estate Management ◽  
The City

The article states the necessity of creating an economic chronicle of Alexander Pushkin’s life. His economic life includes four aspects: publishing activity, estate management, playing cards, and life in the city. It is mentioned that the existing literature lacks accurate data on Pushkin’s incomes and expenses. The article studies a notorious episode concerning Pushkin’s loan received from the Moscow Savings Treasury. It is shown that there are certain questions connected with distribution of the money received and with Pushkin’s deposit in the Moscow Savings Treasury. Besides, the article analyses Pushkin’s loans from the State Treasury. The role of Egor Kankrin, Minister of Finance, in providing to Pushkin his credit conditions, and the attitude of Emperor Nicholas I towards the poet are emphasized. They resulted in the lending conditions being extremely soft: the loans were long-term and interest-free. However, Pushkin still needed money and had to borrow large sums from private persons. After his death, debts to the State Treasury and to private persons amounted to 138,988 rubles 33 kopeks. The author raises the question: did Pushkin have a real opportunity to repay his debts? Data from a Pushkin Trust report concerning incomes collected from the posthumous edition are analyzed. The article provides calculations confirming that Pushkin’s financial bankruptcy was far from being inevitable. Had he survived after the duel with d’Anthès, Pushkin would have been exiled to his village. He would have continued his literary work and, according to the optimistic estimate, could have repaid his debts within approximately four years.

Branding Ideas for the Tokyo Olympics 2020

2017 ◽  
pp. 304-322
Author(s):  
Erica Liu
Keyword(s):  
Planning Process ◽  
Olympic Games ◽  
Public Spaces ◽  
Event Tourism ◽  
Mega Event ◽  
The City

Tokyo successfully won the bid for the 2020 Olympic Games. When planning for mega event tourism such as the Olympics, cities reorder public spaces and arenas often with a long term vision, a legacy. This vision expresses the role of the event in achieving the desired future and goals of the hosting city. The planning process involves not only animating the city for staged spectacles; but also rebranding the city and managing how tourism is consumed - the planned and unplanned experience of consumption. Leisure motivated event tourists are seeking unique, personal and socially rewarding experiences (Getz, 2010). These experiences may be managed through the context in which people act. By altering the context, people's experience of the event changes; hence the perception of the host city and the Olympics' brand may also change. The author is therefore proposing branding directions to enhance these experiences.

scholarly journals Curcumin and Endometriosis

2020 ◽  
Vol 21 (7) ◽  
pp. 2440 ◽  
Author(s):  
Alexandre Vallée ◽  
Yves Lecarpentier
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Responses ◽  
Uterine Cavity ◽  
Main Role ◽  
Oxygen Species ◽  
Inflammatory Agent ◽  
Gynecological Disorders ◽  
Anti Oxidant ◽  
Anti Inflammatory

Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative stress, an imbalance between reactive oxygen species and antioxidants, could have a key role in the initiation and progression of endometriosis by resulting in inflammatory responses in the peritoneal cavity. Nevertheless, the mechanisms underlying this disease are still unclear and therapies are not currently efficient. Curcumin is a major anti-inflammatory agent. Several findings have highlighted the anti-oxidant, anti-inflammatory and anti-angiogenic properties of curcumin. The purpose of this review is to summarize the potential action of curcumin in endometriosis by acting on inflammation, oxidative stress, invasion and adhesion, apoptosis and angiogenesis.

scholarly journals Putative role of pharmacogenetics to elucidate the mechanism of tardive dyskinesia in schizophrenia

2019 ◽  
Vol 20 (17) ◽  
pp. 1199-1223 ◽  
Author(s):  
Anton JM Loonen ◽  
Bob Wilffert ◽  
Svetlana A Ivanova
Keyword(s):  
Oxidative Stress ◽  
Tardive Dyskinesia ◽  
Genetic Variants ◽  
Long Term Potentiation ◽  
Specific Gene ◽  
Medium Spiny Neurons ◽  
Spiny Neurons ◽  
Long Term Treatment

Identifying biomarkers which can be used as a diagnostic tool is a major objective of pharmacogenetic studies. Most mental and many neurological disorders have a compiled multifaceted nature, which may be the reason why this endeavor has hitherto not been very successful. This is also true for tardive dyskinesia (TD), an involuntary movement complication of long-term treatment with antipsychotic drugs. The observed associations of specific gene variants with the prevalence and severity of a disorder can also be applied to try to elucidate the pathogenesis of the condition. In this paper, this strategy is used by combining pharmacogenetic knowledge with theories on the possible role of a dysfunction of specific cellular elements of neostriatal parts of the (dorsal) extrapyramidal circuits: various glutamatergic terminals, medium spiny neurons, striatal interneurons and ascending monoaminergic fibers. A peculiar finding is that genetic variants which would be expected to increase the neostriatal dopamine concentration are not associated with the prevalence and severity of TD. Moreover, modifying the sensitivity to glutamatergic long-term potentiation (and excitotoxicity) shows a relationship with levodopa-induced dyskinesia, but not with TD. Contrasting this, TD is associated with genetic variants that modify vulnerability to oxidative stress. Reducing the oxidative stress burden of medium spiny neurons may also be the mechanism behind the protective influence of 5-HT2 receptor antagonists. It is probably worthwhile to discriminate between neostriatal matrix and striosomal compartments when studying the mechanism of TD and between orofacial and limb-truncal components in epidemiological studies.

scholarly journals Intra-urban connectedness, policy mobilities and creative city-making: national conservatism vs. urban (neo)liberalism

2020 ◽  
Vol 27 (3) ◽  
pp. 246-258 ◽  
Author(s):  
Thomas Borén ◽  
Patrycja Grzyś ◽  
Craig Young
Keyword(s):  
European Union ◽  
Cultural Policy ◽  
Urban Policy ◽  
Creative Economy ◽  
Creative City ◽  
Local Stakeholders ◽  
Policy Mobilities ◽  
The City

This article aims to advance the literature on policy mobility by decentring the primacy of mobility itself and focusing on understanding what cities do in order to ‘arrive at’ localized versions of urban policy in relation to globally circulating ideas around creativity. The paper explores the performance of a particular local ‘creative economy’ in terms of institutional and strategic adjustments, key drivers and individuals and events, and the role of long-term local, national and international influences on ‘creative cityness’. It does this through an analysis of cultural and creativity policy and local stakeholders in the cultural policy scene in Gdańsk, Poland, focusing on the local performative aspects of mobile policies and arguing the need to understand the formation of a ‘common local project’ as a form of intra-urban connectedness alongside inter-urban connectedness. The paper extends the range of contexts in which the ‘creative city’ has been analysed to include post-socialist, post-European Union accession Central and Eastern Europe, thus making an original contribution by studying these issues in the context of the complex multi-scalar relations between the city, national government and the supranational European Union and the ideological conflict between national authoritarian neoliberalism and urban and supranational scale (neo-)liberalism.

scholarly journals Possible Relationship between Long-Term Adverse Health Effects of Gonad-Removing Surgical Sterilization and Luteinizing Hormone in Dogs

Animals ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 599
Author(s):  
Michelle A. Kutzler
Keyword(s):  
Luteinizing Hormone ◽  
Cruciate Ligament ◽  
Transitional Cell ◽  
Reproductive Function ◽  
Receptor Activation ◽  
Main Role ◽  
Nitric Oxide Release ◽  
Neoplastic Tissues

Spaying and neutering dogs is commonly used to prevent the birth of unwanted animals and eliminate the risk of reproductive diseases. However, removal of the gonads prevents the feedback of estrogen and testosterone on the pituitary and hypothalamus. As a result, luteinizing hormone (LH) is continuously elevated at supraphysiologic concentrations. Although the main role of LH is for reproductive function (e.g., ovulation), there are LH receptors present in several normal tissues including the thyroid and adrenal glands, gastrointestinal tract, cranial cruciate ligament and round ligament, and lymphocytes. In addition, there are LH receptors present in several neoplastic tissues (e.g., lymphoma, hemangiosarcoma, mastocytoma, transitional cell carcinoma, and osteosarcoma). The role of LH receptors in non-reproductive normal and neoplastic tissues is not known but may stimulate nitric oxide release and induce cell division. The precise etiology of the increased incidence of several non-reproductive long-term health complications following spaying and neutering is not known but may be related to LH receptor activation in these non-reproductive target tissues. How these effects may be mediated is described in this review.

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