scholarly journals PATHOLOGIC FEATURES OF PERIODONTAL TISSUES IN EXPERIMENTAL OSTEOPOROSIS

2017 ◽  
Vol 21 (2) ◽  
pp. 76-78
Author(s):  
N. I Bykova ◽  
T. L Kobylkina ◽  
V. A Grigoryan ◽  
A. A Adamchik ◽  
A. V Arutyunov
Keyword(s):  
Acute Hypoxia ◽  
Nerve Fibers ◽  
The Body ◽  
Histological Structure ◽  
Pathological Changes ◽  
Periodontal Tissues ◽  
Pathologic Features ◽  
Experimental Osteoporosis ◽  
Autologous Mesenchymal Stem Cells

The article presents information about some pathological changes in periodontal tissues during experimental osteoporosis. The experiments were conducted on 8 three-year sheep, which have at different times after ovariectomy removed dentoalveolar segments in the region of incisors of the lower jaw. Pathological changes in periodontal animals in experimental osteoporosis were local manifestations of the general condition of the body that are typical of acute hypoxia mixed character. It was found that experimental osteoporosis in periodontal develop processes accompanied by acute circulatory disorders, which worsen the conditions of metabolism, which ultimately leads to destructive changes of argyrophilic and collagen fibrils, as well as individual nerve fibers. Studies have shown that these effects are reversible, and after 120 days to the fore the phenomenon of compensation in periodontal starting to recover basic histological structure. Prolonged hypoxia, as the main link in the pathogenesis of degenerative and inflammatory of forms of periodontal disease may be modified by the proven of efficiency pharmacological means. The detected changes at the osteoporosis models can be the basis for further study of the role of autologous mesenchymal stem cells and materials-matrices of various origins in optimizing the osseointegration process.

scholarly journals PSYCHOSOMATIC ASPECTS OF THE COMBINED PATHOLOGY OF PERIODONTAL TISSUE AND ORAL MUCOSA

2018 ◽  
pp. 32-34 ◽  
Author(s):  
T.A. Petrushanko ◽  
N.N. Ilenko
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
The Body ◽  
Psychological Characteristics ◽  
Control Group ◽  
Periodontal Tissue ◽  
Dental Patients ◽  
Periodontal Tissues ◽  
Experimental Group

In the structure of modern diseases, there are 50-75% of psychosomatic diseases. To understand the role of the emotional factor in the onset and progression of somatic disorders, as well as the opposite process – the emergence of psychological and emotional disorders as a response to an acute or chronic disease of internal organs – acquires a particular importance and relevance at the present stage of the causality of the disease. Individual features of the response of the human body to social, biological factors have common mechanisms of combined damage to the mucous membrane of the oral cavity and periodontal tissue. The severity of the damage to these organs and tissues is also determined by the psychological characteristics of individuals. These points are important not only for understanding the causality of the combined pathology of the periodontal and oral mucosa, but also for choosing the optimal tactics for treating such dental patients. The aim of the work was to analyze the role of psychosomatic correlations in the occurrence and development of the combined pathology of the periodontal and oral mucosa, determining the tactics of their treatment. 32 patients were involved in the examination with pathological changes of periodontal and oral mucosa. The essential role of the emotional component in the genesis of diseases was confirmed. Taking into account the psychosomatic nature of the pathology in the experimental group of patients, recommendations were given on diet therapy, psychotherapy, autogenic training. General medical treatment for internists and dentists was maximally individualized, taking into account the psychological characteristics of the response to the disease, differentiated according to the nature of the existing diseases, severity, pathology. After 6 months of follow-up, a stable, reliable positive clinical result was obtained in all patients in the experimental group and in 64% in the control group. Accounting for the state of psychosomatic relationships in the mechanisms of origin, development, treatment of diseases is extremely important. This approach in the supervision of dental patients who have combined changes in periodontal tissues, the oral mucosa allows achieving positive results of treatment, both in relation to the condition of the oral cavity, and for the body as a whole.

scholarly journals Sinonasal Schwannoma with New Bone Formation Expressing Bone Morphogenic Protein

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Satoru Kodama ◽  
Tomoyo Okamoto ◽  
Masashi Suzuki
Keyword(s):  
Bone Formation ◽  
Benign Tumor ◽  
Nerve Fibers ◽  
Bone Morphogenic Protein ◽  
The Body ◽  
Sinus Surgery ◽  
New Bone Formation ◽  
Myelinated Nerve ◽  
Bone Morphogenic Protein 4

Schwannoma is a benign tumor that arises from the sheath of myelinated nerve fibers and may occur in any part of the body. Osteogenesis in schwannoma is extremely rare and, to date, new bone formation in sinonasal schwannoma has not yet been reported. Here, we describe the first reported case of sinonasal schwannoma with new bone formation. The tumor was successfully treated by endoscopic sinus surgery, and the patient showed no evidence of recurrence 24 months postoperatively. Immunohistochemically, the tumor expressed bone morphogenic protein 4, indicating a possible role of this protein in the new bone formation in schwannomas.

scholarly journals Some Aspects of Development and Histological Structure of the Visual System of Nothobranchius Guentheri

Animals ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2755
Author(s):  
Dmitry L. Nikiforov-Nikishin ◽  
Vladimir A. Irkha ◽  
Nikita I. Kochetkov ◽  
Tatyana L. Kalita ◽  
Alexei L. Nikiforov-Nikishin ◽  
...  
Keyword(s):  
Visual System ◽  
Peripheral Vision ◽  
The Body ◽  
Histological Structure ◽  
Lens Fibers ◽  
Initial Stage ◽  
Group A ◽  
The Individual ◽  
Nothobranchius Guentheri

In this, work some aspects of the development of the visual system of Nothobranchius guentheri at the main stages of ontogenesis were described for the first time. It was possible to establish that the formation of the visual system occurs similarly to other representatives of the order Cyprinodontiformes, but significantly differs in terms of the individual stages of embryogenesis due to the presence of diapause. In the postembryonic period, there is a further increase in the size of the fish’s eyes and head, to the proportions characteristic of adult fish. The histological structure of the eye in adult N. guentheri practically does not differ from most teleost fish living in the same environmental conditions. The study of the structure of the retina showed the heterogeneity of the thickness of the temporal and nasal areas, which indicates the predominant role of peripheral vision. Morphoanatomical measurements of the body and eyes of N. guentheri showed that their correlation was conservative. This indicates an important role of the visual system for the survival of fish in natural conditions, both for the young and adults. In individuals of the older age group, a decrease in the amount of sodium (Na) and an increase in magnesium (Mg) and calcium (Ca) were found in the eye lens. Such changes in the elemental composition of the lens can be a sign of the initial stage of cataractogenesis and disturbances in the metabolism of lens fibers as a result of aging. This allows us to propose N. guentheri as a model for studying the structure, formation, and aging of the visual and nervous systems.

scholarly journals Roles of TLR7 in Schistosoma japonicum Infection-Induced Hepatic Pathological Changes in C57BL/6 Mice

2021 ◽  
Vol 11 ◽  
Author(s):  
Yuanfa Feng ◽  
Hongyan Xie ◽  
Feihu Shi ◽  
Dianhui Chen ◽  
Anqi Xie ◽  
...  
Keyword(s):  
T Cells ◽  
B Cells ◽  
Granulomatous Inflammation ◽  
The Body ◽  
Pathological Changes ◽  
Toll Like Receptor ◽  
Host Protection ◽  
Hepatic Macrophages ◽  
Spread Of Infection

S. japonicum infection can induce granulomatous inflammation in the liver of the host. Granulomatous inflammation limits the spread of infection and plays a role in host protection. Toll-like receptor 7 (TLR7) is an endosomal TLR that recognizes single-stranded RNA (ssRNA). In this study, the role of TLR7 in S. japonicum infection-induced hepatitis was investigated in both normal and TLR7 knockout (KO) C57BL/6 mice. The results indicated that TLR7 KO could aggravate S. japonicum infection-induced damage in the body, with less granuloma formation in the tissue, lower WBCs in blood, and decreased ALT and AST in the serum. Then, the expression of TLR7 was detected in isolated hepatic lymphocytes. The results indicated that the percentage of TLR7+ cells was increased in the infected mice. Hepatic macrophages, DCs, and B cells could express TLR7, and most of the TLR7-expressing cells in the liver of infected mice were macrophages. The percentage of TLR7-expressing macrophages was also increased after infection. Moreover, macrophages, T cells, and B cells showed significant changes in the counts, activation-associated molecule expression, and cytokine secretion between S. japonicum-infected WT and TLR7 KO mice. Altogether, this study indicated that TLR7 could delay the progression of S. japonicum infection-induced hepatitis mainly through macrophages. DCs, B cells, and T cells were involved in the TLR7-mediated immune response.

scholarly journals INFEKSI PERIODONTAL SEBAGAI FAKTORRISIKO KONDISI SISTEMIK

2019 ◽  
Vol 6 (2) ◽  
pp. 141
Author(s):  
Oedijani Santoso
Keyword(s):  
Risk Factor ◽  
Respiratory Infections ◽  
Oral Infection ◽  
The Body ◽  
Periodontal Tissue ◽  
Oral Diseases ◽  
Inflammatory Reactions ◽  
Periodontal Tissues ◽  
Periodontal Infection

According to Riskesdas 2018 the prevalence of dental and oral diseases in Indonesia is still high (57.6%) and the most cases are caries and periodontal disease. Periodontal tissue infection is a local oral infection that can be a focal oral infection, and has a risk of affecting systemic conditions. Microorganisms, toxins and inflammatory reactions in infected periodontal tissues can spread systemically to other parts of the body, thatcan cause infections in the area or worsen existing conditions. Systemic conditions that can be affected by periodontal tissue infections including coronary heart disease / arterosclerosis, stroke, diabetes mellitus, pregnancy, chronic pulmonary obstruction, acute respiratory infections. The purpose of this literature review is to refresh about oral focal infection, as well as more convincing that periodontal infection was a risk factor for systemic conditions, in terms of inflammatory reactions.Influencing inflammatory reactions are inflammatory mediators, including interleukin (IL-1α, IL-β, IL-6, IL-8), tumor necotic factors (TNFα) and prostaglandin E2 (PGE2). Biological mechanisms support the role of periodontal infection as a potential risk factor for a number of systemic conditions.Future multidisciplinary research should better illustrate the role of periodontal infections in systemic health, so that the influence between periodontal infections and systemic conditions such as premature LBW, diabetes, cardiovascular and cerebrovascular diseases, and respiratory diseases will be increasingly proven

An Update on the Links Beween Periodontal Health and General Health

2019 ◽  
Vol 8 (4) ◽  
pp. 22-27 ◽  
Author(s):  
Praveen Sharma
Keyword(s):  
Cardiovascular Diseases ◽  
General Health ◽  
The Body ◽  
Health Conditions ◽  
Holistic Care ◽  
Potential Influence ◽  
Periodontal Health ◽  
Periodontal Tissues ◽  
Systemic Health

It should come as no surprise to the reader that the oral cavity, including the periodontal tissues, are not somehow disjointed from the rest of the body. In this paper, we will explore the links between the periodontal and general health of our patients in both directions. That is to say we will explore how someone's general or systemic health conditions/habits are likely to affect their periodontal health, and how someone's periodontal health is likely to affect their systemic health. Before exploring these links, we will discuss the distinction between an association and a causal relationship, which is a subtle but vital distinction to make. We will then discuss the role of systemic conditions/habits such as diabetes, smoking, diet and stress on the periodontal health of individuals. Following from this, we will discuss the potential influence of the periodontal health of our patients on their systemic health, focussing on the more established links with diabetes and cardiovascular diseases as well as exploring the mechanisms by which these links may exist. We will conclude with some tips on the holistic care of our patients, incorporating changes that will benefit their oral and systemic health.

scholarly journals Three cases of Pontine Ischemic Syndrome Analysis (Millard-Gubler)

2021 ◽  
Author(s):  
Camila Maria Bezerra Holanda ◽  
Maurus Marques de Almeida Holanda ◽  
Maurus Marques de Almeida Holanda Filho ◽  
Emílio Pires Diniz Neto ◽  
Hannah Pereira Costa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Basilar Artery ◽  
Abducens Nerve ◽  
Nerve Fibers ◽  
The Body ◽  
Motor Deficit ◽  
The Face ◽  
Ischemic Syndrome

Background: Millard-Gubler syndrome is characterized by crossed paralysis affecting the members on one side of the body and the face on the opposite side. It results from the lesion of the medioinferior (base) region of the pons, compromising the corticospinal tract and the facial nerve fibers. This disorder can also be associated with abducens nerve palsy. The finding of this syndrome in patients with a diagnosis of Ischemic Stroke is uncommon. Objectives and Methods: Report the syndrome in 03 patients diagnosed with ischemic stroke in the territory of branches of the basilar artery due to involvement of the circumferential pontine artery that irrigates the tegumentary territory of the VI and VII nerves. Results: The patients presented with facial weakness with deviation of the labial commissure, with convergent strabismus of the eye bulb on the same side, in addition to contralateral motor deficit. A computed tomography revealed a hypodense lesion located anterior to the pons, suggesting ischemic stroke. In the evolution of the cases, one patient developed coma, with brainstem infarction due to thrombosis of the basilar artery, while the other 2 cases evolved without sequelae. The risk factors that led to this event will be discussed and compared. Conclusions: These cases reports have their importance justified by the unusual presentation of this pons stroke, and it reinforces the fundamental role of neurological semiology, assessment of risk factors and image, for correct early diagnostic suspicion and treatment.

The Role of Polyphenols in the Modulation of Plasma Non-Enzymatic Antioxidant Capacity (NEAC)

2012 ◽  
Vol 82 (3) ◽  
pp. 228-232 ◽  
Author(s):  
Mauro Serafini ◽  
Giuseppa Morabito
Keyword(s):  
Antioxidant Capacity ◽  
Dietary Intervention ◽  
Ex Vivo ◽  
The Body ◽  
Dietary Polyphenols ◽  
Enzymatic Antioxidant ◽  
Endogenous Antioxidant

Dietary polyphenols have been shown to scavenge free radicals, modulating cellular redox transcription factors in different in vitro and ex vivo models. Dietary intervention studies have shown that consumption of plant foods modulates plasma Non-Enzymatic Antioxidant Capacity (NEAC), a biomarker of the endogenous antioxidant network, in human subjects. However, the identification of the molecules responsible for this effect are yet to be obtained and evidences of an antioxidant in vivo action of polyphenols are conflicting. There is a clear discrepancy between polyphenols (PP) concentration in body fluids and the extent of increase of plasma NEAC. The low degree of absorption and the extensive metabolism of PP within the body have raised questions about their contribution to the endogenous antioxidant network. This work will discuss the role of polyphenols from galenic preparation, food extracts, and selected dietary sources as modulators of plasma NEAC in humans.

The Role of Computer Modeling in Electrocardiography

1990 ◽  
Vol 29 (04) ◽  
pp. 282-288 ◽  
Author(s):  
A. van Oosterom
Keyword(s):  
Electrical Activity ◽  
Computer Modeling ◽  
Body Surface ◽  
Electrical Current ◽  
The Body ◽  
Volume Conductor ◽  
Current Generator ◽  
Cardiac Electrical Activity ◽  
Source Models

AbstractThis paper introduces some levels at which the computer has been incorporated in the research into the basis of electrocardiography. The emphasis lies on the modeling of the heart as an electrical current generator and of the properties of the body as a volume conductor, both playing a major role in the shaping of the electrocardiographic waveforms recorded at the body surface. It is claimed that the Forward-Problem of electrocardiography is no longer a problem. Several source models of cardiac electrical activity are considered, one of which can be directly interpreted in terms of the underlying electrophysiology (the depolarization sequence of the ventricles). The importance of using tailored rather than textbook geometry in inverse procedures is stressed.

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