scholarly journals ANTIVIRAL, ANTIOXIDANT AND CATALYTIC ACTIVITY OF TRACE ELEMENTS IN A LOW DEGREE OF OXIDATION

2020 ◽  
Vol 21 (3) ◽  
pp. 3-23
Author(s):  
M.Y. Spivak ◽  
◽  
V.G. Kaplunenko ◽  
M.V. Kosinov ◽  
A.V. Skalny ◽  
...  
Keyword(s):  
Trace Elements ◽  
Raw Materials ◽  
Review Article ◽  
The Body ◽  
Eye Drops ◽  
Low Degree ◽  
Degree Of Oxidation ◽  
New Generation ◽  
High Antiviral Activity

The review article studies the role of trace elements in protecting the body from viruses and focuses on the high antiviral activity of trace elements, which they exhibit if they are in a low degree of oxidation. Trace elements in a degree of oxidation make it possible to create new generation of antiseptics safe for humans. Has been discovered the mechanism of antiviral action of trace elements in a low degree of oxidation based on the suppression of electrostatic Coulomb interaction of virus with the cell. Sanitizers of a new generation can become effective prophylactic means for protecting the body from infection COVID-19 due to the fact that a vaccine against the SARS-CoV-2 coronavirus is under development, and there are no direct drugs for it. Compositions of substances for pharmaceutical use based on antimicrobial trace elements in a low degree of oxidation, which can be used either directly or as raw materials for production of drugs against the SARS-CoV-2 coronavirus, are given. Aqueous solutions of trace element sanitizers are suitable for inhalation and intranasal application and can be used in the form of aerosol or spray for throat and nose or eye drops at the first symptoms of disease, as well as at high risks of infection.

scholarly journals ОЦІНКА БІОЛОГІЧНОЇ ДІЇ ЕЛЕМЕНТВМІСНИХ ЛІПІДНИХ КОМПЛЕКСІВ З CHLORELLA VULGARIS НА ФУНКЦІОНАЛЬНИЙ СТАН ЗДОРОВИХ ЩУРІВ

2020 ◽  
Vol 80 (3-4) ◽  
pp. 50-62
Author(s):  
O. I. Bodnar ◽  
H. B. Kovalska ◽  
O. Ya. Lukashiv ◽  
V. V. Grubinko
Keyword(s):  
Trace Elements ◽  
Antioxidant System ◽  
Lipid Fraction ◽  
Dry Weight ◽  
The Body ◽  
Biologically Active ◽  
Spectrometric Analysis ◽  
Diene Conjugates ◽  
Complete Set

Chlorella is one of the most promising species of algae, which is widely cultivated for the industrial production of nutraceuticals in the form of tablets or powder. The value of Chlorella is primarily due to the high content of proteins and lipids (51–58 % and 20–23 % of dry weight respectively), carotenoids and an almost complete set of vitamins. At the same time, in the process of cultivation, a method was developed to enrich algobiomass and its individual components (primarily the lipid fraction) with selenium, zinc, chromium, as important regulatory trace elements. From chlorella, we obtained seleniumlipid, selenium-zinclipid and selenium-chromiumlipid complexes, and their constancy and structure were grounded by chromatographic and mass spectrometric analysis. After feeding healthy rats with a starch solution of selenium-zinclipid complex (1 ml of which contained 0.4 μg of selenium, 2.5 μg of zinc and 0.5 mg of lipids) and selenium-chromiumlipid complex (1 ml contained 1.85 μg of selenium, 1.1 μg of chromium, 0,45 mg of lipids), no signs of intoxication were found (total medium molecular peptides content was reduced to 1.5 times, the content of TBA-active products and diene conjugates were also decreased), antioxidant processes (increase of glutathione content and activity of glutathione peroxidase while reducing the functional role of catalase) were activated (by increasing of succinate dehydrogenase and cytochrome oxidase activity, glutamate dehydrogenase - the way of glutamate formation), which contributed to the successful functioning of the antioxidant system and maintenance of energy and metabolic homeostasis in the body. The obtained results enable the use of biologically active additives from chlorella, enriched with trace elements Se (IV), Zn (II) and Cr (III), as promising therapeutic and prophylactic substances, which will contribute to the successful functioning of the antioxidant system, maintain energy metabolism and metabolism correction of pathological processes, which is the basis for further studies of the biological activity of the complexes under study.

scholarly journals VULNERABLE ELECTRICALLY CHARGED SARS-COV-2 POINTS, ELECTRIC MODEL OF THE VIRUS AND ROLE OF TRACE ELEMENTS IN ITS INACTIVATION

2021 ◽  
Vol 22 (1) ◽  
pp. 3-20
Author(s):  
V.G. Kaplunenko ◽  
◽  
N.V. Kosinov ◽  
A.V. Skalny ◽  
◽  
...  
Keyword(s):  
Trace Elements ◽  
Antiviral Agents ◽  
Review Article ◽  
Oxidation States ◽  
Special Role ◽  
Electrical Model ◽  
Large Molecules ◽  
Electrically Charged ◽  
Selection Of

In the review article, electrically charged molecular groups on the surface of the virus were considered as targets for antiviral agents. The prospects of trace element application in a low oxidation state as antiviral agents have been shown. An electrical model of SARS-CoV-2 has been developed in the form of a multilayer structure, where each shell corresponds to electrically charged proteins on the surface of the virus. The model reveals the role of Coulomb forces in adsorption and fusion processes and makes it possible to identify vulnerabilities in the coronavirus that are sensitive to electrically charged substances and to an electric field. The mechanism of antiviral action of trace elements is disclosed, based on the suppression of electrostatic interaction of virus with the cell by neutralizing the charges on the surface of the virus and the cell. This allows the selection of oligopeptides and trace elements in low oxidation states to suppress the adsorption capacity of viruses. The special role of trace elements is that many potential targets that are inaccessible to antibodies and other large molecules are easily available to trace elements.

Role of autopsy in COVID-19 patients

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1517-1523
Author(s):  
Vriti Pursnani ◽  
Amit Reche ◽  
Gaurav Majumdar ◽  
Prerna Gautam ◽  
Kumar Gaurav Chhabra ◽  
...  
Keyword(s):  
Respiratory System ◽  
Review Article ◽  
The Body ◽  
Personal Hygiene ◽  
Treatment Modalities ◽  
Shortness Of Breath ◽  
Human Waste ◽  
Entire Country ◽  
Indian Scenario

Coronavirus disease 2019 had caused a pandemic leading to over 6M positive cases worldwide out of which 3.73 lac are demised (until when the article was written). Its first outbreak was seen in Wuhan, China. In the Indian scenario, we have a total of 2 lac cases out of which 5,679 have been deceased (until when the article was written). Due to the high transmissibility of this disease, the entire country is under lockdown to prevent the spread of the virus. The main etiology of this virus is the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2). This affects the respiratory system leading to cough, shortness of breath, and fever. There have been cases with mild or no symptoms reported, but the cause of death is due to the virus. This helps us understand the diagnosis, epidemiology, symptoms, and pathophysiology about the virus, which can help in treatment modalities. An autopsy is one of the methods by which we can understand the systematic involvement other than the respiratory system. Various pathological, microbiological changes can occur in the other organs. Even though the person is deceased, the virus is highly infectious can cause the spread through body fluids. Proper care must be taken while handling the body and performing the procedure. This review article aims to focus on the autopsy findings found in various cases to study the disease pathophysiology of the SARS-CoV-2. This article also helps us understand the guidelines that have been put forward by WHO and CDC must be followed regarding the specification required in the autopsy room; PPE’s to be worn, human waste and fluid disposal, body transportation. Proper personal hygiene must be maintained while handling the COVID-19 patients; this can lead to less susceptibility of acquiring the disease.

scholarly journals Studi Penambatan Molekul Senyawa Curcuma longa pada Bakteri Resisten Carbapenem Acinetobacter baumanii dengan Metode In Silico

2021 ◽  
Vol 3 (1) ◽  
pp. 124-130
Author(s):  
Nabila Shafa Athharani ◽  
Nugraha Sutadipura ◽  
Yuli Susanti
Keyword(s):  
Molecular Docking ◽  
In Silico ◽  
Raw Materials ◽  
Curcuma Longa ◽  
Docking Study ◽  
The Body ◽  
Molecular Docking Study ◽  
Acinetobacter Baumanii ◽  
Docking Method

Penemuan berbagai senyawa obat baru dari berbagai proses penelitian yang semakin memperjelas peran penting studi komputasi sebagai dasar awal untuk menemukan sumber bahan baku obat baik dari alam maupun sintetis. Infeksi nosokomial dapat disebabkan oleh bakteri, virus atau patogen lain di rumah sakit, dan ditularkan melalui peralatan di rumah sakit. Salah satu bakteri yang paling sering menyebabkan infeksi adalah Acinetobacter baumanii bakteri tersebut dapat membangun resistensi dalam tubuh. Metode penelitian ini dilakukan secara in silico dengan metode molecular docking dengan melihat penambatan molekul senyawa yang dimilikinya. Hasil penelitian menunjukkan bahwa senyawa yang diuji terhadap target reseptor yaitu Acinetobacter baumanii memiliki kemampuan sebagai antibakteri, terlihat dari ikatan afinitas yang diperoleh dari sekitar -7,7 kkal/mol hingga -8,1 kkal/mol. Kesimpulannya, kunyit dapat digunakan sebagai kandidat untuk mencegah Acinetobacter baumanii menjadi resisten. Molecular Docking Study of Curcuma Longa Compounds on Bacteria Resistant Carbapenem Acinetobacter Baumanii with in Silico MethodThe discovery of various new medicinal compounds from various research processes that further clarify the important role of computational studies as the initial basis for finding sources of medicinal raw materials both from natural and synthetic. Nosocomial infections can be caused by bacteria, viruses or other pathogens in the hospital and transmitted through equipment in the hospital. One of the bacteria that most often causes infection is Acinetobacter baumanii where these bacteria can build up resistance in the body. Method  of  this research is carried out in silico with the molecular docking method by looking at the docking of its compound molecules. The results showed that of the compounds tested against the receptor target, Acinetobacter Baumanii, had the ability as antibacterial, seen from the affinity bonds obtained from around -7.7 kcal/mol to -8.1 kcal/mol.  Conclusion is turmeric can be used as a candidate to prevent Acinetobacter baumanii from becoming resistance.

scholarly journals STUDY OF THE USE OF EDIBLE POWDERS TOMATO SAUCE TECHNOLOGIES

2018 ◽  
Vol 12 (1) ◽  
Author(s):  
O. Benderska ◽  
А. Bessarab ◽  
V. Shutyuk
Keyword(s):  
Functional Properties ◽  
Raw Materials ◽  
Current Trend ◽  
The Body ◽  
Biologically Active ◽  
Food Powders ◽  
Preservation Technology ◽  
National University ◽  
Vegetable Raw Materials ◽  
New Generation

Considered the technology for the production of edible powders from vegetable raw materials. The technology for producing powders from berries is developed to produce a high-quality product in which all ingredients of raw materials are stored in a concentrated form.The current trend in nutrition is related to the expansion of the range of functional products whose daily use contributes to the prevention of hypovitaminoses and metabolic disorders, and ultimately to the rehabilitation of the population. New, non-traditional sources of local raw materials, including plant based products, need to be explored and exploited in order to address the issue of instantiate new generation of healthy foods, and the development of technologies for obtaining functionalities. The use of fruit crops, the most source of biologically active substances, is very promising in this direction.The Department of Preservation Technology of the National University Food Technology has conducted a study to enable the use of fruit and berries for food powders. To this end, powder has been obtained from the blueberry berries of ordinary, with the establishment of its physico-chemical properties.The patterns of the influence of the blueberry powder on the functional properties of the foodstuffs were investigated in the example of tomato sauces.Analysis of the results of the studies has shown that a blueberry berry powder can be used in the production of canned and other products not only to enrich their functional ingredients but also to provide them with new technological properties. The food powders received do not contain harmful impurities, have high food value, are easily absorbed by the body, compact and long periods of time. Studies have shown that the blueberry powder is a rich source of vitamins (c acid, β-carotene, tocopherol) and can be used successfully in the manufacture of tomato sauces with functional properties.

Polifunctional Liposomes with Trace Elements and Vitamins to Prevent SARS-Cov2 Infection

2021 ◽  
Vol 3 (1) ◽  
pp. 1-6
Author(s):  
Bruno Riccardi ◽  
◽  
Sergio Resta ◽  
Tomas De Paoli ◽  
◽  
...  
Keyword(s):  
Trace Elements ◽  
Drug Therapy ◽  
Effective Drug ◽  
Specific Antagonist ◽  
The Individual ◽  
New Generation

After many months of the SARS-CoV2 pandemic, in the absence of a vaccine or effective drug therapy, we offer a new generation supplement. The supplement is formulated with trace elements and vitamins of undisputed immunostimulating efficacy, included in the individual liposomes, which act as carriers and therefore we define multifunctional, to improve the absorption and bioavailability of the substances used. We focus the discussion on the role of Zinc as an effective immunostimulant and specific antagonist of the SARS-Cov2 virus.

HUMAN PELVIS BUTTRESS SYSTEM AND THE ROLE OF SKELETAL MUSCLES IN ITS FORMATION (REVIEW ARTICLE)

2020 ◽  
pp. 93-100
Author(s):  
Иван Васильевич Гайворонский ◽  
А. А. Родионов ◽  
Геннадий Иванович Ничипорук ◽  
Инга Александровна Горячева ◽  
Мария Георгиевна Гайворонская
Keyword(s):  
Lower Limb ◽  
Skeletal Muscles ◽  
Bone Structure ◽  
Review Article ◽  
The Body ◽  
Vertical Position ◽  
Abdominal Pressure ◽  
Mechanical Forces ◽  
Bone Structures

В связи с вертикальным положением тела на таз человека действуют такие механические силы, как масса тела, внутренностей, внутрибрюшное давление, тяга мышц, связочного аппарата. Под воздействием этих сил происходит моделирование костных структур - внутренних пластинок губчатого вещества и замыкательных пластинок компактного вещества, наибольшая концентрация которых происходит в местах воздействия сил сжатия и растяжении. Указанные места повышенной плотности костной ткани в составе костного таза являются его контрфорсами. Связующим фундаментом контрфорсной системы таза является крестец, воспринимающий воздействия механических сил и передающих их на тазовые кости. Авторами выделены следующие костные контрфорсы: 1 - пояснично-крестцово-подвздошно-бедренный; 2 - пояснично-крестцово-подвздошно-седалищный; 3 - крестцово-седалищный; 4 - крестцово-бедренный; 5 - крестцово-подвздошнолобковый. Рассматривать контрфорсы таза необходимо с позиций арочных конструкций с обязательным взаимодействием контралатеральных сторон. Арочные конструкции, образованные пояснично-крестцово-подвздошно-бедренным, крестцовобедренным и крестцово-подвздошно-лобковыми контрфорсами, функционируют при вертикальном положении тела, а пояснично-крестцово-подвздошно-седалищные и крестцово-седалищные контрфорсы - при сидячем положении тела. Важнейшую роль в формировании и поддержании костных контрфорсов также играют скелетные мышцы, прикрепляющиеся к костям таза. Они не только изменяют его костную структуру, но и передают напряжение при своем сокращении на другие кости, формируя мышечные контрфорсные системы. В работе доказано наличие следующих костно-мышечных контрфорсов: 1 - наружного и внутреннего подвздошно-бедренного; 2 - наружного и внутреннего запирательнобедренного; 3 - лобково-седалищно-бедренно-большеберцового; 4 - седалищно-большеберцово-малоберцового контрфорсов. Показано, что таз является важнейшей частью опорно-двигательного аппарата человека и стабилизационным кольцом для свободной нижней конечности. In connection with the vertical position of the body, such mechanical forces as body weight, viscera, intra-abdominal pressure, traction of muscles, tendons and ligament apparatus act on the human pelvis. The bone structures - the internal plates of the spongy substance and the end plates of the compact substance, the highest concentration of which occurs at the sites of compression and tension - are modeled under the influence of these forces. The aforementioned places of increased bone density in the composition of the bone pelvis are its buttresses. The connecting foundation of the buttress system of the pelvis is the sacrum, perceiving the effects of mechanical forces and transmitting them to the pelvic bones. The authors distinguished the following bone buttresses: 1 - lumbo-sacral-iliac-femoral; 2 - lumbo-sacral-iliac-sciatic; 3 - sacro-sciatic; 4 - sacro-femoral; 5 - sacro-iliac-pubical. It is necessary to consider buttresses of the pelvis from the position of arched structures, with the obligatory interaction of the contralateral sides. Arched structures formed by the lumbo-sacral-iliac-femoral, sacro-femoral and sacro-iliac-pubic buttresses function when the body is in vertical position, and the lumbo-sacral-iliac-sciatic and sacroiliac buttresses when the body is in seated position. Skeletal muscles attached to the bones of the pelvis also play an important role in the formation and maintenance of bone buttresses. They not only change its bone structure, but during their contraction also transmit tension to other bones, forming muscle buttress systems. In the work, the presence of the following musculoskeletal buttresses is proved: 1 - the external and internal ileo-femoral; 2 - external and internal obturator-femoral; 3 - pubic-sciaticfemoral-tibial; 4 - sciatic-tibial-fibular buttresses. It is shown that the pelvis is the most important part of the human musculoskeletal system and the stabilization ring for the free lower limb.

Role of Diet and Nutrition in Pregnancy – An Ayurvedic Perspective

2017 ◽  
Vol 1 (4) ◽  
Author(s):  
Jyoti M. Ganer ◽  
Umapati C. Baragi
Keyword(s):  
Antenatal Care ◽  
Review Article ◽  
Great Emphasis ◽  
The Body ◽  
Pregnant Mother ◽  
Optimum Amount ◽  
Healthy State ◽  
State Of Mind ◽  
Mind And Body

Women have special dietary needs during each stage of her lives, including adolescence, pregnancy, breast feeding and menopause. During pregnancy the mother’s nutrition bears a great impact on the foetus’s growth and its future. Ayurveda lays great emphasis on ensuring holistic nutrition. A combination of Ahara (diet), Vihara (regimen), Vichara (emotions/thoughts) and Aushadha (medications) have been given great significance in Ayurveda in antenatal care called as Garbhini Paricharya (Antenatal care). Diet comprises the most important component of Garbhini Paricharya. Ayurveda advises congenital diet and regimen throughout the pregnancy. It also stresses on the healthy state of mind and body to beget healthy progeny. Milk and ghee stand out as the most common in the pregnant diet that Ayurveda advises. The idea of this is to provide optimum amount of protein and fat to the body. In addition, it provides right amount of calcium and vitamins for the pregnant mother helping in sustaining a comfortable lactation. In this review article a designed protocol of the month wise diet advised by various ancient Ayurvedic physicians, which can be modified according to the age, season, place, constitution and the digestive fire of the pregnant woman has been presented.

Role of porous silicon/hydrogel composites on drug delivery

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
Denisse Rocha-García ◽  
Antonio Guerra-Contreras ◽  
Sergio Rosales-Mendoza ◽  
Gabriela Palestino
Keyword(s):  
Porous Silicon ◽  
The Body ◽  
In Vivo Studies ◽  
Great Success ◽  
Nanoscale Systems ◽  
Wide Range ◽  
Spatial Presentation ◽  
New Generation

AbstractNanomaterials are applied with great success in biomedical applications as templates for the development of new generation devices, which can be used to solve current health problems. These new nanoscale systems are designed with multifunctions to perform specific and selective tasks. One of the most important applications of this new nanotechnology; focuses on developing new systems for the controlled release of drugs, mainly due to their capability to improve the temporal and spatial presentation of drugs in the body and their ability to protect them from physiological degradation or elimination. Hydrogels, porous silicon (PSi), and PSi-composites have been widely adopted in this field due to their biological, morphological, and physicochemical properties; which can be tuned to obtain sensitive responses to physiological stimuli. Despite the fact that some recent academic papers have shown the benefits of these nanomaterials in a wide range of biological applications, more in vivo studies are needed to take these hybrid systems towards clinical trials. In this mini-review some of the hydrogels, PSi, and PSi-composites latest applications and prospects in this field of science are presented.

scholarly journals Sport expertise development and the constraints-led approach

Conexões ◽  
2019 ◽  
Vol 17 ◽  
pp. e019001 ◽  
Author(s):  
Luiz Uehara ◽  
Chris Button ◽  
Keith Davids
Keyword(s):  
Review Article ◽  
The Body ◽  
Movement Behavior ◽  
Expertise Development ◽  
Functional Movement ◽  
Theoretical Concepts ◽  
Sport Expertise ◽  
Study Results

Objective: This review article delineates some important theoretical concepts that inform sport expertise acquisition studies. In particular, the principles of ecological psychology and dynamical systems theory have united together to form the ecological dynamics, a framework that provides the perfect platform through which to study the role of socio-cultural constraints upon sport expertise. Methodology: The body of information collected for this article was primarily extracted from peer- reviewed articles and academic books. This review article used Brazilian soccer as the case study. Results and discussion: Whilst the sports expertise literature has been guilty of somewhat polarising the influence of either practice or inherited attributes upon motor learning there are nonetheless many useful lessons to be learnt from this review article. For example, sport expertise development takes place over many years and includes numerous formal and informal pathways that athletes can take to excel.  Conclusion: The constraints-led approach has been promoted as a framework for understanding how people acquire perceptual-motor skills for sport and physical activities. On a practical level, this approach suggests that the major role of the coach or teacher is to manipulate key constraints in order to facilitate discovery of functional movement behavior.

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