scholarly journals EFFECTS OF IDENTIFYING TRANSFUSIONAL INCIDENTS BY ACTIVE SEARCHING AT A TERTIARY HOSPITAL

2020 ◽  
Vol 11 (1) ◽  
pp. 10-22
Author(s):  
Henrique de Paula Bedaque ◽  
Rodolfo Daniel de Almeida Soares ◽  
Carolina Lemos de Brito ◽  
Gabriela Lia de Aquino Revoredo
Keyword(s):  
Blood Transfusion ◽  
Average Rate ◽  
Tertiary Hospital ◽  
University Hospital ◽  
Blood Transfusions ◽  
Blood Components ◽  
Blood Products ◽  
Chi Square ◽  
Sentinel Network ◽  
Active Searching

Objective: The present study aims to analyze implementation consequences on active search for incidents related to blood transfusion at Onofre Lopes University Hospital (HUOL) and establish a blood transfusion profile in this facility. Methods: Blood transfusion and TIs registered on Hemotherapy Core at HUOL were counted through SPSS 20, comparing IT/1000 blood transfusion averages between 2012 and 2014. T Test of Student was used to compare data and chi-square (X²) and relative risk calculation to associate the use of blood components and risk to develop TI. Results: An increase of TI numbers at HUOL was shown by active searching and its equivalence to reference French and Brazilian services, liked to ANVISA sentinel network. Thus, there was a change in the average rate from 1.86 TI/1000 blood transfusions in 2012 to 5.36 TI/1000 blood transfusions in 2013 and 5.86 TI/1000 in 2014 (p = 0.001). It was also observed that the red blood cell concentrate is the fraction with the highest risk of occurrence of TIs (p = 0.003) and the greatest chance of causing any type of TI in relation to the other blood products, RR = 1.848 (95% CI; 1.042 - 3.266). It was also seen that the infusion of platelet concentrate is related to the allergic reaction (p <0.01), and greater risk compared to other blood components, RR = 2.746 (95% CI; 1.477 - 5.107). Conclusion: This study demonstrates active Hemovigilance importance on Tis subnotifications decrease.

scholarly journals DIFFERENCES IN CHANGES OF HEMOGLOBIN BETWEEN 6-12 HOURS AND 12-14 HOURS AFTER TRANSFUSION

2018 ◽  
Vol 24 (2) ◽  
pp. 108
Author(s):  
Rosita Linda ◽  
Devita Ninda
Keyword(s):  
Blood Transfusion ◽  
Secondary Data ◽  
Hemoglobin Concentration ◽  
Fresh Frozen Plasma ◽  
Blood Components ◽  
Blood Products ◽  
Fresh Frozen ◽  
Frozen Plasma ◽  
Hemoglobin Measurement ◽  
Baseline Hemoglobin

Each year more than 41,000 blood donations are needed every day and 30 million blood components are transfused. Blood products that can be transfused include Packed Red Cells (PRC), Whole Blood (WB), Thrombocyte Concentrate (TC), Fresh Frozen Plasma (FFP). Monitoring Hemoglobin (Hb) after transfusion is essential for assessing the success of a transfusion. The time factor after transfusion for Hemoglobin (Hb) examination needs to be established, analyze to judge the success of a blood transfusion which is performed. The aim of this study was to analyze the differences in changes of hemoglobin between 6-12 hours, and 12-24 hours after-transfusion. This study was retrospective observational using secondary data. The subjects were patients who received PRC, and WBC transfusion. At 6-12, and 12-24 hours after-transfusion, hemoglobin, RBC, and hematocrit were measured. Then the data were analyzed by unpaired t-test. The collected data included the results of the Hb pre-transfusion, 6-12, and 12-24 hours after-transfusion. The subjects of this study were 98 people. The administration of transfusion increased by 10-30% in hemoglobin concentration at 6-12 hours after-transfusion. While at 12-24 hours after-transfusion, hemoglobin after-transfusion increased 15-37% from the baseline. Hemoglobin values were not different at any of the defined after-transfusion times (p = 0.76 (p>0.05)). Hemoglobin values were not different at 6-12 hours, and 12-24 hours after-transfusion.    Keywords: Hemoglobin, measurement, after-transfusion 

A Child has a Right to Blood Transfusion Services in Nigeria, despite the Religious Status of the Parents or Guardians

2021 ◽  
Vol 4 (4) ◽  
Author(s):  
Uchejeso M Obeta
Keyword(s):  
Intensive Care ◽  
Blood Transfusion ◽  
Blood Cell ◽  
Neonatal Intensive Care ◽  
Healthcare Providers ◽  
Red Blood Cell Transfusion ◽  
Blood Transfusions ◽  
Blood Products ◽  
Serious Illness ◽  
Life Saving

Red blood cell transfusion is an important and frequent component of neonatal intensive care. Whereas blood and blood products transfusion can help a patient (child) recover from a serious illness, surgery or injury, because of the religious beliefs of some parents or guardians, a child may be denied the benefit of this life-saving service. Several legal statutes and precedents exist to protect the rights of children in need of life-saving blood transfusions where denied this opportunity to be transfused and survive. The awareness of these extant laws and statutes are critical for the empowerment of healthcare providers in the performance of their role within the provisions of the law and medical ethics.

scholarly journals Practices for rational use of blood components in a universitary hospital

2015 ◽  
Vol 61 (4) ◽  
pp. 355-361
Author(s):  
Sydney Correia Leão ◽  
Mariana Araújo Bezerra Gomes ◽  
Mila Cintra de Azevedo Aragão ◽  
Iza Maria Fraga Lobo
Keyword(s):  
Comparative Analysis ◽  
Health Professionals ◽  
Educational Program ◽  
University Hospital ◽  
Theoretical Knowledge ◽  
Blood Transfusions ◽  
Significant Gain ◽  
Blood Components ◽  
Post Intervention ◽  
The University

SummaryObjective:to produce improvements in transfusion practices through the implementation of an educational program for health professionals in a university hospital.Methods:this is an interventional and prospective study, with pre- and postanalysis of an educational intervention. The research was developed at the University Hospital of the Universidade Federal de Sergipe, involving participation of health professionals in the stage of training, during the month of February 2011, in addition to the monitoring of blood transfusions performed in the preand post-intervention periods. Transfusion practices were investigated upon request for transfusion or devolution of unused blood components. Knowledge of health professionals was assessed based on the responses to a questionnaire about transfusion practices.Results:during the educative campaign, 63 professionals were trained, including 33 nurses or nursing technicians and 30 physicians. Among the doctors, there was a statistically significant gain of 20.1% in theoretical knowledge (p=0.037). Gain in the nursing group was even higher: 30.4% (p=0.016). The comparative analysis of transfusion request forms showed a non-significant decrease from 26.7 to 19.5% (p=0.31) in all forms with incomplete information. We also observed a statistically significant improvement in relation to the filling of four items of transfusion request.Conclusion:there was a significant improvement of the entire process related to blood transfusions after interventional project conducted in February 2011.

scholarly journals Transfusion Immunology

2020 ◽  
Author(s):  
Fahri Yüce Ayhan ◽  
Hasan Ağın
Keyword(s):  
Major Histocompatibility Complex ◽  
Blood Transfusion ◽  
Adverse Effects ◽  
Immune Responses ◽  
Blood Cells ◽  
Clinical Manifestations ◽  
Blood Transfusions ◽  
Blood Components ◽  
Histocompatibility Complex ◽  
Complex Process

Transfusion as a transplantation of blood cells is a complex process with many immunological consequences which are variably related to the features of donors, recipients and blood components. In all allogeneic blood transfusions immune responses are stimulated by effecting innate and adaptive immunities. Red blood cell antigens, platelet antigens, neutrophil antigens and major histocompatibility complex antigens have important roles in blood transfusion. The interactions of the stimulated antibodies with these antigens have significant consequences that result in various clinical manifestations, some of them may be life-threating. More improved understanding of the immunological processes associated with transfusion will make obtaining more effective results possible in the management of the adverse effects of transfusion as for safety of the patient and transfusion applications.

Evaluation of Erythropoietin Stimulating Agents (ESA) and Their Effect on Blood Optimization for Cardiac Surgery

2020 ◽  
pp. 089719002096927
Author(s):  
Kristina S. Gill ◽  
Abigail D. Antigua ◽  
A. Kacee Barnett ◽  
Aubrey J. Hall ◽  
Charles T. Klodell
Keyword(s):  
Cardiac Surgery ◽  
Blood Transfusion ◽  
Retrospective Cohort ◽  
Blood Transfusions ◽  
Transfusion Rate ◽  
Blood Products ◽  
Single Center ◽  
Drug Reactions ◽  
Significant Difference ◽  
Erythropoietin Stimulating Agents

Background: Cardiovascular surgeries increase the risk of receiving blood transfusions. Erythropoietin stimulating agents (ESAs) have been used to decrease the transfusion rate. The objective of this study was to evaluate the administration of blood products post-cardiothoracic surgery after receiving ESAs. Methods: This is a single-center, retrospective cohort study. Results: Between May 2017 to May 2018, 52 adult patients underwent cardiac surgery and received ESAs pre-operatively and/or post-operatively. A total of 35 patients were included in the study and 21 (60%) patients did not require a blood transfusion while 14 (40%) patients required a blood transfusion ( p = 0.597). The change in hemoglobin (Hgb = 0.773 g/dL, 1.7 g/dL; p = 0.002) and hematocrit (Hct = 2.31%, 4.3%; p = 0.04) was significantly different in patients who received ESAs alone versus ESAs with blood transfusion. Adverse drug reactions showed no significant difference between groups. Conclusions: In patients undergoing cardiac surgery, ESAs did not significantly reduce the need for blood transfusion. Future and larger studies are necessary to evaluate the effect of ESAs on blood transfusion.

scholarly journals Do Blood Transfusions Cause Pulmonary Complications Following Hematopoietic CELL Transplantation?

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 2477-2477
Author(s):  
Melhem Solh ◽  
Shanna Morgan ◽  
Jeffrey Mc Cullough ◽  
Ryan Shanley ◽  
Daniel J. Weisdorf
Keyword(s):  
Relative Density ◽  
Umbilical Cord ◽  
Hematopoietic Cell Transplantation ◽  
Pulmonary Complications ◽  
Control Group ◽  
P Value ◽  
Blood Transfusions ◽  
Blood Components ◽  
Blood Products ◽  
Blood Utilization

Abstract Introduction Transfusion of blood products is an essential component of the hematopoietic cell transplantation (HCT) process. Blood transfusions mainly platelets and plasma, carry several risks including, but not limited to, acute and delayed lung injury, especially in critically ill patients. The effect of transfusions on lung complications post HCT has not been previously investigated. We studied 215 adult allogeneic HCT recipients at the University of Minnesota and examined the association between transfusion of blood components and development of lung complications post HCT. Methods 215 consecutive adult allogeneic HCT recipients were retrospectively analyzed for blood product utilization. Patients without lung complications were used as a control group and those with any lung complication prior to day 180 post HCT were the study cohort. Blood utilization was quantitated as the total number of transfusion episodes and the number of transfusion episodes per week divided into three time intervals: day 0-30, day 31-60, and day 61-180 after HCT. Transfusions were analyzed as density (episodes or units per week). Lung complication data was collected from the transplant database and merged with the transfusion data. The effects of transfusion density and other factors on the odds of ever having a lung complication were modeled using multivariable logistic regression. Results 195 patients were included in the analysis and 20 were excluded, mostly due to incomplete data. 113 (58%) of the patients developed lung events prior to day 180 post HCT. Of the 113 patients with lung events, 81 (72%) were related to infectious causes. The study group with pulmonary complications and controls had similar baseline demographic characteristics (age, gender, CMV serostatus, disease and disease risk and donor source). Six months survival was significantly lower in the lung complications group (52%) versus the controls (78%) p=0.01. Patients who developed lung events received more transfusions including: episodes per week during the first month following HCT (median 4.3 (range x-y) vs. 2.7 (x-y) for controls); platelet units per week (3.5 (range x-y) vs. 2.0 (x-y)); and RBC units per week (1.8 (x-y) vs. 1.4 (x-y)); p <0.01 for all. Transfusion episodes increased significantly in the week following each lung event compared to the preceding week (7.1 (range x-y) versus 5.5 (x-y); p=0.04). In multivariate analysis, the presence of any lung complication, use of an umbilical cord graft and occurrence of chronic GVHD were each independently associated with increased number of transfusion episodes post HCT. Table 1 shows factors that were significantly associated with increased blood utilization up to day 180. Conclusion These data suggest that transfusion of more blood products is associated with lung complications and their use increases after the lung events. Limiting use of blood components in the post HCT period is recommended, potentially to reduce the risks of lung events. Table 1: Risk factors for Transfusion episodes/week from day 1-180 post HCT All Transfusion Episodes RBC Units Platelet Units Risk factor Relative transfusion density P-value Relative density P-value Relative density P-value Control group 1.0 1.0 1.0 ARDS/IPS 4.1 <.01 3.7 <.01 3.5 <.01 DAH 4.3 <.01 4.7 <.01 5.7 <.01 Bacterial pneumonia 2.6 <.01 2.7 <.01 3.1 <.01 Pulmonary edema 2.6 <.01 3.4 <.01 2.9 <.01 Female 1.0 1.0 1.0 Male 0.9 0.36 1.0 0.83 1.0 0.86 Reduced intensity conditioning 1.0 1.0 1.0 Myeloablative with TBI 1.4 0.02 1.2 0.20 1.7 <.01 Myeloablative without TBI 1.8 0.05 1.6 0.14 1.3 0.66 CMV serostatus Recipient+ 1.0 1.0 1.0 CMV R-/Donor- 0.7 0.03 0.9 0.48 0.6 0.05 CMV R-/D+ 1.2 0.39 1.0 0.91 1.2 0.55 Sibling donor 1.0 1.0 1.0 Unrelated Adult donor 0.9 0.70 0.8 0.60 0.6 0.40 Unrelated umbilical cord blood donor 1.7 <.01 1.8 <.01 2.0 <.01 Standard risk disease 1.0 1.0 1.0 High risk disease 1.2 0.19 1.3 0.04 1.2 0.47 Abbreviations ARDS/IPS: Adult respiratory distress syndrome/Idiopathic pneumonia syndrome; DAH: Diffuse alveolar hemorrhage; NOS: not otherwise specified; TBI: total body irradiation; CMV: cytomegalovirus. Disclosures No relevant conflicts of interest to declare.

scholarly journals COVID-19 pandemic: Challenges and approaches in blood transfusions

2020 ◽  
Keyword(s):  
Blood Transfusion ◽  
Blood Donation ◽  
Virus Transmission ◽  
Blood Transfusions ◽  
Blood Products ◽  
Screening Programs ◽  
Self Sufficiency ◽  
Comprehensive Information ◽  
Bacterial Transmission ◽  
Donated Blood

One of the goals of the Iranian Blood Transfusion Organization is to provide adequate healthy blood and reduce the risk of various viral and bacterial transmission infections. With the removal of alternative blood donation, all blood units and blood products are provided through voluntary blood donation in Iran. The Blood Transfusion Organization screens the donated blood according to standard guidelines to ensure blood recipients and physicians of providing healthy and pathogen-free components. With the emergence of novel pathogens, such as the pandemic of the COVID-19 virus, despite Iranchr('39')s self-sufficiency in blood supply and blood products, the number of blood donors has decreased significantly since there is a lack of comprehensive information on pathophysiology and virus transmission ways. Moreover, the existence of some shortages in screening programs can cause problems. Therefore, this study was performed to review the studies conducted investigating this emerging virus regarding blood transfusions and the supply of blood components worldwide.

scholarly journals Children are not little adults: blood transfusion in children with burn injury

2017 ◽  
Vol 5 ◽  
Author(s):  
Tina L. Palmieri
Keyword(s):  
Blood Transfusion ◽  
Body Surface ◽  
Burn Injury ◽  
Total Body Surface Area ◽  
Blood Transfusions ◽  
Blood Products ◽  
Physiologic Response ◽  
Risks And Benefits ◽  
Transfusion Requirements ◽  
Total Body

Abstract Blood transfusion in burns larger than 20% total body surface area (TBSA) are frequent due to operative procedures, blood sampling, and physiologic response to burn injury. Optimizing the use of blood transfusions requires an understanding of the physiology of burn injury, the risks and benefits of blood transfusion, and the indications for transfusion. Age also plays a role in determining blood transfusion requirements. Children in particular have a different physiology than adults, which needs to be considered prior to transfusing blood and blood products. This article describes the physiologic differences between children and adults in general and after burn injury and describes how these differences impact blood transfusion practices in children.

scholarly journals Delayed Hemolytic Transfusion Reaction - A Case Report

2012 ◽  
Vol 4 (2) ◽  
pp. 15-19
Author(s):  
Rajay A. D. Kamath ◽  
Kiran V. Neswi ◽  
Shiva Bharani K.S.N. ◽  
M.A. Giri Sankar
Keyword(s):  
Case Report ◽  
Blood Transfusion ◽  
Blood Cells ◽  
Blood Transfusions ◽  
Transfusion Reaction ◽  
Blood Products ◽  
Hemolytic Transfusion Reaction ◽  
Delayed Hemolytic Transfusion Reaction ◽  
Cross Matching ◽  
Hematological Tests

Abstract Blood transfusion is the process of receiving blood products into one's circulation intravenously. Transfusions are used in a variety of medical conditions to replace lost components of the blood. Transfusions of blood products are associated with several complications, many of which can be grouped as immunological or infection. Acute hemolytic reactions occur with transfusion of red blood cells and are due to destruction of donor erythrocytes by preformed recipient antibodies. Most often this occurs due to clerical” errors or improper typing and cross matching. Delayed hemolytic reactions occur more frequently and are due to the same mechanism as in acute hemolytic reactions. However, the consequences are generally mild and a great proportion of patients may not have symptoms. However, evidence of hemolysis and falling hemoglobin levels may still occur. Treatment is generally not needed, but due to the presence of recipient antibodies, future compatibility may be affected. Hereby we share our experience of such a case of delayed hemolytic transfusion reaction and discussing the various measures to be taken during any such incidence and the biochemical and hematological tests to confirm the diagnosis.

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