scholarly journals Comparison of rat tooth eruption in rats born from diabetic mothers

2021 ◽  
Vol 54 (3) ◽  
pp. 137
Author(s):  
Salsabila Qotrunnada ◽  
Dina Z. Ummah ◽  
Mei Syafriadi
Keyword(s):  
Blood Glucose ◽  
Simple Random Sampling ◽  
Tooth Eruption ◽  
Alveolar Epithelial ◽  
Control Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Diabetic Treatment ◽  
Group B ◽  
Diabetic Mothers

Background: Tooth eruption begins after crown and root formation and may be delayed by gestational diabetes mellitus. Metformin can control blood glucose levels through gluconeogenesis inhibition, and consuming thymoquinone for diabetic treatment will regenerate pancreatic β cells and reduce oxidative stress. Purpose: The objective of this study is to compare the tooth eruption in rats that were born with diabetes and are being treated with either metformin or thymoquinone. Methods: This study used 48 Wistar rats (Rattus norvegicus L.), and the rat sample was divided into four groups, including rats who were born from healthy mothers, rats who were born from untreated diabetic mothers, rats who were born from diabetic mothers that were treated with metformin and rats who were born from diabetic mothers that were treated with thymoquinone. Diabetes was induced by intraperitoneal injection of a single dose of streptozotocin (40 mg/kg BB). Each rat sample was taken with simple random sampling from different mothers, and body weight, blood glucose levels and levels of tooth eruption were recorded. Eruptions of the maxillary right first molar were measured from the cusp of the tooth to the alveolar epithelial lining. Results: Based on the measurements of tooth eruption, it was found that groups A, C and D were closer to mucosa on day 1, 7 and 14 than group B. Based on statistical analysis, there were significant differences (p = 0.03) between group B and groups C and D. Conclusions: Rats born from untreated diabetic mothers have more delays in tooth eruption than those born from diabetic mothers who are treated with metformin and thymoquinone. Thymoquinone has the potential to be an alternative to metformin because it has been shown to be similarly effective.

Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis?

2020 ◽  
Vol 207 ◽  
pp. 111877 ◽  
Author(s):  
Kenia Mendes Rodrigues Castro ◽  
Rodrigo Leal de Paiva Carvalho ◽  
Geraldo Marco Rosa Junior ◽  
Beatriz Antoniassi Tavares ◽  
Luis Henrique Simionato ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Muscle Glycogen ◽  
Glycogen Synthesis ◽  
Photobiomodulation Therapy ◽  
Control Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Muscle Glycogen Synthesis

scholarly journals Effects of Controling of Post Operative Hypergycemia (Stress Induced Hyperglycemia) in Adult Non-Diabetic Patients Undergoing Mitral Valve Replacement Surgery Under Cardiopulmonary Bypass

2019 ◽  
Vol 34 (1) ◽  
pp. 44-51
Author(s):  
Md Armane Wadud ◽  
Syed Tanvir Ahmed ◽  
Shahnoor Aziz ◽  
Ibrahim Khalilullah ◽  
CM Shaheen Kabir
Keyword(s):  
Blood Glucose ◽  
Mitral Valve ◽  
Valve Replacement ◽  
Mitral Valve Replacement ◽  
Postoperative Morbidity ◽  
Replacement Surgery ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Group B ◽  
Valve Replacement Surgery

Objectives: The objective of this study was to see whether there is an association between high blood glucose levels after operation under CPB and post operative morbidity and mortality. Methodology: This cohort study was carried out in the Department of Cardiac Surgery at National Institute of Cardiovascular DiseaseS (NICVD), Sher-e-Bangla Nagar, Dhaka from January, 2012 to December, 2013 for a period of twenty four (24) months. A total number of 110 patients who underwent MVR operation with CPB were enrolled in this study as per inclusion and exclusion criteria. Patients were divided into two groups according to their post operative blood glucose levels, recorded with in first 60 hrs after mitral valve replacement surgery under cardiopulmonay bypass. Patients having blood glucose level of less than 10.1 mmol/L (unexposed) and patients having blood lactate level of 10.1 mmol/L or more (exposed) were grouped. Post operative variables were observed and recorded during the hospital course of the patient. Result: A total number of 110 patients were enrolled in this study. Blood glucose levels lower than or equal to10 mmol/L after MVR were present in 55(50%) patients (Group A) Blood glucose levels higher than 10 mmol/L after MVR were present in 55(50%) patients. Postoperative morbidity was higher in this group ( Group B) than in the patients who had peak blood glucose levels of less than or equal to 10 mmol/L MVR (p 0.001). Postoperative ICU stay was prolonged in patients with elevated levels of blood glucose after MVR under CPB compared with of patients with lower blood glucose levels (p 0.001). Other common morbidities are neurological complication (p 0.04), renal dysfunction (p 0.01) , wound infection (p 0.04), post-operative hospital stay ( p0.004). also higher in group B patient, as well as mortality. Conclusions: Blood glucose concentration of 10.1 mmol/ L or higher after MVR under CPB is an important issues related to postoperative morbidity and mortality. Bangladesh Heart Journal 2019; 34(1) : 44-51

Effectiveness of acarbose in treating elderly patients with diabetes with postprandial hypotension

2017 ◽  
Vol 65 (4) ◽  
pp. 772-783 ◽  
Author(s):  
Jie Zhang ◽  
Lixin Guo
Keyword(s):  
Blood Pressure ◽  
Blood Glucose ◽  
Elderly Patients ◽  
Controlled Trial ◽  
Clinical Trial Registry ◽  
Postprandial Hypotension ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Patients With Diabetes ◽  
Group B

Postprandial hypotension (PPH) is a common condition that occurs primarily in elderly patients with type 2 diabetes mellitus (T2DM). This study aimed to assess the effectiveness of acarbose for PPH; it also investigated possible mechanisms behind PPH development. This single-blind, randomized controlled trial included 91 elderly patients with T2DM, aged between 60 and 80 years, who were inpatients at Beijing Hospital between March 2012 and November 2014. The patients were included into one of three groups: Group A, patients with T2DM without PPH; Group B, patients with T2DM with PPH receiving placebo; and Group C, patients with T2DM with PPH receiving acarbose. After an overnight fast, patients received a single dose of acarbose (100 mg) or placebo and then consumed a standardized 450 kcal meal. Blood pressure, glucose levels, heart rate (HR), and catecholamine levels were evaluated. Acarbose ameliorated PPH as determined by significant improvements in the duration and maximal fall in blood pressure (both p<0.001); however, no differences in HR and blood glucose levels were observed. In patients with PPH, blood pressure was correlated with blood glucose and HR variability values (p<0.05). Correlations between epinephrine and glucagon-like peptide-1 with blood pressure in groups A and C were largely lost in group B. Acarbose reduced postprandial blood pressure fluctuations in elderly patients with diabetes. PPH may be related to impaired autonomic nervous system function, reduced catecholamine secretion, and postprandial fluctuations in blood glucose levels.Trial registration numberChinese Clinical Trial Registry ChiCTR-IPR-15006177.

scholarly journals Pengaruh Pemberian Minuman Fungsional Terhadap Penurunan Kadar Glukosadarah Puasa Pada Penderita Diabetes Melitus

2019 ◽  
Vol 4 (2) ◽  
pp. 114
Author(s):  
Tutut Zikra Anjani ◽  
Suhaema Suhaema ◽  
Fifi Lutfiah ◽  
Ni Ketut Sri Sulendri
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Female Gender ◽  
Simple Random Sampling ◽  
Control Group ◽  
Risk Category ◽  
Control Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Post Test

Indonesia is currently the fourth country with the largest number of DM patients in the world. Functional food is beneficial for the health of DM patients, for example bananas and soybeans. Kepok bananas contain dietary fiber inulin and antioxidants (β carotene). Soybeans contain isoflavones, fiber, and proteins in the form of amino acids arginine and glycine. This study aims to look at the effect of giving functional drinks a mixture of soybean and banana milk on decreasing fasting blood glucose levels in type II DM patients. Type of Quasy-experimental research with pre test and post test with control group design. Subjects were taken using the Simple Random Sampling method and the subjects involved until the end of the study were 26 people. The intervention was carried out for 14 days and given as much as 330 ml. The equality of the subject characteristics of the two groups was analyzed using the chy squere test, and the effect of giving intervention materials on decreasing blood glucose levels was tested by independent t test. The results of the study were characteristics (84.6%) aged 50-60 years, (53.8%) female gender, (57.1%) having a family history of disease, 58.4% using glibenclamide anti-hyperglycemic drugs and BMI average in the risk category. . Result Δ It is known that there is an effect of giving functional drinks on decreasing fasting blood glucose levels where the average change is 11.5 mg / dl (p = 0.03). 

scholarly journals Correlation Between Blood Glucose Control And Decrease Of Peripheral Vascularization In Diabetes Mellitus Patient

2018 ◽  
Vol 4 (1) ◽  
pp. 18
Author(s):  
Fitria Endah Janitra ◽  
Dinda Sandika
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Glucose Control ◽  
Diabetes Management ◽  
Blood Glucose Control ◽  
Nursing Intervention ◽  
Tissue Ischemia ◽  
Control Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels

Introduction: Diabetes mellitus (DM) is a metabolic disorder characterized by elevated blood glucose levels. Chronic complications of DM affect coronary circulation, peripheral vascularization, and blood vessels of the brain. Decrease in peripheral vascularization increases the risk of tissue ischemia and weakens functional status, therefore it is necessary to control blood glucose levels. Islam teaches to its believers to control their diet, where diet is one of the four pillars of diabetes management. Methodology: this is analytic descriptive research with cross sectional methods in 67 respondents taken by consecutive sampling technique. Results: There was a significant correlation within blood glucose control and decreased peripheral vascularization in DM patients (p-value 0.010). Discussion: need further research regarding nursing intervention to control blood glucose.

Ankle Brachial Indeks (ABI), Kadar Glukosa Darah dan Nutrisi Pada Ulkus Diabetikum

2019 ◽  
Vol 4 (3) ◽  
pp. 449
Author(s):  
Riwanti Silaban ◽  
Pina Lestari ◽  
May Daryeti ◽  
Diah Merdekawati
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Sampling Technique ◽  
P Value ◽  
Cross Sectional ◽  
Diabetic Ulcer ◽  
Control Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
And Control

<p><em>The increasing number of people with diabetes mellitus each year, the client has also experienced one of the complications, namely ulcers. During this time, the concern of nurses at Raden Mattaher Jambi Hospital is only an ulcer on the client, but no intervention has been made to determine the factors causing the duration of the client's ulcer resolved. The kind of is a cross-sectional. The sample in this study was 27 respondents who had criteria by what was to be studied. The sampling technique is done by accidental sampling that is taking samples by taking cases or respondents who happen to be available or available. Analysis of the data in this study was Univariate and Bivariate. It was held on April 29th until June 29th 2019 with uses observation sheets and questionnaires as aids in data collection. Statistical test results obtained p-value &lt;0.05, meaning that there is a relationship between ABI values, blood glucose levels and nutrients with the area of diabetic ulcer. It can be concluded that the ABI value, blood glucose level and nutrition affect the area of diabetic ulcer. It is expected that Raden Mattaher Jambi Hospital can make ABI examination a Standard Operational Procedure and control blood glucose and nutrition levels as a factor in accelerating wound healing.</em></p><p> </p><p><em>Semakin meningkatnya angka penderita diabetes mellitus tiap tahunnya, maka semakin meningkat pula klien mengalami salah satu komplikasinya yaitu ulkus. Selama ini, yang menjadi perhatian perawat di RSUD Raden Mattaher Jambi hanya ulkus pada klien, namun belum ada intervensi yang dilakukan guna mengetahui faktor penyebab lamanya ulkus klien teratasi. Jenis penelitian ini adalah penelitian cros sectional. Sampel dalam penelitian ini 27 responden yang memiliki kriteria sesuai dengan yang akan diteliti. Teknik pengambilan sampel dilakukan dengan cara accidental sampling yaitu pengambilan sampel dilakukan dengan mengambil kasus atau responden yang kebetulan ada atau tersedia. Analisa data dalam penelitian ini secarra Univariat dan Bivariat. Penelitian ini dilaksanakan dari 29 April-29 Juni 2019 dengan menggunakan lembar observasi dan kuesioner sebagai alat bantu dalam pengumpulan data. Hasil uji statistik diperoleh nilai p-value &lt; 0,05, artinya ada hubungan antara nilai ABI, kadar glukosa darah dan nutrisi dengan luas ulkus diabetikum. Dapat disimpulkan bahwa nilai ABI, kadar glukosa darah dan nutrisi mempengaruhi luas ulkus diabetikum. Diharapkan kepada pihak RSUD Raden Mattaher Jambi dapat menjadikan pemeriksaan ABI sebagai Standar Prosedur Operasional dan melakukan pengontrolan kadar glukosa darah serta nutrisi sebagai faktor mempercepat penyembuhan luka.</em></p>

scholarly journals Effect Of Withania Coagulans And Liraglutide On Serum Glp-1, Postprandial And Fasting Blood Glucose In Streptozotocin Induced Diabetic Rats

2019 ◽  
Vol 09 (02) ◽  
pp. 120-123
Author(s):  
Abdul Samad ◽  
Noor Nasir Rajpoot ◽  
Hira Ayaz ◽  
Noman Sadiq
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Postprandial Blood Glucose ◽  
Controlled Study ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Withania Coagulans ◽  
Group B ◽  
Experimental Group

Objective: To evaluate effect of Withania coagulans and liraglutide on serum Glucagon like peptide-1, Postprandial and Fasting Blood Glucose levels in streptozotocin induced diabetic rat. Study Design and Setting: This randomize control trile was conducted at Islamic International Medical College in collaboration with National Institute of Health Islamabad. Methodology: This randomized controlled study was performed on a total of forty male Sprague dawly rats, which were initially divided into two groups; Group A (n=10) and Experimental Group (n=30). Diabetes in the Experimental group B was induced by intraperitoneal administration of streptozotocin for 5 days (30mg/kg/day). Diabetes was checked in experimental group by measuring fasting blood glucose (mg/dl) on day 6. Experimental group was further divided into Group B (Diabetic control), Group C (Withania coagulans-treated) and Group D (Liraglutide-treated). Blood sampling was done at day 30 and serum GLP-1, postprandial and fasting blood glucose levels were measured and compared in all groups. Results: Fasting and postprandial blood glucose levels of group C and D were significantly reduced as compared to group B. Serum GLP-1 levels were significantly increased in group C and D as compared to group B. Conclusion: Withania coagulans reduces hyperglycemia in diabetic rats through increasing GLP-1 hormone.

scholarly journals Estimating the enzyme specificity and glucose concentration of sugar solutions

2019 ◽  
Vol 6 (14) ◽  
pp. 493-496
Author(s):  
Rishan Singh
Keyword(s):  
Blood Glucose ◽  
Human Body ◽  
Glucose Concentration ◽  
Serum Insulin ◽  
Enzyme Specificity ◽  
Data Set ◽  
Control Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Insulin Control

The function of the human body are controlled by enzymes and hormones. Similarly, in the laboratory, the enzyme, glucose oxidase, is used to hydrolyse glucose. In the human body, glucose and insulin control blood glucose levels, which are dependent on food intake. In this study, the enzyme specificity and glucose concentration of sugar solutions would be estimated. In order to achieve this, an experiment involving the use of indicator strips and a two-fold serial dilution was performed. Furthermore, conclusions on blood glucose and serum insulin levels would also be discussed from a given data set.

ASSESSMENT OF BLOOD GLUCOSE LEVELS AND SEVOFLURANE REQUIREMENT IN PATIENTS ON DEXMEDETOMIDINE INFUSION FOR INTRA-PERITONEAL SURGERIES

2018 ◽  
Author(s):  
Krishna Kumar
Keyword(s):  
Blood Glucose ◽  
Normal Saline ◽  
Study Groups ◽  
Medical College ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Group A ◽  
Group B ◽  
Dexmedetomidine Infusion ◽  
Adrenergic Receptor Agonist

The aim of the present study was to observe the effect of intravenous Dexmedetomidine on levels of blood glucose, which is one among several stress response markers under General Anesthesia (GA) for laparoscopic intra-peritoneal surgeries. The study was planned in the Department of Anaesthesia in Sri  Krishna  Medical  College  and  Hospital,  Muzaffarpur, from Jan 2016 to Oct 2016.The 30 patients undergoing for laparoscopic intra-peritoneal surgeries of 1-2 hours duration with minimal expected blood loss were enrolled.  The approval of the institutional committee was taken prior conduct of study. All the patients were informed consents. The 15 patients in Group A received loading dose of Inj. Dexmedetomidine 1µg/kg/10min diluted to 50ml with Normal Saline, given before induction, followed by maintenance dose 0.5µ/kg/hour till the end of surgery. The 15 patients in Group B received Normal Saline in a similar manner. Dexmedetomidine, a highly selective α2-adrenergic receptor agonist has generated lot of interest for its sedative, analgesic, perioperative sympatholytic, anesthetic-sparing, and hemodynamic-stabilizing properties. The data generated in the two study groups in the present study concludes that the use of dexmedetomidine maintains blood glucose levels and favourably influencing the intra operative stress induced blood glucose levels. Keywords:  Dexmedetomidine, Stress induced blood glucose levels, laparoscopic intra-peritoneal surgeries, etc.

scholarly journals Antihyperglycemic effect of turmeric aqueous root extract and morphological changes in the pancreas of alloxan-induced hyperglycemic Wistar rats

2021 ◽  
Vol 11 (5-S) ◽  
pp. 19-24
Author(s):  
Samuel I. Ogenyi ◽  
Ezinne Imoko ◽  
Anthony A. Ngokere ◽  
Amalachukwu O. Ike
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Wistar Rats ◽  
Control Group ◽  
Root Extract ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Body Weights ◽  
Group A ◽  
Group B

Introduction: The study aims to evaluate the anti-hyperglycaemic effect of turmeric and the histological changes in the pancreas of adult Wistar rats. Materials and Methods: Forty adult Wistar rats were divided into four groups of [A-D] ten rats per group. Group A was normal control, group B was diabetic control, group C was treated with 300mg/kg weight of extract and group D was 500mg/kg body weight. All animals had access to food and water ad libitum.  Aqueous extract of turmeric was administered orally, once daily for 14 days. The rats were then anaesthetized with dichloromethane before sacrifice and sample collection. Pancreatic tissues were processed, stained using the hematoxylin and eosin (H&E) method. Blood glucose estimation was determined using the glucose oxidase method. Results: The mean body weights of the rats across groups were not statistically significant. Similarly, blood glucose levels across groups revealed a progressive statistically significant increase from group A to D and from day one to day 17. Pairwise comparison of group A with B, C and D showed a statistically significant increase but a comparison of Group B with C and D were not significant. Discussion: There was progressive body weight increase of the rats from day one to the final day across all groups and reduction in the blood glucose levels of the animals treated with 300mg/kg and 500mg/kg body weights, after seven days of treatment, but these, progressively increased with time even with treatment. The overall pancreas features indicate moderate inflammatory changes. Keywords: turmeric, anti- hyperglycemia, alloxan, Wistar rats

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