scholarly journals Alopecia and Clinical Presentation of Endocrinopathies: Pathogenetic and Diagnostic Aspects

2021 ◽  
Vol 11 (4) ◽  
pp. 245-254
Author(s):  
E. A. Praskurnichiy ◽  
S. A. Gracheva ◽  
N. V. Kugan ◽  
O. M. Maslennikova
Keyword(s):  
Differential Diagnosis ◽  
Growth Factors ◽  
Clinical Presentation ◽  
Endocrine System ◽  
Biologically Active ◽  
Frequent Symptom ◽  
Diagnostic Aspects ◽  
Key Aspects ◽  
Active Substances

The review examines the key aspects of the pathogenesis of alopecia in endocrine system pathology. The role of hormones, growth factors, cytokines and other biologically active substances has been demonstrated. Alopecia is a frequent symptom that can be the result of not only gerontological, but also endocrinological problems. Therefore, time-consuming differential diagnosis is often necessary. Diagnosis is more effective if a team of specialists is involved: endocrinologist, gynecologist, andrologist, dermatologist / trichologist, and others.

Revitalization of facial skin based on preparations of patient own blood

2017 ◽  
Vol 86 (2) ◽  
pp. 173
Author(s):  
Teresa Matthews-Brzozowska ◽  
Aleksandra Krzyżanowska ◽  
Maciej Lichaj
Keyword(s):  
Growth Factors ◽  
Cell Types ◽  
Biologically Active ◽  
National Literature ◽  
Facial Skin ◽  
Aesthetic Medicine ◽  
Cellular Repair ◽  
Different Cell Types ◽  
Active Substances

Aging is a natural, unavoidable physiological process of every human being. Aesthetic medicine, a rapidly growing on field of medicine, slows down this process. Autonomic mezotherapy is a specific type of needle mezotherapy using autologous platelets suspended in a small amount of plasma. Possibilities of use of blood preparations were discussed using 9 items of national literature and 5 foreign reports. The role of the plaques is not only a hemostatic function but also a function of cellular repair by the content of biologically active substances. The biostimulating effect consists in the activation of different cell types by growth factors. The technological change of the gel formulation creates new possibilities for the extension of aesthetic medicine.

PRP application in dermatology: review of current approaches

2021 ◽  
pp. 55-58
Author(s):  
V. V. Bondarenko
Keyword(s):  
Growth Factors ◽  
Blood Plasma ◽  
Tissue Repair ◽  
Skin Diseases ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Biologically Active ◽  
Tissue Repair And Regeneration ◽  
Positive Results ◽  
Active Substances

In recent years, the possibilities of a dermatologist in the treatment of patients with chronic dermatoses have significantly expanded due to the emergence of new highly effective methods, such as autologous blood plasma enriched with platelet-rich-growth factors (platelet-rich-plasma, PRP). The positive results of using this technology due to its constituent growth factors, cytokines and other biologically active substances, which have a pronounced normalizing effect on the processes of tissue repair and regeneration, expands the possibilities of its use in such skin diseases as erosive and ulcerative lichen planus, scleroatrophic lichen, acne and post-acne. The aim of this review was to analyze the literature on the mechanisms of PRP action in patients with dermatological diseases.

Immune cells of the epithelial ovarian cancer microenvironment

2021 ◽  
pp. 67-78
Author(s):  
Varvara Nikolaevna Zhurman ◽  
Natalia Gennadevna Plekhova ◽  
Ekaterina Valeryevna Eliseeva
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Immune Cells ◽  
Ovarian Tumor ◽  
Biologically Active ◽  
Cancer Microenvironment ◽  
Review Of The Literature ◽  
Prognostic Role ◽  
Active Substances

The article is a review of the literature, which analyzes the data on the role of cells of the immune system, cytokines and other biologically active substances secreted by them in the interstitial space of an ovarian tumor. The emphasis is made on the mechanism of realization by immune cells of the stimulating and suppressing action on the development of the tumor. Considerable attention is paid to the prognostic role of immune cells in the development of epithelial ovarian cancer.

Platelets – an important element of the immune system

2013 ◽  
Vol 16 (2) ◽  
pp. 407-413 ◽  
Author(s):  
A. Trzeciak-Ryczek ◽  
B. Tokarz-Deptuła ◽  
W. Deptuła
Keyword(s):  
Endothelial Cells ◽  
Growth Factors ◽  
Immune System ◽  
Inflammatory Response ◽  
Immunological Response ◽  
Biologically Active ◽  
Effector Cells ◽  
Cytokines And Chemokines ◽  
Active Substances ◽  
Monocytes And Lymphocytes

Abstract Platelets are anucleate cells derived from the megakaryocyte series, and have long been considered only as cells responsible for coagulation and the fibrinolysis process. However, recently more data shows that they are also effector cells in the inflammatory response and important elements of the immunological response. Platelets store and release many biologically active substances, including growth factors, cytokines and chemokines (tab. 1), which actively affect i.a. elements of the immune system, and thus become regulators of immunity and mediators of inflammatory response. Their impact on the immune system cells is also associated with the induction of leucocytes and progenitor cells to the site of pathogen permeation or vascular injury inflow, as well as endothelial cells. Interacting with neutrophils, monocytes and lymphocytes, they not only activate them, but also form platelet-leukocyte aggregates that immobilise pathogens and prevent their spreading. Furthermore, platelets are capable of absorbing pathogens, affecting anti-infection immunity of the system. It is also assumed that the presence of receptors on their surface, such as Toll-like receptors (TLRs), affects their initiation and activity of the immunological response.

SWEET SAWBERRY (Comarum Palustre L.) IN MEDICAL PRACTICE (literature review)

2020 ◽  
Vol 5 (4) ◽  
pp. 66-70 ◽  
Author(s):  
V. Platonov ◽  
Aleksandr Hadarcev ◽  
Elena Belyaeva
Keyword(s):  
Chemical Composition ◽  
Medical Practice ◽  
Clinical Medicine ◽  
Biologically Active ◽  
General Description ◽  
Plant Origin ◽  
Comarum Palustre ◽  
Practice Literature ◽  
Active Substances

The review substantiates the use of biologically active substances of plant origin, derived from marsh saber, common on the territory of Russia – in various sections of clinical medicine. The General description and zones of its distribution, possibilities of extraction of Sabel-nick rhizomes are given. The chemical composition was charac-terized and the role of proanthocyanidins in the anti-inflammatory effects of sabelnik was clarified. The possibility of obtaining various medicinal forms of drugs from the rhizomes of sabelnik is shown. A well-known range of applications in medical practice for lesions of the musculoskeletal system, arthrosis and arthritis, nephropathy, after transurethral resection of the prostate, etc.

scholarly journals DEVELOPMENT OF SOUR-MILK HEALTHY BEVERAGES WITH THE USE OF NATURAL HERBAL NANOADDITIVES

2019 ◽  
Vol 13 (4) ◽  
Author(s):  
R. Pavlyuk ◽  
V. Pogarskaya ◽  
K. Balaba ◽  
T. Kravchuk ◽  
A. Pogarskiy
Keyword(s):  
Shelf Life ◽  
Fruits And Vegetables ◽  
Raw Materials ◽  
Food Additives ◽  
Jerusalem Artichoke ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Fresh Cheese ◽  
Active Substances

Technologies of healthfull products - bioyogurts with unique characteristics have been developed. The new products are characterized by a high content of naturally occurring biologically active substances - phytocomponents of fruits and vegetables (carrots, lemons with zest, apples, Jerusalem artichoke), in particular, β-carotene, phenolic compounds, tannins, ascorbic acid, ie substances having antioxidants. Besides, they have a high content of prebiotic substances - soluble pectic substances, cellulose, inulin and proteins. Recent biogurts play the role of natural thickeners and structure-forming agents. This makes it possible to eliminate the need for the use in the production of bio yoghurt food additives and synthetic additives. Technologies for making bio yoghurts are based on the use of nanosized cryo-additives from nanosize with the record content of biologically active substances (BAS), whose mass fraction in cryo-additives is 2.5 - 5.0 times greater than the original fresh cheese. Obtaining the latter is based on the complex action on the raw materials of cryogenic "shock" freezing with the use of liquid and gaseous nitrogen and cryodestruction with fine grinding. When making bioyoghurts, cryoadditives act as natural enrichment agents, structure-forming agents, texture stabilizers and dyes. In addition, phytoextracts from natural spices and medicinal herbs (echinacea, coriander, burkun, oregano) are included in the formulations for the enrichment of the BAS and for longer shelf life of new bio yoghurts. Whey was used as the basis for the production of bio yoghurts. New types of bio yoghurts in terms of the content of BAS exceed the known analogues and have 2 times longer shelf life (than control samples). Technological modes of production of bioyoghurts on bench semi-industrial equipment have been worked out. New yoghurts are recommended for introduction into production at large food enterprises, in establishments of restaurant business, for individual food.

COLONIC MICROBIOTA AND CHRONIC KIDNEY DISEASES INTESTINAL MICROBIOTA AND CHRONIC KIDNEY DISEASE. PART II

2019 ◽  
Vol 23 (1) ◽  
pp. 18-31 ◽  
Author(s):  
B. G. Lukichev ◽  
A. Sh. Rumyantsev ◽  
I. Yu. Panina ◽  
V. Akimenko
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Intestinal Microbiota ◽  
Kidney Diseases ◽  
Biologically Active ◽  
Chronic Kidney Diseases ◽  
Mechanical Removal ◽  
Starting Point ◽  
Active Substances

Interest in studying the role of the gastrointestinal tract in maintaining homeostasis in chronic kidney disease is a traditional one. It served, in particular, as a starting point for the creation of enterosorbents. However, if earlier the main attention was paid to the mechanical removal of a number of potentially dangerous biologically active substances, recently an intestinal microbiota has become an object of interest. The first part of the review of the literature on this topic is devoted to questions of terminology, the normal physiology of the colon microbiota. A detailed description of dysbiosis is given. The features of the main groups of microorganisms are reflected. The hypothetical and confirmed interrelations of the intestine-kidney axis are presented. The pathogenetic mechanisms of the influence of colon dysbiosis on the processes of local and systemic inflammation are discussed. The influence of dysbiosis on the state of the kidney parenchyma and its participation in the progression of CKD are debated.

Poultry farming: current questions and answers

2020 ◽  
Author(s):  
Tamara Okolelova ◽  
Syergyey YEngashyev ◽  
Ivan Yegorov
Keyword(s):  
Biologically Active Substances ◽  
Biologically Active ◽  
Mixed Feed ◽  
Nutritional Factors ◽  
Enzyme Preparations ◽  
Questions And Answers ◽  
Active Substances ◽  
Poultry Farming

In the book in the form of questions and answers considerable attention is paid to data on the needs of all types of poultry in nutritional, mineral and biologically active substances, taking into account age of poultry. The characteristic of the main feed products is given, and the rational norms for including them in mixed feed for poultry are indicated. The role of vitamins, macro- and microelements, enzyme preparations, probiotics, prebiotics, antibiotics, organic acids, antioxidants, emulsifiers and other sources of biologically active substances in poultry nutrition is shown. Both nutritional factors that reduce the immune system and the causes of major feed diseases, which are related to the quality of feed, with violations in the rationing of nutrients and minerals, are indicated, and also biologically active substances, technologies for feeding and keeping poultry, methods of their prevention are given. It is addressed to specialists and managers of poultry farms, feed industry enterprises, researchers, postgraduates and students.

scholarly journals Isolation of complexes formed between insulin-like growth factor-binding protein-3 and transferrin from the human serum

2012 ◽  
Vol 77 (5) ◽  
pp. 607-617 ◽  
Author(s):  
Goran Miljus ◽  
Miomir Petrovic ◽  
Olgica Nedic
Keyword(s):  
Growth Factors ◽  
Binding Protein ◽  
Biologically Active ◽  
Molecular Forms ◽  
Igf Binding Proteins ◽  
Igf Binding ◽  
The Relationship ◽  
Igfbp 3 ◽  
Insulin Like Growth Factors

Insulin-like growth factors (IGFs) play an important role in the regulation of cell growth, differentiation and metabolism. The amount of free, biologically active IGFs is regulated by the IGF-binding proteins (IGFBPs). IGFBP-3 is the most abundant binding protein and it is known to interact with other circulating proteins, including transferrin (Tf). In order to elucidate the possible role of IGF/IGFBP-3 in the iron metabolism, it is necessary to isolate IGFBP-3/Tf complexes. Several affinity-based techniques were employed. Results have shown that only double immunoprecipitation method with anti-Tf and anti-IGFBP-3 antibodies selectively separated complexes from other molecular forms, such as monomers, oligomers or fragments of IGFBP-3 and Tf. Isolated complexes can now be used to investigate the relationship between IGF/IGFBP-3 and iron, both in structural and metabolic t?rms.

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