scholarly journals Is there constitutional and morphological predisposition to akathisia in schizophrenic patients receiving antipsychotic therapy?

2020 ◽  
Vol 18 (4) ◽  
pp. 36-43
Author(s):  
A. A. Goncharova ◽  
E. G. Kornetova ◽  
A. N. Kornetov ◽  
A. V. Semke

Objective: to identify constitutional and morphological predisposition to akathisia in schizophrenic patients receiving antipsychotic therapy.Materials and methods. 250 patients with schizophrenia receiving basic antipsychotic therapy were studied, aged 40 [32; 50] years old; disease duration was 13 [7; 22] years. The age when the schizophrenic process manifested itself was 23 [19; 30] years. Clinical evaluation of akathisia was performed using the Barnes Akathisia Scale (BARS, BAS), so akathisia was detected in 92 (36.8%) patients. All persons included in the study underwent an anthropometric survey according to the Bunak’s method. Statistical analysis was performed using Statistica for Windows software (V. 12.0), the odds ratio was estimated using the MedCalc® online calculator.Results. The comparative analysis of the Rees – Eysenk body index and Tanner stages in groups of schizophrenic patients receiving antipsychotic therapy with and without akathisia showed no significant differences between them (p = 0.317 and p = 0.347, respectively). Comparison of groups in the distribution of constitutional and morphological types also revealed no statistical differences (p = 0.189). Patients with the andromorphic type of somatic sexual differentiation increased the risk of antipsychotic-induced akathisia (OR = 1.73; 95% CI: 1.02–2.94; p = 0.039) almost twofold.Conclusion. Attribution of patients to different constitutional and morphological types does not play a role in the development of antipsychotic-induced akathisia, unlike attribution to andromorphic somatic sexual differentiation types, which significantly increases its risk. 

Author(s):  
Igor Ponomarenko ◽  
Kateryna Volovnenko

The subject of the research is a set of approaches to the statistical analysis ofthe activities of small business entities in Ukraine, including micro-enterprises. The purpose of writing this article is to study of the features of functioningof small business entities in Ukraine. Methodology. The research methodology isto use a system-structural and comparative analysis (to study the change in thenumber of small enterprises by major components); monographic (when studyingmethods of statistical analysis of small businesses); economic analysis (when assessing the impact of small business entities on socio-economic phenomena andprocesses in Ukraine). The scientific novelty consists to determine the features ofthe functioning of small businesses in Ukraine in modern conditions. The influenceof the activities of the main socio-economic and political indicators on the activities of small enterprises in recent periods of time has been identified. It has beenestablished that there is flexibility in the development of strategies by small businesses in conditions of significant competition, which makes it possible to quicklyrespond to changing situations in specific markets. Conclusions. The use of acomprehensive statistical analysis of small businesses functioning in Ukraine willallow government agencies to develop a set of measures to optimize the activitiesof these enterprises, which ultimately will positively affect the strengthening oftheir competitiveness and will contribute to the growth of the national economicsystem.


2019 ◽  
Vol 118 (8) ◽  
pp. 266-274
Author(s):  
Byung- MoonSeol ◽  
Young-Lag KIM

Background/Objectives: This paper investigated and analyzed the phenomena in implementing the curriculum and characteristics of an entrepreneurship education model existing technology-driven agri-food industry. Methods/Statistical analysis: The line-by-line coding method of grounded theory approach by Strauss & Corbin was applied for this study and the collected data was analyzed with the NVIVO 12 program from QSR which is a tool for analyzing quality comparative analysis for better efficiency in open coding.


Author(s):  
Al Hariri Mahmoud Jomaa ◽  
S Semenenko ◽  
A Semenenko ◽  
Sergey Zaikov

Introduction. Despite the world practice, the problem of inflammatory diseases of the paranasal sinuses is still relevant and has an important social meaning. Despite the fact that rhinosinusitis is one of the most common diseases, the reisvery little accurate data on its epidemiology. Therefore, our goal was to conduct a clinical epidemiological analysis with the establishment of the role of rhinosinusitis in the structure of requests for medical care in multidisciplinary polyclinics. Materials and methods. The data on the prevalence of various forms of sinusitis in the structure of ambulatory-polyclinic patients in the period 2011-2015 have been studied. In patients with acute rhinosinusitis, the following parameters were analyzed: gender and age of patients, duration, clinical variant of the disease, duration of treatment. Results. A clinical and statistical analysis of medical aid appeals at the level of the multidisciplinary outpatient clinic of the Vinnytsia City Clinical Hospital of ambulatory care and the Communal Medical Center "City Medical and Diagnostic Center" of Vinnytsia during 2011-2015. A statistical analysis based on the criterion approach included 896 patients with rinosunsitis. The following parameters have been analyzed: gender and age of patients, duration, clinical variant of the disease, duration of treatment. The conducted researches indicate that in the structure of appeals to the otolaryngologist rhinosinusitis is dominated by acute rhinosinusitis, the frequency of which remained relatively stable for five consecutive years: 133 cases - in 2011, 143 in 2012, 168 in 2013, 150 and 151 in 2014 and 2015, respectively. Among ambulatory polyclinic patients with different clinical variants of sinusitis prevailing persons of young working age. In general, patients with acute bacterial rhinosinusitis in the age group up to 60 years old make up 90.6%, which emphasizes the socioeconomic significance of this pathology. The frequency of treatment with rhinosinusitis is dominated by maxillary sinus lesions. The median duration of treatment was greatest in the case of hemi-sinusitis and polysynytes – 11.27±3.69 and 11.23±3.99 days, respectively, and the lowest in patients with frontal lobe was 9.48±3,76 days (p=0.032). A reduction in the mean duration of treatment for patients during the last three years of observation was observed (p<0.001). Conclusions: The study of the main clinical and epidemiological indicators of rhinosinusitis in the Ukrainian population can be the basis for the in for medplanning of medical care and social activities for this category of otolaryngological patients.


2021 ◽  
Vol 8 (2) ◽  
pp. 51-56
Author(s):  
Ratna Sari Dyah ◽  
Lies Elina

Knowledge of how to maintain proper dental health will greatly affect the incidence of dental caries, brushing and rinsing teeth - gargling is one of the behaviors to maintain oral hygiene. behavior based on correct knowledge will last longer than behavior that is not based on knowledge, an effort to increase knowledge is through health education. Online media is one of the educational media to increase knowledge of dental and oral health. The type of research in this study is a comparative comparative analysis or "causal-comparative". Quota sampling technique sampling, the research location was conducted in SMA N 3 Bandar Lampung ..as many as 100 people. The research variable was the online media instagram in increasing knowledge of caries. Statistical analysis used the T-test to see the relationship between Instagram in increasing knowledge. The results showed instagram can that there was a role for online media education in increasing knowledge of cavities.


2011 ◽  
Vol 139 (1-2) ◽  
pp. 81-87 ◽  
Author(s):  
Vladimir Gajic ◽  
Dragan Milojevic ◽  
Aleksandar Raskovic ◽  
Jasminka Smailagic ◽  
Nela Djonovic ◽  
...  

Introduction. Biometeorological circumstances have a big influence on all traffic participants, especially reflexes, moving coordination and perception ability. With a lower attention and drivers? and pedestrians? concentration, there was a larger amount of pedestrian trauma in certain biometeorological phases. Objective. The aim of this study was to establish the correlation between pedestrian trauma and biometeorological phases. Methods. The comparative analysis of everyday biometeorological phases for the city of Kragujevac determined by RHMI and the evidence of knocked-down pedestrians from the Kragujevac traffic police for the period 2003-2008. Results. There were 6,127 accidents, with 696 knocked pedestrians in 666 (10.87%) accidents. Most of them happened in 2003 (135), and the fewest in 2005 (90). Most accidents were during December (74), the fewest were in June (46). The fewest accidents were during 04-05-06 hour interval (by 2), most during 13-14 hours (61). There were 374 males and 349 females. Most of the males (by 60) were 0-10 and 11-20 years old, most of the females (74) were 11-20 years old. There were 443 pedestrians who suffered slight body injuries (112 were 11-20), 225 suffered heavy and 28 had lethal injuries (most over 70). As provokers, the pedestrians suffered because of improper crossing roads (185), while as a casualties, they suffered due to speeding of vechicles (285). Most accidents happened in biometeorological phases 4 (168) and 9 (151), the fewest in phase 10 (4). Conclussion. Statistical analysis shows a significant correlation between pedestrians? accidents and biometeorological phases, when the most accidents occurred during penetrations of cold fronts, while there was a sudden switch of weather conditions from warm-dry to cold-wet weather.


2021 ◽  
Vol 7 (2) ◽  
pp. 108-120
Author(s):  
Gregory Xavier ◽  
Anselm Su Ting ◽  
Norsiah Fauzan

Quantitative electroencephalogram enables mathematical analysis of neurological recordings while conventional electroencephalogram lacks the mathematical output; hence, its usage is limited to neurological experts. This study was to determine if quantified conventional electroencephalogram recordings were compatible and comparable with quantitative electroencephalogram recordings. A group of post-call doctors was recruited and subjected to an EEG recording using a conventional electroencephalogram followed by a quantitative electroencephalogram device. The patterns and quantified recording results were compared. A comparative analysis of the two recording sets did not find differences in the recording patterns and statistical analysis. The findings promoted the use of a readily available conventional electroencephalogram in quantitative brain wave studies and have cleared potential compatibility bias towards data merging.


2020 ◽  
Vol 92 (2) ◽  
pp. 43-47
Author(s):  
Yu. G. Sandler ◽  
K. G. Saliev ◽  
S. N. Backih ◽  
S. G. Khomeriki ◽  
T. Yu. Khaymenova ◽  
...  

Due to the absence of the pathognomonic diagnostic criteria and to the diversity of clinical, serological and morphological manifestations, the diagnostic of the autoimmune hepatitis (AIH) remains to be a difficult task, which might lead to the delay of the timely beginning of the immunosuppressive therapy (IST), which in turn affects the disease outcomes. Aim.To studying the clinical, biochemical, immunological and morphological markers in patients with seronegative (SN) and seropositive (SP) AIH and the qualities of their response to the IST. Materials and methods.This retrospective cohort study included 82 AIH patients over the course of the years 20142019. All patients were selected in accordance with the criteria of the simplified assessment system of the IAIHG. Clinical, laboratorial and morphological characteristics of the AIH were analyzed. Therapy response was evaluated by the level of the ALT and IgG in 612 months after the start of the IST. The study material underwent statistical analysis using methods of parametrical and nonparametrical analysis. Statistical analysis was performed in the Statistica 13.3 (developed by StatSoft Inc., USA). Results.67/82 (81.70%) of the patients studied were women, median age of 54 years old [38; 70]. Patients with the diagnosis of the possible AIH according to the IAIHG made 85.4% (70 people). Almost everyone 96% (79/82) had morphological features of the interface-hepatitis with the lymphocytic/plasmocytic infiltration; emperipolesis was discovered in 63% of patients (49/82), hepatocellular rosette in 23% (19/82). Patients with SN AIH comprised 36.5% (30/82), with SP 63.4% (52/82). Comparative analysis demonstrated that the clinical profile in patients with SN and SP AIH is the same, while the incidence of immuno-associated diseases is significantly higher in the group of seronegative AIH. The morphological profile in the two AIH groups is identical in both typical and atypical manifestations. The number of responders to IST was 63% (19/30) SN AIH vs 67% SP AIH (35/52), did not differ significantly (p=0.529).However, that the number of patients with liver cirrhosis in the SN AIH group was twice as big as the ones with SP: 37% vs 17% (p=0.089). Conclusions.A comparative analysis of clinical, laboratory, morphological and clinical manifestations in the SN and SP AIH groups did not detected statistically significant significant differences, which may indicate that SN and SP AIH are the faces of one disease. It is possible that AB cannot be identified within the known spectrum of antibodies, or antibodies have slow expression, or are suppressed by the immune system. In any case, suspicions of AIH, in the absence of antibodies, it is recommended that liver biopsy be performed for the timely diagnosis of AIH and IST. Сirrhosis was more often diagnosed in the group SN AIH, which may be due to a later diagnosis, and therefore to untimely IST. The found frequent association of SN AIH with other immune-associated diseases requires a carefully study of this problem. The variety of clinical manifestations of AIH requires further study, the identification of clinical phenotypes with certain feature. This can help in the future to timely identify potentially problematic patients and predict a response to IST.


2021 ◽  
pp. 1-10
Author(s):  
Mahmoud S. Gewaily ◽  
Mohamed Kassab ◽  
Asmaa Aboelnour ◽  
Essam A. Almadaly ◽  
Ahmed E. Noreldin

Lectins are glycoproteins of a non-immune origin often used as histochemical reagents to study the distribution of glycoconjugates in different types of tissues. In this study, we performed a comparative cellular localization of sugar residues in bull and donkey testes using immunofluorescent lectin histochemistry. We inspected the cellular localization of the glycoconjugates within the testes using 11 biotin-labeled lectins (LCA, ConA, PNA, WGA, DBA, SBA, ECA, BPL, PTL-II, UEA-1, and PHA-E4) classified under six groups. Although the basic testicular structure in both species was similar, the cellular components showed different lectin localization patterns. The statistical analysis revealed no significant association between the intensity of labeling and different variables, including group and type of lectin and type of cell examined, at p < 0.05. However, a stronger response tended to occur in the donkey than in the bull testes (odds ratio: 1.3). These findings may be associated with the different cellular compositions of the glycoproteins and modification changes during spermatogenesis. Moreover, glycoconjugate profiling through lectin histochemistry can characterize some cell-type selective markers that will be helpful in studying bull and donkey spermatogenesis.


2021 ◽  
pp. 73-77
Author(s):  
A. V. Starshinin ◽  
A. A. Tyazhelnikov ◽  
A. V. Pogonin ◽  
E. V. Kostenko

The article presents the results of a dynamic analysis of the satisfaction of patients diagnosed with CAVID‑19 with the quality of medical services provided remotely at the telemedicine centre in Moscow in 2020.Purpose of research. Conduct a dynamic assessment of patient satisfaction with the quality of remote medical services provided in different time periods.Material and methods. The results of an anonymous survey of 424 patients on the quality of remote medical services were dynamically evaluated. The first group (138) received medical care from 01.04 to 30.04, the second one (286) – from 01.06 to 30.06 of 2020 after the implementation of measures to improve them. Statistical analysis was performed using IBM SPSS Statistics 20.0.Results. When analysing the results, a high level of patient satisfaction was revealed, but there was a significant (p < 0.05) difference in the level of satisfaction between the groups. The factors of connection between telemedicine services and patient satisfaction were identified, which served as the basis for organizational measures.Conclusion. Providing medical services using telemedicine technologies can be considered as one of the most effective ways to provide medical care.


Author(s):  
Т.Ф. Шарифьянов

Объектом статьи выступает региональная инфраструктура цифровой экономики, а предметом - институциональные механизмы распространения инфраструктуры от карскаса расселения к малым населенным пунктам на периферийных территориях региона. Выполнен анализ объемов, структуры и приоритетов финансирования национального проекта «Цифровая экономика». Сделан прогноз финансирования НИОКР в РФ в период 2019-2024 на основе правительственных документов, прогнозов ВВП и курса рубля. Выполнен сравнительный анализ достаточности финансирования НИОКР в РФ. Определена проблема, с которой столкнутся регионы России при переходе к цифровой экономике - дефицит инфраструктуры цифровой экономики и выявлены пространственные характеристики этого дефицита. Сформулированы понятия объективного (структурного) и субъективного (стратегического) барьеров на пути инвестиций в региональную инфраструктуру. На основе статистического анализа, разработаны методы решения вскрытой проблемы реиональными силами. Сформулированы региональные задачи снижения субъективных барьеров на пути развития инфраструктуры и доказана возможность их решения. Regional infrastructure of the digital economy is the object of this paper. And the subject is the institutional mechanisms for the infrastructure distribution from the urban lattice to the small rural settlement in the districts peripheral territories. Authors made analysis of the volumes, structure and priorities of the national project "Digital Economy" financing. A forecast is made for financing R&D in the Russian Federation in the period 2019-2024 based on government documents, forecasts of GDP and the ruble exchange rate. A comparative analysis of the adequacy of R&D funding in the Russian Federation is carried out. The problem that Russian districts will face in the transformation to the digital economy is identified - a deficit in the infrastructure of the digital economy and the spatial characteristics of this deficit are revealed. The author formulated the concepts of objective (structural) and subjective (strategic) barriers to investment in regional infrastructure. Methods for solving a district level open problem based on statistical analysis are proposed. Based on the institutional approach, two tasks have been set for the district authorities and the possibility of solving them has been proved.


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