scholarly journals 3D Printed Biosensor Arrays for Medical Diagnostics

2018 ◽  
Author(s):  
Mohamed Sharafeldin ◽  
Abby Jones ◽  
James F. Rusling
Keyword(s):  
3D Printing ◽  
Human Life ◽  
Low Cost ◽  
Chemical Properties ◽  
Medical Diagnostics ◽  
Ease Of Use ◽  
3D Design ◽  
Biosensor Arrays ◽  
Biomedical Diagnostics ◽  
3D Printers

AbstractWhile the technology is relatively new, low cost 3D printing has impacted many aspects of human life. 3D printers are being used as manufacturing tools for a wide variety of devices in a spectrum of applications ranging from diagnosis to implants to external prostheses. The ease of use and availability of 3D design software and low cost has made 3D printing an accessible manufacturing and fabrication tool in many research laboratories. 3D printers can print materials with varying density, optical character, strength and chemical properties providing platforms for a huge number of strategies that can be chosen for user’s needs. In this review, we focus on applications in biomedical diagnostics and how this revolutionary technique is facilitating development of low cost, sensitive and often geometrically complex tools. 3D printing in fabrication of microfluidics, supporting equipment, optical and electronic components of diagnostic devices is presented. Emerging diagnostic 3D bioprinting as a tool to incorporate living cells or biomaterials into 3D printing is also discussed.

scholarly journals 3D-Printed Biosensor Arrays for Medical Diagnostics

Micromachines ◽  
2018 ◽  
Vol 9 (8) ◽  
pp. 394 ◽  
Author(s):  
Mohamed Sharafeldin ◽  
Abby Jones ◽  
James Rusling
Keyword(s):  
3D Printing ◽  
Human Life ◽  
Low Cost ◽  
Chemical Properties ◽  
Medical Diagnostics ◽  
Ease Of Use ◽  
3D Design ◽  
Biosensor Arrays ◽  
Biomedical Diagnostics ◽  
3D Printers

While the technology is relatively new, low-cost 3D printing has impacted many aspects of human life. 3D printers are being used as manufacturing tools for a wide variety of devices in a spectrum of applications ranging from diagnosis to implants to external prostheses. The ease of use, availability of 3D-design software and low cost has made 3D printing an accessible manufacturing and fabrication tool in many bioanalytical research laboratories. 3D printers can print materials with varying density, optical character, strength and chemical properties that provide the user with a vast array of strategic options. In this review, we focus on applications in biomedical diagnostics and how this revolutionary technique is facilitating the development of low-cost, sensitive, and often geometrically complex tools. 3D printing in the fabrication of microfluidics, supporting equipment, and optical and electronic components of diagnostic devices is presented. Emerging diagnostics systems using 3D bioprinting as a tool to incorporate living cells or biomaterials into 3D printing is also reviewed.

scholarly journals Effects of Filament Diameter Tolerances in Fused Filament Fabrication

2016 ◽  
Vol 2 (1) ◽  
pp. 44-47 ◽  
Author(s):  
Carolina Cardona ◽  
Abigail H Curdes ◽  
Aaron J Isaacs
Keyword(s):  
3D Printing ◽  
Low Cost ◽  
Acrylonitrile Butadiene Styrene ◽  
Fused Filament Fabrication ◽  
Important Indicator ◽  
Extrusion Rate ◽  
Filament Diameter ◽  
Printing Quality ◽  
3D Printers ◽  
And Control

Fused filament fabrication (FFF) is one of the most popular additive manufacturing (3D printing) technologies due to the growing availability of low-cost desktop 3D printers and the relatively low cost of the thermoplastic filament used in the 3D printing process. Commercial filament suppliers, 3D printer manufacturers, and end-users regard filament diameter tolerance as an important indicator of the 3D printing quality. Irregular filament diameter affects the flow rate during the filament extrusion, which causes poor surface quality, extruder jams, irregular gaps in-between individual extrusions, and/or excessive overlap, which eventually results in failed 3D prints. Despite the important role of the diameter consistency in the FFF process, few studies have addressed the required tolerance level to achieve highest 3D printing quality. The objective of this work is to develop the testing methods to measure the filament tolerance and control the filament fabrication process. A pellet-based extruder is utilized to fabricate acrylonitrile butadiene styrene (ABS) filament using a nozzle of 1.75 mm in diameter. Temperature and extrusion rate are controlled parameters. An optical comparator and an array of digital calipers are used to measure the filament diameter. The results demonstrate that it is possible to achieve high diameter consistency and low tolerances (0.01mm) at low extrusion temperature (180 °C) and low extrusion rate (10 in/min). 

scholarly journals Effect of infill density and raster angle on the mechanical properties of PLA

2021 ◽  
Vol 2080 (1) ◽  
pp. 012002
Author(s):  
M.A. Tan ◽  
C. K. Yeoh ◽  
P. L. Teh ◽  
N. A. Rahim ◽  
C. C. Song ◽  
...  
Keyword(s):  
3D Printing ◽  
Food Packaging ◽  
Acrylonitrile Butadiene Styrene ◽  
High Strength ◽  
3D Design ◽  
Raster Angle ◽  
3D Printers ◽  
Design Objects ◽  
Mechanical Performances ◽  
The Relationship

Abstract Polylactic acid (PLA) is derived from natural aliphatic polyester resources for instance sugarcane or starch based plants. PLA also known as a biocompatible and biodegradable thermoplastic and found widely in multiple applications like electronic and electrical devices, biomedical, food packaging and the engineering field. PLA have attracted attention in production potential due to its superior attributes like ease of processing, high strength and high modulus. Infill density, raster angle and infill pattern can influence the mechanical characteristics of materials like PLA, acrylonitrile-butadiene-styrene (ABS), polyetheretherketone (PEEK). In this paper, the relationship between infill density and raster angle was studied to investigate the mechanical performances of PLA by using 3D printers. 3D printing is used to fabricate more complex 3D design objects. The tensile test was involved to evaluate the properties of pure PLA. For pure PLA, 0° raster angles with 100% infill density show the highest tensile strength and Young’s modulus which are 28.926MPa and 1262.7MPa respectively. However, a decreasing trend of break elongation reveals in PLA as infill density increases for both 0° and 90° raster angle. Optimization of printing parameters become crucial to provide high quality materials for 3D printing in order for education, packaging, engineering and biomedical applications.

scholarly journals Low-Cost Prototype to Automate the 3D Digitization of Pieces: An Application Example and Comparison

Sensors ◽  
2021 ◽  
Vol 21 (8) ◽  
pp. 2580
Author(s):  
Ramón González-Merino ◽  
Elena Sánchez-López ◽  
Pablo E. Romero ◽  
Jesús Rodero ◽  
Rafael E. Hidalgo-Fernández
Keyword(s):  
Low Cost ◽  
Cost Effective ◽  
3D Models ◽  
3D Scanner ◽  
3D Design ◽  
Robotic Arms ◽  
Effective System ◽  
3D Printers ◽  
Preliminary Study ◽  
3D Digitization

This work is aimed at describing the design of a mechanical and programmable 3D capturing system to be used by either 3D scanner or DSLR camera through photogrammetry. Both methods are widely used in diverse areas, from engineering, architecture or archaeology, up to the field of medicine; but they also entail certain disadvantages, such as the high costs of certain equipment, such as scanners with some precision, and the need to resort to specialized operatives, among others. The purpose of this design is to create a robust, precise and cost-effective system that improves the limitations of the present equipment on the market, such as robotic arms or rotary tables. For this reason, a preliminary study has been conducted to analyse the needs of improvement, later, we have focused on the 3D design and prototyping. For its construction, there have been used the FDM additive technology and structural components that are easy to find in the market. With regards to electronic components, basic electronics and Arduino-based 3D printers firmware have been selected. For system testing, the capture equipment consists of a Spider Artec 3D Scanner and a Nikon 5100 SLR Camera. Finally, 3D models have been developed by comparing the 3D meshes obtained by the two methods, obtaining satisfactory results.

What Is Next?

2017 ◽  
pp. 78-92
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Chemical Reactions ◽  
Digital Control ◽  
Industrial Revolution ◽  
Low Cost ◽  
Science And Technology ◽  
Fourth Industrial Revolution ◽  
3D Printers ◽  
Design Construction

Fourth Industrial Revolution gave birth to few different technologies, not known until now. One of them is 3D printing. If subtracting manufacturing is part of Industrial Revolution 3, Additive manufacturing is for sure part of Industrial Revolution 4.0. 3D printing has the potential to transform science and technology by creating bespoke, low-cost appliances that previously required dedicated facilities to make. 3D printers are used to initiate chemical reactions by printing the reagents directly into a 3D reactionware matrix, and so put reactionware design, construction and operation under digital control. Some models of 3D Printers can print uniquely shaped sugar confections in flavors such as chocolate, vanilla, mint, cherry, sour apple and watermelon. They can also print custom cake toppers–presumably in the likeness of the guest of honor.

3D Printing of Microfluidics for Point of Care Diagnosis

2017 ◽  
Author(s):  
John P. Sibbitt ◽  
Mei He
Keyword(s):  
3D Printing ◽  
Low Income ◽  
Point Of Care ◽  
Low Cost ◽  
High Sensitivity ◽  
Disease Diagnosis ◽  
Low Income Countries ◽  
3D Design ◽  
Resource Limited ◽  
Production Techniques

Microfluidic lab-on-a-chip (MLOC) technology is a promising approach for point-of-care (POC) diagnosis; low reagent consumption, high sensitivity and quick analysis time are the most prominent benefits. However, microfabrication of MLOCs utilizes specialized techniques and infrastructure, making conventional fabrication time consuming and difficult. While relatively inexpensive production techniques exist for POC diagnoses, such as replication of polymer-based (e.g., PDMS) microfluidic POC devices on lithographic molds, this approach has limitations including: further hydrophilic surface modifications of PDMS, inability to change lithographic mold Z dimensions, and slow prototyping. In contrast, stereo-lithographical (SLA) printing can integrate all of the necessary fabrication resources in one instrument, allowing highly versatile microfluidic devices to be made at low cost. In this paper, we report two microfabrication approaches of microfluidics utilizing (SLA) 3D printing technology: I) Direct SLA printing of channels and structures of a monolithic microfluidic POC device; II) Indirect fabrication, utilizing SLA 3D printed molds for PDMS based microfluidic device replication. Additionally, we discuss previous work providing a proof of concept of applications in POC diagnosis, using direct 3D printing fabrication (approach I). The robustness and simplicity of these protocols allow integrating 3D design and microfabrication with smartphone-based disease diagnosis as a stand-alone system, offering strong adaptability for establishing diagnostic capacity in resource-limited areas and low-income countries.

Low-Cost 3D Printing of Controlled Porosity Ceramic Parts

2012 ◽  
Vol 6 (5) ◽  
pp. 618-626 ◽  
Author(s):  
Olaf Diegel ◽  
◽  
Andrew Withell ◽  
Deon de Beer ◽  
Johan Potgieter ◽  
...  
Keyword(s):  
3D Printing ◽  
Low Cost ◽  
Controlled Porosity ◽  
3D Printers ◽  
The Cost

This research was initiated to develop low cost powders that could be used on 3D printers. The paper describes experiments that were undertaken with different compositions of clay-based powders, and different print saturation settings. An unexpected sideeffect of printing ceramic parts was the ability to control the part porosity by varying the powder recipe and print parameters. The cost of clay-based powder was, depending on the specific ingredients used, around US$2.00/Kg.

On the Analysis of a Compromised Additive Manufacturing System Using Spatio-Temporal Decomposition

2019 ◽  
Author(s):  
Sakthi Kumar Arul Prakash ◽  
Tobias Mahan ◽  
Glen Williams ◽  
Christopher McComb ◽  
Jessica Menold ◽  
...  
Keyword(s):  
3D Printing ◽  
Structural Integrity ◽  
Low Cost ◽  
Cyber Attack ◽  
Printing Process ◽  
Solid Models ◽  
Statistical Validity ◽  
3D Printers ◽  
Phase Variations ◽  
Spatio Temporal

Abstract 3D printing systems have expanded the access to low cost, rapid methods for attaining physical prototypes or products. However, a cyber attack, system error, or operator error on a 3D printing system may result in catastrophic situations, ranging from complete product failure, to small types of defects which weaken the structural integrity of the product, making it unreliable for its intended use. Such defects can be introduced early-on via solid models or through G-codes for printer movements at a later stage. Previous works have studied the use of image classifiers to predict defects in real-time as a print is in progress and also by studying the printed entity once the print is complete. However, a major restriction in the functionality of these methods is the availability of a dataset capturing diverse attacks on printed entities or the printing process. This paper introduces a visual inspection technique that analyzes the amplitude and phase variations of the print head platform arising through induced system manipulations. The method uses an image sequence of a 3D printing process captured via an off the shelf camera to perform an offline multi-scale, multi-orientation decomposition to amplify imperceptible system movements attributable to a change in system parameters. The authors hypothesize that a change in the amplitude envelope and instantaneous phase response as a result of a change in the end effector translational instructions, to be correlated with an AM system compromise. A case study is presented that tests the hypothesis and provides statistical validity in support of the method. The method has the potential to enhance the robustness of cyber-physical systems such as 3D printers that rely on secure, high quality hardware and software to perform optimally.

scholarly journals HP 3D Color Gamut – A Reference System for HP’s Jet Fusion 580 Color 3D Printers

2020 ◽  
Vol 2020 (5) ◽  
pp. 120-1-120-5
Author(s):  
Ingeborg Tastl ◽  
Alexandra Ju
Keyword(s):  
3D Printing ◽  
Reference System ◽  
Color Gamut ◽  
3D Design ◽  
Printing Process ◽  
3D Objects ◽  
Color System ◽  
3D Printers ◽  
Color Printing ◽  
Cost Efficient

Designers need to specify the colors for their 3D objects in form of sRGB values, but, given the limitations of the color 3D printing process, they have no idea how those colors chosen on a screen will look once printed in 3D. In addition, HP Inc. wants to showcase the color capabilities of our 3D color printing systems in an effective way. This paper describes an aesthetically pleasing tool to effectively showcase the color capabilities of our color 3D printing systems. It is also a reference color system that enables designers 1) to select colors that are achievable with our printing systems, 2) to interactively composite color palettes for their 3D design and 3) to get the desired printed color in a time and cost-efficient way that minimizes iterations. The system itself consists of a series of subobjects where each sub-object shows how a color looks like when manufactured in different surface orientations. It can be disassembled and used for compositing color palettes for 3D objects, and it is also designed to be manufactured and cleaned fully assembled, showcasing the power of 3D printing.

scholarly journals 3D-Printed Microfluidics and Potential Biomedical Applications

2021 ◽  
Vol 3 ◽  
Author(s):  
Priyanka Prabhakar ◽  
Raj Kumar Sen ◽  
Neeraj Dwivedi ◽  
Raju Khan ◽  
Pratima R. Solanki ◽  
...  
Keyword(s):  
3D Printing ◽  
Biomedical Applications ◽  
Chemical Properties ◽  
Microfluidic Devices ◽  
Microfluidic Chips ◽  
3D Printers ◽  
Broad Variety ◽  
3D Printed ◽  
Diagnostic Technologies ◽  
Printing Techniques

3D printing is a smart additive manufacturing technique that allows the engineering of biomedical devices that are usually difficult to design using conventional methodologies such as machining or molding. Nowadays, 3D-printed microfluidics has gained enormous attention due to their various advantages including fast production, cost-effectiveness, and accurate designing of a range of products even geometrically complex devices. In this review, we focused on the recent significant findings in the field of 3D-printed microfluidic devices for biomedical applications. 3D printers are used as fabrication tools for a broad variety of systems for a range of applications like diagnostic microfluidic chips to detect different analytes, for example, glucose, lactate, and glutamate and the biomarkers related to different clinically relevant diseases, for example, malaria, prostate cancer, and breast cancer. 3D printers can print various materials (inorganic and polymers) with varying density, strength, and chemical properties that provide users with a broad variety of strategic options. In this article, we have discussed potential 3D printing techniques for the fabrication of microfluidic devices that are suitable for biomedical applications. Emerging diagnostic technologies using 3D printing as a method for integrating living cells or biomaterials into 3D printing are also reviewed.

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