scholarly journals Binding Epitopes of 2019-nCoV Proteins for Perspective Diagnostic and Therapeutic Applications: Insights from Computational Approaches

2020 ◽  
Author(s):  
Ilda D'Annessa ◽  
Filippo Marchetti ◽  
Giorgio Colombo
Keyword(s):  
Human Health ◽  
Viral Proteins ◽  
Economic Consequences ◽  
The Novel ◽  
Computational Approaches ◽  
Therapeutic Applications ◽  
Major Threat ◽  
The World ◽  
Therapeutic Molecules ◽  
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The appearance of the novel betacoronavirus 2019-nCoV represents a major threat to human health, and its diffusion around the world is predicted to have dramatic economic consequences. The knowledge of the 3D structures of 2019-nCoV proteins can facilitate the development of diagnostic and therapeutic molecules. Herein, we apply our energy-based method for the prediction of potential epitopes on viral proteins to design peptide-based molecules that can subsequently be used in diagnostic and therapeutic applications. We discuss these aspects in the paper.The designs have not been tested. Our aim is to share information that can be useful in the development of novel biomolecules with potential interesting activities against 2019-nCoV.

scholarly journals An outline of SARS-CoV-2 pathogenesis and the complement cascade of immune system

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Padmalochan Hembram
Keyword(s):  
Immune System ◽  
Dark Side ◽  
Main Body ◽  
The Novel ◽  
Transmission Chain ◽  
The World ◽  
Therapeutic Molecules ◽  
Rapid Transmission ◽  
Novel Coronavirus ◽  
Near Future

Abstract Background Coronavirus disease 19 is a viral infection caused by a novel coronavirus, SARS-CoV-2. It was first notified in Wuhan, China, is now spread into numerous part of the world. Thus, the world needs urgent support and encouragement to develop a vaccine or antiviral treatments to combat the atrocious outbreak. Main body of the abstract The origin of this virus is yet unknown; however, rapid transmission from human-to-human “Anthroponosis” has widely confirmed. The world is witnessing a continuous hike in SARS-CoV-2 infection. In light of the outbreak of coronavirus disease 19, we have aimed to highlight the basic and vital information about the novel coronavirus. We provide an overview of SARS-CoV-2 transmission, timeline and its pathophysiological properties which would be an aid for the development of therapeutic molecules and antiviral drugs. Immune system plays a crucial role in virus infection in order to control but may have dark side when becomes uncontrollable. The host and SARS-CoV-2 interaction describe how the virus exploits host machinery and how overactive host immune response can cause disease severity also addressed in this review. Short conclusion Safe and effective vaccines may be the game-changing tools, but in the near future wearing mask, washing hands at regular intervals, avoiding crowed, maintaining physical distancing and hygienic surrounding, must be good practices to reduce and break the transmission chain. Still, research is ongoing not only on how vaccines protect against disease, but also against infection and transmission.

scholarly journals EPR Effect-Based Tumor Targeted Nanomedicine: A Promising Approach for Controlling Cancer

2022 ◽  
Vol 12 (1) ◽  
pp. 95
Author(s):  
Jun Fang
Keyword(s):  
Human Health ◽  
Epr Effect ◽  
Major Threat ◽  
The World

Cancer remains the major threat to human health in most advanced countries in the world [...]

scholarly journals Epidemiological Characteristics of COVID-19 in Mexico and the Potential Impact of Lifting Confinement Across Regions

2020 ◽  
Vol 8 ◽  
Author(s):  
Cristy Leonor Azanza Ricardo ◽  
Esteban A. Hernandez-Vargas
Keyword(s):  
The Elderly ◽  
The Novel ◽  
Major Threat ◽  
Large Fluctuations ◽  
The World ◽  
High Death ◽  
Mexican Government ◽  
Potential Impact ◽  
Novel Coronavirus ◽  
Epidemiological Characteristics

The novel coronavirus SARS-CoV-2 has paralyzed our societies, leading to self-isolation and quarantine for several days. As the 10th most populated country in the world, Mexico is on a major threat by COVID-19 due to the limitations of intensive care capacities, about 1.5 hospital beds for every 1,000 citizens. In this paper, we characterize the COVID-19 pandemic in Mexico and projected different scenarios to evaluate sharp or gradual quarantine lifting strategies. Mexican government relaxed strict social distancing regulations on June 1, 2020, deriving to pandemic data with large fluctuations and uncertainties of the tendency of the pandemic in Mexico. Our results suggest that lifting social confinement must be gradually sparse while maintaining a decentralized region strategy among the Mexican states. To substantially lower the number of infections, simulations highlight that a fraction of the population that represents the elderly should remain in social confinement (approximately 11.3% of the population); a fraction of the population that represents the confined working class (roughly 27% of the population) must gradually return in at least four parts in consecutive months; and to the last a fraction of the population that assumes the return of students to schools (about 21.7%). As the epidemic progresses, deconfinement strategies need to be continuously re-adjusting with the new pandemic data. All mathematical models, including ours, are only a possibility of many of the future, however, the different scenarios that were developed here highlight that a gradual decentralized region deconfinement with a significant increase in healthcare capacities is paramount to avoid a high death toll in Mexico.

scholarly journals Regime Type and COVID-19 Response

2020 ◽  
Vol 9 (3) ◽  
pp. 152-160 ◽  
Author(s):  
Ilan Alon ◽  
Matthew Farrell ◽  
Shaomin Li
Keyword(s):  
Political System ◽  
Authoritarian Regimes ◽  
Economic Consequences ◽  
Regime Type ◽  
The Novel ◽  
Huge Number ◽  
Policy Suggestions ◽  
The World ◽  
Heated Debate ◽  
Novel Coronavirus

From late 2019 to the first half of 2020, the world has witnessed the epic spread and destruction of the novel coronavirus which was discovered in Wuhan, China. The huge number of infections and deaths caused by the virus, the collapse of the healthcare system and the economic consequences have few modern equivalents. While governments of all countries are responding to the pandemic, a heated debate rages about which political system, democracy versus authoritarian, is better positioned to respond to the pandemic. While the worldwide effort to contain the virus continues, we offer a preliminary comparison between democracies and authoritarian regimes in their responses to COVID-19, and policy suggestions for democracies to improve their governance and their ability to respond to crises.

COVID-19: Socio-Economic Consequences on the Hospitality Industry in Malaysia

2021 ◽  
Vol 12 (1) ◽  
pp. 52-52
Author(s):  
Nur Hidayah Che Ahmat ◽  
Syafiqah Rahamat ◽  
Susan Wohlsdorf Arendt
Keyword(s):  
Public Health ◽  
Hospitality Industry ◽  
Economic Consequences ◽  
World Health ◽  
The Novel ◽  
Virus Spread ◽  
The World ◽  
Control And Prevention ◽  
Novel Coronavirus ◽  
Health Organization

The novel Coronavirus disease (COVID-19) first appeared in December 2019 in Wuhan, Hubei Province China before emerging in neighbouring countries in early 2020. The World Health Organization (WHO) declared COVID-19 a pandemic when the spreading of the virus started accelerating in many parts of the world and killing thousands of people. As of 22nd May 2021, there were more than 166 million confirmed cases with more than 147 million recovered and nearly 3.5 million deaths (Worldometers, n.d.). According to the WHO (2020) and Centers for Disease Control and Prevention (2020), the virus easily spreads through coughing and sneezing. Therefore, many countries implemented social distancing between individuals and various other restriction orders or recommendations (e.g., stay-at-home policies, closure of non-essential businesses) to help curb virus spread. How governments in each country reacted to control the spread of the virus appeared crucial to mitigate public health and economic impacts. Keywords: Foodservice, Hospitality, Hotel, Malaysia, Pandemic

scholarly journals COVID-19 pandemic: The deadly respiratory disease of 21st century

2021 ◽  
Vol 11 (1) ◽  
pp. 01-18
Author(s):  
Shweta Jain ◽  
◽  
Pankaj Kumar Jain ◽  
Ramakant Yadav ◽  
Surendra Kumar Jain ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Respiratory Disease ◽  
Clinical Investigation ◽  
Respiratory Illness ◽  
The Novel ◽  
Major Threat ◽  
The World ◽  
Prevention And Treatment ◽  
Novel Coronavirus ◽  
Severe Respiratory Illness

The sudden outbreak of 2019 novel coronavirus (2019-nCoV) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated from Wuhan, China. SARS-CoV-2 causes severe respiratory illness and becomes a major threat for humanity. Recently the entire scientist, researchers and physicians all over the countries focused to find the treatment of this pandemic disease. Numerous drugs and or vaccines have been trialed for prevention and treatment against 2019-nCoV but no therapy has been shown effective to date. Currently, numerous vaccines are under clinical investigation and mRNA-1273 vaccine (LNP- encapsulated mRNA vaccine encoding S protein) from Moderna is ahead. Although chloroquine, hydroxychloroquine, remdesivir and many other drugs had recommended against SARS-CoV-2, but still they are not the guarantee treatment of COVID-19. Recently, India, America, Russia and China introduced vaccines against COVID-19 in the market, however assurance of their 100% effectiveness are doubtful. The speed of daily new cases threatens the world and urges the scientist to crack this pandemic condition. KEYWORDS: 2019-nCoV; Chloroquine; COVID-19; Moderna; Respiratory disease; Remdesivir.

scholarly journals The Risk of Lifting COVID-19 Confinement in Mexico

2020 ◽  
Author(s):  
Cristy Leonor Azanza Ricardo ◽  
Esteban A. Hernandez-Vargas
Keyword(s):  
Fold Increase ◽  
The Elderly ◽  
The Novel ◽  
Bed Occupancy ◽  
Major Threat ◽  
Hypothetical Scenario ◽  
The World ◽  
High Death ◽  
Mexican Government ◽  
Novel Coronavirus

ABSTRACTThe novel coronavirus SARS-CoV-2 has paralysed our societies, leading to self isolation and quarantine for several days. As the 10th most populated country in the world, Mexico is on a major threat by COVID-19 due to the limitations of intensive care capacities, and a total of about 1.5 hospital beds for every 1000 citizens. In this paper, we projected different scenarios to evaluate sharp or gradual quarantine lifting strategies, however, even in the hypothetical scenario that Mexico would continue with full confinement, hospitals would be reaching the maximum capacity of hospital bed occupancy. Mexican government is planning to relax the strict social distancing regulations on 1 June 2020, however, epidemic rebound risks are latent.Our results suggest that lifting social confinement needs to be gradually sparse while maintaining a decentralized region strategy among the Mexican states. To substantially lower the number of infections, predictions highlight that the elderly should remain in social confinement (approximately 11.3% of the population); the confined working class (roughly 27% of the population) must gradually return in at least four parts in consecutive months; and to the last the return of students to schools (about 21.7%). As the epidemic progresses, de-confinement strategies need to be continuously re-adjusting with the new pandemic data. Assuming the most optimistic scenario by our predictions, the smallest number of new COVID-19 cases, Mexico would require at least a 3 fold increase in hospital capacities dedicated for COVID-19. Furthermore, to observe the real dimension of the epidemic, Mexico would need to increase to at least 18 samples per 1000 people, currently is only 0.6 per 1000.All mathematical models, including ours, are only a possibility of many of the future, however, the different scenarios that were developed here highlight that a gradual decentralized region de-confinement with a significant increase in healthcare capacities is paramount to avoid a high death toll in Mexico.

Coda: The Rosetta Stone

2018 ◽  
Author(s):  
Jesse Schotter
Keyword(s):  
Twentieth Century ◽  
New Media ◽  
Digital Media ◽  
The Novel ◽  
Digital Code ◽  
Media Technologies ◽  
Rosetta Stone ◽  
The World ◽  
Western Imagination ◽  
Origin Point

Hieroglyphs have persisted for so long in the Western imagination because of the malleability of their metaphorical meanings. Emblems of readability and unreadability, universality and difference, writing and film, writing and digital media, hieroglyphs serve to encompass many of the central tensions in understandings of race, nation, language and media in the twentieth century. For Pound and Lindsay, they served as inspirations for a more direct and universal form of writing; for Woolf, as a way of treating the new medium of film and our perceptions of the world as a kind of language. For Conrad and Welles, they embodied the hybridity of writing or the images of film; for al-Hakim and Mahfouz, the persistence of links between ancient Pharaonic civilisation and a newly independent Egypt. For Joyce, hieroglyphs symbolised the origin point for the world’s cultures and nations; for Pynchon, the connection between digital code and the novel. In their modernist interpretations and applications, hieroglyphs bring together writing and new media technologies, language and the material world, and all the nations and languages of the globe....

Basic Andragogy-Oriented Strategies and Communication in Online Education

2020 ◽  
Vol 26 (2) ◽  
pp. 350-356
Author(s):  
Anca Sîrbu
Keyword(s):  
Adult Learners ◽  
Online Education ◽  
Social Status ◽  
Rapid Onset ◽  
Learning Goals ◽  
The Novel ◽  
Academic Education ◽  
Online Instructors ◽  
New Methods ◽  
The World

AbstractWith the rapid onset of an unprecedented lifestyle due to the new coronavirus COVID-19 the world academic scene was forced to reform and adapt to the novel circumstances. Although online education cannot be regarded as a groundbreaking endeavour anymore in the21st century, its current character of exclusivity calls for deeper understanding of, and a sharper focus on the “end-consumer” thereof as well as more cautious procedures to be exercised while teaching. While millennials are no longer thought of as being born with a silver spoon in their mouth but with an iPad or any sort of device in their hand (irrespective of their social status), adults are more hesitant when coerced to alter course unexpectedly and turn to new methods of attaining their learning goals. This is why proper communicative approaches need to be thoroughly considered by online instructors. This article aims at presenting teachers with a set of strategies to employ when the beneficiaries of online academic education are adult learners.

A Compact Embodiment of Pluralities and Denial of Origins: Atwood’s The Year of The Flood

2016 ◽  
Vol 1 (3) ◽  
pp. 141
Author(s):  
Rana Sağıroğlu
Keyword(s):  
Science Fiction ◽  
21St Century ◽  
Social Order ◽  
Margaret Atwood ◽  
Rapid Change ◽  
The Novel ◽  
The World ◽  
Narrative Techniques ◽  
Why Questions ◽  
Near Future

Margaret Atwood, one of the most spectacular authors of postmodern movement, achieved to unite debatable and in demand critical points of 21st century such as science fiction, postmodernism and ecocriticism in the novel The Year of The Flood written in 2009. The novel could be regarded as an ecocritical manifesto and a dystopic mirror against today’s degenerated world, tending to a superficial base to keep the already order in use, by moving away from the fundamental solution of all humanity: nature. Although Atwood does not want her works to be called science fiction, it is obvious that science fiction plays an introductory role and gives the novel a ground explaining all ‘why’ questions of the novel. However, Atwood is not unjust while claiming that her works are not science fiction because of the inevitable rapid change of 21st century world becoming addicted to technology, especially Internet. It is easily observed by the reader that what she fictionalises throughout the novel is quite close to possibility, and the world may witness in the near future what she creates in the novel as science fiction. Additionally, postmodernism serves to the novel as the answerer of ‘how’ questions: How the world embraces pluralities, how heterogeneous social order is needed, and how impossible to run the world by dichotomies of patriarchal social order anymore. And lastly, ecocriticism gives the answers of ‘why’ questions of the novel: Why humanity is in chaos, why humanity has organized the world according to its own needs as if there were no living creatures apart from humanity. Therefore, The Year of The Flood meets the reader as a compact embodiment of science fiction, postmodernism and ecocriticism not only with its theme, but also with its narrative techniques.

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