scholarly journals EPR Effect-Based Tumor Targeted Nanomedicine: A Promising Approach for Controlling Cancer

2022 ◽  
Vol 12 (1) ◽  
pp. 95
Author(s):  
Jun Fang
Keyword(s):  
Human Health ◽  
Epr Effect ◽  
Major Threat ◽  
The World

Cancer remains the major threat to human health in most advanced countries in the world [...]

scholarly journals Binding Epitopes of 2019-nCoV Proteins for Perspective Diagnostic and Therapeutic Applications: Insights from Computational Approaches

2020 ◽  
Author(s):  
Ilda D'Annessa ◽  
Filippo Marchetti ◽  
Giorgio Colombo
Keyword(s):  
Human Health ◽  
Viral Proteins ◽  
Economic Consequences ◽  
The Novel ◽  
Computational Approaches ◽  
Therapeutic Applications ◽  
Major Threat ◽  
The World ◽  
Therapeutic Molecules ◽  
Share Information

The appearance of the novel betacoronavirus 2019-nCoV represents a major threat to human health, and its diffusion around the world is predicted to have dramatic economic consequences. The knowledge of the 3D structures of 2019-nCoV proteins can facilitate the development of diagnostic and therapeutic molecules. Herein, we apply our energy-based method for the prediction of potential epitopes on viral proteins to design peptide-based molecules that can subsequently be used in diagnostic and therapeutic applications. We discuss these aspects in the paper.The designs have not been tested. Our aim is to share information that can be useful in the development of novel biomolecules with potential interesting activities against 2019-nCoV.

The Compost Wars

2018 ◽  
Author(s):  
Gregory A. Barton
Keyword(s):  
Human Health ◽  
First World War ◽  
League Of Nations ◽  
World War ◽  
The First World War ◽  
The World ◽  
Popular Audience ◽  
First World

After the death of Gabrielle Howard from cancer, Albert married her sister Louise. Louise had been pressured to leave Cambridge as a classics lecturer as a result of her pro-peace writings during the First World War. After working for Virginia Wolf, she then worked for the League of Nations in Geneva. Louise was herself an expert on labor and agriculture, and helped Albert write for a popular audience. Albert Howard toured plantations around the world advocating the Indore Method. After the publication of the Agricultural Testament (1943), Albert Howard focused on popularizing his work among gardeners and increasingly connected his composting methods to issues of human health.

scholarly journals Rapamycin: Drug Repurposing in SARS-CoV-2 Infection

2021 ◽  
Vol 14 (3) ◽  
pp. 217
Author(s):  
Jiri Patocka ◽  
Kamil Kuca ◽  
Patrik Oleksak ◽  
Eugenie Nepovimova ◽  
Martin Valis ◽  
...  
Keyword(s):  
Literature Review ◽  
Human Health ◽  
World Economy ◽  
Web Of Science ◽  
Drug Repurposing ◽  
Final Analysis ◽  
High Rate ◽  
Suitable Candidate ◽  
Promising Strategy ◽  
The World

Since December 2019, SARS-CoV-2 (COVID-19) has been a worldwide pandemic with enormous consequences for human health and the world economy. Remdesivir is the only drug in the world that has been approved for the treating of COVID-19. This drug, as well as vaccination, still has uncertain effectiveness. Drug repurposing could be a promising strategy how to find an appropriate molecule: rapamycin could be one of them. The authors performed a systematic literature review of available studies on the research describing rapamycin in association with COVID-19 infection. Only peer-reviewed English-written articles from the world’s acknowledged databases Web of Science, PubMed, Springer and Scopus were involved. Five articles were eventually included in the final analysis. The findings indicate that rapamycin seems to be a suitable candidate for drug repurposing. In addition, it may represent a better candidate for COVID-19 therapy than commonly tested antivirals. It is also likely that its efficiency will not be reduced by the high rate of viral RNA mutation.

scholarly journals Informed consent and informed intervention: SARS-CoV-2 vaccinations not just call for disclosure of newly emerging safety data but also for hypothesis generation and testing

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Johannes C. Fischer ◽  
Albrecht G. Schmidt ◽  
Edwin Bölke ◽  
Verena Keitel ◽  
Torsten Feldt ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Providers ◽  
Viral Infections ◽  
Safety Data ◽  
Hypothesis Generation ◽  
Care Providers ◽  
Vaccination Programs ◽  
Major Threat ◽  
The World ◽  
Population Scale

Abstract Background COVID-19 infection is a major threat to patients and health care providers around the world. One solution is the vaccination against SARS-CoV-2. Methods We performed a comprehensive query of the latest publications on the prevention of viral infections including the recent vaccination program and its side effects. Results The situation is evolving rapidly and there is no reasonable alternative to population-scale vaccination programs as currently enrolled. Conclusion Therefore, regulatory authorities should consider supplementing their conventional mandate of post-approval pharmacovigilance, which is based on the collection, assessment, and regulatory response to emerging safety findings.

PANDEMIC AND ITS RELATION TO ENVIRONMENTAL CHANGES ACCORDING TO AYURVEDA

2021 ◽  
Vol 9 (10) ◽  
pp. 2423-2427
Author(s):  
Sangeeta Gupta ◽  
Anupama Patra ◽  
Sarita Yadav ◽  
Akanksha Thakur
Keyword(s):  
Viral Infection ◽  
Human Health ◽  
Environmental Changes ◽  
Remedial Measures ◽  
Considerable Contribution ◽  
Traditional System ◽  
Root Cause ◽  
The World ◽  
Modern System ◽  
Entire World

The entire world faced the corona crisis recently, still undergoing it. The world merely is seeing through it as a pandemic and is connecting it to a kind of viral infection invading the human community. The whole of the health machinery got paralyzed fighting the pandemic leading to millions of deaths around the globe. Moreover, the ad- vanced modern system of medicine was almost helpless in combating the virus-related hazards to human health. At this time, the considerable contribution was provided by the Ayurveda, our ancient traditional system of medi- cine. If we see the ayurvedic literature, the concept of Janpadodhwamsa provides answers to the mystery behind the fatal covid virus. The paper aims to provide a view about the Janpadodhwamsa which states various factors relating to the pandemic, the root cause of such events and the remedial measures for it. Keywords: Vayu, Jala, Desh, Kala, Janpadodhwamsa, Nidana Parivarjana, Prajnapradha

Special Issue on "Immunomodulatory and therapeutic approaches against infectious diseases"

2011 ◽  
Vol 1 (5) ◽  
pp. 1-2
Author(s):  
Lavkush Dwivedi
Keyword(s):  
Immune Response ◽  
Infectious Diseases ◽  
Human Health ◽  
Immune Stimulation ◽  
Defense System ◽  
Special Issue ◽  
Therapeutic Approaches ◽  
Major Constraint ◽  
The World ◽  
Insight Into

Infectious diseases and consequent immune imbalancesare major constraint in human health managementthroughout the world. However, in recentdecades enormous efforts have been made to elucidatethe immunomodulatory approaches againstinfectious diseases. Immunomodulation is a therapeuticapproach in which we try to intervene inauto regulating processes of the defense system toadjust the immune response at a desired level.The present special issue on cutting edge issues inImmunomodulation like Immune stimulation, Immunesuppression, Immune potentiating and immunereinforcement summarizes our current understandingof this complex mosaic. The accompanyingselection of recent articles from across theworld provides further insight into this topic. 

scholarly journals Population Growth - The Social Development and Poverty Dimension

1999 ◽  
Vol 4 (1) ◽  
pp. 41-52
Author(s):  
M.S. Jillani
Keyword(s):  
Reproductive Health ◽  
Population Growth ◽  
Social Development ◽  
Human Health ◽  
Reproductive System ◽  
Social Wellbeing ◽  
The Social ◽  
The World ◽  
Relationship Of ◽  
The Relationship

The debate over the relationship of population and development is now more than 200 years old, starting with the treatise on population by Malthus, in 1798. The increase in population, ever since, has remained a matter of concern for economists and development planners. The most recent high point of the issue was witnessed at Cairo in September, 1994. The conference which was attended by more than 10,000 persons from all over the world ended with an agreement on the issues involved in the growth of population and the economy. The outcome was a Plan of Action for the next twenty years, which would concentrate on Reproductive Health in order to obtain, “a state of complete physical, mental and social wellbeing, and not merely the absence of disease or infirmity in all matters relating to the reproductive system and its functions and process”. This can be a turn-around in global efforts for human health and welfare, if properly implemented.

scholarly journals Evaluation of Salt-water Intrusion in the Coastal Area of Igbokoda, Southwestern Nigeria

2018 ◽  
Vol 6 (01) ◽  
Author(s):  
Talabi A. O ◽  
Ajayi C. A ◽  
Afolagboye L. O ◽  
Oyedele A. A ◽  
Ojo O. F ◽  
...  
Keyword(s):  
Coastal Area ◽  
Salt Water ◽  
Silty Sand ◽  
High Resistivity ◽  
Salt Water Intrusion ◽  
Southwestern Nigeria ◽  
Major Threat ◽  
Sandy Clay ◽  
The World ◽  
Electrical Sounding

Saltwater intrusion into the coastal aquifer has long been recognized as a major threat to groundwater quality around the world. Groundwater evaluation of salt water intrusions in Igbokoda coastal area, southwestern Nigeria was carried out employing combined Horizontal Profiling and Vertical electrical sounding. Two traverses each with two sounding points were occupied. The result from the survey revealed 4 to 5 major layers comprising the unconsolidated silty sand and sandy clay (overburden), clayey zone, consolidated sand zone, partly intruded salt water intruded sandy clay zone and salt water intruded clay zone. The curves were the complex types KQH, KHA, QH and HKH curves. The overburden has resistivity that ranged from 253 to 1316.7Ω-m, thickness that ranged from 0.2 m to 7m. The clayey zone had resistivity of 846.0 Ω-m and thickness of 4m. The consolidated sand zone had resistivity that ranged from 2848.7 to 2865.7Ω-m and thickness that ranged between 4 and 21m. The partly intruded salt water zone is characterized by resistivity that varies between 18.4Ω-m and 93.0Ω-m and thickness of about 7-25m. The salt water intruded zone is characterized by resistivity that ranges between 4.1Ω-m and 9.7Ω-m and thickness of 4-48m. The partly-salt water intruded zones and salt water intruded zone were characterized with low resistivity while the high resistivity zones of consolidated sand layer constitute fresh water bearing zone that could serve as boreholes in the study area.

scholarly journals BEFORE LATE: LET’S ACCOMPLISH THE GREAT- AN ARGUMENT TO SAVE ENVIRONMENT WITH SPECIAL REFERENCE TO CONDITION OF NEPAL

2016 ◽  
Vol 4 (4) ◽  
pp. 13-19
Author(s):  
Atindra
Keyword(s):  
Special Reference ◽  
Human Health ◽  
Environmental Degradation ◽  
Future Generation ◽  
The World

Development and civilization have been top-rated priorities and indication of human success in the world; and the largest segment of world talent are immersing to mark new and ever un-experimented record in this course. But paying more attention towards money centric gain and material prosperity centric civilization, an irrational attack on environment is rife everywhere. In last few decades, the environmental strength of world has been largely damaged and it has offered severe impacts on human health now. Though, people were more over-swayed with anthropomorphic use of environment and some transitory progress gained, slowly the imbalance of environment and its reverse effects on human lives have started taking limelight of people. And now, environment seems to be equally pressing and compelling agendas of human checklist to do. If not initiated anything great, it may be more than late to save us and future generation. Thus, the article tries to disclose the impacts of environmental degradation and urges to have efficient actions to alleviate the situation with acknowledging and accessing few of initiatives taken, here so forth.

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