scholarly journals Karakterisasi Aktivitas Antioksidan Ekstrak Daun Mimba (Azadirachta Indica A. Juss) dari Desa Jagaraga, Kecamatan Sawan, Kabupaten Buleleng, Bali

2021 ◽  
Vol 27 (1) ◽  
pp. 51
Author(s):  
Arrohmatus Syafaqoh Li'aini ◽  
I Putu Agus Hendra Wibawa ◽  
I Nyoman Lugrayasa
Keyword(s):  
Azadirachta Indica

<p>Mimba merupakan tumbuhan daerah tropis dan subtropis yang telah banyak digunakan sebagai bahan obat tradisional sejak jaman prasejarah. Ekstrak mimba terbukti memiliki spektrum aktivitas biologi yang luas, antara lain antimikroba, antiinflamasi, dan antioksidan. Antioksidan merupakan senyawa kimia yang berfungsi untuk menghambat pembentukan radikal bebas. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan daun mimba yang diperoleh dari Desa Jagaraga, Kecamatan Sawan, Kabupaten Buleleng, Bali. Pada penelitian ini, aktivitas antioksidan daun mimba diuji melalui metode 1,1-Diphenyl-2-picrylhydrazyl radical (DPPH) dengan mengukur daya serap larutan menggunakan spektrofotometer pada panjang gelombang 516 nm. Konsentrasi<br />ekstrak daun mimba yang digunakan adalah 100, 200, 300, 400, 500, 600, dan 700 ppm. Hasil pengamatan menunjukkan bahwa konsentrasi ekstrak berbanding terbalik dengan nilai daya serap larutan. Rendahnya nilai daya serap larutan menunjukkan tingginya aktivitas antioksidan ekstrak daun mimba. Larutan DPPH yang ditambahkan dalam ekstrak daun mimba juga menyebabkan<br />perubahan warna larutan. Hal tersebut menunjukkan bahwa semakin tinggi konsentrasi ekstrak, semakin tinggi pula aktivitas antioksidannya. Hasil analisis menunjukkan rerata nilai IC50 ekstrak daun mimba sebesar 51,74, sehingga dikategorikan memiliki aktivitas antioksidan kuat. Hasil karakterisasi ini merupakan informasi awal mendukung program sumber daya genetik lokal,<br />khususnya di daerah Kabupaten Buleleng, Bali.</p>

Traditional, Pharmacological and Patenting Potential of Neem (Azadirachta indica): A Review

2017 ◽  
Vol 3 (4) ◽  
pp. 383-391
Author(s):  
Mohd Asif Khan ◽  
Shashi Bhooshan Tiwari ◽  
Himanshu Gupta ◽  
Huma Noor
Keyword(s):  
Azadirachta Indica ◽  
Indian Subcontinent ◽  
National Academy Of Sciences ◽  
Neem Tree ◽  
Commercial Plant ◽  
Pharmacological Potential ◽  
Pharmacologically Active ◽  
In The Beginning ◽  
Prevention And Cure ◽  
Academy Of Sciences

Since ancient time, herbal drugs were highly used in the prevention and cure of various human illnesses. In India, Azadirachta indica being commonly known as Neem or Margosa is one of the multi-functional trees; belonging to Meliaceae family. In 1992, the US National Academy of Sciences was published a report entitled ‘Neem- a tree for solving global problems’. It is still considered as ‘village dispensary’ throughout the India. There are two species of Azadirachta which have been investigated; Azadirachta indica that is found in the Indian subcontinent and Azadirachta excelsa Kack that is homegrown to Indonesia and Philippines. A large number of pharmacologically active substances have been identified and isolated from the different parts of neem including azadirachtin, meliacin, gedunin, salanin, nimbin, valassin and various other components which are derived from these main compounds. Many different studies have been evaluated and authenticated for its various traditional and pharmacological activities like itching, leprosy, wound healing, spermicidal, anti-inflammatory, insecticidal, antidiabetic and analgesic etc. In the beginning of 1979, patenting on neem was started by CSIR to separate the active compounds from neem oil. Its great implantation fights with soil erosion, global warming, deforestations and desertification world-wide. In 2002, World Neem Conference raised the neem tree as an industrial or commercial plant. This review is going to explore comprehensively; traditional, pharmacological potential along with patenting, environmental & industrial significant of various parts of neem tree with safety concerns.

PHYTOCHEMICAL SCREENING AND LARVICIDAL EFFECT EVALUATION OF AZADIRACHTA INDICA (L) LEAF EXTRACT ON DERMESTES MACULATUS (DE GEER, 1774) INFESTATION OF SMOKED CLARIAS GARIEPINUS (BURCHELL, 1822)

2020 ◽  
Vol 4 (2) ◽  
pp. 41-45
Author(s):  
Sadam Sulaiman Indabo ◽  
Rufai Zakari
Keyword(s):  
Azadirachta Indica ◽  
Leaf Extract ◽  
Standard Procedure ◽  
Clarias Gariepinus ◽  
Phytochemical Screening ◽  
Range Finding ◽  
Dermestes Maculatus ◽  
Randomized Design ◽  
Fish Samples ◽  
Initial Source

Dermestes maculatus is a major pest of stored fish in Nigeria, fish is preserved with highly persistent synthetic chemicals. There have been an increasing effort at developing plant-based toxicants that are environmentally friendly. Therefore, this study was conducted to screen the leaf extract of Azadirachta indica for phytochemical constituents. The efficacy of the methanolic leaf extract of the plant against D. maculatus was also evaluated. The leaves of A. indica were obtained, processed and taken to laboratory for methanolic extraction. Phytochemical screening was carried out to identify saponins, flavonoids, alkaloids, tannins, steroids, cardiac glycosides, glycosides, triterpenes and carbohydrates using standard procedure.  Both clean and infested samples of smoke-dried Clarias gariepinus were purchased from Sabon Gari Market, Zaria. The infested samples were used as initial source of D. maculatus larvae. Range finding test was carried out prior to the bioassay. During the bioassay, clean un-infested fish samples were weighed and introduced into kilner jars and respective dosages of 0.2g, 0.4g, 0.6g and 0.8g of extract were added. Another set of fish samples without the extract were maintained as control. The experiment was arranged in Completely Randomized Design with three replicates. Fifteen larvae of D. maculatus were introduced into both treated and control containers and covered. Mortality was recorded after 24, 48, 72 and 96 hours. Data obtained revealed an increase in mortality with increasing dose and time. Mortality ranged from 1.67 to 11.00. Therefore, leaf extract of A. indica should be incorporated in the development of larvicide against D. maculatus.   

Dairy Farmers Empowerment in Subak Anggabaya Penatih Timur Denpasar Bali Indonesia

2018 ◽  
Vol 9 (05) ◽  
pp. 20218-20223
Author(s):  
I Ketut Arnawa ◽  
I Wayan Runa ◽  
I Made Sukerta ◽  
Putu Sri Astuti ◽  
Dan Luh Kadek Budi Martini
Keyword(s):  
Rice Straw ◽  
Azadirachta Indica ◽  
Nutritional Value ◽  
Organic Fertilizer ◽  
Process Technology ◽  
Dairy Farmers ◽  
Training Activity ◽  
Good Nutrition ◽  
And Training ◽  
Spraying Method

The main purpose for the application of science and technology for livestock group of cow, is to form a group of skilled and professional livestock, as vaccinators, can take advantage of Azadirachta indica leaves a plant insecticide, apply a good cage sanitation, can produce organic fertilizer from feces of cow, can treat hay as feed to good nutritional value. The method used is education and training. Activity results obtained, that 10 percent of members of the group have managed to become vaccinators cadres, able to implement good sanitation stables, feces of cow (Stomoxys calsitrans) can process technology with EM4 into organic fertilizer and can process the rice straw with urea spraying method, to produce feed hay to the value of good nutrition for growing cattle.

Formulation and Evaluation of Polyherbal Cream Containing Cinnamomum zeylanicum Blume, Glycyrrhiza glabra L and Azadirachta indica A. Juss. Extracts to Topical Use

2020 ◽  
Vol 25 (2) ◽  
pp. 61-71
Author(s):  
Rajendra Gyawali ◽  
Rupesh Kumar Gupta ◽  
Sahana Shrestha ◽  
Rajendra Joshi ◽  
Prem Narayan Paudel
Keyword(s):  
Azadirachta Indica ◽  
Antioxidant Properties ◽  
Flow Property ◽  
Antioxidant Property ◽  
Glycyrrhiza Glabra ◽  
Cinnamomum Zeylanicum ◽  
Cream Formulation ◽  
Glycyrrhiza Glabra L ◽  
Lipid Peroxidase ◽  
Dpph Scavenging

Alcoholic extracts of medicinal plants Cinnamomum zeylanicum Blume, Glycyrrhiza glabra L, and Azadirachta indica A. Juss were subjected to the evaluation of antioxidant properties and combined for the cream formulation. The antioxidant property was determined by using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay and inhibition of lipid peroxidase assays. The cream formulation was designed using Minitab software and a central composite design was used to study the effect of dependent variables, steric acid and cetyl alcohol on the response variables such as, viscosity, pH, and spreadability. The phytochemical screening of extracts showed the presence of tannin, phenol, flavonoids, saponins, and alkaloids. Antioxidant properties of the extracts and their relative composition were found variable. Composition F3 (C. zeylanicum Blume: G. glabra L: A. indica A. Juss; 01: 02: 01) possessed the highest antioxidant capacity compared to other ratios. The cream prepared from this composition was found stable for pH, viscosity as well as antioxidant activity under normal condition (25) and accelerated condition (40 ). The cream with DPPH scavenging activity of 93.86 % at 15 µg/mL (IC50 8.58±0.30) and lipid peroxidase assay 90.93 % at 200 µg/mL (IC50 72.30±0.60) with pH 5.50 was found with a non-Newtonian positive thixotropic flow property. Parameters like pH, viscosity, and spreadability of the cream were within the acceptance range, and found stable and permeable

Bioenhancing Effect of Cow Urine Distillate and Pepper Extract on Antibacterial Activity of Azadirachta Indica Leaves

1970 ◽  
Vol 9 (2) ◽  
pp. 3212-3214
Author(s):  
Pramod Dhakal ◽  
Ankit a Achary ◽  
Vedamurthy Joshi
Keyword(s):  
Antibacterial Activity ◽  
Azadirachta Indica ◽  
Pathogenic Bacteria ◽  
Ethanol Extract ◽  
Watery Diarrhea ◽  
Diffusion Method ◽  
E Coli ◽  
Drug Molecules ◽  
Cow Urine

Bioenhancers are drug facilitator which do not show the typical drug activity but in combination to enhance the activity of other molecule in several way including increase the bioavailability of drug across the membrane, potentiating the drug molecules by conformational interaction, acting as receptor for drug molecules and making target cell more receptive to drugs and promote and increase the bioactivity or bioavailability or the uptake of drugs in combination therapy. The objective of the present study was to evaluate the antibacterial and activity of combination in Azadirachta indica extract with cow urine distillate and pepper extract against common pathogenic bacteria, a causative agent of watery diarrhea. It has been found that Indian indigenous cow urine and its distillate also possess bioenhancing ability. Bioenhancing role of cow urine distillate (CUD) and pepper extract was investigated on antibacterial activity of ethanol extract of Azadirachta indica. Antibacterial activity of ethanol extract neem alone and in combination with CUD and pepper extract were determined the ATCC strains against Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa and E-coli by cup plate diffusion method. Ethanol extract of neem has showed more effect on P. aeruginosa, E-coli than S. aureus and K. pneumonia with combination of CUD and pepper extract. CUD and pepper did not show any inhibition of test bacteria in low concentration. The antibacterial effect of combination of extract and CUD was higher than the inhibition caused by extract alone and is suggestive of the bioenhancing role of cow urine distillate and pepper. Moreover, inhibition of test bacteria was observed with less concentration of extract on combining with CUD

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