SmartWater Synergy with Microsphere Injection for Permeable Carbonates

2021 ◽  
Author(s):  
Dongqing Cao ◽  
Ming Han ◽  
Salah Saleh ◽  
Subhash Ayirala ◽  
Ali Al-Yousef
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Pore Volume ◽  
Water Injection ◽  
Oil Production ◽  
Differential Pressure ◽  
Suspension Stability ◽  
Oil Displacement ◽  
Carbonate Cores ◽  
Injection Water

Abstract This paper presents a laboratory study on combination of SmartWater with microsphere injection to improve oil production in carbonates, which increases the sweep efficiency and oil displacement efficiency. In this study, the properties of a micro-sized polymeric microsphere were investigated including size distribution, rheology, and zeta potential in SmartWater, compared with conventional high salinity injection water. Coreflooding tests using natural permeable carbonate cores were performed to evaluate flow performance and oil production potential at 95°C and 3,100 psi pore pressure. The flow performance was evaluated by the injection of 1 pore volume microspheres, followed by excessive water injection. Oil displacement tests were also performed by injecting 1 pore volume of microspheres dissolved in SmartWater after conventional waterflooding. The median particle size of the microsphere in conventional injection water with a salinity of 57,670 ppm was about 0.25 µm. The particle size was increased by 50% to 100% with reduced elastic modulus when the microsphere dispersed in SmartWater with lower salinity. The zeta potential value of microsphere was decreased in SmartWater compared to that in conventional injection water, showing more negatively charge property. Flow performance of microsphere solutions in the carbonate cores was found to be dependent on their particle size, strength, and suspension stability. The results from coreflooding tests showed that the microsphere dispersed in SmartWater would result in higher differential pressure than that observed in conventional injection water. The SmartWater caused the microspheres swell to larger but softer particles with better suspension stability, which enhanced both the migration and blocking efficiency of microsphere injection. The oil displacement tests confirmed that the microsphere in SmartWater displaced more oil than that obtained with conventional injection water. This result was clearly supported by the higher differential pressure from microsphere injection in SmartWater. The oil bank appeared historically in the post water injection stage, which was quite different from the reported findings of typical mobility controlling agents in the existing knowledge. The microspheres were observed in the core flood produced fluids, indicating the improvement of microsphere migration by SmartWater. This work, for the first time, demonstrated that the combination of SmartWater and microsphere injection yields additional oil production. The proposed hybrid technique can provide a cost-effective way to improve waterflooding performance in heterogeneous carbonates.

Dispersion Stability of Drinking Water Treatment Sludge

2015 ◽  
Vol 659 ◽  
pp. 69-73 ◽  
Author(s):  
Siriporn Larpkiattaworn ◽  
Wasana Khongwong ◽  
Siriporn Tong-On ◽  
Chutima Eamchotchawalit ◽  
Chaiwat Vorapeboonpong
Keyword(s):  
Particle Size ◽  
Drinking Water ◽  
Water Treatment ◽  
Zeta Potential ◽  
Particle Surface ◽  
Drinking Water Treatment ◽  
Particle Dispersion ◽  
Dispersion Force ◽  
Suspension Stability ◽  
Water Treatment Sludge

The objective of this study is to improve the particle suspension stability of drinking water treatment sludge (DWTS) and comparable to other silicate powder which are bentonite, micro silica (micro-SiO2), and nano-silica (nano-SiO2). The main dispersion characteristic are related to particle size, and dispersion force. The representative samples of bentonite, micro-SiO2, nano-SiO2, and DWTS were dispersed at the same solid content in water. The particle size distribution and chemical composition of samples were analyzed. The suspended samples were measured for Zeta potential at the controlled pH value. Furthermore, turbidity of suspended samples were investigated at various sedimenting time. The results indicated that nano-SiO2 has the highest Zeta potential value at pH 8-12. The stability of particle dispersion could be implied from turbidity of suspension at various sedimenting time. Bentonite suspension performed more stability than other samples for longer time. However, stability of DWTS particles can be improved by particle size controlling and treatment with dispersion agent to create repulsive force from the charge on the particle surface.

Value of DTS in Multi-Stacked Reservoirs to Better Understand Injectivity and Water Flood Effectiveness – A Field Example from the UAE

2021 ◽  
Author(s):  
Jorge Gomes ◽  
Jane Mason ◽  
Graham Edmonstone
Keyword(s):  
Lower Cretaceous ◽  
Fiber Optic ◽  
Water Movement ◽  
Water Injection ◽  
Reservoir Management ◽  
Oil Production ◽  
Temperature Sensing ◽  
Dense Layer ◽  
Distributed Temperature Sensing ◽  
Injection Water

This paper highlights the application of downhole fiber optic (FO) distributed temperature sensing (DTS) measurements for well and reservoir management applications: 1) Wellbore water injectivity profiling. 2) Mapping of injection water movement in an underlying reservoir. The U.A.E. field in question is an elongated anticline containing several stacked carbonate oil bearing reservoirs (Figure 1). Reservoir A, where two DTS monitored, peripheral horizontal water injectors (Y-1 and Y-2) were drilled, is less developed and tighter than the immediately underlying, more prolific Reservoir B with 40 years of oil production and water injection history. Reservoirs A and B are of Lower Cretaceous age, limestone fabrics made up of several 4th order cycles, subdivided by several thin intra dense, 2-5 ft thick stylolitic intervals within the reservoir zones. Between Reservoir A and Reservoir B there is a dense limestone interval (30-50 ft), referred as dense layer in the Figure 1 well sections.

Clarithromycin Loaded Chitosan Nanoparticles: Development and Characterization

2020 ◽  
Vol 04 ◽  
Author(s):  
Ashvini Herimatha ◽  
Shivanand K. Mutta ◽  
Anirbandeep Bose ◽  
Anudeep Balla
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Process Parameters ◽  
Chitosan Nanoparticles ◽  
Morphological Characteristics ◽  
Chitosan Solution ◽  
Physicochemical Characteristics ◽  
Polydispersity Index ◽  
Suspension Stability ◽  
Optimum Conditions

Background:: Chitosan nanoparticles have been extensively studied and used due to their well-recognized applicability in various fields. Chitosan, a natural polysaccharide polymer and is extensively used in pharmaceuticals to deliver a wide variety of therapeutic agents. Chitosan is a biocompatible and biodegradable mucoadhesive polymer that has been extensively used in the preparation of multi particles, particularly nano- and microparticles. Objective:: The main aim of the present study was to optimize the conditions for the preparation of chitosan nanoparticles to get optimal particle size, with optimal zeta potential and narrow polydispersity index, and antibacterial activity. Methods:: Methods include the ionic gelation technique for chitosan nanoparticle preparation. The influence of formulation parameters and process parameters on the Chitosan nanoparticles were investigated. Besides, the suspension stability of the prepared nanoparticles is also assessed on storage at 4°C. Results: clearly showed that the formulation and process parameters showed a significant effect on the physicochemical and morphological characteristics of the chitosan nanoparticles. The chitosan nanoparticles prepared under optimum conditions (chitosan concentration of 0.5% w/v, CS: TPP mass ratio of 1:3, initial pH of chitosan solution of 4.5, stirred at 750 rpm for 30 min) had shown a mean particle size of ~326.8±15 nm, the zeta potential of +28.2 ± 0.5 mV, PDI of 0.21 ± 0.02. The encapsulation of the clarithromycin slightly increased the polydispersity index but the zeta potential of the unloaded nanoparticles was not affected while the particle size increased. Under optimum conditions, clarithromycin encapsulation efficiency into nanoparticles was found to be 70%. Additionally, chitosan-tripolyphosphate nanoparticles were shown to be stable for a minimum of fifteen days in deionized water at 4°C. Conclusion:: The current study concludes on the optimal conditions to formulate the chitosan nanoparticles with optimal physicochemical characteristics.

Research of the Impurities Causes in Water Injection Well in Longhop Oilfield

2015 ◽  
Vol 733 ◽  
pp. 55-58
Author(s):  
Pei Long Wang ◽  
Guang Sheng Cao ◽  
Guo Jing Miao ◽  
Hong Fei Cui
Keyword(s):  
Particle Size ◽  
Water Injection ◽  
Impurity Content ◽  
Size Composition ◽  
Oil Field ◽  
Injection Well ◽  
Sand Production ◽  
Injection Wells ◽  
Injection Water ◽  
Low Permeability Reservoirs

Due to the particularity of its percolation of low permeability reservoirs, water injection is very difficult and damage to the reservoir, especially the impurities in injection Wells, at the same time affect the injection efficiency, it will ultimately affect the recovery of the reservoir and the oilfield production. So it is necessary to carry out the ingredients and the causes of impurities in injection wells, clearing the Source for different kinds of impurity to provide the basis for reduce the impurity content in injection wells. In this paper, the author analyzed impurities particle size, composition and content in oilfield injection water In Longhop Oilfield through the indoor experiment, and with the comparison between the ion content and composition of the filtered water samples, analyzing the cause of the impurity within the wellbore. Experimental results show that in oil field water injection well, impurities particle size are mainly distributed between 2.6 and 5.4 um, impurity content mainly changes between 0.003746% and 0.017189%, the main ingredients of impurities is Fe2O3 and acid insoluble substances (SiO2). Fe2O3 mainly comes from the injection water; acid insoluble substances mainly come from the formation sand production.

scholarly journals Experimental Study on Rational Water Injection Rate in Continental Sandstone Reservoirs

2019 ◽  
Vol 13 (1) ◽  
pp. 114-121
Author(s):  
Manping Yang ◽  
Lu Jiang ◽  
Shuxiang Guo ◽  
Liming Zheng ◽  
Ling Meng
Keyword(s):  
Experimental Model ◽  
Pore Volume ◽  
Water Injection ◽  
Injection Rate ◽  
Water Flooding ◽  
Displacement Efficiency ◽  
Displacement Effect ◽  
Injection Speed ◽  
Oil Displacement ◽  
Oil Displacement Efficiency

Objective: In this paper, an experimental model of water flooding was designed and manufactured, and experiments on high permeability and low permeability models were carried out. Methods: The relationship between injection rate, injection pore volume multiple and oil displacement efficiency, injection rate, injection pore volume multiple and water content in two kinds of permeability was analyzed. Results: There is a certain relationship between oil displacement efficiency and water injection speed. There is a reasonable water injection speed, which can achieve the highest oil displacement efficiency. The lower the permeability the lower will be the reasonable injection rate . In the reasonable range of water injection rate, the injection rate increases gradually, and the best oil displacement effect can be obtained. Conclusion: Through analysis, it was concluded that the oil displacement efficiency of artificial rocks with various water injection rates was different even in the same permeability experimental model. It was indicated that the water flooding recovery of the reservoir can be improved by using the method of strong injection and strong production in the middle and later stage of development.

Incorporation of micro/nanoparticles of PCL with essential oil of Cymbopogon nardus in bacterial cellulose

2018 ◽  
Vol 1 (2) ◽  
pp. 37
Author(s):  
Aline Krindges ◽  
Vanusca Dalosto Jahno ◽  
Fernando Morisso
Keyword(s):  
Particle Size ◽  
Particulate Matter ◽  
Essential Oil ◽  
Zeta Potential ◽  
Bacterial Cellulose ◽  
Culture Medium ◽  
Static Culture ◽  
Cymbopogon Nardus ◽  
Cellulose Membranes

Incorporation studies of particles in different substrates with herbal assets growing. The objective of this work was the preparation and characterization of micro/nanoparticles containing cymbopogon nardus essential oil; and the incorporation of them on bacterial cellulose. For the development of the membranes was used the static culture medium and for the preparation of micro/nanoparticles was used the nanoprecipitation methodology. The incorporation of micro/nanoparticles was performed on samples of bacterial cellulose in wet and dry form. For the characterization of micro/nanoparticles were carried out analysis of SEM, zeta potential and particle size. For the verification of the incorporation of particulate matter in cellulose, analyses were conducted of SEM and FTIR. The results showed that it is possible the production and incorporation of micro/nanoparticles containing essential oil in bacterial cellulose membranes in wet form with ethanol.

Novel Formulation Development and Evaluation of Nanoparticles Based in Situ Gelling System for The Ophthalmic Delivery of Ciprofloxacin Hydrochloride

2015 ◽  
Vol 5 (4) ◽  
Author(s):  
Kranti Singh ◽  
Surajpal Verma ◽  
Shyam Prasad ◽  
Indu Bala
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Drug Loading ◽  
In Vitro Release ◽  
Formulation Development ◽  
Ciprofloxacin Hydrochloride ◽  
Potential Value ◽  
The Mean ◽  
In Situ Gelling

Ciprofloxacin hydrochloride loaded Eudragit RS100 nanoparticles were prepared by using w/o/w emulsification (multiple emulsification) solvent evaporation followed by drying of nanoparticles at 50°C. The nanoparticles were further incorporated into the pH-triggered in situ gel forming system which was prepared using Carbopol 940 in combination with HPMC as viscosifying agent. The developed nanoparticles was evaluated for particle size, zeta potential value and loading efficiency; nanoparticle incorporated in situ gelling system was evaluated for pH, clarity, gelling strength, rheological studies, in-vitro release studies and ex-vivo precorneal permeation studies. The nanopaticle showed the mean particle size varying between 263.5nm - 325.9 nm with the mean zeta potential value of -5.91 mV to -8.13 mV and drug loading capacity varied individually between 72.50% to 98.70% w/w. The formulation was clear with no suspended particles, showed good gelling properties. The gelling was quick and remained for longer time period. The developed formulation was therapeutically efficacious, stable and non-irritant. It provided the sustained release of drug over a period of 8-10 hours.

Formulation and Evaluation of Nanosuspension of Simvastatin

2015 ◽  
Vol 8 (2) ◽  
pp. 2858-2873
Author(s):  
Rupali L. Shid ◽  
Shashikant N. Dhole ◽  
Nilesh Kulkarni ◽  
Santosh L Shid
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Factorial Design ◽  
Dissolution Rate ◽  
In Vitro Dissolution ◽  
Total Drug ◽  
23 Factorial Design ◽  
Rate Of Dissolution

Poor water solubility and slow dissolution rate are issues for the majority of upcoming and existing biologically active compounds. Simvastatin is poorly water-soluble drug and its bioavailability is very low from its crystalline form. The purpose of this study wasto increase the solubility and dissolution rate of simvastatin by the  preparation of nanosuspension by emulsification solvent diffusion method at laboratory scale. Prepared nanosus-pension was evaluated for its particle size and in vitro dissolution study and characterized by zeta potential,differential scanning calorimetry (DSC) and X-Ray diffractometry (XRD), motic digital microscopy, entrapment efficiency, total drug content, saturated solubility study and in vivo study. A 23 factorial design was employed to study the effect of independent variables, amount of SLS (X1), amount of PVPK-30 (X2) and poloxamer-188 (X3) and dependent variables are total drug content and polydispersity Index. The obtained results showed that particle size (nm) and rate of dissolution has been improved when nanosuspension prepared with the higherconcentration of PVPK-30 with the higher concentration of PVP K-30 and Poloxamer-188 and lower concentration of SLS. The particle size and zeta potential of optimized formulation was found to be 258.3 nm and 23.43. The rate of dissolution of the optimized nanosuspension was enhanced (90% in 60min), relative to plain simvastatin  (21% in 60 min), mainly due to the formation of nanosized particles. These results indicate the suitability of 23 factorial  design for preparation of simvastatin loaded nano-suspension significantly improved in vitro dissolution rate and thus possibly enhance fast onset of therapeutic drug effect. In vivo study shows increase in bioavailability in nanosuspension formulation than the plain simvastatin drug.

Optimization and Characterization of Aqueous Micellar Formulations for Ocular Delivery of an Antifungal Drug, Posaconazole

2020 ◽  
Vol 26 (14) ◽  
pp. 1543-1555 ◽  
Author(s):  
Meltem E. Durgun ◽  
Emine Kahraman ◽  
Sevgi Güngör ◽  
Yıldız Özsoy
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Size Distribution ◽  
Encapsulation Efficiency ◽  
Fungal Infections ◽  
In Vitro Release ◽  
Pluronic F127 ◽  
Glycol Succinate ◽  
Vitro Release

Background: Topical therapy is preferred for the management of ocular fungal infections due to its superiorities which include overcoming potential systemic side effects risk of drugs, and targeting of drugs to the site of disease. However, the optimization of effective ocular formulations has always been a major challenge due to restrictions of ocular barriers and physiological conditions. Posaconazole, an antifungal and highly lipophilic agent with broad-spectrum, has been used topically as off-label in the treatment of ocular fungal infections due to its highly lipophilic character. Micellar carriers have the potential to improve the solubility of lipophilic drugs and, overcome ocular barriers. Objective: In the current study, it was aimed optimization of posaconazole loaded micellar formulations to improve aqueous solubility of posaconazole and to characterize the formulations and to investigate the physical stability of these formulations at room temperature (25°C, 60% RH), and accelerated stability (40°C, 75% RH) conditions. Method: Micelles were prepared using a thin-film hydration method. Pre-formulation studies were firstly performed to optimize polymer/surfactant type and to determine their concentration in the formulations. Then, particle size, size distribution, and zeta potential of the micellar formulations were measured by ZetaSizer Nano-ZS. The drug encapsulation efficiency of the micelles was quantified by HPLC. The morphology of the micelles was depicted by AFM. The stability of optimized micelles was evaluated in terms of particle size, size distribution, zeta potential, drug amount and pH for 180 days. In vitro release studies were performed using Franz diffusion cells. Results: Pre-formulation studies indicated that single D-ɑ-tocopheryl polyethylene glycol succinate (TPGS), a combination of it and Pluronic F127/Pluronic F68 are capable of formation of posaconazole loaded micelles at specific concentrations. Optimized micelles with high encapsulation efficiency were less than 20 nm, approximately neutral, stable, and in aspherical shape. Additionally, in vitro release data showed that the release of posaconazole from the micelles was higher than that of suspension. Conclusion: The results revealed that the optimized micellar formulation of posaconazole offers a potential approach for topical ocular administration.

Moxifloxacin Hydrochloride-Loaded Eudragit® RL 100 and Kollidon® SR Based Nanoparticles: Formulation, In vitro Characterization and Cytotoxicity.

2020 ◽  
Vol 23 ◽  
Author(s):  
Gülsel Yurtdaş Kırımlıoğlu ◽  
Sinan Özer ◽  
Gülay Büyükköroğlu ◽  
Yasemin Yazan
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Spray Drying ◽  
Prolonged Release ◽  
Ocular Delivery ◽  
Corneal Permeability ◽  
Release Pattern ◽  
In Vitro Characterization ◽  
Ocular Bioavailability

Background: Considering the low ocular bioavailability of conventional formulations used for ocular bacterial infection treatment, there’s a need for designing efficient novel drug delivery systems that may enhance of precorneal retention time and corneal permeability. Aim and Objective: The current research focuses on developing nanosized and non-toxic Eudragit® RL 100 and Kollidon® SR nanoparticles loaded with moxifloxacin hydrochloride (MOX) for its prolonged release to be promising for effective ocular delivery. Methods: In this study, MOX was incorporation was carried out by spray drying method aiming ocular delivery. In vitro characteristics were evaluated in detail with different methods. Results: MOX was successfully incorporated into Eudragit® RL 100 and Kollidon® SR polymeric nanoparticles by spray-drying process. Particle size, zeta potential, entrapment efficiency, particle morphology, thermal, FTIR, XRD and NMR analyses and MOX quantification using HPLC method were carried out to evaluate the nanoparticles prepared. MOX loaded nanoparticles demonstrated nanosized and spherical shape while in vitro release studies demonstrated modified release pattern which followed Korsmeyer-Peppas kinetic model. Following successful incorporation of MOX into the nanoparticles, the formulation (MOX: Eudragit® RL 100, 1:5) (ERL-MOX 2) was selected for further studies by the reason of its better characteristics like cationic zeta potential, smaller particle size, narrow size distribution and more uniform prolonged release pattern. Moreover, ERL-MOX 2 formulation remained stable for 3 months and demonstrated higher cell viability values for MOX. Conclusion: In vitro characterization analyses showed that non-toxic, nano-sized and cationic ERLMOX 2 formulation has the potential of enhancing ocular bioavailability.

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