scholarly journals Association of Subclinical Hypothyroidism and Dyslipidemia in Children and Adolescents

2020 ◽  
Author(s):  
Ashkan Habib ◽  
Asadollah Habib
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Subclinical Hypothyroidism ◽  
Cross Sectional Study ◽  
Specific Pattern ◽  
Cross Sectional ◽  
Lipid Disorder ◽  
Significant Difference ◽  
Sh Group ◽  
Tsh Levels

Abstract Background: Correlation of higher levels of TSH and dyslipidemia in children is controversial. This study was designed to assess the relation between lipid profile components and TSH levels in children. Method: This cross-sectional study was performed in a growth assessment clinic in Shiraz. Children aged between 2 to 18 years that came to the clinic from January till April 2018 were considered. TSH levels equal or above 5 and lower than 10 mIU/L with normal FT4 were considered as subclinical hypothyroidism. Results: 666 children were euthyroid while 181 had subclinical hypothyroidism. Mean total cholesterol in euthyroid children was 160.50 ± 29.070 mg/dl and in SH group 161.39 ± 28.694 mg/dl (P=0.713). Mean LDL-C in euthyroid children was 90.96 ± 24.996 mg/dl and in SH group 89.10 ± 23.852 mg/dl (P=0.369). Mean HDL-C in euthyroid children was 47.94 ± 10.560 mg/dl and in SH group 49.04 ± 10.361 mg/dl. (P=0.211). Mean non HDL-C in euthyroid children was 112.56 ± 27.696 mg/dl and in SH group 112.35 ± 28.136 mg/dl. (P=0.929). Mean triglyceride in euthyroid children was 104.98 ± 54.934 mg/dl and in SH group 113.83 ± 91.342 mg/dl (P=0.215). There was no significant difference in mean serum total cholesterol, LDL, HDL, non-HDL and triglyceride levels between euthyroid and subclinical hypothyroid. Adjusted correlation was not significant between TSH levels and any lipid profile component. Conclusion: By comparing the results of this study with other studies, it is evident that lipid disorder in subclinical hypothyroid children does not have a specific pattern.

scholarly journals No association between subclinical hypothyroidism and dyslipidemia in children and adolescents

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ashkan Habib ◽  
Asadollah Habib
Keyword(s):  
Lipid Profile ◽  
Subclinical Hypothyroidism ◽  
Meta Analysis ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Pediatric Endocrinology ◽  
Free T4 ◽  
Cross Sectional ◽  
Significant Difference ◽  
Tsh Levels

Abstract Background There are controversies about the correlation between higher levels of thyroid stimulating hormone (TSH) and dyslipidemia in children. This study was designed to assess the relation between lipid profile components and TSH levels in children. Method This cross-sectional study was performed in a pediatric endocrinology growth assessment clinic in Shiraz, southern Iran. Children aged 2–18 years who referred to the clinic from January until April 2018 were included. TSH levels equal or above 5 mIU/L and lower than 10 mIU/L with normal free T4 (FT4) were considered as having subclinical hypothyroidism (SH). Results Six hundred sixty-six children were euthyroid while 181 had SH. No significant difference was found between the mean serum total cholesterol (P = 0.713), LDL-C (P = 0.369), HDL-C (P = 0.211), non-HDL-C (P = 0.929), and triglyceride (P = 0.215) levels between euthyroid children and subjects with SH. There was also no significant difference in the prevalence of dyslipidemias in any lipid profile components between the two groups. The adjusted correlation was not significant between TSH levels and any lipid profile component. Conclusion Based on the results of our study, we found no correlation between SH and dyslipidemia in children. The association between dyslipidemia and SH in children still seems to be inconsistent based on the results of this and previous studies. We recommend a meta-analysis or a significantly larger retrospective study on this subject.

scholarly journals Perbedaan Profil Lipid pada Akseptor Depo Medroksi Progesteron Asetat dengan Implant Levonorgestrel di Wilayah Kerja Puskesmas Air Tawar Padang Tahun 2014

2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Rafika Oktova ◽  
Desmiwarti Desmiwarti ◽  
Arni Amir
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Medroxyprogesterone Acetate ◽  
Colorimetric Method ◽  
Cross Sectional Study ◽  
Hormonal Contraceptives ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Significant Difference

AbstrakDepo Medroksiprogesteron Asetat dan Implant Levonorgestrel merupakan kontrasepsi hormonal progestin sintetik yang memiliki efek samping yaitu peningkatan berat badan dan mempengaruhi metabolisme lipid. Tujuan penelitian ini adalah untuk mengetahui perbedaan profil lipid pada akseptor Depo Medroksiprogesteron Asetat dengan Implant Levonorgestrel. Ini adalah studi observasional dengan desain cross sectional comparative. Penelitian dilakukan di laboratorium Bagian Biokimia Fakultas Universitas Andalas dari Maret sampai Mei 2014. Subjek penelitian terdiri dari dua kelompok, masing-masing 20 subjek. Pemeriksaan dengan metode enzimatis kolorimetri yaitu GPO-PAP untuk trigliserida, dan CHOD-PAP untuk kolesterol total, HDL dan LDL. Data dianalisis menggunakan uji t dengan nilai p<0.05 dianggap bermakna secara statistik. Rerata kadar LDL pada Depo Medroksiprogesteron Asetat lebih tinggi (95,51 ± 20,47) mg/dl daripada Implant Levonorgestrel (79,35 ± 12,55) mg/dl dengan nilai p<0,05 artinya terdapat perbedaan yang bermakna sedangkan kadar trigliserida, kolesterol total dan HDL tidak bermakna. Kesimpulan penelitian in adalah terdapat perbedaan yang bermakna rerata kadar LDL pada Depo MedroksiprogesteronAsetat dan Implant Levonorgestrel, sedangkan kadar trigliserida, kolesterol total dan HDL tidak bermakna. Secara klinis profil lipid pada kedua kelompok dalam keadaan normal.Kata kunci: profil lipid, depo medroksiprogesteron asetat, implant levonorgestrelAbstractDepo Medroxyprogesterone Acetate and Levonorgestrel Implants are synthetic progestine hormonal contraceptives that have side effect in body weight and lipid metabolism. The objective of this study was to determine the differences of lipid profile between acceptors Depo Medroxyprogesterone Acetate and Levonorgestrel Implants. This was a comparative cross sectional study. The study was done at laboratory of Biochemistry Departement in Medical Faculty of Andalas University from March until May 2014. The subjects were consisted of two groups, each group had 20 subjects. The examination used an enzymatic colorimetric method GPO-PAP for trygliserides and CHOD-PAP for total cholesterol, HDL and LDL. Data was analyzed using analysis of t-test with p<0.05 was considered to be significantly different. LDL levels average in Depo Medroxyprogesterone Acetate was (95,51 ± 20,47) mg/dl and Levonorgestrel Implants was (79,35 ± 12,55) mg/dl with p-value, it means there is a significantly difference, but levels of trygliserides, total cholesterol and HDL means there is no significantly difference. This research concluded that there is a significant difference on average levels of LDL in the Depo Medroxyprogesterone Acetate and Levonorgestrel Implants but levels of trygliserides, total cholesterol and HDL there is no significantly difference. The clinically lipid profile in the two groups is in normal range.Keywords: lipid profile, depo medroxyprogesterone acetate and levonorgestrel implants

Serum Lipid Profile in Diffuse versus Limited Systemic Sclerosis Data from the SASS cohort

2018 ◽  
Vol 69 (2) ◽  
pp. 403-406
Author(s):  
Codrina Ancuta ◽  
Cristina Pomirleanu ◽  
Cristina Iordache ◽  
Magda Ecaterina Antohe ◽  
Rodica Chirieac ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Total Cholesterol Level ◽  
Cross Sectional Study ◽  
Serum Lipid Profile ◽  
Serum Triglycerides ◽  
Cross Sectional ◽  
Topoisomerase 1

Data about lipoprotein changes and their link with cardiovascular disease and atherosclerosis in systemic sclerosis (SSc) are still challenging. We aimed to evaluate serum lipid profile of patients with SSc and to identify potential relation with different disease specific characteristics (clinical, serological, inflammatory tests) in a cross-sectional study. Standard assessments comprised SSc-related parameters (disease subtype, clinical spectrum, immunological tests) and lipid metabolism (total cholesterol and fractions, triglycerides). Impaired lipid profile (low serum HDL- and high LDL-cholesterol, increased serum triglycerides, slightly modification in total cholesterol level) significantly correlated with diffuse SSc, activity (EUSTAR) and severity (MEDSGER), as well as seropositivity for specific antibodies (anti-centromere and anti-topoisomerase 1). The dyslipidemic profile might represent a pathobiological pathway for atherosclerosis in SSc.

scholarly journals perbandingan kadar HDL dan LDL akseptor Depo Medroksi Progesteron Asetat dengan IUD

2019 ◽  
Vol 7 (2) ◽  
pp. 47-51
Author(s):  
Suci Syahril ◽  
Meldafia Idaman ◽  
Dewi Fransisca
Keyword(s):  
Weight Gain ◽  
Lipid Profile ◽  
Medroxyprogesterone Acetate ◽  
Colorimetric Method ◽  
Cross Sectional Study ◽  
First Year ◽  
Sectional Study ◽  
Normal Range ◽  
Cross Sectional ◽  
Significant Difference

Abstract The use of contraceptive depot medroxyprogesterone acetate (DMPA) increasing lately, but some studies suggest has the side effects of weight gain and contraceptives that have side effect in lipid metabolism. Therefore, about 35% of acceptors of DMPA in the first year to stop the use of DMPA. The objective of this study was to determine the differences of lipid profile between acceptors DMPA with acceptors IUD. This was a obcervational study with cross sectional study. The study wasdone at health center Lubuk Buaya in Padang and at laboratory of Biochemistry Departement in Medical Faculty of Andalas University from Januari until September 2016. The subjects were consisted of two groups, each group had 26 subjects. The examination for LDL and HDL used an enzymatic colorimetric method CHOD-PAP.  Data was analyzed using analysis of t-test with p < 0.05 was considered to be significantly different. HDL levels average in Depo Medroxyprogesterone Acetate was 87,54±14,28 mg/dl and IUD was 75,90±8,67 mg/dl with p < 0.05 (significantly difference). Levels of  LDL means there is no significantly difference between DMPA and IUD acceptors (p> 0.05). This research concluded that there isa significant difference on average levels of HDL in the Depo Medroxyprogesterone Acetate and IUD but levels of LDL there is no significantly difference. The clinically lipid profile in the two groups is in normal range.  

scholarly journals Thoracic periaortic adipose tissue is increased in patients with subclinical hypothyroidism

2015 ◽  
Vol 172 (5) ◽  
pp. 553-559
Author(s):  
Ömer Akyürek ◽  
Duran Efe ◽  
Zeynettin Kaya
Keyword(s):  
Adipose Tissue ◽  
Subclinical Hypothyroidism ◽  
Smoking Status ◽  
Control Group ◽  
Laboratory Findings ◽  
Significant Difference ◽  
Sh Group ◽  
The Difference ◽  
And Control ◽  
Tsh Levels

ObjectiveTo evaluate thoracic periaortic adipose tissue (TAT) volume in patients with subclinical hypothyroidism (SH) in comparison with controls and in relation to cardiovascular risk factors.MethodsThe study population consisted of 28 newly diagnosed SH patients (mean (s.d.) age: 37.3 (±11.4) years, 85.7% were females) and 37 healthy volunteers (mean (s.d.) age: 35.3 (±10.7) years, 81.5% were females). Comparisons between patient and control groups used demographic characteristics, anthropometrics, and laboratory findings. All participants underwent thoracic radiographic assessment in the supine position, using an eight-slice multidetector computed tomography scanner and TAT volume was measured.ResultsThe TAT volume was determined to be 27.2 (±12.7) cm3 in the SH group and 16.3 (±8.1) cm3 in the control group, and the difference was statistically significant (P<0.001). In addition, TSH levels were significantly higher in the patient group compared with the control group (P<0.001). A significant correlation was also found between TSH levels and TAT volume (r=0.572; P<0.001). In SH patients, no significant difference was noted in TAT levels with respect to sex (P=0.383) or concomitant smoking status (P=0.426).ConclusionsOur findings indicate that SH patients have significantly higher TAT values than controls and that increased TAT levels correlate with increased TSH levels.

scholarly journals Hubungan Kadar Profil Lipid dengan Kejadian Hipertensi pada Masyarakat Etnik Minangkabau di Kota Padang Tahun 2012

2014 ◽  
Vol 3 (2) ◽  
Author(s):  
Rahmat Feryadi ◽  
Delmi Sulastri ◽  
Husnil Kadri
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Cross Sectional Study ◽  
Common Disease ◽  
Ethnic Communities ◽  
Sectional Study ◽  
Significant Relation ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

AbstrakHipertensi merupakan masalah kesehatan yang banyak dijumpai pada masyarakat dan berkorelasi dengan penyakit lainnya. Banyak faktor penyebab terjadinya hipertensi, salah satunya adalah gangguan profil lipid. Profil lipid dapat memicu terjadinya hipertensi melalui berbagai mekanisme, baik secara langsung atau tidak langsung. Penelitian ini bertujuan untuk meneliti lebih lanjut tentang hubungan obesitas dengan kejadian hipertensi. Penelitian dilakukan pada masyarakat Etnik Minangkabau di 8 kelurahan di kota Padang. Ini adalah studi komparatif menggunakan desain cross sectional study, dengan jumlah subjek 160 responden. Pengumpulan data responden dilakukan dengan wawancara. Pengukuran tekanan darah dilakukan berdasarkan cara yang direkomendasikan WHO dan penetapan nilainya berdasarkan JNC VII. Profil lipid diukur dilaboratorium dengan acuan penilaian berdasarkan NCEP ATP III. Analisis statistik yang digunakan adalah uji chi square. Hasil penelitian ini menunjukkan bahwa sebagian besar gangguan kadar kolesterol terdapat pada penderita hipertensi dari pada normotensi. Uji statistik chi square menunjukkan hubungan yang bermakna antara kadar kolesterol dan trigliserida dengan kejadian hipertensi (total kolesterol p < 0,05; OR = 2,40, trigliserida p< 0,05; OR = 2,49). Kadar HDL dan LDL tidak menunjukkan hubungan yang bermakna terhadap kejadian hipertensi (p > 0,05). Dari hasil tersebut dapat disimpulkan bahwa sebagian fraksi profil lipid mempengaruhi kejadian hipertensi pada etnik Minangkabau yang berada di kota Padang, yaitu kadar kolesterol total dan trigliserida.Kata kunci: Hipertensi, kolestertol total, HDL, LDL, Trigliserida, etnik Minangkabau.AbstractHypertension is a common disease in the community and have correlation with other diseases. Many factor can leads hypertension, such as disturbance of lipid profile. Lipid profile can lead hypertension through a variety of mechanism, either directly or indirectly. This study aims to investigate the lipid profile relation with the incident of hypertension. The research was conducted at the Minangkabau ethnic communities in 8 district in Padang city. This was s a comparative study using a cross sectional study in 160 respondents. Data was collected by interview to get respondent characteristics. Measurement of blood preasure waist and carried out by the WHO recommended and appointment value based on JNC VII. Profile lipid was measured in laboratory and appointment value based on NCEP ATP III. The statistical analysis used chi square test. The result found that the disturbance of total cholesterol and trigliceride more existed in hypertension than normotension population. Chi square statistical test showed there was relation between total cholesterol and triglycerides with hypertension incident (total cholesterol p < 0,05; OR = 2,40 , triglycerides p < 0,05 ; OR = 2,49 ). HDL and LDL had not significant relation with hypertension incident (p > 0.05). The conclusion of this study is some of profil lipid effected hypertension incident at Minangkabau Ethnic in Padang, especially total cholesterol and triglycerides.Keywords: Hypertension, total cholesterol, HDL, LDL, triglycerides, Minangkabau Ethnic

scholarly journals Senam aerobik dan konsumsi zat gizi serta pengaruhnya terhadap kadar kolesterol total darah wanita

2011 ◽  
Vol 8 (1) ◽  
pp. 23
Author(s):  
Siti Fatimah ◽  
Apoina Kartini
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Adult Women ◽  
Chi Square ◽  
Cross Sectional ◽  
Nutrient Adequacy ◽  
Significant Difference

Background: Hypercholesterolemia is a condition in which levels of cholesterol in the blood above normal levels (≥ 240 mg/dl). Physical exercises done regularly useful in the regulation of cholesterol, is total cholesterol, LDL cholesterol and triglycerides in the blood decreased, while HDL cholesterol increased. Food has an important role in association with the incident hypercholesterolemia.Objective: The purpose of this study was to determine the effect of aerobic exercise on blood total cholesterol level of adult women in the city of Semarang.Method: This research was explanatory research with cross sectional study. Subject was women aged 20-49 years gymnastic participants, as a comparison group was a housewife who was not doing gymnastics. Twenty three samples for group2 by matching on nutritional status and age and with the sampling purposive sampling. Adequacy levels of carbohydrates, proteins, fats, and also vitamins A and C were obtained through 2x24-hour recall was not a sequence, and processed using NutriSurvey. Results of independent t-test used to determine the effect of cholesterol levels between groups, and chi square test was used to determine association with nutrient adequacy levels of total cholesterol.Results: The results showed no significant difference in mean total cholesterol level between groups of gymnastic participants (201.2 g/dl) with housewife group (208.3 g/dl). Housewife group was belonging to hypercholesterolemia by 52.2%, while in group of exercise participants at 43.5%. Sufficiency level of protein showed a role in the total cholesterol level of adult women.Conclusion: The aerobic gymnastics did not affect total cholesterol. Moderate level of protein adequacy contributes to the total cholesterol level of adult women.

scholarly journals The Clinical Implications of Thyroid Hormones and its Association with Lipid Profile: A Comparative Study from Western Nepal

1970 ◽  
Vol 1 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Ankush Mittal ◽  
Brijesh Sathian ◽  
Arun Kumar ◽  
Nishida Chandrasekharan ◽  
Sanjeev Dwedi
Keyword(s):  
Thyroid Hormones ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Subclinical Hypothyroidism ◽  
Laboratory Tests ◽  
Thyroid Dysfunction ◽  
Reference Range ◽  
Thyroid Disorder ◽  
The Mean ◽  
Tsh Levels

BackgroundThyroid dysfunction is one of the major public health problems in Nepal. Laboratory tests facilitate early diagnosis before clinical features are obvious, increased sensitivity carries the price of decreased diagnostic specificity. Laboratory tests coupled with supportive clinical findings are frequently used to diagnose thyroid dysfunction. Historically, hypercholesterolemia and raised serum low density lipoprotein (LDL) cholesterol levels have been found to be associated with subclinical hypothyroidism. Therefore, assessment of altered lipid profile plays a supportive role in diagnosis of thyroid dysfunction. The aim of our study was to find out the variations of thyroid hormones and lipid profile in hyperthyroidism and hypothyroidism with their clinical implications.Materials and Methods  It was a hospital based retrospective study carried out from the  data  retrieved  from  the  register  maintained  in  the Department of Biochemistry of the Manipal Teaching Hospital, Pokhara, Nepal between 1st July, 2009 and 30th June, 2010. The variables collected were age, gender, T4, T3, TSH, fT4, total cholesterol and triglyceride levels. Descriptive statistics and testing of hypothesis were used for the analysis of data.Results122 out of the 365 subjects selected for the study had some form of thyroid disorder. Of the 122 cases, 40 had hyperthyroidism, 42 had hypothyroidism and the remaining 40 were diagnosed to have subclinical hypothyroidism.  The frequency of thyroid disorders was much higher in females as compared to their male counterparts. The mean value of each variable in cases, except for age, was statistically significant as compared to controls (p=0.001). Elevated levels of total T3 (CI 2.14 to 2.59), T4 (CI 13.00 to 15.30) and fT4 (CI 2.51 to 2.81) associated with decreased TSH levels (CI 0.29 to 0.35) were found in cases of hyperthyroidism. The TSH values (CI 17.05 to 22.85) were markedly increased while T4 and T3 values were found to be less than the reference range in cases of hypothyroidism. There was significant increase in the mean concentration of total cholesterol (CI 268.83 to 289.79) and triglycerides (CI 154.81to 182.05) in cases of hypothyroidism. The fT4 (CI 1.08 to 1.22) levels were in reference range and TSH levels (CI 9.59 to 10.50) were moderately raised in cases of subclinical hypothyroidism.ConclusionThyroid dysfunction is common across all age groups and shows a strong female preponderance in Pokhara valley. It necessitates the measurement of thyroid hormones in women after the age of 50, in pregnancy and after delivery, and in women and men with hypercholesterolemia. Therefore, timely screening and check ups are necessary in order to curtail the problem of undiagnosed cases, giving specific consideration to patients who have high artherogenic profile. This will reduce the risk of future negative health events in older adults.Key Words: Thyroid hormones; Hyperthyroidism; Hypothyroidism; Lipid profile; NepalDOI: 10.3126/nje.v1i1.4102Nepal Journal of Epidemiology 2010;1 (1):11-16

scholarly journals Lipid profiles of vegetarian and non-vegetarian children at risk of overweight or obesity

2010 ◽  
Vol 50 (5) ◽  
pp. 291
Author(s):  
Arie Purwana ◽  
IKG Suandi ◽  
Endy Paryanto Prawirohartono
Keyword(s):  
At Risk ◽  
Total Cholesterol ◽  
Vegetarian Diet ◽  
Cross Sectional Study ◽  
Lipid Profiles ◽  
Children At Risk ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Significant Difference ◽  
Overweight Or Obesity

Background The type, amount, and composition of a diet may affect the levels of cholesterol in blood. Itis believed that children adhering to a vegetarian diet have lower total cholesterol levels and lower body mass indexes compared to children with non-vegetarian (omnivorous) diets. We wish to compare cholesterol levels of vegetarian and non-vegetarian Indonesian children who are at risk of overweight or obesity.Objective To compare lipid profiles of vegetarian and no-vegetarian children who are at risk for overweight or obesity.Methods We performed a cross-sectional study in January and February 2010. Subjects for this study came from Denpasar, Bali. Subjects filled questionnaires as well as underwent history-taking, anthropometric measurements, and blood testing. We performed lipid profile analyses on their blood samples. We used the independent t test and Mann-Whitney test for statistical analysis of the data. The level of significance was set at P <0.05.Results Our study included forty-four children at risk for overweight or obesity with a vegetarian or non-vegetarian diet. We found that vegetarian children had lower mean total cholesterol (144 mg/dL) than that of non-vegetarian children (171 mg/dL), a statistically significant difference of P=0.014. In addition, vegetarian children had lower mean triglyceride levels (150 mg/dL) than those of non􀀶vegetarian children (264 mg/dL), a statistically significant difference of P =0 .025.Conclusion Among Balinese children at risk of overweight or obesity, vegetarians have significantly lower mean total cholesterol and triglyceride levels than non-vegetarians.

scholarly journals Comparison of Atherogenic Index of Plasma (AIP) Between Postmenopausal Women with Central Obesity and Postmenopausal Nonobese Women

2014 ◽  
Vol 13 (2) ◽  
pp. 47-50 ◽  
Author(s):  
Monowara Khanam ◽  
Md Aminul Haque Khan ◽  
Md Rewanur Rahman ◽  
Rukhsana Parvin ◽  
Selima Akhter ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Postmenopausal Women ◽  
Central Obesity ◽  
Cross Sectional Study ◽  
Atherogenic Index ◽  
Obese Women ◽  
Lipid Parameter ◽  
Cross Sectional ◽  
Atherogenic Index Of Plasma ◽  
Significant Difference

Background: Following menopause there are changes in values of lipid profile parameters. Abdominal obesity has also been linked to significant metabolic abnormalities including changes in lipid parameter values. Atherogenic index of plasma (AIP) calculated as log (TG/HDL-C) has been used as some practitioners as a significant predictor of atherosclerosis. So, we designed this study to observe the pattern of lipid profile parameters and to find out AIP in postmenopausal central obese women and to compare these between postmenopausal women with central obesity and postmenopausal nonobese women. Objectives: To assess the lipid profile status and AIP of postmenopausal women with central obesity and to compare these parameters with that of postmenopausal nonobese women.Materials & Methods: This cross sectional study was carried out in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Sixty six postmenopausal women with central obesity and age matched 56 nonobese postmenopausal women were included in the study. Central obesity was defined having waist hip ratio more than 0.8 and BMI <25.0. All statistical analyses were done by SPSS 18.0. p values <0.05 were considered significant.Results: Statistically no significant difference was observed between the central obese women and nonobese women in lipid profile parameters. But AIP was found significantly higher in postmenopausal central obese women.Conclusion: Central obese postmenopausal women may be at higher risk of cardiovascular events compared with postmenopausal nonobese women in spite of no difference in lipid profile parameters as their AIP values are significantly different.DOI: http://dx.doi.org/10.3329/cmoshmcj.v13i2.21064

Sign in / Sign up

Export Citation Format

Share Document