scholarly journals Dietary inflammatory index, risk of incident hypertension, and effect modification from BMI

2020 ◽  
Author(s):  
Conor-James MacDonald ◽  
Nasser Laouali ◽  
Anne-Laure Madika ◽  
Francesca Romana Mancini ◽  
Marie-Christine Boutron-Ruault
Keyword(s):  
Positive Association ◽  
Population Based ◽  
Effect Modification ◽  
Dietary Inflammatory Index ◽  
Incident Hypertension ◽  
Inflammatory Index ◽  
Hazard Ratios ◽  
Reimbursement Database ◽  
Cox Proportional Hazard Models ◽  
Diet History Questionnaire

Abstract Introduction Previous studies have identified a positive association between the inflammatory potential of the diet and hypertension. It is not known if BMI is an effect modifier for this association, nor if the association is dose-respondent. This study aimed to assess the association between the dietary inflammatory index (DII) and the risk of hypertension, and assess any effect modification from BMI. Methods Data from the E3N cohort study, a French prospective population-based study initiated in 1990 was used. From the women in the study, we included those who completed a detailed diet history questionnaire, and who did not have prevalent hypertension or cardiovascular disease at baseline, resulting in 46,652 women. The adapted DII was assessed with data from the dietary questionnaire. Hypertension cases were self-reported and verified through a drug-reimbursement database. Cox proportional hazard models were used to calculate hazard ratios. Spline regression was used to determine any dose-respondent relationship. Results During 884,267 person-years, 13,183 cases of incident hypertension were identified. The median DII in the population was slightly pro-inflammatory (DII = + 0.44). A highly pro-inflammatory diet (DII > 3.0) was associated with a slight increase in hypertension risk (HR Q1-Q5 = 1.07 [1.02: 1.13]). Evidence was observed for effect modification from BMI, with associations strongest amongst women in the 18.5 - 21.0 BMI range (HR Q1-Q5 = 1.17 [1.06: 1.29]). A weak dose-respondent relationship was observed. Conclusion Evidence for a weak association between DII and hypertension was observed. Associations were stronger amongst leaner women.

scholarly journals Dietary inflammatory index, risk of incident hypertension, and effect modification from BMI

2020 ◽  
Author(s):  
Conor-James MacDonald ◽  
Nasser Laouali ◽  
Anne-Laure Madika ◽  
Francesca Romana Mancini ◽  
Marie-Christine Boutron-Ruault
Keyword(s):  
Positive Association ◽  
Population Based ◽  
Effect Modification ◽  
Dietary Inflammatory Index ◽  
Incident Hypertension ◽  
Inflammatory Index ◽  
Hazard Ratios ◽  
Reimbursement Database ◽  
Cox Proportional Hazard Models ◽  
Diet History Questionnaire

Abstract Introduction: Previous studies have identified a positive association between the inflammatory potential of the diet and hypertension. It is not known if BMI is an effect modifier for this association, nor if the association is dose-respondent. This study aimed to assess the association between the dietary inflammatory index (DII) and the risk of hypertension, and assess any effect modification from BMI.Methods: Data from the E3N cohort study, a French prospective population-based study initiated in 1990 was used. From the women in the study, we included those who completed a detailed diet history questionnaire, and who did not have prevalent hypertension or cardiovascular disease at baseline, resulting in 46,652 women. The adapted DII was assessed with data from the dietary questionnaire. Hypertension cases were self-reported and verified through a drug-reimbursement database. Cox proportional hazard models were used to calculate hazard ratios. Spline regression was used to determine any dose-respondent relationship.Results: During 884,267 person-years, 13,183 cases of incident hypertension were identified. The median DII in the population was slightly pro-inflammatory (DII = + 0.44). A highly pro-inflammatory diet (DII > 3.0) was associated with a slight increase in hypertension risk (HRQ1-Q5 = 1.07 [1.02: 1.13]). Evidence was observed for effect modification from BMI, with associations strongest amongst women in the 18.5 - 21.0 BMI range (HRQ1-Q5 = 1.17 [1.06: 1.29]). A weak dose-respondent relationship was observed.Conclusion: Evidence for a weak association between DII and hypertension was observed. Associations were stronger amongst healthy-lean women.

scholarly journals Cholesterol and Egg Intakes, and Risk of Hypertension in a Large Prospective Cohort of French Women

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1350
Author(s):  
Conor-James MacDonald ◽  
Anne-Laure Madika ◽  
Fabrice Bonnet ◽  
Guy Fagherazzi ◽  
Martin Lajous ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Population Based ◽  
Dietary History ◽  
Egg Consumption ◽  
Hazard Ratios ◽  
Increased Risk ◽  
Cholesterol Intake ◽  
Cox Proportional Hazard Models ◽  
Diet History Questionnaire ◽  
Meta Analyses

Purpose: The relationship between egg and cholesterol intakes, and cardiovascular disease is controversial. Meta-analyses indicate that egg consumption is associated with increased cardiovascular disease and mortality, but reduced incidence of hypertension, a major risk factor for cardiovascular disease. This study aims to investigate the associations between consumption of egg and cholesterol, and hypertension risk in a cohort of French women. Methods: We used data from the E3N cohort study, a French prospective population-based study initiated in 1990. From the women in the study, we included those who completed a detailed diet history questionnaire, and who did not have prevalent hypertension or cardiovascular disease at baseline, resulting in 46,424 women. Hypertension cases were self-reported. Egg and cholesterol intake was estimated from dietary history questionnaires. Cox proportional hazard models with time-updated exposures were used to calculate hazard ratios. Spline regression was used to determine any dose–respondent relationship. Results: During 885,321 person years, 13,161 cases of incident hypertension were identified. Higher cholesterol consumption was associated with an increased risk of hypertension: HRQ1–Q5 = 1.22 [1.14:1.30], with associations similar regarding egg consumption up to seven eggs per week: HR4–7 eggs = 1.14 [1.06:1.18]. Evidence for a non-linear relationship between hypertension and cholesterol intake was observed. Conclusions: Egg and cholesterol intakes were associated with a higher risk of hypertension in French women. These results merit further investigation in other populations.

scholarly journals Positive Association of Dietary Inflammatory Index with Incidence of Cardiovascular Disease: Findings from a Korean Population-Based Prospective Study

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 588
Author(s):  
Imran Khan ◽  
Minji Kwon ◽  
Nitin Shivappa ◽  
James R. Hébert ◽  
Mi Kyung Kim
Keyword(s):  
Cardiovascular Disease ◽  
Positive Association ◽  
Population Based ◽  
Proportional Hazard ◽  
Dietary Inflammatory Index ◽  
Cvd Risk ◽  
Inflammatory Index ◽  
Cox Proportional Hazard ◽  
Increased Risk

Recently, diets with higher inflammatory potentials based on the dietary inflammatory index (DII®) have been shown to be associated with increased cardiovascular disease (CVD) risk in the general population. We aimed to prospectively investigate the association between the DII and CVD risk in the large Korean Genome and Epidemiology Study_Health Examination (KoGES_HEXA) cohort comprised of 162,773 participants (men 55,070; women 107,703). A validated semi-quantitative food frequency questionnaire (SQ-FFQ) was used to calculate the DII score. Statistical analyses were performed by using a multivariable Cox proportional hazard model. During the mean follow-up of 7.4 years, 1111 cases of CVD were diagnosed. Higher DII score was associated with increased risk of CVD in men (hazard ratio [HR]Quintile 5 vs. 1 1.43; 95% CI 1.04–1.96) and in women (HRQuintile 5 vs. 1 1.19; 95% CI 0.85–1.67), although not significant for women. The risk of CVD was significantly higher in physically inactive men (HRQuintile 5 vs. 1 1.80; 95% CI 1.03–3.12), obese men (HRQuintile 5 vs. 1 1.77; 95% CI 1.13–2.76) and men who smoked (HRQuintile 5 vs. 1 1.60; 95% CI 1.10–2.33), respectively. The risk of developing stroke was significantly higher for men (HRQuintile 5 vs. 1 2.06; 95% CI 1.07–3.98; p = 0.003), but not for women. A pro-inflammatory diet, as indicated by higher DII scores, was associated with increased risk of CVD and stroke among men.

scholarly journals Dietary inflammatory index, risk of incident hypertension, and effect modification from BMI

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Conor-James MacDonald ◽  
Nasser Laouali ◽  
Anne-Laure Madika ◽  
Francesca Romana Mancini ◽  
Marie-Christine Boutron-Ruault
Keyword(s):  
Effect Modification ◽  
Dietary Inflammatory Index ◽  
Incident Hypertension ◽  
Inflammatory Index

Association between dietary inflammatory index and cardiometabolic risk factors among Brazilian adolescents: results from a national cross-sectional study

2021 ◽  
pp. 1-24
Author(s):  
Pâmela Ferreira Todendi ◽  
Rafaela Salla ◽  
Nitin Shivappa ◽  
James R. Hebert ◽  
Julianna Ritter ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiometabolic Risk ◽  
Positive Association ◽  
Dietary Factors ◽  
Cardiometabolic Risk Factors ◽  
Model Assessment ◽  
Dietary Inflammatory Index ◽  
Cardiovascular Risks ◽  
Cross Sectional ◽  
Inflammatory Index

Abstract Dietary factors play a role in modulating chronic inflammation and in the development of cardiovascular disease. We aimed to investigate the association between the dietary inflammatory index (DII) and cardiometabolic risk factors among adolescents.A total of 31,684 Brazilian adolescents (12–17 years), from the Study of Cardiovascular Risks in Adolescents (ERICA) were included. Dietary intake was assessed using a 24-hour dietary recall. The E-DII (energy-adjusted)score was calculated based on data for 25available nutrients. The anthropometric profile, blood pressure, lipid profile, glucose, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), and glycated hemoglobin were measured. Poisson regression models were used to examine the associations between sex-specific quartiles of the E-DII and cardiometabolic risk factors. In the energy-adjusted models, when comparing a high pro-inflammatory diet (quartile 4) withananti-inflammatory diet (quartile 1), there was a positive association with high HOMA-IR among boys(prevalence ratios (PR)Q4=1.37, 95%CI: 1.04–1.79); and with high fasting glucose (PRQ4 = 1.96, 95%CI: 1.02–3.78), high triglycerides (PRQ4 = 1.92, 95%CI: 1.06–3.46),low HDL-c (PRQ4 = 1.16, 95%CI: 1.02–1.32) and high LDL-c (PRQ4 = 1.93, 95%CI: 1.12–3.33) among girls. Additionally, a moderately pro-inflammatory diet was positively associated with high HOMA-IR (PRQ2 = 1.14, 95%CI: 1.02–1.29) among girls, and high total cholesterol (PRQ3 = 1.56, 95%CI: 1.20–2.01) among boys.In conclusion, this study provides new evidence on the association between inflammatory diets with cardiometabolic risk factors among adolescents.

Dietary inflammatory index and risk of multiple sclerosis: Findings from a large population-based incident case–control study

2020 ◽  
Vol 39 (11) ◽  
pp. 3402-3407 ◽  
Author(s):  
Ibrahim Abdollahpour ◽  
Dejan Jakimovski ◽  
Nitin Shivappa ◽  
James R. Hébert ◽  
Farhad Vahid ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Case Control Study ◽  
Large Population ◽  
Population Based ◽  
Case Control ◽  
Dietary Inflammatory Index ◽  
Incident Case ◽  
Inflammatory Index ◽  
Control Study

scholarly journals Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged Adults

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 281 ◽  
Author(s):  
Lucas Jurado-Fasoli ◽  
Manuel J. Castillo ◽  
Francisco J. Amaro-Gahete
Keyword(s):  
Plasma Levels ◽  
Solid Phase ◽  
Positive Association ◽  
Enzyme Linked Immunosorbent Assay ◽  
Dietary Inflammatory Index ◽  
Middle Aged ◽  
Close Link ◽  
Food Frequency ◽  
Inflammatory Index ◽  
Middle Aged Adults

Background: Soluble Klotho (S-Klotho) is an aging suppressor with a close link with inflammation. However, it is still unknown whether the dietary inflammatory potential is associated with S-Klotho plasma level. We aimed to investigate the association of the Dietary Inflammatory Index (DII) with S-Klotho plasma levels in middle-aged sedentary adults. Methods: 73 middle-aged sedentary adults (40–65 years old) participated in the present study. DII was determined from 28 dietary items obtained by 24 h recalls and food frequency questionnaires. The S-Klotho plasma levels were measured using a solid-phase sandwich enzyme-linked immunosorbent assay. Results: a weak positive association was observed between DII and S-Klotho plasma levels (β = 52.223, R2 = 0.057, p = 0.043), which disappeared after controlling for body mass index (p = 0.057). Conclusions: A pro-inflammatory dietary pattern measured with the DII was slightly and positively associated with S-Klotho plasma levels in middle-aged sedentary adults.

scholarly journals Dietary inflammatory index and risk of reflux oesophagitis, Barrett’s oesophagus and oesophageal adenocarcinoma: a population-based case–control study

2017 ◽  
Vol 117 (9) ◽  
pp. 1323-1331 ◽  
Author(s):  
Nitin Shivappa ◽  
James R. Hebert ◽  
Lesley A. Anderson ◽  
Martha J. Shrubsole ◽  
Liam J. Murray ◽  
...  
Keyword(s):  
Reflux Oesophagitis ◽  
Cell Cancer ◽  
Acid Reflux ◽  
Population Based ◽  
Barrett’S Oesophagus ◽  
Oesophageal Adenocarcinoma ◽  
Dietary Inflammatory Index ◽  
Barrett's Oesophagus ◽  
Inflammatory Index ◽  
Reflux Œsophagitis

AbstractThe dietary inflammatory index (DIITM) is a novel composite score based on a range of nutrients and foods known to be associated with inflammation. DII scores have been linked to the risk of a number of cancers, including oesophageal squamous cell cancer and oesophageal adenocarcinoma (OAC). Given that OAC stems from acid reflux and that the oesophageal epithelium undergoes a metaplasia-dysplasia transition from the resulting inflammation, it is plausible that a high DII score (indicating a pro-inflammatory diet) may exacerbate risk of OAC and its precursor conditions. The aim of this analytical study was to explore the association between energy-adjusted dietary inflammatory index (E-DIITM) in relation to risk of reflux oesophagitis, Barrett’s oesophagus and OAC. Between 2002 and 2005, reflux oesophagitis (n219), Barrett’s oesophagus (n220) and OAC (n224) patients, and population-based controls (n256), were recruited to the Factors influencing the Barrett’s Adenocarcinoma Relationship study in Northern Ireland and the Republic of Ireland. E-DII scores were derived from a 101-item FFQ. Unconditional logistic regression analysis was applied to determine odds of oesophageal lesions according to E-DII intakes, adjusting for potential confounders. High E-DII scores were associated with borderline increase in odds of reflux oesophagitis (OR 1·87; 95 % CI 0·93, 3·73), and significantly increased odds of Barrett’s oesophagus (OR 2·05; 95 % CI 1·22, 3·47), and OAC (OR 2·29; 95 % CI 1·32, 3·96), when comparing the highest with the lowest tertiles of E-DII scores. In conclusion, a pro-inflammatory diet may exacerbate the risk of the inflammation-metaplasia-adenocarcinoma pathway in oesophageal carcinogenesis.

scholarly journals A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS)

2013 ◽  
Vol 17 (8) ◽  
pp. 1825-1833 ◽  
Author(s):  
Nitin Shivappa ◽  
Susan E Steck ◽  
Thomas G Hurley ◽  
James R Hussey ◽  
Yunsheng Ma ◽  
...  
Keyword(s):  
Seasonal Variation ◽  
High Sensitivity ◽  
Population Based ◽  
Blood Cholesterol ◽  
Dietary Inflammatory Index ◽  
C Reactive Protein ◽  
Dietary Recall ◽  
Inflammatory Index ◽  
Reactive Protein ◽  
Hs Crp

AbstractObjectiveTo perform construct validation of the population-based Dietary Inflammatory Index (DII) using dietary data from two different dietary assessments and serum high-sensitivity C-reactive protein (hs-CRP) as the construct validator.DesignUsing data derived from (i) three 24 h dietary recalls (24HR) at baseline and at the end of each subsequent quarter (i.e. up to fifteen over a year) and (ii) a 7 d dietary recall (7DDR) measured at baseline and then quarterly, regression analyses were conducted to test the effect of the DII score on serum hs-CRP as dichotomous (≤3 mg/l, >3 mg/l), while controlling for important potential confounders.SettingExisting data from the Seasonal Variation of Blood Cholesterol Study (SEASONS), a longitudinal observational study of healthy participants recruited in Worcester, MA, USA and participants were followed for 1 year.SubjectsParticipants who had at least one hs-CRP measurement over her/his 1-year participation (n495 for 24HR,n559 for 7DDR).ResultsHigher DII scores were associated with values of hs-CRP >3 mg/l (OR = 1·08; 95 % CI 1·01, 1·16,P= 0·035 for the 24HR; and OR = 1·10; 95 % CI 1·02, 1·19,P= 0·015 for the 7DDR).ConclusionsThe population-based DII was associated with interval changes in hs-CRP using both the 24HR and 7DDR. The success of this first-of-a-kind attempt at relating individuals’ intakes of inflammation-modulating foods using this refined DII, and the finding that there is virtually no drop-off in predictive capability using a structured questionnaire in comparison to the 24HR standard, sets the stage for use of the DII in a wide variety of other epidemiological and clinical studies.

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