scholarly journals Studying Effects of Laser Penetration-Depth and Temperature on the Stability of Gabapentin-Loaded Au Nanoparticles

2021 ◽  
Author(s):  
Zhenli Wei ◽  
Reza Tayebee ◽  
Ehsan Koushki
Keyword(s):  
Drug Release ◽  
Laser Beam ◽  
Penetration Depth ◽  
Metallic Nanoparticles ◽  
Green Laser ◽  
Effect Of Temperature ◽  
Chicken Breast ◽  
Primary Position ◽  
Au Nps ◽  
Drug Molecules

Abstract Herein, release of gabapentin molecules from gold nanoparticles (Au NPs) is studied by using two kinds of laser beams. The first is a green laser, which matches well with the frequency of the Au NPs’ SPR and the second is a red laser that has the longest penetration depth in the tissue. Au NPs are synthesized by the Turkevich method and characterized with different techniques such as FT-IR, XRD, TEM, UV-VIS, and DLS. Then, the effects of two green and red lasers as well as temperature are investigated in the delivery of gabapentin drug molecules from Au NPs. Slices of chicken breast muscle with different thicknesses are also used in order to disclose an experimental condition close to the in vivo study. The drug release amount is, then, correlated with the return of the absorption-peak to its primary position. The effects of temperature and penetration depth of the laser beam investigated on the UV-VIS spectrum of Au NPs and the results are compared to attain the best release conditions. It is found that although the green laser is better than the red one to stimulate the SPR of Au NPs, however, the red laser is preferred for the drug delivery purposes due to its greater penetration depth. Also, increasing the temperature of the capped nanocolloid enhances the rate of drug release by the laser irradiation. Therefore, this investigation is helpful to understand the effect of temperature and a red laser beam on different metallic nanoparticles carrying drug molecules.

scholarly journals Luminescence from Droplet-Etched GaAs Quantum Dots at and Close to Room Temperature

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 690
Author(s):  
Leonardo Ranasinghe ◽  
Christian Heyn ◽  
Kristian Deneke ◽  
Michael Zocher ◽  
Roman Korneev ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Penetration Depth ◽  
Gaas Substrate ◽  
Room Temperature ◽  
Green Laser ◽  
Significant Loss ◽  
Blue Laser ◽  
Ambient Conditions ◽  
Thermal Escape ◽  
Intensity Loss

Epitaxially grown quantum dots (QDs) are established as quantum emitters for quantum information technology, but their operation under ambient conditions remains a challenge. Therefore, we study photoluminescence (PL) emission at and close to room temperature from self-assembled strain-free GaAs quantum dots (QDs) in refilled AlGaAs nanoholes on (001)GaAs substrate. Two major obstacles for room temperature operation are observed. The first is a strong radiative background from the GaAs substrate and the second a significant loss of intensity by more than four orders of magnitude between liquid helium and room temperature. We discuss results obtained on three different sample designs and two excitation wavelengths. The PL measurements are performed at room temperature and at T = 200 K, which is obtained using an inexpensive thermoelectric cooler. An optimized sample with an AlGaAs barrier layer thicker than the penetration depth of the exciting green laser light (532 nm) demonstrates clear QD peaks already at room temperature. Samples with thin AlGaAs layers show room temperature emission from the QDs when a blue laser (405 nm) with a reduced optical penetration depth is used for excitation. A model and a fit to the experimental behavior identify dissociation of excitons in the barrier below T = 100 K and thermal escape of excitons from QDs above T = 160 K as the central processes causing PL-intensity loss.

Synthesis, characterization and drug release studies of poly(2-hydroxyethyl methacrylate)/KIT-5 nanocomposite as an innovative organic–inorganic hybrid carrier system

RSC Advances ◽  
2015 ◽  
Vol 5 (16) ◽  
pp. 12463-12471 ◽  
Author(s):  
Roozbeh Javad Kalbasi ◽  
Ali Zirakbash
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Hybrid Material ◽  
Great Promise ◽  
Hydroxyethyl Methacrylate ◽  
Carrier System ◽  
Inorganic Hybrid ◽  
Drug Molecules ◽  
System P ◽  
Release Studies

PHEMA/KIT-5 with various pore sizes was prepared. Efficient encapsulation of drug molecules inside the pores of the hybrid material and controlled release of them in an aqueous medium, suggest the great promise of the composite as a carrier system.

A centrifuge-based stepwise chemical loading disc for the production of multiplex anisotropic metallic nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (3) ◽  
pp. 1846-1851 ◽  
Author(s):  
Byung Hyun Park ◽  
Ji Hyun Lee ◽  
Jae Hwan Jung ◽  
Seung Jun Oh ◽  
Doh C. Lee ◽  
...  
Keyword(s):  
High Throughput ◽  
Metallic Nanoparticles ◽  
Au Nps ◽  
High Throughput Manner ◽  
Chemical Loading

We have proposed a novel rotary microdevice in which multiplex anisotropic Au NPs could be synthesized under diverse conditions in a high-throughput manner.

scholarly journals Chemiluminescence-initiated and in situ-enhanced photoisomerization for tissue-depth-independent photo-controlled drug release

2019 ◽  
Vol 10 (5) ◽  
pp. 1401-1409 ◽  
Author(s):  
Yufu Tang ◽  
Xiaomei Lu ◽  
Chao Yin ◽  
Hui Zhao ◽  
Wenbo Hu ◽  
...  
Keyword(s):  
Drug Release ◽  
Penetration Depth ◽  
Controlled Drug Release ◽  
Tissue Penetration

Tissue-penetration-depth-independent self-luminescence is highly expected to perform photoisomerization-related bioapplications in vivo to overcome the limitation of shallow tissue-penetration from external photoexcitation.

scholarly journals Spectroscopic closed loop control of penetration depth in laser beam welding process

2012 ◽  
Author(s):  
Teresa Sibillano ◽  
Antonio Ancona ◽  
Domenico Rizzi ◽  
Francesco Mezzapesa ◽  
Ali Riza Konuk ◽  
...  
Keyword(s):  
Laser Beam ◽  
Penetration Depth ◽  
Closed Loop ◽  
Laser Beam Welding ◽  
Welding Process ◽  
Closed Loop Control ◽  
Loop Control

scholarly journals Elucidating the Drug Release from Metal-Organic Framework Nanocomposites via in Situ Synchrotron Microspectroscopy and Theoretical Modelling

2019 ◽  
Author(s):  
Barbara Souza ◽  
Lorenzo Dona ◽  
Kirill Titov ◽  
Paolo Bruzzese ◽  
Zhixin Zeng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Density Functional ◽  
Metal Organic Framework ◽  
Density Functional Theory Calculations ◽  
Theoretical Modelling ◽  
Time Resolved ◽  
Drug Molecules ◽  
Metal Organic

Nanocomposites comprising metal-organic frameworks (MOFs) embedded in a polymeric matrix are promising carriers for drug delivery applications. While understanding the chemical and physical transformations of MOFs during the release of confined drug molecules is challenging, this is central to devising better ways for controlled release of therapeutic agents. Herein we demonstrate the efficacy of synchrotron microspectroscopy to track the in situ release of 5-fluorouracil (5-FU) anticancer drug molecules from a drug@MOF/polymer composite (5-FU@HKUST-1/polyurethane). Using experimental time-resolved infrared spectra jointly with newly developed density functional theory calculations, we reveal the detailed dynamics of vibrational motions underpinning the dissociation of 5-FU bound to the framework of HKUST-1 upon water exposure. We discover that HKUST-1 creates hydrophilic channels within the hydrophobic polyurethane matrix hence helping to tune drug release rate. The synergy between a hydrophilic MOF with a hydrophobic polymer can be harnessed to engineer a tunable nanocomposite that alleviates the unwanted burst effect commonly encountered in drug delivery.<br>

scholarly journals Elucidating the Drug Release from Metal-Organic Framework Nanocomposites via in Situ Synchrotron Microspectroscopy and Theoretical Modelling

2019 ◽  
Author(s):  
Barbara Souza ◽  
Lorenzo Dona ◽  
Kirill Titov ◽  
Paolo Bruzzese ◽  
Zhixin Zeng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Density Functional ◽  
Metal Organic Framework ◽  
Density Functional Theory Calculations ◽  
Theoretical Modelling ◽  
Time Resolved ◽  
Drug Molecules ◽  
Metal Organic

Nanocomposites comprising metal-organic frameworks (MOFs) embedded in a polymeric matrix are promising carriers for drug delivery applications. While understanding the chemical and physical transformations of MOFs during the release of confined drug molecules is challenging, this is central to devising better ways for controlled release of therapeutic agents. Herein we demonstrate the efficacy of synchrotron microspectroscopy to track the in situ release of 5-fluorouracil (5-FU) anticancer drug molecules from a drug@MOF/polymer composite (5-FU@HKUST-1/polyurethane). Using experimental time-resolved infrared spectra jointly with newly developed density functional theory calculations, we reveal the detailed dynamics of vibrational motions underpinning the dissociation of 5-FU bound to the framework of HKUST-1 upon water exposure. We discover that HKUST-1 creates hydrophilic channels within the hydrophobic polyurethane matrix hence helping to tune drug release rate. The synergy between a hydrophilic MOF with a hydrophobic polymer can be harnessed to engineer a tunable nanocomposite that alleviates the unwanted burst effect commonly encountered in drug delivery.<br>

Drug-loaded ultrafine poly(vinyl alcohol) fibre mats prepared by electrospinning

e-Polymers ◽  
2005 ◽  
Vol 5 (1) ◽  
Author(s):  
Chunxue Zhang ◽  
Xiaoyan Yuan ◽  
Lili Wu ◽  
Jing Sheng
Keyword(s):  
Drug Release ◽  
Photoelectron Spectroscopy ◽  
Vinyl Alcohol ◽  
Phosphate Buffer Solution ◽  
Poly Vinyl Alcohol ◽  
High Porosity ◽  
Buffer Solution ◽  
Drug Molecules ◽  
Alcohol Fibre

AbstractSubmicron poly(vinyl alcohol) (PVA) fibre mats embedded with Aspirin and bovine serum albumin (BSA) were prepared by electrospinning of their aqueous solutions. Fibre morphology was investigated by scanning electron microscopy. The composition of the fibre mats was characterized by Fourier transform IR spectroscopy and X-ray photoelectron spectroscopy. The in vitro drug release was investigated by immersing the fibre mats in phosphate buffer solution at 37°C. Results indicated that the morphology of fibre mats was influenced by the amount of drug, and more beaded and irregularly shaped fibres were found with increasing drug amounts. There were drug molecules distributed on the surface of the PVA fibres. Studies of in vitro drug release showed that both Aspirin and BSA were released more quickly from PVA fibre mats than from PVA films because of the large surface area and high porosity of the fibre mats.

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