scholarly journals Computer Modeling of Carotid Endarterectomy With the Different Shape Patches and Prediction of the Atherosclerotic

2022 ◽  
Author(s):  
Vladimir Geraldovich Borisov ◽  
Yuri Nikolaevich Zakharov ◽  
Anton Nilolaevich Kazantsev ◽  
Alexander Vladimirovich Korotkikh ◽  
Yuri Ivanovich Shokin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Comparative Evaluation ◽  
Vessel Wall ◽  
Carotid Bifurcation ◽  
Doppler Velocimetry ◽  
Optimal Variant ◽  
Risk Zones ◽  
Using Data ◽  
Reconstructed Model ◽  
Results Of Surgery

Abstract Objective: The article describes a method for constructing geometric models of the carotid bifurcation and computer simulation of endarterectomy surgery with the patches of various configurations. The purpose of this work is to identify the areas of the greatest risk of restenosis in the constructed models and to conduct a comparative analysis of risk factors when using the patches of different widths and shapes. Methods: The method is demonstrated on a reconstructed model of a healthy vessel. Its building is based on a preoperative computed tomography study of a particular patient's affected vessel. The flow in the vessel is simulated by computational fluid dynamics using data from the patient's ultrasound Doppler velocimetry. Risk factors are assessed through the hemodynamic indices on the vessel wall associated with Wall Shear Stress. Results: The distribution of risk zones in the healthy vessel, presumably leading to its observed lesion (plaque), is analyzed. Comparative evaluation of 10 various patches implantation results is carried out and the optimal variant is determined. The proposed method can be used to predict the hemodynamic results of surgery using patches of various sizes and shapes.

Apolipoprotein(a), Fibrinopeptide A and Carotid Atherosclerosis in Middle-Aged Men

1994 ◽  
Vol 72 (04) ◽  
pp. 563-566 ◽  
Author(s):  
Tuomo Rankinen ◽  
Sari Väisänen ◽  
Michele Mercuri ◽  
Rainer Rauramaa
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Carotid Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Bifurcation ◽  
Carotid Intima Media Thickness ◽  
Fibrinopeptide A ◽  
Carotid Imt ◽  
Apolipoprotein A ◽  
The Difference

SummaryThe association between apolipoprotein(a) [apo(a)], fibrinogen, fibrinopeptide A (FPA) and carotid intima-media thickness (IMT) was analyzed in Eastern Finnish men aged 50 to 60 years. Apo(a) correlated directly with carotid bifurcation (r = 0.26, p = 0.001), but not with common carotid IMT. Men in the lowest quartile of apo(a) had thinner (p = 0.013) IMT in bifurcation [1.59 mm (95% Cl 1.49; 1.68)] compared to the men in the highest [1.91 mm (95% Cl 1.73; 2.09)] apo(a) quartile. The difference remained (p=0.038) after adjusting for confounders. Plasma fibrinogen was not related to carotid IMT, whereas FPA correlated with common carotid (r = 0.21, p = 0.016) and carotid bifurcation (r = 0.21, p = 0.018) IMT. These associations abolished after adjusting for the confounders. The data suggest that apo(a) associate with carotid atherosclerosis independent of other risk factors for ischemic cardiovascular diseases.

scholarly journals High-Resolution Vessel Wall Magnetic Resonance Imaging of Small Unruptured Intracranial Aneurysms

2021 ◽  
Vol 10 (2) ◽  
pp. 225
Author(s):  
Łukasz Zwarzany ◽  
Ernest Tyburski ◽  
Wojciech Poncyljusz
Keyword(s):  
Magnetic Resonance Imaging ◽  
Risk Factors ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Vessel Wall ◽  
Intracranial Aneurysms ◽  
Aneurysm Rupture ◽  
Resonance Imaging ◽  
Aneurysm Wall ◽  
Conventional Risk Factors

Background: We decided to investigate whether aneurysm wall enhancement (AWE) on high-resolution vessel wall magnetic resonance imaging (HR VW-MRI) coexists with the conventional risk factors for aneurysm rupture. Methods: We performed HR VW-MRI in 46 patients with 64 unruptured small intracranial aneurysms. Patient demographics and clinical characteristics were recorded. The PHASES score was calculated for each aneurysm. Results: Of the 64 aneurysms, 15 (23.4%) showed wall enhancement on post-contrast HR VW-MRI. Aneurysms with wall enhancement had significantly larger size (p = 0.001), higher dome-to-neck ratio (p = 0.024), and a more irregular shape (p = 0.003) than aneurysms without wall enhancement. The proportion of aneurysms with wall enhancement was significantly higher in older patients (p = 0.011), and those with a history of prior aneurysmal SAH. The mean PHASES score was significantly higher in aneurysms with wall enhancement (p < 0.000). The multivariate logistic regression analysis revealed that aneurysm irregularity and the PHASES score are independently associated with the presence of AWE. Conclusions: Aneurysm wall enhancement on HR VW-MRI coexists with the conventional risk factors for aneurysm rupture.

scholarly journals Risk factors for severity on admission and the disease progression during hospitalisation in a large cohort of patients with COVID-19 in Japan

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e047007
Author(s):  
Mari Terada ◽  
Hiroshi Ohtsu ◽  
Sho Saito ◽  
Kayoko Hayakawa ◽  
Shinya Tsuzuki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mechanical Ventilation ◽  
Chronic Respiratory Disease ◽  
Major Effect ◽  
Secondary Outcome ◽  
Healthcare Facilities ◽  
Wide Range ◽  
Registration Number ◽  
Using Data ◽  
Obesity Hypertension

ObjectivesTo investigate the risk factors contributing to severity on admission. Additionally, risk factors of worst severity and fatality were studied. Moreover, factors were compared based on three points: early severity, worst severity and fatality.DesignAn observational cohort study using data entered in a Japan nationwide COVID-19 inpatient registry, COVIREGI-JP.SettingAs of 28 September 2020, 10480 cases from 802 facilities have been registered. Participating facilities cover a wide range of hospitals where patients with COVID-19 are admitted in Japan.ParticipantsParticipants who had a positive test result on any applicable SARS-CoV-2 diagnostic tests were admitted to participating healthcare facilities. A total of 3829 cases were identified from 16 January to 31 May 2020, of which 3376 cases were included in this study.Primary and secondary outcome measuresPrimary outcome was severe or nonsevere on admission, determined by the requirement of mechanical ventilation or oxygen therapy, SpO2 or respiratory rate. Secondary outcome was the worst severity during hospitalisation, judged by the requirement of oxygen and/orinvasive mechanical ventilation/extracorporeal membrane oxygenation.ResultsRisk factors for severity on admission were older age, men, cardiovascular disease, chronic respiratory disease, diabetes, obesity and hypertension. Cerebrovascular disease, liver disease, renal disease or dialysis, solid tumour and hyperlipidaemia did not influence severity on admission; however, it influenced worst severity. Fatality rates for obesity, hypertension and hyperlipidaemia were relatively lower.ConclusionsThis study segregated the comorbidities influencing severity and death. It is possible that risk factors for severity on admission, worst severity and fatality are not consistent and may be propelled by different factors. Specifically, while hypertension, hyperlipidaemia and obesity had major effect on worst severity, their impact was mild on fatality in the Japanese population. Some studies contradict our results; therefore, detailed analyses, considering in-hospital treatments, are needed for validation.Trial registration numberUMIN000039873. https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000045453

scholarly journals Performance and problems of the housing sphere in Russia

2018 ◽  
Vol 251 ◽  
pp. 06029
Author(s):  
Ekaterina Dmitrieva
Keyword(s):  
Risk Factors ◽  
Risk Prevention ◽  
Effective Management ◽  
Risk Zones ◽  
The Creation ◽  
Further Development

Systematization of risks in the field of housing-and-communal services and recommendations on the neutralization of problem zones were offered. The objective is the diagnostics of the situation in the sphere of housing-and-communal services and the identification of risk zones. The author concludes that the information on risk factors is necessary for the creation of the system of risk prevention, and assumes further development of the measures for the effective management in this sector.

scholarly journals Intracranial arterial aneurysms in childhood: case report

2006 ◽  
Vol 64 (3a) ◽  
pp. 676-680 ◽  
Author(s):  
Fernando Campos Gomes Pinto ◽  
Leandro Valiengo ◽  
Pedro Paulo Mariani Lima Santos ◽  
Hamilton Matushita ◽  
José Píndaro Pereira Plese
Keyword(s):  
Case Report ◽  
Cerebral Aneurysm ◽  
Operative Technique ◽  
Vessel Wall ◽  
Internal Carotid ◽  
Carotid Bifurcation ◽  
Early Surgery ◽  
Arterial Aneurysm ◽  
Intraoperative Rupture ◽  
Arterial Aneurysms

A case of an intracranial arterial aneurysm at internal carotid bifurcation in a 10-year-old girl is described with the special features of cerebral aneurysm which occur in children, comparing with the adults. We alert for the necessity of carefully operative technique in order to avoid damage and intraoperative rupture of the aneurysm due to the very thin vessel wall that this population can develop. Our recommendation is early surgery in these patients.

Peripheral arterial disease and Virchow’s triad

2009 ◽  
Vol 101 (06) ◽  
pp. 1032-1040 ◽  
Author(s):  
Philip Bennett ◽  
Stanley Silverman ◽  
Paramjit Gill ◽  
Gregory Lip
Keyword(s):  
Risk Factors ◽  
Peripheral Arterial Disease ◽  
Vessel Wall ◽  
Clinical Utility ◽  
Thrombus Formation ◽  
Arterial Disease ◽  
Blood Constituents ◽  
Global Health Care ◽  
Considerable Morbidity ◽  
Peripheral Arterial

SummaryPeripheral arterial disease (PAD) is an important global health-care problem associated with considerable morbidity and mortality. This disease is an important manifestation of atherosclerosis and the pathophysiological processes involved in its development, progression and complications are atherothrombosis and thromboembolism. Over 150 years ago, Virchow described a triad of abnormalities (abnormal blood flow, abnormal vessel wall and abnormal blood constituents) associated with thrombus formation (thrombogenesis). An improvement in biochemical techniques has allowed quantification of various components of Virchow’s triad, and as a consequence, there has been increasing interest in the measurement of such biomarkers in understanding the development and progression of PAD, as well as its symptomatic complications. This review discusses quantifiable components of Virchow’s triad that have been associated with PAD and their clinical utility as risk factors for PAD.

scholarly journals Analysis Factors That Affecting the Incidence of Hypertension in Menopausal Woman

2020 ◽  
Vol 6 (1) ◽  
pp. 21-25
Author(s):  
Estin Gita Maringga ◽  
Nunik Ike Yunia Sari
Keyword(s):  
Risk Factors ◽  
Statistical Data ◽  
Free Variable ◽  
Hormonal Contraceptives ◽  
Menopausal Woman ◽  
Cross Sectional ◽  
Menopausal Women ◽  
History Of ◽  
Using Data ◽  
The Village

Hypertension is an increased incidence of blood pressure characterized by the increase of sistole and diastole. Hypertension if not properly administered, can cause a variety of complications such as stroke, heart failure, renal failure, encephalopathy, and others. Based on the statistical data of menopause women risk to experience hypertension of 41% compared with males. This research aims to analyze the risk factors that affect the incidence of hypertension in menopausal women in the village Kayen Kidul. The design of research in this study uses cross sectional, with the population is all menopause women who have hypertension in the village of South Kayen, using simple random samplling technique, obtained as many as 71 respondents . The variables in this study consist of a free variable that is age and a history of the use of KB and variables bound in the form of hypertension in menopausal women. The study was conducted on 16-21 September 2019, collecting data using interview and observation techniques using data collection sheets. Data analysts use linear regression, with calculations using SPSS. The results in this study were obtained from 71 respondents, 59.2% of the mother aged < 60 years, 69% had a history of hormonal contraceptives, 57.6% menopause had hypertension. The aged menopause ≥ 60 years and has a history of hormonal contraceptives have a greater risk of hypertensive incidence in menopause.

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