scholarly journals The association between triglycerides and ectopic fat obesity: An inverted U-shaped curve

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0243068
Author(s):  
Yang Zou ◽  
Guotai Sheng ◽  
Meng Yu ◽  
Guobo Xie
Keyword(s):  
Inflection Point ◽  
Generalized Additive Model ◽  
Additive Model ◽  
Smooth Curve ◽  
Cross Sectional Study ◽  
Ectopic Fat ◽  
Sectional Study ◽  
Cross Sectional ◽  
Adult Participants ◽  
Study Population

Background Ectopic fat obesity and triglycerides are risk factors for diabetes and multiple cardiovascular diseases. However, there have been limited studies on the association between triglycerides and ectopic fat obesity. The purpose of this study was to explore the association between triglycerides and ectopic fat obesity. Methods and results In this cross-sectional study, we retrospectively analyzed 15464 adult participants recruited by Murakami Memorial Hospital (8430 men and 7034 women, average age of 43.71 ± 8.90). All patients were divided into two groups according to the threshold used to diagnose hypertriglyceridemia. The logistic regression model was used to analyze the association between triglycerides and the risk of ectopic fat obesity, and the generalized additive model was used to identify the nonlinear association. In this study population, the prevalence of ectopic fat obesity was 17.73%. After adjusting other covariables, triglycerides were positively correlated with the risk of ectopic fat obesity (OR: 1.54, 95% CI:1.41–1.69, P<0.0001). Through smooth curve fitting, we found that there was an inverted U-shaped curve association between triglycerides and ectopic fat obesity. This association remained unchanged even if the adjusted covariables were removed from the model, and the inflection point of the curve was 3.98. When triglyceride levels were ≤3.98, triglycerides were positively correlated with the risk of ectopic fat obesity (OR:1.784, 95% CI:1.611–1.975, P<0.0001). When triglyceride levels were >3.98 (right side of the inflection point), there was a negative correlation (OR:0.519, 95% CI:0.333–0.810, P = 0.0039). Conclusions Our research showed that there is a significant association between triglycerides and ectopic fat obesity. This relation is not a simple linear relationship but instead an inverted U-shaped curve association.

scholarly journals The Connection Between Triglycerides and Ectopic Fat Obesity: An Inverted U-Shaped Curve

2020 ◽  
Author(s):  
Yang Zou ◽  
Meng Yu ◽  
Guotai Sheng ◽  
Guobo Xie
Keyword(s):  
Inflection Point ◽  
Additive Model ◽  
Smooth Curve ◽  
Cross Sectional Study ◽  
Ectopic Fat ◽  
Cross Sectional ◽  
Adult Participants ◽  
Study Population ◽  
The Right ◽  
The Relationship

Abstract Background: Ectopic fat obesity and Triglycerides are risk factors for diabetes and multiple cardiovascular diseases, but the data on the relationship between Triglycerides and the risk of ectopic fat obesity are limited. The purpose of this study is to explore the connection between Triglycerides and ectopic fat obesity.Methods: This is a cross-sectional study, we retrospectively analyzed 15464 adult participants recruited by Murakami Memorial Hospital from 2004-2015(8430 men and 7034 women, average age 43.71±8.9), to performed the relationship between Triglycerides and ectopic fat obesity, we divided all patients into 4 groups according to the quartile of Triglycerides. Logistic regression model was used to analyze the relationship between Triglycerides and the risk of ectopic fat obesity, and the generalized additive model was used to identify the nonlinear relationship.Results: In the study population, the prevalence of ectopic fat obesity was 17.73%, and gradually increased in the quartile of Triglycerides (2.86,7.89,18.25 and 41.22% respectively, P < 0.001).After adjusting other covariables, Triglycerides was positively correlated with the risk of ectopic fat obesity (OR:1.55,95%CI:1.41-1.69, p<0.00001). Then we carried out smooth curve fitting and found that there was an inverted U-shaped curve relationship between Triglycerides and ectopic fat obesity, even if those adjusted covariables were removed from the model, the result remained unchanged, and the inflection point of the curve was 3.98. On the left side of the inflection point, Triglycerides was positively correlated with the risk of ectopic fat obesity(OR:1.784,95%CI:1.611-1.975,p<0.0001), while on the right side of the inflection point, there was a negative correlation (OR:0.519,95%CI:0.333-0.810,p=0.0039).Conclusions: Our research shows that there is a significant correlation between Triglycerides and ectopic fat obesity, this relation is not a simple linear relationship, but it was an inverted U-shaped curve relationship.

scholarly journals Cow’s milk exposure and atopic dermatitis after six months of age

2017 ◽  
Vol 56 (6) ◽  
pp. 325
Author(s):  
Surya Jayanti Kadek ◽  
Dewi Kumara Wati Ketut ◽  
Karyana Putu Gede
Keyword(s):  
Atopic Dermatitis ◽  
Maternal Diet ◽  
Multiple Logistic Regression Analysis ◽  
Cross Sectional Study ◽  
Cow’S Milk ◽  
Milk Formula ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cow's Milk ◽  
Study Population

Background About 60% of individuals with atopic dermatitis (AD) develop their first manifestation during infancy. Cow’s milk (CM) exposure is considered to be a risk factor for AD.Objective To evaluate for an association between cow’s milk exposure and atopic dermatitis in infants > 6 months of age.  Methods This cross-sectional study consisted of subjects from a previous study and new subjects recruited in order to meet the minimum required number of subjects. Our study population comprised 120 infants, born between 1 February and 30 November, 2012 in Sanglah Hospital, Denpasar. Subjects were divided into CM and non-CM groups and analyzed for their risk of AD. Subjects were included to CM group if they were fed with cow’s milk/formula  and included to non-CM group if they were breastfeed exclusively in the first six months of life. Other possible risk factors were assessed by multivariate analysis. Results One hundred twenty subjects were enrolled and analyzed (59 in the CM and 61 in the non-CM groups). The prevalence of AD was 30%. Multiple logistic regression analysis revealed a significant association between CM exposure and AD, with odds ratio (OR) 2.37 (95%CI 1.036 to 5.420; P=0.04). In addition, maternal diet including eggs and/or cow’s milk during the breastfeeding period was significantly associated with AD in infants (OR 3.18; 95%CI 1.073 to 9.427; P=0.04).Conclusion Cow’s milk exposure is significantly associated with atopic dermatitis in infants  > six months of age. 

scholarly journals Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 360
Author(s):  
Ola Hysaj ◽  
Patricia Marqués-Gallego ◽  
Aline Richard ◽  
Magdeldin Elgizouli ◽  
Alexandra Nieters ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Inflection Point ◽  
Demographic Data ◽  
Late Pregnancy ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
25 Hydroxy Vitamin D ◽  
Maximal Suppression

We aimed to assess the parathyroid hormone (PTH) concentration in pregnant women at the beginning of pregnancy (1st trimester) and within days before delivery (3rd trimester) and evaluate its determinants. From September 2014 through December 2015 in a cross-sectional study, 204 women in the 1st trimester of pregnancy and 203 women in the 3rd trimester of pregnancy were recruited. Blood samples were collected to measure PTH and circulating 25-hydroxy-vitamin D (25(OH)D) concentrations. Lifestyle and demographic data were collected using a questionnaire. Serum 25(OH)D and PTH were inversely correlated in both early and late pregnancy. Our analyses suggest that in the 3rd trimester of pregnancy, a 25(OH)D level of 18.9 ng/mL (47.3 nmol/L) could serve as an inflection point for the maximal suppression of PTH. Statistically significant determinants of PTH concentrations in multiple regression were 25(OH)D concentrations, season, multiparity and education of the partner (all p < 0.05) in early pregnancy. In late pregnancy, 25(OH)D concentrations and country of origin were statistically significant determinants of PTH concentrations (all p < 0.05). These factors and their effect on PTH appear to be vastly determined by 25(OH)D; however, they might also affect PTH through other mechanisms besides 25(OH)D.

scholarly journals A cross sectional study to assess the prevalence and associated factors of computer vision syndrome among engineering students of Hyderabad, Telangana

2018 ◽  
Vol 6 (1) ◽  
pp. 308
Author(s):  
Anupama Pulla ◽  
Asma . ◽  
Nanduri Samyuktha ◽  
Soumya Kasubagula ◽  
Aishwarya Kataih ◽  
...  
Keyword(s):  
Computer Vision ◽  
Engineering Students ◽  
Prolonged Exposure ◽  
Significant Proportion ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Computer Vision Syndrome ◽  
Study Population ◽  
Near Work

Background: Computer vision syndrome is a complex of eye and vision problems related to near work which are experienced due to prolonged computer use. Computers demand near work, for longer duration which increases discomfort of eye and prolonged exposure to the discomfort leads to a cascade of symptoms that can be referred as computer vision syndrome. The aims and objectives of the study were to determine the prevalence of computer vision syndrome among engineering students of Hyderabad, Telangana and to determine the factors related to computer vision syndrome among study population.Methods: A cross sectional study was carried out from March to June 2017 among students of an engineering college in Hyderabad, Telangana. A convenient sample of 300 students was taken and a predesigned, pre tested questionnaire was used to obtain information.Results: Majority of study population were males (56.3%). Around 75.1% of study population were using all the electronic gadgets like computers, laptops and smartphones. The prevalence of computer vision syndrome was found to be 60.3%. Around 46.7% of study population viewed the screen from a distance of 22-40 centimeters.Conclusions: As students pursuing engineering stream are the future IT and Computer software engineers, preventive strategies adopted by them will significantly decrease the burden of computer vision syndrome and improve productivity. In this study a significant proportion of the engineering students were found to be having vision problems, which emphasizes the need to adopt preventive measures to avoid computer vision syndrome. 

scholarly journals Costs of reusable and disposable aprons in a public teaching hospital

2014 ◽  
Vol 48 (5) ◽  
pp. 915-921
Author(s):  
Paloma de Souza Cavalcante Pissinati ◽  
Maria do Carmo Lourenço Haddad ◽  
Mariana Ângela Rossaneis ◽  
Roseli Broggi Gil ◽  
Renata Aparecida Belei
Keyword(s):  
Direct Cost ◽  
Teaching Hospital ◽  
Average Cost ◽  
Secondary Data ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hospital Managers ◽  
Study Population ◽  
The Cost

Objective To analyze the direct cost of reusable and disposable aprons in a public teaching hospital. Method Cross-sectional study of quantitative approach, focusing on the direct cost of reusable and disposable aprons at a teaching hospital in northern Paraná. The study population consisted of secondary data collected in reports of the cost of services, laundry, materials and supplies division of the institution for the year 2012 Results We identified a lower average cost of using disposable apron when compared to the reusable apron. The direct cost of reusable apron was R$ 3.06, and the steps of preparation and washing were mainly responsible for the high cost, and disposable apron cost was R$ 0.94. Conclusion The results presented are important for hospital managers properly allocate resources and manage costs in hospitals
.

scholarly journals Dentition status and treatment needs of human immunodeficiency virus-positive patients on anti retro viral therapy in Raichur taluk, Karnataka, India: A cross sectional study

2017 ◽  
Vol 11 (02) ◽  
pp. 238-241 ◽  
Author(s):  
Shrikanth Muralidharan ◽  
Arunkumar Acharya ◽  
Shanthi Margabandhu
Keyword(s):  
Dental Caries ◽  
Cross Sectional Study ◽  
Hiv Positive ◽  
Sectional Study ◽  
Treatment Needs ◽  
Cross Sectional ◽  
Viral Therapy ◽  
Immunodeficiency Virus ◽  
Study Population ◽  
Convenience Sampling

ABSTRACTObjective: The aim of the study was to assess the dentition status and the treatment needs of the HIV-positive patients on ART for more than a year in Raichur, Karnataka. Materials and Methods: Convenience sampling was followed. The sample size was 170. The dentition status and treatment needs of the patients were recorded as per the WHO guidelines. Results: The overall prevalence of dental caries was 79.4%. Males had higher percentage of dental caries than the females, and this was found to be statistically significant. The prevalence of dental caries was higher among the participants who used finger to clean their teeth compared to the toothbrush, neem stick, and charcoal users, and this was found to be statistically significant. Conclusion: Higher prevalence of dental caries was observed among the study population. Most of them required some type of treatment. Patients with a low CD4 count required higher treatments than the others.

scholarly journals A cross sectional study on knowledge, attitude, practice regarding emergency contraception

2018 ◽  
Vol 7 (7) ◽  
pp. 2869
Author(s):  
Jahnavi Putchakayala ◽  
Manjula Rao ◽  
Prashanthy Edwards ◽  
Mini Mohan
Keyword(s):  
Emergency Contraception ◽  
Economic Status ◽  
Unwanted Pregnancy ◽  
Medical Personnel ◽  
Time Frame ◽  
Cross Sectional Study ◽  
Contraceptive Device ◽  
Sectional Study ◽  
Cross Sectional ◽  
Study Population

Background: Emergency contraception (EC) is the contraception administered to a woman after unprotected intercourse. This study aims to assess the knowledge, attitude, practice of emergency contraception among patients of 15-45 years attending Obstetrics and Gynaecology outpatient department.Methods: A cross sectional study was conducted in Durgabai Deshmukh Hospital, Hyderabad during June 2014 to June 2016. This study included 300 women. A pre structured questionnaire was employed after obtaining informed written valid consent from the patient and institutional ethical committee clearance. Data on age, socio economic status, education, religion, marital status, their knowledge, attitude, practice regarding emergency contraception was obtained, tabulated and analysed using chi-square test.Results: Out of 300 women, 52% belong to 15-25 years, 31% belong to 26-35 years, 17% belong to 36-45 years. 21.6% of the study population heard of EC. Among these 51% heard from media, 24% from friends, 25% from medical personnel. 18.6% of the study population knew the correct time frame of use, knew that is not an abortion pill, effective in preventing pregnancy, could not prevent the spread of sexually transmitted diseases. 85% of the study population have positive attitude. 14.6% of the population practiced EC. Out of them 88% have used emergency contraceptive pills, 12% have used Intra uterine contraceptive device. 77% got EC over the counter, 23% got through prescription.Conclusions: The study highlights the need to motivate women for effective and appropriate use of emergency contraception when required and arrest the trend towards unwanted pregnancy.

scholarly journals Thyroid dysfunction and electrocardiographic changes in subjects without arrhythmias: a cross-sectional study of primary healthcare subjects from Copenhagen

BMJ Open ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. e023854 ◽  
Author(s):  
Bhupendar Tayal ◽  
Claus Graff ◽  
Christian Selmer ◽  
Kristian Hay Kragholm ◽  
Magnus Kihlstrom ◽  
...  
Keyword(s):  
Heart Rate ◽  
Primary Healthcare ◽  
Thyroid Dysfunction ◽  
Low Voltage ◽  
Study Groups ◽  
Cross Sectional Study ◽  
Qtc Interval ◽  
Sectional Study ◽  
Cross Sectional ◽  
Study Population

ObjectiveThe objective of the present study was to investigate associations of both overt and subclinical thyroid dysfunction with common ECG parameters in a large primary healthcare population.DesignCross-sectional study.Setting and participantsThe study population comprised of primary healthcare patients in Copenhagen, Denmark, who had a thyroid function test and an ECG recorded within 7 days of each other between 2001 and 2011.Data sourcesThe Danish National Patient Registry was used to collect information regarding baseline characteristics and important comorbidities.Outcome measure and study groupsCommon ECG parameters were determined using Marquette 12SL software and were compared between the study groups. The study population was divided into five groups based on their thyroid status. Euthyroid subjects served as the reference group in all analyses.ResultsA total of 132 707 patients (age 52±17 years; 50% female) were included. Hyperthyroidism was significantly associated with higher heart rate and prolonged QTc interval with significant interaction with age (p<0.009) and sex (p<0.001). These associations were less pronounced for patients with higher age. Subclinical hyperthyroidism was associated with higher heart rate among females, and a similar trend was observed among males. Hypothyroidism was associated with slower heart rate and shorter QTc but only in women. Moreover, longer P-wave duration, longer PR interval and low voltage were observed in patients with both subclinical and overt hypothyroidism. However, the presence of low voltage was less pronounced with higher age (p=0.001).ConclusionBoth overt and subclinical thyroid disorders were associated with significant changes in important ECG parameters. Age and gender have significant impact on the association of thyroid dysfunction particularly on heart rate and QTc interval.

scholarly journals Oculo-Visual Findings among Industrial Mine Workers at Goldfields Ghana Limited, Tarkwa

2012 ◽  
Vol 4 ◽  
pp. OED.S9204 ◽  
Author(s):  
GO Ovenseri-Ogbomo ◽  
S Ocansey ◽  
EK Abu ◽  
S Kyei ◽  
SB Boadi-Kusi
Keyword(s):  
Visual Impairment ◽  
Demographic Data ◽  
Cross Sectional Study ◽  
Eye Diseases ◽  
Sectional Study ◽  
Cross Sectional ◽  
Visual Status ◽  
Study Population ◽  
The Mean ◽  
Mine Workers

Objective The focus of this study was to evaluate the visual status of mine workers who were directly involved in mining and/or are exposed to the mining environment. Methods A hospital based cross-sectional study was conducted. Four hundred and six (406) workers were conveniently sampled for the study. Information on their socio-demographic data was also collected. In addition, all participants underwent ophthalmic examination. Results The mean age of the workers was 41.1 years. Visual impairment was found in 114 (28.1%) of the study population of which refractive error (56.8%) was the major cause. Presbyopia was also observed in 45.5% of the workers with only 30.3% of them wearing near correction. The prevalence of eye diseases were pterygium/pingueculae (25.8%), conjunctivitis (26.8%), suspected glaucoma (15.3%), and cataract (7.4%). Conclusions Visual impairment and eye diseases were found among the miners.

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