Anxiety, depression and social support in Chinese pregnant women with a history of recurrent miscarriage: a prospective study

Abstract Background: Women with a history of recurrent miscarriage(RM) are a more vulnerable population, caring for the pregnant women with a history of RM is quite needed. Although evidence suggests an association among anxiety, depression and social support. Yet, it is unclear about changes in and relationships between anxiety, depression and social support among the pregnant women with a history of RM throughout the pregnancy period. The aim of this study was to examine the changes in and relationships among anxiety, depression and social support across three trimesters of pregnancy in Chinese women with a history of RM. Methods: A prospective, longitudinal study was employed. The study was carried out between September 2016 and October 2017 in a teaching hospital in Guangzhou, China. A convenience sample of 166 pregnant women with a history of RM completed the measures at their 6-12, 20-24 and 32-36 gestational weeks. data were collected by a master student with Zung Self-Rating Anxiety Scale, the Edinburgh Postnatal Depression Scale, and the Perceived Social Support Scale. Results: Anxiety decreased from the early pregnancy to late pregnancy while depression first declined from early pregnancy to mid-pregnancy then remained to late pregnancy. Social support increased from early pregnancy to mid-pregnancy and then remained to late pregnancy. There were correlations in anxiety, depression and social support across the three trimesters of pregnancy. Conclusions: Anxiety and depression are highly prevalent in pregnant women with a history of RM, especially in early pregnancy, which merits clinical attention. Social support was an important buffer against anxiety and depression across the pregnancy. Interventions targeting women with RM may improve the health outcomes of women and their children.

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Anxiety, depression and social support in pregnant women with a history of recurrent miscarriage: a cross-sectional study

Journal of Reproductive and Infant Psychology ◽

10.1080/02646838.2019.1652730 ◽

2019 ◽

Vol 38 (5) ◽

pp. 497-508 ◽

Cited By ~ 5

Author(s):

Lingling Gao ◽

Jia Qu ◽

Alex Y Wang

Keyword(s):

Social Support ◽

Pregnant Women ◽

Recurrent Miscarriage ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

History Of ◽

Anxiety Depression

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Gene-gene interactions and prevalence of gene polymorphism associated with disorders of hemostasis and folate metabolism in patients with recurrent miscarriage

GYNECOLOGY ◽

10.26442/20795696.2019.2.190345 ◽

2019 ◽

Vol 21 (2) ◽

pp. 18-22

Author(s):

Nataly I Frolova ◽

Tatiana E Belokrinitskaya ◽

Nataliya N Strambovskaya ◽

Evgeniya P Belozertseva

Keyword(s):

Pregnant Women ◽

Spontaneous Abortion ◽

Early Pregnancy ◽

Gene Polymorphisms ◽

Recurrent Miscarriage ◽

Gene Interaction ◽

Control Group ◽

Minor Alleles ◽

History Of ◽

Pai 1

Aim. To assess the association between polymorphisms of FVL-1691G>A, FII-20210G>A, MTHFR-677C>T, MTHFR-1298А>C, РАІ-1-6755G>4G and their combinations in patients with recurrent early pregnancy losses (RPL). Materials and methods. This study included two groups of women (age range 20-35 years): 50 currently non-pregnant women with a history of 2-5 unexplained recurrent early spontaneous abortion and unknown causes of miscarriages (RPL group), and 50 currently non-pregnant women with a history of having given birth to at least one live baby and without a history of spontaneous abortion, preterm labor, stillbirth, preeclampsia and other pregnancy complications (control group). Gene polymorphisms were detected by the technique of polymerase chain reaction-real time. We have analyzed the frequencies, Hardy-Weinberg equilibrium, V-Kramer test, χ2 test, odds ratio (OR) and its 95% confidence interval (95% CI). General (χ2 test, df=2) and multiplicative (χ2 test, df=1) models of inheritance have been used to assess the presence of gene polymorphisms. Results. Significant association between heterozygotes genotype PAI-1-5G4G (72% vs 32%, p=0.000; OR 5.46; 95% CI 2.32-12.87) and RPL was found. Heterozygous genotype FII-20210GA was detected only in RPL group (4% vs 0%). Combinations of genetic polymorphisms of FVL-1691G>A, FII-20210G>A, MTHFR-677C>T, MTHFR-1298А>C, РАІ-1-6755G>4G increase the risk of RPL by 2.4 times (56% vs 20%; χ2=29.20, р=0.000; OR 3.69, 95% CI 1.52-8.97; strong V-Kramer association). The combination of two heterozygotes variants of minor alleles was found to be a risk factor for RPL (34% vs 10%; χ2=8.73, р=0.004; OR 4.64, 95% CI 1.55-3.84). Combined PAI-1-5G4G + FVL-1691GA genotypes was detected only in RPL group of women (2% vs 0%). No significant association between the combination of three heterozygotes variants of minor alleles and RPL. Conclusion. Our data suggest significant gene-gene interaction of the heterozygotes variants of minor alleles of FVL-1691G>A, FII-20210G>A, MTHFR-677C>T, MTHFR-1298А>C, РАІ-1-6755G>4G polymorphisms in patients with recurrent miscarriage. Combined genotypes FVL-1691GA/PAI-1-5G4G can be considered as a genetic molecular predictor of recurrent early pregnancy losses.

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Anxiety, depression and social support across pregnancy in women with a history of recurrent miscarriage: A prospective study

International Journal of Nursing Practice ◽

10.1111/ijn.12997 ◽

2021 ◽

Author(s):

Jia Qu ◽

Xue‐ling Weng ◽

Ling‐ling Gao

Keyword(s):

Social Support ◽

Prospective Study ◽

Recurrent Miscarriage ◽

History Of ◽

A Prospective Study ◽

Anxiety Depression

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Identifying Symptom Clusters Among Pregnant Women During Early and Late Pregnancy

10.21203/rs.3.rs-1048258/v1 ◽

2021 ◽

Author(s):

Yunxue Zhang ◽

Xiaofang Xu ◽

Zihui Xie ◽

Yuanyuan Li ◽

Di Zhao ◽

...

Keyword(s):

Pregnant Women ◽

Early Pregnancy ◽

Late Pregnancy ◽

Symptom Assessment ◽

Optimal Number ◽

Symptom Clusters ◽

Symptom Cluster ◽

Dry Mouth ◽

Convenience Sample ◽

Psychosomatic Symptoms

Abstract Objectives Symptom assessment and management among women in early and late pregnancy remains concerned, in consideration of multiple co-occurring symptoms; however, evaluation of multidimensional nature of symptom experience (e.g., frequency, severity and distress) and relevant symptom cluster among them is insufficient. To shed light on this understudied field, our study investigated the status of multiple psychosomatic symptoms among women and identified symptom clusters in different gestational stages. Methods A convenience sample of 557 pregnant women were recruited at two tertiary hospitals in Shandong, China. They were asked to complete the Memorial Symptom Assessment Scale, and sociodemographic and clinical information. Spearman correlation analysis, partial correlation networks, and hierarchical cluster analysis were carried out to identify optimal number of symptom clusters. Results Top five scores for symptoms in early pregnancy were nausea, lack of appetite, feeling drowsy, lack of energy, and vomiting; and weight gain, difficulty sleeping, sweating, lack of energy, and dry mouth scored highly in late pregnancy. Four clusters (pregnancy reaction symptom cluster, mood-fatigue symptom cluster, change in libido and food taste symptom cluster, and dry mouth-bloating symptom cluster) were identified in early pregnancy, and three clusters (mood-fatigue symptom cluster, sleep-bloating symptom cluster, and fluid deficiency symptom cluster) were determined in late pregnancy. Conclusion Women experience multiple psychosomatic symptoms during pregnancy, and the manifestation of symptoms varies in different stages. Our study has provided new insights into symptom clusters of pregnant women. These results might potentially support the development of assessment and management of multiple co-occurring symptoms in this population.

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Levels of anxiety, depression and denial in patients with myocardial infarction

European Psychiatry ◽

10.1016/s0924-9338(97)80204-0 ◽

1997 ◽

Vol 12 (3) ◽

pp. 149-151 ◽

Cited By ~ 4

Author(s):

D Sarantidis ◽

A Thomas ◽

K Iphantis ◽

N Katsaros ◽

J Tripodianakis ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Intensive Care Unit ◽

Family History ◽

Positive Family History ◽

Anxiety And Depression ◽

Previous Myocardial Infarction ◽

History Of ◽

Seeking Help ◽

Anxiety Depression

SummaryIn this study we investigated 1) the changes in anxiety, depression and denial from admission to discharge in patients admitted to the intensive care unit following an acute myocardial infarction and 2) the effect of smoking habits, time lapsed from the appearance of symptoms to seeking help behavior, presence of a person that motivated the patient to seek help, previous myocardial infarction (MI) and family history of MI, on these changes. The results indicated that 1) the levels of both anxiety and depression increased from admission to discharge, while denial decreased; 2) positive family history of MI was associated with lower difference of denial between admission and discharge.

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Anxiety and depression in children and adolescents with obesity: a nationwide study in Sweden

BMC Medicine ◽

10.1186/s12916-020-1498-z ◽

2020 ◽

Vol 18 (1) ◽

Cited By ~ 9

Author(s):

Louise Lindberg ◽

Emilia Hagman ◽

Pernilla Danielsson ◽

Claude Marcus ◽

Martina Persson

Keyword(s):

Risk Factors ◽

Family History ◽

General Population ◽

Children And Adolescents ◽

Neuropsychiatric Disorders ◽

Obesity Treatment ◽

Sensitivity Analyses ◽

Anxiety And Depression ◽

History Of ◽

Anxiety Depression

Abstract Background Anxiety and depression are more common in children with obesity than in children of normal weight, but it is unclear whether this association is independent of other known risk factors. Interpretation of results from previous studies is hampered by methodological limitations, including self-reported assessment of anxiety, depression, and anthropometry. The aim of this study was to investigate whether obesity increases the risk of anxiety or depression independently of other risk factors in a large cohort of children and adolescents, using robust measures with regard to exposure and outcome. Methods Children aged 6–17 years in the Swedish Childhood Obesity Treatment Register (BORIS, 2005–2015) were included (n = 12,507) and compared with a matched group (sex, year of birth, and area of residence) from the general population (n = 60,063). The main outcome was a diagnosis of anxiety or depression identified through ICD codes or dispensed prescribed medication within 3 years after the end of obesity treatment. Hazard ratios (HRs) with 95% confidence intervals (CIs) from Cox proportional models were adjusted for several known confounders. Results Obesity remained a significant risk factor for anxiety and depression in children and adolescents after adjusting for Nordic background, neuropsychiatric disorders, family history of anxiety/depression, and socioeconomic status. Girls in the obesity cohort had a 43% higher risk of anxiety and depression compared to girls in the general population (adjusted HR 1.43, 95% CI 1.31–1.57; p < 0.0001). The risk in boys with obesity was similar (adjusted HR 1.33, 95% CI 1.20–1.48; p < 0.0001). In sensitivity analyses, excluding subjects with neuropsychiatric disorders and a family history of anxiety/depression, the estimated risks in individuals with obesity were even higher compared with results from the main analyses (adjusted HR [95% CI]: girls = 1.56 [1.31–1.87], boys = 2.04 [1.64–2.54]). Conclusions Results from this study support the hypothesis that obesity per se is associated with risk of both anxiety and depression in children and adolescents.

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The COVID-19 Pandemic and Mental Well-Being of Pregnant Women in Japan: Need for Economic and Social Policy Interventions

Disaster Medicine and Public Health Preparedness ◽

10.1017/dmp.2020.334 ◽

2020 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Midori Matsushima ◽

Hanna Horiguchi

Keyword(s):

Social Support ◽

Depressive Symptoms ◽

Pregnant Women ◽

Perceived Risk ◽

Depression Scale ◽

Well Being ◽

Anxiety And Depression ◽

Cutoff Score ◽

Economic Wealth ◽

Mental Well Being

ABSTRACT Objective: This study explores the mental well-being of pregnant women in Japan during the coronavirus disease (COVID-19) pandemic. Methods: We collected 1777 responses from pregnant women through an online survey. Using the Japanese version of the Edinburgh Postnatal Depression Scale (EPDS), we calculated the percentage of pregnant women above the cutoff (≥ 13), and the factor scores of anhedonia, anxiety, and depression. Regression analyses were performed to identify factors and socioeconomic characteristics correlated with depressive symptoms. Results: The point prevalence of pregnant women with an EPDS score of ≥ 13 was 17%. The mean scores were 0.73, 3.68, and 1.82 for anhedonia, anxiety, and depression, respectively. The probability of becoming above the cutoff score positively correlated with the cancellation of planned informal support, higher perceived risk for infection of COVID-19, difficulties in household finances, and lack of social support. Moreover, being younger, less wealthy, unemployed, and without a partner showed a significantly higher possibility of having a score above the cutoff. Conclusions: The present study found a high percentage of pregnant women with depressive symptoms. Notably, COVID-19-related variables, including perceived risk for the infection, fear of decreasing economic wealth, and social support, were significantly associated with depressive symptoms.

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Women Whose Mental Illnesses Recur after Childbirth and Partners' Levels of Expressed Emotion During Late Pregnancy

The British Journal of Psychiatry ◽

10.1192/bjp.161.2.211 ◽

1992 ◽

Vol 161 (2) ◽

pp. 211-216 ◽

Cited By ~ 9

Author(s):

M. N. Marks ◽

A. Wieck ◽

A. Seymour ◽

S. A. Checkley ◽

R. Kumar

Keyword(s):

Psychiatric Disorder ◽

Pregnant Women ◽

Social Adjustment ◽

Expressed Emotion ◽

Severe Depression ◽

Late Pregnancy ◽

Mental Illnesses ◽

Control Subjects ◽

History Of

Expressed emotion (EE) in the partners of 25 pregnant women with a history of psychosis or severe depression and in 13 pregnant control subjects without any previous psychiatric disorder was assessed in the ninth month of pregnancy. At this time, no patient presented as a case according to RDC. Eleven subjects with a history of psychiatric disorder experienced a further episode of illness in the six months following delivery. Partners of women who became ill had made fewer critical and positive comments about their wives during the pregnancy than the partners of women who remained well. Poor self-rated social adjustment in the partners was also predictive of recurrence of illness after delivery.

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