Comparison and Clinical Characteristics of COVID-19 in Different Time Period in Wuhan, China

Abstract Background SARS-CoV-2 is making deadly impact on the human lives all over the world. Therefore, we aimed to analyze the changes involved in clinical characteristics of COVID-19 patients over time. Methods We conducted a retrospective study to compare the patients whose onset of illness in January with the patients whose onset of illness in February in Wuhan, China.Results Among enrolled 896 patients, the median age was 60 years (47-69 years), 685 (76.5%) were categorized into group A (patients with illness onset in January), and 211 (23.5%) were categorized into group B (patients with illness onset in February). Compared with group B, group A had a higher rate of fever (p<0.001), the lower rate of asymptomatic (p<0.001). Group A had a higher incidence of neutrophilia (p=0.043), elevated D-miner (p<0.001), increased LDH (p=0.002), but lower incidence of normal CT scan (p=0.001). CD3 cells (p=0.015) and CD4 cells p=0.04) count significantly reduced in group A. Critical patients decreased (p=0.005) and mild patients increased (p=0.001) in group B. The fatality rate significantly decreased in group B (p=0.028).Conclusions The condition of patients with onset of illness in January were more serious than patients with onset of illness in February. It indicates that virulence showed reducing effect, but more basic research is required to support the hypothesis.

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Effect of short-term use of oral contraceptive pills on intraocular pressure

Pakistan Journal of Ophthalmology ◽

10.36351/pjo.v35i3.871 ◽

2020 ◽

Vol 35 (3) ◽

Author(s):

Tayyaba Gul Malik ◽

Hina Nadeem ◽

Eiman Ayesha ◽

Rabail Alam

Keyword(s):

Oral Contraceptive ◽

Childbearing Age ◽

Short Term ◽

Oral Contraceptive Pills ◽

Contraceptive Pills ◽

Time Period ◽

Significant Difference ◽

Group A ◽

Group B ◽

Short Time

Objective: To study the effect of short-term use of oral contraceptive pills on intra-ocular pressures of women of childbearing age. Methods: It was a comparative observational study, conducted at Arif memorial teaching hospital and Allied hospital Faisalabad for a period of six months. Hundred female subjects were divided into two groups of 50 each. Group A, included females, who had been taking oral contraceptive pills (OCP) for more than 6 months and less than 36 months. Group B, included 50 age-matched controls, who had never used OCP. Ophthalmic and systemic history was taken. Careful Slit lamp examination was performed and intraocular pressures (IOP) were measured using Goldman Applanation tonometer. Fundus examination was done to rule out any posterior segment disease. After collection of data, we analyzed and compared the intra ocular pressures between the two groups by using ANOVA in SPSS version 21. Results: Average duration of using OCP was 14.9 months. There was no significant difference of Cup to Disc ratios between the two groups (p= 0.109). However, significant difference was noted between the IOP of OCP group and controls. (p=0.000). Conclusion: OCP significantly increase IOP even when used for short time period.

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Anterior approach levator plication for congenital ptosis, absorpable versus non absorpable sutures

European Journal of Ophthalmology ◽

10.1177/11206721211005320 ◽

2021 ◽

pp. 112067212110053

Author(s):

Moustafa Salamah ◽

Ashraf Mahrous Eid ◽

Hani Albialy ◽

Sherif Sharaf EL Deen

Keyword(s):

Randomized Study ◽

Early Postoperative Period ◽

Polyglactin 910 ◽

Exclusion Criteria ◽

Congenital Ptosis ◽

History Of ◽

Group A ◽

Group B ◽

Over Time

Purpose: To compare the efficacy of two different suture types in levator plication for correction of congenital ptosis. Subjects and methods: Prospective comparative interventional randomized study involving 42 eyes of 42 patients aged more than 6 years with congenital ptosis and good levator action. The exclusion criteria were as follows: bilateral ptosis, history of previous surgery, fair or poor levator action, and associated other ocular diseases. Patients were randomized into group A, in which double-armed 5/0 polyester Ethibond were used, and group B, in which double-armed 5/0 Coated Vicryl® (polyglactin 910) suture material we used. Outcomes including eyelid height and stability of eyelid height over time were compared with follow-up data. The MRD was 4.05 ± 0.36 mm and 3.95 ± 0.34 after 1 week for both groups A and B, respectively. At the end of study follow up period (24 weeks), the MRD was 3.60 ± 0.42 mm in group A, and 2.52 ± 0.85 mm in group B. Conclusion: No difference in eyelid height between two groups in early postoperative period, but the postoperative eyelid height was more stable over time in the 5/0 polyester Ethibond group (group A) than in the 5/0 Coated Vicryl® (polyglactin 910) group (group B).

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TAP Block in Postoperative Analgesia, A First Time Clinical Trial In Bangladesh

Journal of the Bangladesh Society of Anaesthesiologists ◽

10.3329/jbsa.v27i1.28992 ◽

2016 ◽

Vol 27 (1) ◽

pp. 3-11

Author(s):

Bidhan Paul ◽

Debashis Banik ◽

AKM Shamsul Alam

Keyword(s):

Postoperative Analgesia ◽

Total Abdominal Hysterectomy ◽

Abdominal Hysterectomy ◽

Transversus Abdominis ◽

Control Group ◽

Tap Block ◽

Analgesic Regimen ◽

Time Period ◽

Group A ◽

Group B

Background: In perioperative care, a reliable pain management is a vital appeal. Over recent years, Transversus Abdominis Plane (TAP) block is introduced as an important component of multimodal analgesia.Objective: To evaluate efficacy of TAP block in postoperative analgesia for Total Abdominal Hysterectomy (TAH) with subarachnoid block (SAB) in comparison of morphine consumption and VAS score.Methods: 60 patients were randomly allocated into 2 groups (TAP group-A & control group-B). Standard SAB was applied to all patients for elective TAH. Immediate after operation classical TAP block was performed through both Lumber Triangle Of Petit (LTOP) of group A patients. Both groups were placed in Post Anesthesia Care Unit (PACU), arranged a common standard postoperative analgesic regimen for all, observed periodically and documented it accordingly in pre-designed data sheet.Results: TAP block prolonged the mean time of 1st required I/V morphine (TAP vs control, mean±SD 271.23±40.34 vs 195.33±22.16 min., p=0.001HS). Morphine requirement was also reduced (17.4±5.4 vs 26.2±4.4 mg, p=0.001HS). Pain VAS scores at rest and movement were also reduced at all time period (p? 0.01 to 0.001). There was no complication attributed to the TAP block.Conclusion: TAP block provided considerably effective postoperative analgesia in first 24 hours after major abdominal surgery like TAH.Journal of Bangladesh Society of Anaesthesiologists 2014; 27(1): 3-11

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Study on impact of duration of tympanic membrane perforation on hearing loss and audiological outcome after surgery

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20213280 ◽

2021 ◽

Vol 7 (9) ◽

pp. 1462

Author(s):

Raies Ahmad ◽

Gopika Kalsotra ◽

Kamal Kishore ◽

Aditiya Saraf ◽

Parmod Kalsotra

Keyword(s):

Hearing Loss ◽

Tympanic Membrane ◽

Pure Tone ◽

Tympanic Membrane Perforation ◽

Medical College ◽

Time Period ◽

Membrane Perforation ◽

Group A ◽

Duration Of Disease ◽

Group B

Background: The aim of the study was to assess impact of duration of tympanic membrane perforation on hearing loss and postoperative audiological outcome using pure tone audiogram.Methods: The present study was conducted on 100 patients in department of ENT and HNS, SMGS Hospital, Government Medical College Jammu during a time period of November 2018 to October 2019. All the patients with age 15 to 60 years who presented with tympanic membrane (pars tensa) perforation were included in the study. Results: In our study, mean preoperative hearing loss (AC threshold) of group A was 36.23±1.07 dB and of group B was 25.67±6.38 dB. Group C had mean preoperative hearing loss (AC threshold) of 28.78±6.50 dB. Mean preoperative air-bone gap (AB gap) of group A was 12.9±8.05dB and of group B was 13.86±4.19 dB. Group C had mean preoperative air-bone gap (AB gap) of 16.47±5.51 dB. Postoperatively, pure tone threshold at three months was least in group B (15.09±5.80 dB), followed by group C (15.68±4.66 dB) and group A (19.33±2.81 dB). Whereas, postoperative AB gap at 3 months was least in group C (10±3 dB), followed by group C (8.44±3.59 dB). Group B had maximum postoperative AB gap of 8.49±4.34 dB.Conclusions: This study did not show any correlation between duration of disease and degree of hearing loss.

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Pathophysiology of Marshallagia marshalli in experimentally infected lambs

Parasitology ◽

10.1017/s0031182013001042 ◽

2013 ◽

Vol 140 (14) ◽

pp. 1762-1767 ◽

Cited By ~ 9

Author(s):

NONA MORADPOUR ◽

HASSAN BORJI ◽

GHOLAMREZA RAZMI ◽

MOHSEN MALEKI ◽

HOSSEIN KAZEMI

Keyword(s):

Morphological Changes ◽

Parietal Cells ◽

Mucosal Cell ◽

Cell Hyperplasia ◽

Third Stage ◽

The World ◽

Undifferentiated Cells ◽

Group A ◽

Group B ◽

Free Ranging

SUMMARYSpecies of Marshallagia are abomasal parasites in free-ranging and domesticated ungulates in temperate climatic zones throughout the world. Pervasiveness of these nematodes is significant in various parts of the world. There has been limited research in the area of Marshallagi amarshalli pathogenesis. The aim of this study was to investigate the effects of M. marshalli on the acid secretory capacity of the abomasal mucosa and the morphological changes due to parasitic migration to different parts of abomasal tissue in sheep. Ten lambs, approximately around 6 months old, were allotted to two groups of five (A and B). The sheep from group A were infected orally with a dose of 5000 third-stage larvae (L3) of M. marshalli whereas the sheep of group B were not infected. The results indicated that the development of M. marshalli in the abomasal glands of ruminants causes pathophysiological changes, which include a reduced acidity of the abomasal contents, increased abomasal pH and increased serum pepsinogen concentrations. The reduced acid secretion is explained by a replacement of functional parietal cells by undifferentiated cells. Histology changes include mucosal cell hyperplasia, loss of parietal cells and inflammatory cell infiltration, which includes numerous granulocytes and lymphocytes.

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Age-related differences in clinical characteristics of invasive group G streptococcal infection: Comparison with group A and group B streptococcal infections

PLoS ONE ◽

10.1371/journal.pone.0211786 ◽

2019 ◽

Vol 14 (3) ◽

pp. e0211786 ◽

Cited By ~ 2

Author(s):

Yoshihiro Fujiya ◽

Kayoko Hayakawa ◽

Yoshiaki Gu ◽

Kei Yamamoto ◽

Momoko Mawatari ◽

...

Keyword(s):

Clinical Characteristics ◽

Streptococcal Infection ◽

Streptococcal Infections ◽

Invasive Group ◽

Age Related ◽

Group A ◽

Group B

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P205 THREE YEARS EXPERIENCE OF THE FIRST SPECIALIZED ESOPHAGEAL CENTER IN EGYPT

Diseases of the Esophagus ◽

10.1093/dote/doz092.205 ◽

2019 ◽

Vol 32 (Supplement_2) ◽

Author(s):

R Ezz

Keyword(s):

Mortality Rates ◽

Esophageal Disease ◽

Esophageal Reflux ◽

Benign Diseases ◽

The World ◽

Group A ◽

Specialized Department ◽

Malignant Lesions ◽

Group B ◽

The Impact

Abstract Introduction Subspecialty policy is increasing all over the world aiming to improve the results of heavy esophageal surgeries. Aim To define the impact of having surgical specialized esophageal unit on the volume of patients and the results. Methodology We reviewed all esophageal cases managed in our esophageal specialized department (from May 2016 to May 2019 Group A) and we compared the results to previous 3 years (from May 2013 to May 2016 Group B) and to the international results. Results Esophageal surgeries performed during this period was 394 cases in group A compared to 104 cases in group B. One hundred eighty operations were performed for Gastro esophageal reflux disease (GERD) in group a (45.7%) compared to 61 cases in group B (68.7%). Forty two (10.7%) modified Heller’s cardiomyotomy (Open and laparoscopic) for achalasia were performed in group A compared to 17 cases (16.3%) in group B. Surgeries for malignant lesions were performed for 122 cases (30.9%) in group A compared to 13 cases (12.5%) in group B. Other Esophageal operations were also done for 50 cases (12.7%) in group A compared to 13 cases (12.5%) in group B. Mortalities in group A was 5 cases in benign diseases (1.8%) and 13 cases for malignant cases (10.7%) compared to 7 cases in benign diseases (7.7%) and 5 cases for malignant conditions (23%) in group B. Morbidities in group A was 46 cases in benign diseases (16.9%) and 31cases for malignant cases (25.4%) Compared to 23 cases in the benign diseases (25.2%) and 5 cases for malignant conditions (38.5%) in group B. Our results in group A are comparable to Hospital mortality rates for patients in medium-volume centers (7.5%)(1).Also we approach the International results for morbidities of benign esophageal disease (5.7 to- 12.7%) for fundoplication (2). Conclusion Having a specialized esophageal unit resulted in increase of the volume of patients and improvement of the results.

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Role of enteric pathogens in the aetiology of neonatal diarrhoea in lambs and goat kids in Spain

Epidemiology and Infection ◽

10.1017/s0950268800001321 ◽

1996 ◽

Vol 117 (1) ◽

pp. 203-211 ◽

Cited By ~ 80

Author(s):

M. Muñoz ◽

M. Álvarez ◽

I. Lanza ◽

P. Cármenes

Keyword(s):

Escherichia Coli ◽

Synergistic Effect ◽

Cryptosporidium Parvum ◽

Clinical Characteristics ◽

Enteric Pathogens ◽

E Coli ◽

Neonatal Diarrhoea ◽

Group A ◽

Group B

SummaryFaeces samples from diarrhoeic and non-diarrhoeic lambs and goat kids aged 1–45 days were examined for enteric pathogens.Cryptosporidium parvumwas detected in both diarrhoeic lambs (45%) and goat kids (42%) but not in non-diarrhoeic animals. F5+(K99+) and/or F41+Escherichia colistrains were isolated from 26% and 22% of the diarrhoeic lambs and goat kids, respectively, although these strains, which did not produce enterotoxins ST I or LT I, were found with similar frequencies in non-diarrhoeic animals. A F5−F41−ST I+E. colistrain was isolated from a diarrhoeic lamb (0·6%). VerotoxigenicE. coliwas isolated from both diarrhoeic and non-diarrhoeic lambs (4·1% and 8·2%, respectively) and there was no association between infection and diarrhoea. The prevalence of group A rotavirus infection in diarrhoeic lambs was very low (2·1%). Groups A and B rotaviruses were detected in three (8·1%) and five (13·5%) diarrhoeic goat kids from two single outbreaks. Group C rotaviruses were detected in four non-diarrhoeic goat kids. An association of diarrhoea and infection was demonstrated only for group B rotavirus.Clostridium perfringenswas isolated from 10·8% of the diarrhoeic goat kids but not from non-diarrhoeic goat kids or lambs.Salmonella arizonaewas isolated from a diarrhoeic goat kid (2·7%) and the clinical characteristics of the outbreaks where these two latter enteropathogens were found different from the rest. Picobirnaviruses were detected in a diarrhoeic lamb. No coronaviruses were detected using a bovine coronavirus ELISA. No evidence was found of synergistic effect between the agents studied. Enteric pathogens were not found in four (8·7%) and three (20%) outbreaks of diarrhoea in lambs and goat kids, respectively.

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Experimental Study on Early Diagnosis of Malignant Pleural Mesothelioma with Computed Tomography Combined Serum Soluble Mesothelin-Related Proteins

Journal of Medical Imaging and Health Informatics ◽

10.1166/jmihi.2021.3314 ◽

2021 ◽

Vol 11 (3) ◽

pp. 667-671

Author(s):

Jiang Jie ◽

Qin Zhanxiong ◽

Wu Li ◽

Xie Xiaojie ◽

Zhao Xunran ◽

...

Keyword(s):

Serum Level ◽

Early Diagnosis ◽

Pleural Cavity ◽

Control Group ◽

Post Injection ◽

Pleural Thickening ◽

Time Period ◽

Group A ◽

Group B ◽

Related Proteins

Objective: To investigate the value on early diagnosis of experimental rat according to computed tomography (CT) combined with the serum level of Serum Soluble Mesothelin-related Proteins (SMRP). Methods: Thirty-two SD rat were divided into three groups, including group A (experimental group) of 20 rats with pleural cavity injection of crocidolite suspension, group B (negative control group) of 6 rats with pleural cavity injection of saline, group C (blank control group) of 6 rats without any processing. Chest and abdominal CT scan and enhancement were performed in the three months and six months after induction and the pleural thickening was analyzed. The serum level of SMRP was measured at the different time period including pre-injection, the postinjection first month, the second month, the third month and the sixth month. The correlation between pleural thickening and serum level of SMRP was analyzed. Results: In group A: 20 cases were performed on CT scan in post-injection third month and we found 13 cases without pleural lesions and 7 cases with pleural lesions including of 4 cases with mild pleural thickening, 1 moderate thickening and 2 severe thickening (2 cases died). Moreover, 18 cases were done by CT in post-injection third month and we found 3 cases without pleural lesions and 15 cases with pleural lesions including of 6 cases with mild pleural thickening, 5 moderate thickening and 4 severe thickening (3 cases died). No pleural lesions were found in group B and group C. SMRP expression level differences in the three groups was statistically significant. However, there was no difference in pre-injection in the three groups and there were no difference in group B and C at the different time period. In group A, there was no difference between post-injection first month and second month, whereas, there had statistically difference in post-injection third and sixth month. In group A, SMRP level gradually increased over time. The high correlation between pleural thickening and serum level of SMRP was seen at the post-injection third and sixth month, which the expression of SMRP gradually increased as the pleural thickening. Conclusion: Serum SMRP expression level has a certain value for early diagnosis and staging of MPM, which can be used as an important biomarker for early screening of high-risk groups exposed to asbestos.

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HYPERLIPIDEMIC PATIENTS;

The Professional Medical Journal ◽

10.29309/tpmj/2019.26.03.3241 ◽

2019 ◽

Vol 26 (03) ◽

Author(s):

Marium Shoukat ◽

Hijab Batool ◽

Faiza Javaid

Keyword(s):

Protective Role ◽

Lipid Lowering ◽

Atheromatous Plaque ◽

P Value ◽

Cross Sectional ◽

Apo B ◽

Time Period ◽

Significant Difference ◽

Group A ◽

Group B

Objectives: Role of niacin in decreasing cardiovascular accidents by lowering the levels of Apo-B in hyperlipidemic patients. Background: In hyperlipidemia, there are high levels of atherogenic lipoproteins leading to higher risk of atherosclerotic cardiovascular events. Patients with dyslipidemia use statins as a mainstay of therapy over last many decades. Recent studies show that apolipoproteins play a major role in formation of atheromatous plaque, thus there is an urgent need to study the effects of lipid lowering medication on apolipoprotiens levels. Study Design: Cross sectional analytical study. Setting: Sheikh Zayed Hospital Lahore (Department of Biochemistry and Chemical Pathology). Period: 12 weeks from July to Sep 2014. Materials and Methods: Recently diagnosed hyperlipidemic patients (n=44) were selected for the study purpose and divided into two equal groups; A and B. Each group was given different medication. Group A took only statin while group B took a combination of statin and niacin. Blood samples were taken at the start of medication and then after completion of 12 week time period. Results: At the start of the treatment there was no significant difference in the Apo B cholesterol level between the two groups (p value 0.972). However, after the end of 12 week duration, there was a significant reduction in the Apo level of group B taking statin and niacin as compared to group A taking statin alone (p value 0.003). Conclusions: Niacin has cardio-protective role when used in combination with niacin.

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