scholarly journals The Predictive Role of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio on Intensive Care Unit Admission and Mortality of COVID-19 Patients in Iran

2021 ◽  
Author(s):  
Peiman Foroughi ◽  
Mojtaba Varshochi ◽  
Mehdi Hassanpour ◽  
Meisam Amini ◽  
Behnam Amini ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Risk Factor ◽  
Intensive Care ◽  
Independent Risk Factor ◽  
Multivariate Logistic Regression Analysis ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Icu Admission ◽  
Inflammatory Index

Abstract Since the outbreak of COVID-19 several studies conducted to identify predictive factors which are associated with prognosis of COVID-19. In this study we aimed to determine whether the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) could help the clinicians to predict intensive care unit (ICU) admission and mortality of COVID-19 patients. This retrospective cohort study involved examining the medical records of 311 Iranian COVID-19 patients from 22 July 2020 to 22 August 2020. All characteristic data and laboratory results were recorded. The receiver operating characteristic (ROC) curve was used to identify the predictive value of studied parameters for ICU admission and death. Comparison of data revealed that some factors were jointly higher in non-survivors and ICU admitted patients than survivors and non-ICU admitted patients, such as: age, hemoglobin (HB), NLR, derived neutrophil-to-lymphocyte ratio (dNLR), PLR, systemic inflammatory index (SII), lactate dehydrogenase (LDH), Respiratory diseases, ischemic heart disease (IHD). Multivariate logistic regression analysis showed that only hypertension (OR 3.18, P=0.02) is an independent risk factor of death in COVID-19 patients, and also PLR (OR 1.02, P=0.05), hypertension (OR 4.00, P=0.002) and IHD (OR 5.15, P=0.008) were independent risk factor of ICU admission in COVID-19 patients. This study revealed that the NLR, PLR, platelet-to-white blood Cell ratio (PWR), dNLR and SII are valuable factors for predicting ICU admission and mortality of COVID-19 patients.

Maternal Obesity Is an Independent Risk Factor for Intensive Care Unit Admission during Delivery Hospitalization

2018 ◽  
Vol 35 (14) ◽  
pp. 1423-1428
Author(s):  
Heather Masters ◽  
Emily Housley ◽  
James Van Hook ◽  
Emily DeFranco
Keyword(s):  
Intensive Care Unit ◽  
Risk Factor ◽  
Intensive Care ◽  
Relative Risk ◽  
Independent Risk Factor ◽  
Admission Rate ◽  
Maternal Body Mass Index ◽  
Adjusted Relative Risk ◽  
Icu Admission ◽  
The Impact

Objective We aim to quantify the impact of obesity on maternal intensive care unit (ICU) admission. Materials and Methods This is a population-based, retrospective cohort study of Ohio live births from 2006 to 2012. The primary outcome was maternal ICU admission. The primary exposure was maternal body mass index (BMI). Relative risk (RR) of ICU admission was calculated by BMI category. Multivariate logistic regression quantified the risk of obesity on ICU admission after adjustment for coexisting factors. Results This study includes 999,437 births, with peripartum maternal ICU admission rate of 1.10 per 1,000. ICU admission rate for BMI 30 to 39.9 kg/m2 was 1.24 per 1,000, RR: 1.20 (95% confidence interval [CI]: 1.07, 1.35); BMI 40 to 49.9 kg/m2 had ICU admission rate of 1.80 per 1,000, RR: 1.73 (95% CI: 1.38, 2.17); and BMI ≥ 50 kg/m2 had ICU admission rate of 2.98 per 1,000, RR: 1.73 (95% CI: 1.77, 4.68). After adjustment, these increases persisted in women with BMI 40 to 49.9 kg/m2 with adjusted relative risk (adjRR) of 1.37 (95% CI: 1.05, 1.78) and in women with BMI ≥ 50 kg/m2, adjRR: 1.69 (95% CI: 1.01, 2.83). Conclusion Obesity is a risk factor for maternal ICU admission. Risk increases with BMI. After adjustment, BMI ≥ 40 kg/m2 is an independent risk factor for ICU admission.

scholarly journals Platelet-to-Lymphocyte ratio (PLR) is a Novel Independent Risk Factor for Newborn Patients in the Neonatal Intensive Care Unit (NICU)

2021 ◽  
Author(s):  
Yanfei Tang ◽  
Yiqun Teng ◽  
Lingyan Xu ◽  
Guangtao Xu ◽  
Deqing Chen ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Risk Factor ◽  
Intensive Care ◽  
Hospital Mortality ◽  
Neonatal Intensive Care Unit ◽  
Hospital Stay ◽  
Neonatal Intensive Care ◽  
Independent Risk Factor ◽  
Predictive Ability ◽  
Platelet To Lymphocyte Ratio

Abstract Objective: To investigate the prognostic significance of the platelet-to-lymphocyte ratio (PLR) for newborn patients in the neonatal intensive care unit (NICU).Design: A retrospective cohort study.Setting and participants: Data on 5240 newborn patients in the NICU extracted from the Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC III) database.Methods: Spearman correlation was used to analyze the association of PLR with length of hospital and ICU stays. The chi-square test was used to analyze the association of PLR with mortality rate. Multivariable logistic regression was used to determine whether the PLR was an independent prognostic factor of mortality. The area under the receiver operating characteristic (ROC) curve was used to assess the predictive ability of models combining PLR with other variables.Results: PLR was negatively associated with length of hospital stay and ICU stay (hospital stay: Spearman’s rho=-0.416, P<0.0001; ICU stay: Spearman’s rho=-0.442, P<0.0001). PLR was significantly correlated with hospital mortality (P<0.0001). Lower PLR was associated with higher hospital mortality (OR=0.85, 95% CI=0.75-0.95, P=0.005) and 90-day mortality (OR=0.85, 95% CI=0.76-0.96, P=0.010). The prognostic predictive ability of models combining PLR with other variables for hospital mortality was moderately good (AUC for Model 1=0.804; AUC for Model 2=0.964).Conclusion: PLR is a novel independent risk factor for newborn patients in the NICU.

Interhospital transfer: An independent risk factor for mortality in the surgical intensive care unit

2012 ◽  
Vol 215 (3) ◽  
pp. S51
Author(s):  
Katherine R. Arthur ◽  
Rachel R. Kelz ◽  
Matthew Robertson ◽  
Carrie A. Sims ◽  
Jose L. Pascual ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Risk Factor ◽  
Intensive Care ◽  
Independent Risk Factor ◽  
Surgical Intensive Care Unit ◽  
Surgical Intensive Care ◽  
Interhospital Transfer

scholarly journals Prognostic value of rise in neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in predicting the mortality in paediatric intensive care

2019 ◽  
Vol 6 (3) ◽  
pp. 1052
Author(s):  
Siby Mathews ◽  
Aswathy Rajan ◽  
Santosh T. Soans
Keyword(s):  
Intensive Care ◽  
Prognostic Value ◽  
Demographic Data ◽  
Medical Science ◽  
Predictive Biomarkers ◽  
Pediatric Intensive Care ◽  
The Body ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio

Background: When the body is stressed in diverse pathological conditions, it responds by mounting an inflammatory response. Predictive biomarkers reflecting the response may serve as guide to management. Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio has been frequently used in adult patients as an indicator for mortality. However, no study has looked into their use within pediatric population. The objective of the study is to assess the prognostic value of rise in NLR and PLR in pediatric intensive care as markers of mortality.Methods: A retrospective study based on 3 year data from HIMS and G-HEALTH data systems of AJ Institute of Medical Science, of all patients admitted to PICU after excluding those in whom all the study parameters were not retrievable, were postoperative patients and/or stay was less than 5 days. NLR and PLR ratios were determined and compared to PELOD 2 using SPSS version 17.0.Results: The demographic data was matched. PELOD 2 (>20) predicted mortality in 72.2% of the patients, while NLR increase predicted in 61.1% and PLR increase in 77.8%. A decreasing trend in NLR and PLR were both closely related to better survival. Among the 3, Rise in PLR had higher sensitivity, specificity, PPV, NPV, and overall accuracy of 72.73% (p <0.001) to predict mortality.Conclusions: The study gives an insight into the fact that simple and inexpensive markers such as rise in NLR and PLR helps in predicting the mortality in the pediatric intensive care which is comparable to PELOD 2 score.

Relation between neutrophil-to-lymphocyte ratio and mortality in patients with hypertrophic cardiomyopathy

2020 ◽  
Vol 14 (18) ◽  
pp. 1693-1701
Author(s):  
Ziqiong Wang ◽  
Liming Zhao ◽  
Sen He
Keyword(s):  
Risk Factor ◽  
Hypertrophic Cardiomyopathy ◽  
Mortality Rate ◽  
Subgroup Analysis ◽  
Prognostic Value ◽  
Independent Risk Factor ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
The Third ◽  
All Cause Mortality

Aim: We assessed the prognostic value of neutrophil-to-lymphocyte ratio (NLR) for all-cause mortality in patients with hypertrophic cardiomyopathy (HCM). Methods & results: A total of 354 HCM patients were enrolled. There were 44 all-cause mortality in total. Patients in the third tertile of NLR had the highest all-cause mortality rate of 5.2 per 100 person-years. Patients in tertile 3 had a significantly higher risk of all-cause mortality with adjusted hazard ratio of 2.4 (95% CI: 1.0–5.4; p = 0.040) when compared with that of patients in tertile 1. No significant interactions between NLR and other variables were observed during subgroup analysis. Conclusion: NLR was an independent risk factor for all-cause mortality in HCM patients.

scholarly journals Associations of procalcitonin, C-reaction protein and neutrophil-to-lymphocyte ratio with mortality in hospitalized COVID-19 patients in China

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jian-bo Xu ◽  
Chao Xu ◽  
Ru-bing Zhang ◽  
Meng Wu ◽  
Chang-kun Pan ◽  
...  
Keyword(s):  
Risk Factor ◽  
Retrospective Study ◽  
Independent Risk Factor ◽  
Neutrophil To Lymphocyte Ratio ◽  
Age Group ◽  
Lymphocyte Ratio ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Increasing Risk ◽  
Baseline Levels

Abstract Coronavirus disease 2019 (COVID-19) is an important and urgent threat to global health. Inflammation factors are important for COVID-19 mortality, and we aim to explore whether the baseline levels of procalcitonin (PCT), C-reaction protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) are associated with an increased risk of mortality in patients with COVID-19. A retrospective study was conducted and a total of 76 patients with confirmed COVID-19 were included between January 17, 2020 to March 2, 2020, of these cases, 17 patients were dead. After adjusting covariates, PCT (≥ 0.10 ng/mL) and CRP (≥ 52.14 mg/L) exhibited independent increasing risks of mortality were used hazard ratio (HR) of 52.68 (95% confidence interval [CI]: 1.77–1571.66) and 5.47 (95% CI: 1.04–28.72), respectively. However, NRL (≥ 3.59) was not found to be an independent risk factor for death in our study. Furthermore, the elevated PCT levels were still associated with increasing risk of mortality in the old age group (age ≥ 60 y), and in the critically severe and severe patients after adjustment for complications. Thu Baseline levels of PCT and CRP have been addressed as independent predictors of mortality in patients with COVID-19.

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