scholarly journals Integrating transcriptome and proteome analysis to determine the lignin synthesis pathway involved in Panax notoginseng in fungal stress

2021 ◽  
Author(s):  
Qian Yang ◽  
Jianbin Li ◽  
Lin Xiao ◽  
Jiani Peng ◽  
Jialing Sun ◽  
...  
Keyword(s):  
Proteome Analysis ◽  
Panax Notoginseng ◽  
Defense Responses ◽  
Lignin Synthesis ◽  
New Information ◽  
Wide Range ◽  
Proteomics Technology ◽  
Challenging Environment ◽  
First Time

Abstract Background Plants are constantly threatened by various pathogens in a challenging environment. Altemaria panax Whetzel is a destructive pathogen that affects many plants, including Panax notoginseng, and significantly reduces the yield and product quality of Panax notoginseng. It is not clear how Panax notoginseng responds to pathogen infection.Methods Using the advanced advantages of transcriptome and proteomics technology, we studied the response of Panax notoginseng to Altemaria panax stress.Results Compared with the control, fungal infection caused significant changes in the Panax notoginseng transcriptome and proteome. Specifically, a total of 136,100 transcripts and 4,468 proteins were identified. The integration of transcriptome and proteome profiles revealed many candidate transcripts/proteins, which may be involved in lignin synthesis during the activation of defense responses by Panax notoginseng. Many genes and proteins are induced or inhibited by fungi. Among them, the expression levels of genes PAL, 4CL, COMT, CAD and POX in the lignin synthesis pathway are significantly increased, which indicates that the fungus activates the defense response of Panax notoginseng.Conclusions As far as we know, this is the first time that transcriptome and proteome analysis have been combined to study the response of Panax notoginseng to disease. This study provides a wide range of new information about the transcriptome, proteome and their correlation of Panax notoginseng in response to fungal stress. The analysis of this resource allows us to examine the mechanisms of transcription and protein diversification, which expands the knowledge of the complexities of the transcriptome and proteome in traditional Chinese medicines.

scholarly journals Study of Oil in the North of Russia by the Geological Committee at the End of the 19th Century – the Beginning of the 20th Century

2021 ◽  
Vol 937 (4) ◽  
pp. 042082
Author(s):  
T P Filippova
Keyword(s):  
Field Studies ◽  
The Arctic ◽  
Russian Science ◽  
The North ◽  
New Information ◽  
Wide Range ◽  
Northern Territories ◽  
The 19Th Century ◽  
First Time

Abstract The article draws attention to the study of the historical experience of Russian science in the development of the Arctic and northern territories of Russia. Based on a wide range of archival and published sources, the role of the Geological Committee in the scientific study of the Ukhta oil-bearing region is analyzed. The chronological framework of the study covers the period of the organization’s activity from 1882 to 1929. The field studies carried out by the Geological Committee which started during this period in the Ukhta region are considered in detail. As a result of this activity, this territory was comprehensively studied for the first time, including a detailed geological survey, the search for oil deposits, and an assessment of its industrial potential. It has been determined that as a result of the surveys of the Geological Committee, new information about the features of the geological and orographic structure of the region was obtained and the oil-bearing potential was proved. It has been concluded that the research of the scientists of the committee laid a fundamental basis for the study of the Ukhta oil-bearing region and predetermined its further development history and great significance for the state.

Deep Learning in IoT

2021 ◽  
pp. 1-54
Author(s):  
Devika G. ◽  
Asha Gowda Karegowda
Keyword(s):  
Big Data ◽  
Deep Learning ◽  
Big Data Analytics ◽  
Future Research ◽  
Great Success ◽  
Sensory Data ◽  
Digital Era ◽  
New Information ◽  
Wide Range

The internet of things (IoT), big data analytics, and deep learning (DL) applications in the mechanical internet are expanding. The current digital era has various sensory devices for a wide range of fields and applications, which all generate various sensory data. DL is being applied for handling big data and has achieved great success in the IoT and other fields. The applications for data streams to discover new information, predict future insights, and make control decisions are crucial processes that make the IoT a worthy paradigm for businesses and a quality-of-life improving technology. This chapter provides a detailed account of the IoT domain, machine learning, and DL techniques and applications. The IoT that consists of DL with intelligence backgrounds is also discussed. Recent research on DL in the IoT within the big data domain is also discussed. Current challenges and potential areas for future research are discussed.

Alfred Schnittke's Concerto Grosso no. 1

2019 ◽  
Author(s):  
Peter J. Schmelz
Keyword(s):  
Soviet Union ◽  
Primary Sources ◽  
The Novel ◽  
Concerto Grosso ◽  
The Soviet Union ◽  
Novel Structure ◽  
New Information ◽  
Wide Range ◽  
Serial Music ◽  
First Time

This book provides for the first time an accessible, comprehensive study of Alfred Schnittke’s Concerto Grosso no. 1 (1977). One of Schnittke’s best-known and most compelling works, the Concerto Grosso no. 1 sounds the surface of late Soviet life, resonating as well with contemporary compositional currents around the world. This innovative monograph builds on existing publications about the Concerto Grosso no. 1 in English, Russian, and German, augmenting and complicating them. It adds new information from underused primary sources, including Schnittke’s unpublished correspondence and his many published interviews. It also engages further with his sketches for the Concerto Grosso no. 1 and contemporary Soviet musical criticism. The result is a more objective, historical appraisal of this rich, multifaceted composition. The Concerto Grosso no. 1 provided a utopian model of the contemporary soundscape. It was a decisive point in Schnittke’s development of the approach he called polystylism, which aimed to contain in a single composition the wide range of contemporary musical styles, including jazz, pop, rock, and serial music. Thanks to it and his other similar compositions, Schnittke became one of the most-performed and most-recorded living composers at the end of the twentieth century. The novel structure of this book engages the Concerto Grosso no. 1 conceptually, historically, musically, and phenomenologically: the six movements of the composition frame the six chapters. The present volume thus provides a holistic accounting of Schnittke’s Concerto Grosso no. 1, its influences, and its impact on subsequent music making in the Soviet Union and worldwide.

Using CFD model of furnace for improvement of the quality of alumina-containing sinter

2014 ◽  
Vol 31 (1) ◽  
pp. 48-58 ◽  
Author(s):  
Alexander V. Aleksandrov ◽  
Valera V. Aleksandrov
Keyword(s):  
Stable State ◽  
Radiant Heat ◽  
Content Type ◽  
Cooling Conditions ◽  
New Information ◽  
Technical Solutions ◽  
First Time ◽  
Practical Implications ◽  
Fuel Burner

Purpose – The purpose of the study is to improve the quality of alumina-containing sinter produced in a rotary kiln. Simulating sintering furnace assessment of technical solutions aimed at creating optimal phase composition of clinker. Design/methodology/approach – The computer model of the sintering furnace is developed. Influence of characteristics of material streams on thermal processes in the furnace was considered. Balance of energy, including heat conductivity, convection and radiant heat exchange has been solved in a stable state. Between actual and calculated variables of work of the furnace, good correlation was observed. Findings – The evaluation of the effect of increasing primary air and fuel burner extension to changes in temperature of the material. The modeling found that the most effective solution to reduce the temperature of the sinter is lengthening fuel burner to 5 m. Practical implications – The model can be applied to analyze and optimize the alteration of temperatures of materials and gases in an industrial furnace under various conditions. Originality/value – The article provides new information for specialists in the production of alumina. For the first time shows the influence of cooling conditions on the alumina-containing sinter quality. According to the results of computer modeling, it has been established that for creating of optimal cooling conditions of the sinter in the furnace, the length of coal burner must be not less than 5 m.

Mutation m.3395A > G in MT-ND1 leads to variable pathologic manifestations

2020 ◽  
Vol 29 (6) ◽  
pp. 980-989
Author(s):  
Nicolás Gutiérrez Cortés ◽  
Claire Pertuiset ◽  
Elodie Dumon ◽  
Marine Börlin ◽  
Barbara Da Costa ◽  
...  
Keyword(s):  
Complex I ◽  
Mitochondrial Diseases ◽  
Mitochondrial Respiratory Chain ◽  
Functional Study ◽  
Mtdna Mutation ◽  
Wide Range ◽  
Complex I Assembly ◽  
First Time ◽  
Do So

Abstract A non-synonymous mtDNA mutation, m.3395A > G, which changes tyrosine in position 30 to cysteine in p.MT-ND1, was found in several patients with a wide range of clinical phenotypes such as deafness, diabetes and cerebellar syndrome but no Leber’s hereditary optic neuropathy. Although this mutation has already been described, its pathogenicity has not been demonstrated. Here, it was found isolated for the first time, allowing a study to investigate its pathogenicity. To do so, we constructed cybrid cell lines and carried out a functional study to assess the possible consequences of the mutation on mitochondrial bioenergetics. Results obtained demonstrated that this mutation causes an important dysfunction of the mitochondrial respiratory chain with a decrease in both activity and quantity of complex I due to a diminution of p.MT-ND1 quantity. However, no subcomplexes were found in cybrids carrying the mutation, indicating that the quality of the complex I assembly is not affected. Moreover, based on the crystal structure of p.MT-ND1 and the data found in the literature, we propose a hypothesis for the mechanism of the degradation of p.MT-ND1. Our study provides new insights into the pathophysiology of mitochondrial diseases and in particular of MT-ND1 mutations.

Communication Sciences and Disorders PhD Graduates' Perceptions of Their PhD Program

2020 ◽  
Vol 5 (2) ◽  
pp. 463-478
Author(s):  
Elizabeth Crais ◽  
Melody Harrison Savage
Keyword(s):  
Detailed Examination ◽  
Career Expectations ◽  
Doctoral Preparation ◽  
Creative Solutions ◽  
Phd Education ◽  
Doctor Of Philosophy ◽  
First Time ◽  
Students Success ◽  
Phd Program

Purpose The shortage of doctor of philosophy (PhD)–level applicants to fill academic and research positions in communication sciences and disorders (CSD) programs calls for a detailed examination of current CSD PhD educational practices and the generation of creative solutions. The intended purposes of the article are to encourage CSD faculty to examine their own PhD program practices and consider the perspectives of recent CSD PhD graduates in determining the need for possible modifications. Method The article describes the results of a survey of 240 CSD PhD graduates and their perceptions of the challenges and facilitators to completing a PhD degree; the quality of their preparation in research, teaching, and job readiness; and ways to improve PhD education. Results Two primary themes emerged from the data highlighting the need for “matchmaking.” The first time point of needed matchmaking is prior to entry among students, mentors, and expectations as well as between aspects of the program that can lead to students' success and graduation. The second important matchmaking need is between the actual PhD preparation and the realities of the graduates' career expectations, and those placed on graduates by their employers. Conclusions Within both themes, graduate's perspectives and suggestions to help guide future doctoral preparation are highlighted. The graduates' recommendations could be used by CSD PhD program faculty to enhance the quality of their program and the likelihood of student success and completion. Supplemental Material https://doi.org/10.23641/asha.11991480

A memoir of Hugh Miller (1802–1856) attributed to his son Hugh Miller FGS (1850–1896)

2017 ◽  
Vol 44 (1) ◽  
pp. 103-109 ◽  
Author(s):  
M. A. Taylor
Keyword(s):  
Family Member ◽  
New Information ◽  
Newspaper Editor ◽  
Interesting Contribution ◽  
First Time

A manuscript memoir of Hugh Miller (1802–1856), geologist, writer and newspaper editor, is attributed to his son Hugh Miller FGS (1850–1896). It is published here, apparently for the first time. It was written sometime in 1881–1896, more probably 1882–1895. Its intended place of publication is discussed. It is an interesting contribution to Miller biography, written by a family member and providing some new information and anecdotes.

COMBINATORIAL POLYNOMIALLY COMPUTABLE CHARACTERISTICS OF SUBSTITUTIONS AND THEIR PROPERTIES

2020 ◽  
Vol 7 (2) ◽  
pp. 34-41
Author(s):  
VLADIMIR NIKONOV ◽  
◽  
ANTON ZOBOV ◽  
Keyword(s):  
Mathematical Expectation ◽  
Point Of View ◽  
Small Range ◽  
Computational Point ◽  
Wide Range ◽  
Bijective Function ◽  
The Difference ◽  
Element Base ◽  
Selection Of

The construction and selection of a suitable bijective function, that is, substitution, is now becoming an important applied task, particularly for building block encryption systems. Many articles have suggested using different approaches to determining the quality of substitution, but most of them are highly computationally complex. The solution of this problem will significantly expand the range of methods for constructing and analyzing scheme in information protection systems. The purpose of research is to find easily measurable characteristics of substitutions, allowing to evaluate their quality, and also measures of the proximity of a particular substitutions to a random one, or its distance from it. For this purpose, several characteristics were proposed in this work: difference and polynomial, and their mathematical expectation was found, as well as variance for the difference characteristic. This allows us to make a conclusion about its quality by comparing the result of calculating the characteristic for a particular substitution with the calculated mathematical expectation. From a computational point of view, the thesises of the article are of exceptional interest due to the simplicity of the algorithm for quantifying the quality of bijective function substitutions. By its nature, the operation of calculating the difference characteristic carries out a simple summation of integer terms in a fixed and small range. Such an operation, both in the modern and in the prospective element base, is embedded in the logic of a wide range of functional elements, especially when implementing computational actions in the optical range, or on other carriers related to the field of nanotechnology.

A reflection of the polyethnic phenomenon in the Slovak novel of the 21 st century

2019 ◽  
pp. 462-471
Author(s):  
Lyudmila Shirokova
Keyword(s):  
Interpersonal Relations ◽  
Slovak Republic ◽  
Main Character ◽  
Jewish Family ◽  
Wide Range ◽  
Provincial Society ◽  
A Chain ◽  
Middle Generation ◽  
Artistic Quality

The historical polyethnicity of the Slovak society and the connected problems of the interrelations of cultures, ethics, interpersonal relations, are reflected in the works of modern Slovak prose. They are represented most clearly in the novels of middle generation writers P. Rankov, S. Lavrík, P. Krištúfek. They dwell upon the dramatical events of the 20 th century. They cover wide range problems, from the fruitful coexistence of various ethnic groups and their representatives to national contradictions and racial repressions. The artistic quality of the mentioned works, their composition, the way of narrating, the type of the main character, can be highly evaluated. For example, in a novel by P. Rankov the plot, in spite of its linearity, is a chain of episodes in the span of 30 years from the life of the main characters. It reflects not only their fates, but also the historical and political changes of the world they live in. The main female character of a S. Lavrík ’s novel narrates about everyday life and tragedies in the lives of the dwellers of a Slovak town in the Slovak Republic during the war. P. Krištúfek in his novel focuses on several decades from the life of a Slovak-Jewish family and dwellers of a Slovak provincial society with types and relations specific for this milieu.

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