scholarly journals Characteristics and Bioactivities of Carrageenan/Chitosan Microparticles Loading Α-mangostin

2021 ◽  
Author(s):  
Hien Thi Nguyen ◽  
Chinh Thuy Nguyen ◽  
Tu Thi Minh Nguyen ◽  
Hoa Dinh Hoang ◽  
Trang Do Mai Tran ◽  
...  
Keyword(s):  
Sodium Tripolyphosphate ◽  
Crosslinking Agent ◽  
Control Release ◽  
Morphological Properties ◽  
Cross Linking ◽  
Ionic Gelation ◽  
Chitosan Microparticles ◽  
Buffer Solutions ◽  
Anti Oxidant ◽  
Ph Buffer

Abstract This study attempted to develop carrageenan/chitosan based microparticles loading α-mangostin which was extracted from Vietnamese mangosteen skin. The carrageenan/chitosan/α-mangostin microparticles were prepared by ionic gelation method by mixing chitosan, carrageenan with α-mangostin and subsequently cross-linking the mixtures with sodium tripolyphosphate crosslinking agent. The content of α-mangostin in microparticles was changed to evaluate the effect of α-mangostin content on physical, morphological properties, particles size and bioactivities of the carrageenan/chitosan/α-mangostin microparticles. The obtained results showed that carrageenan, chitosan was interacted together and with α-mangostin. The presence of polymers matrix improved the release ability of α-mangostin into ethanol/pH buffer solutions. The carrageenan/chitosan/ α-mangostin microparticles have antibacterial (gram (+) strains) and anti-oxidant activities. The results suggested that combination of chitosan and carrageenan in the microparticles can enhance the control release of α-mangostin into solutions as well as keep the bioactivities of α-mangostin.

Preparation of Thermoresponsive Chitosan Polymers and Its Application Controlling Release of Antifouling Agent

2013 ◽  
Vol 562-565 ◽  
pp. 664-667 ◽  
Author(s):  
Feng Ling Xu ◽  
Cun Guo Lin ◽  
Ji Yong Zheng ◽  
Jin Wei Zhang ◽  
Li Wang
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Encapsulation Efficiency ◽  
Sodium Tripolyphosphate ◽  
Ionic Gelation ◽  
Gelation Process ◽  
Chitosan Microparticles ◽  
Antifouling Agent ◽  
Physicochemical Structure ◽  
Scanning Electron

Thermoresponsive chitosan copolymers embed with antifouling agent paeonol in chitosan(CS) microparticles were prepared and the release dynamics was studied at different temperature. Chitosan microparticles have been formed based on ionic gelation process of CS and sodium tripolyphosphate (TPP). Paeonol was incorporated into the CS microparticles with the size about 0.1 μm. The physicochemical structure of samples was analyzed by FTIR and scanning electron microscopy (SEM). We investigated the influence of sodium tripolyphosphate (TPP) and paeonol on Encapsulation efficiency. Increasing TPP concentration from 1 to 3 mg/ml increased encapsulation efficiency of paeonol from 63% to 92%. Increasing peaonol concentration from 1.0 to 3.0 mg/ml increased peaonol encapsulation efficiency from 72% to 85%.

scholarly journals Microencapsulation of Copper(II) Sulfate in Ionically Cross-Linked Chitosan by Spray Drying for the Development of Irreversible Moisture Indicators in Paper Packaging

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2039 ◽  
Author(s):  
Sandra Rojas-Lema ◽  
Jorge Terol ◽  
Eduardo Fages ◽  
Rafael Balart ◽  
Luis Quiles-Carrillo ◽  
...  
Keyword(s):  
Spray Drying ◽  
Flow Rate ◽  
Gas Flow ◽  
Sodium Tripolyphosphate ◽  
Great Promise ◽  
Cross Linking ◽  
Inlet Temperature ◽  
Chitosan Microparticles ◽  
Cellulose Substrates

Copper(II) sulfate-loaded chitosan microparticles were herein prepared using ionic cross-linking with sodium tripolyphosphate (STPP) followed by spray drying. The microencapsulation process was optimal using an inlet temperature of 180 °C, a liquid flow-rate of 290 mL/h, an aspiration rate of 90%, and an atomizing gas flow-rate of 667 nL/h. Chitosan particles containing copper(II) sulfate of approximately 4 µm with a shrunken-type morphology were efficiently attained and, thereafter, fixated on a paper substrate either via cross-linking with STPP or using a chitosan hydrogel. The latter method led to the most promising system since it was performed at milder conditions and the original paper quality was preserved. The developed cellulose substrates were reduced and then exposed to different humidity conditions and characterized using colorimetric measurements in order to ascertain their potential as irreversible indicators for moisture detection. The results showed that the papers coated with the copper(II) sulfate-containing chitosan microparticles were successfully able to detect ambient moisture shown by the color changes of the coatings from dark brown to blue, which can be easily seen with the naked eye. Furthermore, the chitosan microparticles yielded no cytotoxicity in an in vitro cell culture experiment. Therefore, the cellulose substrates herein developed hold great promise in paper packaging as on-package colorimetric indicators for monitoring moisture in real time.

scholarly journals Preparation of insulin loaded chitosan- TPP nanoparticles by ionic gelation method

2015 ◽  
Vol 18 (3) ◽  
pp. 125-134
Author(s):  
Trang Thi Huyen Dinh ◽  
Hao Duc Nguyen ◽  
Hieu Van Le ◽  
Ha Thanh Ho
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Concentration Ratio ◽  
Sodium Tripolyphosphate ◽  
Chitosan Nanoparticles ◽  
Entrapment Efficiency ◽  
Cross Linking ◽  
Ionic Gelation ◽  
Chitosan Concentration

In study, insulin loaded chitosan nanoparticles were prepared via ionic gelation method using cross-linking agent sodium tripolyphosphate (STPP). To have best result for the preparation of nanoparticles, a commercial chitosan with a degree of deacetylation DD of 75 % was adjusted to 85 % - 90 % which was determined by FTIR method. The obtained deacetylated chitosan was studied for the effect of pH, concentration, ratio of chitosan and STPP. Then the insulin loaded chitosan TPP nanoparticles were prepared by ionic gelation method. These nanoparticles could deliver 91.6 % insulin at pH = 3.5, with the chitosan concentration of 1 mg/mL and the chitosan:STPP ratio of 4:1. The TEMs indicate that chitosan nanoparticles were spherical in shape and the particles size was smaller than 100 nm. Investigation of FTIR and entrapment efficiency assert that insulin loaded chitosan nanopartiles have been prepared and can become a drug delivery system via oral in the future.

Study on the Characterization of Cross-Linked Cassava Starch Prepared by Microwave Radiation

2013 ◽  
Vol 821-822 ◽  
pp. 1051-1054 ◽  
Author(s):  
Ke Xi Zhang ◽  
Zhu Zheng ◽  
Xiao Feng Zhang ◽  
Xiao Hong Wang
Keyword(s):  
Microwave Irradiation ◽  
Processing Time ◽  
Sodium Tripolyphosphate ◽  
Crosslinking Agent ◽  
Ester Group ◽  
Cassava Starch ◽  
Microwave Oven ◽  
Cross Linking ◽  
Microwave Time

In this article,cassava starch was cross-linked by crosslinking agent sodium tripolyphosphate in the microwave oven. The effect of microwave time on the cross-linking degree and morphology of cross-linked starch were investigated. The results show that with the increase of microwave processing time, the degree of crosslinking of starch increases.Phosphate ester group is formed on the starch molecular chains and the structure of cross-linked starch becomes amorphous by microwave irradiation .

SINTESIS DAN KARAKTERISASI NANOPARTIKEL KITOSAN – EKSTRAK KULIT BUAH MANGGIS (Garcinia Mangostana)

2013 ◽  
Vol 14 (3) ◽  
Author(s):  
Eriawan Rismana ◽  
Susi Kusumaningrum ◽  
Olivia Bunga P ◽  
Idah Rosidah ◽  
Marhamah Marhamah
Keyword(s):  
Particle Size ◽  
Sodium Tripolyphosphate ◽  
Chitosan Solution ◽  
The Other ◽  
Ionic Gelation ◽  
Garcinia Mangostana ◽  
Particle Size Analyzer ◽  
Cadmium Lead ◽  
Solvent Residue ◽  
Mold And Yeast

The chitosan – Garcinia Mangostana extract nanoparticles has been prepared by ionic gelation reaction by mixture 0.2 % chitosan solution in acetic acid with Garcinia Mangostana extract and it’s continued by reaction process with 0.1 % sodium tripolyphosphate. The particle size of material was determined by Particle Size Analyzer (PSA) that it showed in the range of 200 – 500 nm. The color, pH, water, α- mangostin, mercury, arsenic, cadmium, lead, totally microbe aerobic, totally mold and yeast, and solvent residue contents of nanoparticles were also examined by many methods that these resulted are yellow, 4.50 – 5.50, 89 – 90 %, 1.05 %, < 0.005 ppm, < 0.01 ppm, < 0.01 ppm, < 0.05 ppm, < 10 CFU/g, < 10 CFU/g and not detected, respectively. The other characterization was also observed that it’sincluded stability andTLC chromatogram. A mixture of nanoparticles with cosmetics bases was showed that it’s increased stability, homogeneity and easy to formed.

Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems

2018 ◽  
Vol 69 (7) ◽  
pp. 1756-1759 ◽  
Author(s):  
Luminita Confederat ◽  
Iuliana Motrescu ◽  
Sandra Constantin ◽  
Florentina Lupascu ◽  
Lenuta Profire
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Average Diameter ◽  
Delivery Systems ◽  
Cross Linking ◽  
Low Molecular Weight ◽  
Polymeric Systems ◽  
Chitosan Microparticles ◽  
Degree Of Swelling

The aim of this study was to optimize the method used for obtaining microparticles based on chitosan � a biocompatible, biodegradable, and nontoxic polymer, and to characterize the developed systems. Chitosan microparticles, as drug delivery systems were obtained by inotropic gelation method using pentasodiumtripolyphosphate (TPP) as cross-linking agent. Chitosan with low molecular weight (CSLMW) in concentration which ranged between 0.5 and 5 %, was used while the concentration of cross-linking agent ranged between 1 and 5%. The characterization of the microparticles in terms of shape, uniformity and adhesion was performed in solution and dried state. The size of the microparticles and the degree of swelling were also determined. The structure and the morphology of the developed polymeric systems were analyzed by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).The average diameter of the chitosan microparticles was around 522 �m. The most stable microparticles were obtained using CSLMW 1% and TPP 2% or CSLMW 0.75%and TPP 1%. The micropaticles were spherical, uniform and without flattening. Using CSLMW in concentration of 0.5 % poorly cross-linked and crushed microparticles have been obtained at all TPP concentrations. By optimization of the method, stable chitosan-based micropaticles were obtained which will be used to develop controlled release systems for drug delivery.

scholarly journals Effect of degree of cross linking on physicochemical, rheological and morphological properties of sorghum starch

2021 ◽  
pp. 100073
Author(s):  
Kawaljit Singh Sandhu ◽  
Anil Kumar Siroha ◽  
Sneh Punia ◽  
Lalit Sangwan ◽  
Manju Nehra ◽  
...  
Keyword(s):  
Morphological Properties ◽  
Cross Linking

Effects of a crosslinking agent on a supramolecular gel to control lost circulation

2021 ◽  
Vol 45 (16) ◽  
pp. 7089-7095
Author(s):  
Bo Wang ◽  
Jinsheng Sun ◽  
Kaihe Lv ◽  
Feng Shen ◽  
Yingrui Bai
Keyword(s):  
Crosslinking Agent ◽  
Network Density ◽  
Cross Linking ◽  
Supramolecular Gel ◽  
Lost Circulation ◽  
The Cross

The Cr3+ can improve the cross-linking degree and network density of the GP-A gel, and enhance its strength and plugging ability to control lost circulation.

scholarly journals SYNTHESIS OF ENCAPSULATED CHROMOLAENA ODORATA LEAF EXTRACT IN CHITOSAN NANOPARTICLE BY USING IONIC GELATION METHOD AND ITS ANTIOXIDANT ACTIVITY

2021 ◽  
pp. 112-115
Author(s):  
KENI IDACAHYATI ◽  
WINDA TRISNA WULANDARI ◽  
FIRMAN GUSTAMAN AND INDRA INDRA
Keyword(s):  
Antioxidant Activity ◽  
Zeta Potential ◽  
Leaf Extract ◽  
Crosslinking Agent ◽  
Average Diameter ◽  
Ionic Gelation ◽  
Chromolaena Odorata ◽  
Dpph Method ◽  
Chitosan Nanoparticle

Objective: The aim of this study was to determine the antioxidant activity of Chromolaena odorata. Methods: Encapsulation of Chromolaena odorata leaf extract by nano chitosan was synthesized by using chitosan and NaTPP as the crosslinking agent. The antioxidant activity was conducted by using the DPPH method. Results: Nanoparticles of Chromolaena odorata leaf extract has an average diameter of 675±218 nm and+23.4±7.14 mV of zeta potential. The antioxidant activity of its extract was 0.86 ppm, while its nanoparticle has the better antioxidant activity of 0.21 ppm. Conclusion: Nanoparticles of Chromolaena odorata have very strong antioxidant activity and the potential to be external antioxidants.

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