scholarly journals The Value of Neutrophil/monocyte Ratio in Early Diagnosis of Children Mycoplasma Pneumoniae Pneumonia

2020 ◽  
Author(s):  
Shasha Yao ◽  
Yao Xie ◽  
Fei Chen ◽  
Xiao Chen ◽  
Miao Zhang ◽  
...  
Keyword(s):  
Platelet Count ◽  
Early Diagnosis ◽  
Blood Cell ◽  
Mycoplasma Pneumoniae ◽  
Viral Infections ◽  
Clinical Symptoms ◽  
Monocyte Count ◽  
Neutrophil Lymphocyte Ratio ◽  
Imaging Characteristics ◽  
Mycoplasma Pneumoniae Pneumonia

Abstract Background:To investigate the value of blood cell analysis in early diagnosis of mycoplasma pneumoniae pneumonia (MP). Methods:The clinical parameters, including patient characteristics, clinical symptoms, imaging characteristics and laboratory examination data of the patients hospitalized in the Department of Pediatrics, Nanjing Jiangning Hospital from January 2018 to March 2020 due to community-acquired pneumonia were collected for retrospective analysis. The data were analyzed by SPSS 22.0 software for statistical analysis. P<0.05 was considered statistically significant.Results:The levels of white blood cell count (WBC), absolute neutrophil count (NEU), absolute monocyte count (MON), platelet count (PLT), neutrophil/lymphocyte ratio(NLR), mean platelet volume/platelet count (MPV/PLT) and neutrophil/monocyte ratio (NMR) in children with bacterial pneumonia (BP)were significantly higher than those of children withMP and children withviral pneumonia (VP), the NMR level in children withMP was higher than that of children with VP,the NMR levelsin the three groups of children were significantly different (P<0.05).Combined with the NMR level, the children’s age andpulmonary consolidation information,the AUC areas of MP, BP and VP had high accuracy fordifferential diagnosis of MP. Conclusion:As a comprehensive indicator of neutrophils and monocytes, NMR may differentiate pneumonia caused by mycoplasma pneumoniae, bacterial and viral infections, which provides new direction for early differential diagnosis of pneumonia.

A high C-reactive protein/procalcitonin ratio predicts Mycoplasma pneumoniae infection

2019 ◽  
Vol 57 (10) ◽  
pp. 1638-1646 ◽  
Author(s):  
Olivia L. Neeser ◽  
Tanja Vukajlovic ◽  
Laetitia Felder ◽  
Sebastian Haubitz ◽  
Angelika Hammerer-Lercher ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Mycoplasma Pneumoniae ◽  
Viral Infections ◽  
Tertiary Care ◽  
Multivariate Logistic Regression Analysis ◽  
Empiric Antibiotic Therapy ◽  
Care Hospital ◽  
C Reactive Protein ◽  
Neutrophil Lymphocyte Ratio ◽  
Reactive Protein

Abstract Background Discriminating Mycoplasma pneumoniae (MP) from Streptococcus pneumoniae (SP) and viral etiologies of community-acquired pneumonia (CAP) is challenging but has important implications regarding empiric antibiotic therapy. We investigated patient parameters upon hospital admission to predict MP infection. Methods All patients hospitalized in a tertiary care hospital between 2013 and 2017 for CAP with a confirmed etiology were analyzed using logistic regression analyses and area under the receiver operator characteristics (ROC) curves (AUC) for associations between demographic, clinical and laboratory features and the causative pathogen. Results We analyzed 568 patients with CAP, including 47 (8%) with MP; 152 (27%) with SP and 369 (65%) with influenza or other viruses. Comparing MP and SP by multivariate logistic regression analysis, younger age (odds ration [OR] 0.56 per 10 years, 95% CI 0.42–0.73), a lower neutrophil/lymphocyte ratio (OR 0.9, 0.82–0.99) and an elevated C-reactive protein/procalcitonin (CRP/PCT) ratio (OR 15.04 [5.23–43.26] for a 400 mg/μg cut-off) independently predicted MP. With a ROC curve AUC of 0.91 (0.80 for the >400 mg/μg cutoff), the CRP/PCT ratio was the strongest predictor of MP vs. SP. The discriminatory value resulted from significantly lower PCT values (p < 0.001) for MP, while CRP was high in both groups (p = 0.057). Comparing MP and viral infections showed similar results with again the CRP/PCT ratio providing the best information (AUC 0.83; OR 5.55 for the >400 mg/μg cutoff, 2.26–13.64). Conclusions In patients hospitalized with CAP, a high admission CRP/PCT ratio predicts M. pneumoniae infection and may improve empiric management.

scholarly journals Clinical Symptoms and Outcomes of Severe Pneumonia Caused by Chlamydia psittaci in Southwest China

2022 ◽  
Vol 11 ◽  
Author(s):  
Fuxun Yang ◽  
Jiajia Li ◽  
Bo Qi ◽  
Longfei Zou ◽  
Zongming Shi ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Southwest China ◽  
Distress Syndrome ◽  
Clinical Symptoms ◽  
Severe Pneumonia ◽  
Chlamydia Psittaci ◽  
Molecular Testing ◽  
Imaging Characteristics ◽  
Prevention System ◽  
Generation Sequencing

Here, we aimed to retrospectively analyze the clinical characteristics of 27 patients with severe pneumonia caused by Chlamydia psittaci between January 2019 and April 2021 in southwest China. To this end, we collected data on the exposure history, clinical symptoms, laboratory examination, imaging characteristics, evolution, etiology, treatment, and outcomes to suggest a better diagnosis and prevention system. Our results showed that a metagenomic next-generation sequencing test could provide early diagnosis. All patients were sensitive to quinolones and tetracyclines, and the recovery rate was relatively high. Overall, all patients were in critical condition with moderate to severe acute respiratory distress syndrome and shock. In conclusion, early diagnosis of pneumonia caused by C. psittaci depends on effective molecular testing, and most patients recover after treatment.

scholarly journals Association of Common Available Blood cell indices With Rapid Kidney Function Decline in General Population

2020 ◽  
Author(s):  
Yichun Cheng ◽  
Meian He ◽  
Nanhui Zhang ◽  
Gang Xu ◽  
Shuwang Ge
Keyword(s):  
Platelet Count ◽  
General Population ◽  
Blood Cell ◽  
Kidney Function ◽  
Underlying Mechanism ◽  
Monocyte Count ◽  
High Platelet Count ◽  
Red Blood Cell Count ◽  
Clinic Practice ◽  
Kidney Function Decline

Abstract Background: Blood cell morphology analysis is commonly used in clinic practice. The association of common available blood cell indices with rapid kidney function decline in general population is unknown. Methods: Participants with complete data of blood cell indices and eGFR≥60 ml/min/1.73m2 from Dongfeng-Tongji cohort were enrolled. Rapid kidney function decline was defined as a ≥25% decrease in eGFR from baseline. 16 common available blood cell indices were included and logistic regression analysis adjusted for potential confounders was used to assess if these blood cell indices were related to rapid kidney function decline.Results: A total of 9026 participants were enrolled in our study, 345 (3.8%) participants experienced a ≥25% eGFR decrease from baseline after 5 years follow-up. High red blood cell count, hemoglobin, hematocrit, monocyte count tended to be related to low kidney function at baseline. After adjustment for a set of potential confounders, low hemoglobin, high platelet count and high monocyte count were significantly associated with rapid kidney function decline.Conclusions: we presented low hemoglobin, high monocyte and high platelet count as predictors of rapid kidney function decline in general population. Further studies are needed to investigate the underlying mechanism.

scholarly journals Early Corticosteroid Therapy for Mycoplasma pneumoniae Pneumonia Irrespective of Used Antibiotics in Children

2019 ◽  
Vol 8 (5) ◽  
pp. 726 ◽  
Author(s):  
Eun-Ae Yang ◽  
Hyun-Mi Kang ◽  
Jung-Woo Rhim ◽  
Jin-Han Kang ◽  
Kyung-Yil Lee
Keyword(s):  
Disease Progression ◽  
Mycoplasma Pneumoniae ◽  
Corticosteroid Therapy ◽  
Clinical Symptoms ◽  
Severe Pneumonia ◽  
Oral Prednisolone ◽  
Female Ratio ◽  
A Prospective Study ◽  
Male To Female ◽  
Mycoplasma Pneumoniae Pneumonia

Antibiotics’ effect on Mycoplasma pneumoniae (MP) infection still remains controversial. A prospective study of 257 children with MP pneumonia during a recent epidemic (2015–2016) was conducted. All MP pneumonia patients were treated with corticosteroids within 24–36 h after admission. Initially, oral prednisolone (1 mg/kg) or intravenous methylprednisolone (IVMP; 1–2 mg/kg) was administered for mild pneumonia patients, and IVMP (5–10 mg/kg/day) for severe pneumonia patients. If patients showed a persistent fever for 36–48 h or disease progression, additive IVMP (5 mg/kg or 10 mg/kg) was given. Thirty-three percent of patients received only a broad-spectrum antibiotic without a macrolide. The mean age and the male-to-female ratio was 5.6 ± 3.1 years and 1:1, respectively. Seventy-four percent of patients showed immediate defervescence within 24 h, and 96% of patients showed defervescence within 72 h with improvements in clinical symptoms. Three percent of patients (8/257) who received additive IVMP also showed clinical improvement within 48 h without adverse reactions. There were no clinical or laboratory differences between patients treated with a macrolide (n = 172) and without (n = 85). Early corticosteroid therapy might reduce disease morbidity and prevent disease progression in MP pneumonia patients without side effects, and antibiotics may have limited effects on MP infection.

scholarly journals Early Diagnosis of Mycoplasma pneumoniae Pneumonia by Antigen Detection Using Immunobinding Assay

1991 ◽  
Vol 65 (10) ◽  
pp. 1276-1280
Author(s):  
Naofumi SUYAMA ◽  
Mitsuo KAKU ◽  
Hiroshi TOMITA ◽  
Shigeru KOHNO ◽  
Kouhei HARA
Keyword(s):  
Early Diagnosis ◽  
Mycoplasma Pneumoniae ◽  
Antigen Detection ◽  
Mycoplasma Pneumoniae Pneumonia

scholarly journals OBSERVATIONS ON THE BLOOD CYTOLOGY IN EXPERIMENTAL SYPHILIS

1934 ◽  
Vol 59 (6) ◽  
pp. 711-720 ◽  
Author(s):  
Paul D. Rosahn ◽  
Louise Pearce ◽  
Albert E. Casey
Keyword(s):  
Platelet Count ◽  
Blood Cell ◽  
Cell Count ◽  
Normal Control ◽  
Lymphocyte Count ◽  
White Cell Count ◽  
White Cell ◽  
Monocyte Count ◽  
Total White Cell Count ◽  
The Mean

Weekly observations were made on the blood cytology of seven syphilitic and nine normal control rabbits. Each animal was examined seven times prior to and fifteen times after inoculation of the experimental group. Comparisons were made between the mean blood cell values obtained from all counts on the experimental and control groups in the preinoculation and postinoculation periods. The mean blood cell formula of the syphilitic group for the 3½ month period after inoculation was significantly different from the preinoculation mean values observed in the same group in the following respects: higher total white cell count, platelet count, neutrophil count, and monocyte count, and lower lymphocyte count. The mean blood cell formula of the syphilitic group for the 3½ month period after inoculation was significantly different from the mean blood cell formula of the normal control group in the same time interval in the following respects: higher total white cell count, platelet count, neutrophil and monocyte counts, and lower lymphocyte count. From these results it was concluded that during the period of disease activity, the blood cytology of rabbits infected with Tr. pallidum is characterized by an increase in the total white cell count, the platelet, neutrophil, and monocyte counts, and a decrease in the lymphocyte count from normal values. These changes were statistically significant.

scholarly journals Risk factors for delayed radiographic resolution in children with refractory Mycoplasma pneumoniae pneumonia

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110155
Author(s):  
Qiuli Yan ◽  
Wensi Niu ◽  
Wujun Jiang ◽  
Chuangli Hao ◽  
Meiyuan Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mycoplasma Pneumoniae ◽  
Clinical Symptoms ◽  
Clinical Course ◽  
Chest Radiographs ◽  
Interventional Bronchoscopy ◽  
Corticosteroid Resistance ◽  
Mucus Plug ◽  
Plug Formation ◽  
Mycoplasma Pneumoniae Pneumonia

Objective To determine the risk factors for delayed radiographic resolution in children with refractory Mycoplasma pneumoniae pneumonia (RMPP) and explore the most suitable time for interventional bronchoscopy. Methods This retrospective study involved 142 children with RMPP who were admitted to our hospital from 1 January 2015 to 31 December 2017. They were divided into a common resolution group and a delayed resolution group based on their chest radiograph series. Results Among the 142 patients, 67 showed common resolution on chest radiographs and 75 showed delayed resolution. Independent risk factors for delayed resolution were a clinical course of ≥11.5 days before the performance of interventional bronchoscopy, mucus plug formation, corticosteroid resistance, and atelectasis. When bronchoscopy was performed before the disease had been present for <11.5 days, the length of hospitalization, total fever duration, and duration of time until disappearance of coughing were shorter than those in children who underwent bronchoscopy after the disease had been present for ≥11.5 days. Conclusions Corticosteroid resistance, the time to interventional bronchoscopy, atelectasis, and mucus plug formation were associated with delayed resolution on chest radiographs. Performance of interventional bronchoscopy before the clinical course has reached 11.5 days may help alleviate clinical symptoms and improve radiographic resolution.

scholarly journals Increased Total Serum Immunoglobulin E Is Likely to Cause Complications of Mycoplasma pneumoniae Pneumonia in Children

2021 ◽  
Vol 11 ◽  
Author(s):  
Lili Zhou ◽  
Yuan Li ◽  
Zhufei Xu ◽  
Xuyun Peng ◽  
Xiaoyan Gong ◽  
...  
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Immunoglobulin E ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Pulmonary Complications ◽  
Serum Immunoglobulin ◽  
Total Serum ◽  
Laboratory Findings ◽  
Significant Difference ◽  
Mycoplasma Pneumoniae Pneumonia

ObjectiveTo investigate the correlation between serum immunoglobulin E (IgE) levels and the complications in children with Mycoplasma pneumoniae pneumonia (MPP).MethodsA retrospective study of MPP patients hospitalized from May 2019 to July 2021 was performed. We analyzed the clinical manifestations, complications, laboratory findings, and treatments.ResultsA total of 275 patients who met the inclusion criteria were enrolled in the study. We divided patients into two groups based on whether there were complications. Complications occurred in 147 patients, of which pulmonary complications were more common than extrapulmonary complications. The IgE level in the complication group was higher than that in the non-complication group with p = 0.041. Patients with complications of necrotizing pneumonitis, pneumothorax, skin rash, or bronchiolitis obliterans had higher IgE levels. There was no statistically significant difference in IgE levels between pulmonary complications and extrapulmonary complications. The older the age, the greater the probability of complications (p = 0.001). The group with complications was more likely to have chest pain (p = 0.000), while the group without complications was more likely to have wheezing (p = 0.017). The use of bronchoscopy and glucocorticoids was higher in the complication group than in the non-complication group (p = 0.000).ConclusionsMPP patients with higher IgE levels had more severe clinical symptoms and complications. We speculated that IgE might be a biomarker for complications after MP infection.

scholarly journals Comparative analysis of clinical features of SARS-CoV-2 and adenovirus infection among children

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Kuanrong Li ◽  
Ling Li ◽  
Xianfeng Wang ◽  
Hui Li ◽  
Jun Chen ◽  
...  
Keyword(s):  
Viral Infections ◽  
Clinical Symptoms ◽  
Pediatric Population ◽  
Severe Infection ◽  
Human Adenovirus ◽  
Reactive Protein ◽  
Thoracic Computed Tomography ◽  
Imaging Characteristics ◽  
Neutrophil Percentage ◽  
Lactate Dehydrogenase C

Abstract Background The new emerging coronavirus disease 2019 (COVID-19) overall shares similar symptoms with other common respiratory viral infections. We aimed in this study to compare COVID-19 and human adenovirus (HAdV) infections in pediatric patients regarding the frequencies of major clinical symptoms and the potential disparities in laboratory and imaging parameters. Methods Following a case–control-like design, we built 72 age-matched pediatric COVID-19 and HAdV patient pairs. Their early symptoms and laboratory and imaging characteristics were then retrieved and compared. Results Fever and cough were the most common symptoms for both infections but were seen more often in HAdV than in COVID-19 patients (92% vs. 66% and 60% vs. 18%, respectively). Compared with COVID-19 patients, children with HAdV infection had statistically significantly higher values of neutrophil count, neutrophil percentage, activated partial thromboplastin time, prothrombin time, lactate dehydrogenase, C-reactive protein, procalcitonin but lower values of lymphocyte percentage, total bilirubin, potassium and sodium. Thoracic computed tomography also revealed more anomalies in HAdV patients than in COVID-19 patients (95% vs. 67%). Conclusions COVID-19 is an overall less symptomatic and less severe infection at admission compared to HAdV respiratory infection in pediatric population.

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