scholarly journals What is The Impact of CSN5 on The Prognosis of Digestive System Cancers: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Yonghua Guo ◽  
Meng Gao ◽  
Ye Yao ◽  
Jinghua Li ◽  
Xi Chen ◽  
...  
Keyword(s):  
Distant Metastasis ◽  
Lymphatic Metastasis ◽  
Digestive System ◽  
Meta Analysis ◽  
Conclusive Evidence ◽  
Clinicopathological Parameters ◽  
Invasion Depth ◽  
Differentiation Degree ◽  
System Tumor ◽  
The Impact

Abstract Background: Despite the understanding of COP9 signalosome subunit 5 (CSN5) in tumor genesis, there is no conclusive evidence on CSN5 value to predict digestive system tumor patients' survival and prognosis. The article was performed to evaluate the impact of CSN5 expression levels on survival consequence and clinicopathological parameters of digestive system neoplasm patients.Methods: A comprehensive search was conducted through four databases. We utilized Hazard Ratio (HR) with a 95% confidence interval (CI) to evaluate the prognostic value of CSN5 in overall survival (OS) and recurrence free survival (RFS). We estimated the connection between CSN5 and clinicopathological parameters based on Odds Ratio (OR) with a corresponding 95% CI. Results: The meta-analysis contained 22 studies, involving 2,193 patients diagnosed with digestive system tumor. High CSN5 expression level was indicated to predict poorer OS (HR = 2.28, 95% CI: 1.71–3.03; p < 0.00001). Additionally, high CSN5 was correlated with worse invasion depth (OR = 0.49, 95% CI: 0.25-0.96, p = 0.04), positive lymphatic metastasis (OR = 0.28, 95% CI: 0.16-0.47, p = 0.00001), positive distant metastasis (OR = 0.32, 95% CI: 0.13-0.76, p = 0.01) and poorer differentiation degree (OR = 0.34, 95% CI: 0.19-0.60, p = 0.0003). However, we could not find a correlation between CSN5 expression and age, gender, tumor stage, tumor size or vascular invasion. Furthermore, no significant publication bias was detected.Conclusion: This meta-analysis demonstrated that the overexpression of CSN5 level could foresee poorer OS in digestive system cancer patients. Additionally, CSN5 level was related to tumor invasion depth, lymphatic metastasis, distant metastasis and differentiation degree.

scholarly journals A Review of the Impact of Selected Anthropogenic Chemicals from the Group of Endocrine Disruptors on Human Health

Toxics ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 146
Author(s):  
Katarzyna Goralczyk
Keyword(s):  
Human Health ◽  
Endocrine Disruptors ◽  
Digestive System ◽  
Meta Analysis ◽  
Holistic Approach ◽  
Public Healthcare ◽  
Endocrine Activity ◽  
Daily Lives ◽  
Food Packages ◽  
The Impact

Background: The aim of the study was to review data on the impact of anthropogenic chemicals (endocrine disruptors) on various diseases, which, consequently, may facilitate their prevention and be used as a tool for managing public healthcare. Every day, humans are exposed to chemicals, including xenoestrogens, which are similar to female hormones. Methods: This manuscript was prepared based on a meta-analysis of research on the impacts of selected EDCs on human health. Results: Special attention should be paid to bisphenol A (BPA), benzo-α-pyrene, and phthalates due to their proven endocrine activity and presence in our daily lives. Xenoestrogens are absorbed by human organisms through the digestive system since they can migrate to food from food packages and drinks as well as from plastic products used daily. The presence of these chemicals in human organisms is considered a potential cause for some diseases commonly referred to as ‘diseases of civilization’. Conclusions: The biomonitoring of xenoestrogens, which are chemicals with unfavorable impacts on human health, is a crucial tool for assessing the risk from the pollution of the environment. The novelty is a holistic approach to assessing the occurrence of risk factors for civilization diseases.

scholarly journals Diagnostic significance and carcinogenic mechanism of pan-cancer gene POU5F1 in liver hepatocellular carcinoma

2020 ◽  
Author(s):  
Dingdong He ◽  
Xiaokang Zhang ◽  
Jiancheng Tu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Meta Analysis ◽  
Diagnostic Value ◽  
Gene Set Enrichment Analysis ◽  
Clinicopathological Parameters ◽  
Cancer Gene ◽  
Hub Genes ◽  
Liver Hepatocellular Carcinoma ◽  
The Impact ◽  
Pan Cancer

Abstract Background The prognostic and clinicopathological significance of POU Class 5 Homeobox 1 (POU5F1) among various cancers is disputable heretofore. The diagnostic value and function mechanism of POU5F1 in liver hepatocellular carcinoma (LIHC) have not been studied thoroughly. Methods An integrative strategy of meta-analysis, bioinformatics and wet-lab approach was used to explore the diagnostic and prognostic significance of POU5F1 in various types of tumors, especially in LIHC. Meta-analysis was utilized to investigate the impact of POU5F1 on prognosis and clinicopathological parameters in various cancers. The expression level and diagnostic value of POU5F1 were assessed by qPCR in plasma collected from LIHC patients and controls. The correlation between POU5F1 and tumor infiltrating immune cells (TIICs) in LIHC was evaluated by CIBERSORT. Gene set enrichment analysis (GSEA) was performed based on TCGA. Hub genes and related pathways were identified on the basis of co-expression genes of POU5F1. Results Elevated POU5F1 was associated with poor OS, DFS, RFS and DSS in various cancers. POU5F1 was confirmed as an independent risk factor for LIHC and correlated with tumor occurrence, stage and invasion depth. The combination of POU5F1 and AFP in plasma was with high diagnostic validity (AUC = 0.902, P < 0.001). Specifically, the level of POU5F1 was correlated with infiltrating levels of B cells, T cells, dendritic cells and monocytes in LIHC. GSEA indicated POU5F1 participated in multiple cancer related pathways and cell proliferation pathways. Moreover, CBX3, CCHCR1 and NFYC were filtered as the central hub genes of POU5F1. Conclusions Our study identified POU5F1 as a pan-cancer gene could not only be a prognostic and diagnostic biomarker in various cancers, especially in LIHC, but functionally carcinogenic in LIHC.

scholarly journals Pretreatment Lymphocyte Monocyte Ratio Predicts Long-Term Outcomes in Patients with Digestive System Tumor: A Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Jingwen Zhang ◽  
Lishan Chen ◽  
Rui Zhou ◽  
Huiying Sun ◽  
Yulin Liao ◽  
...  
Keyword(s):  
Digestive System ◽  
Meta Analysis ◽  
Disease Recurrence ◽  
Sensitivity Analyses ◽  
Prognostic Impact ◽  
Cancer Specific Survival ◽  
Digestive System Cancer ◽  
Hazard Ratios ◽  
System Tumor

Purpose.The prognostic value of pretreatment lymphocyte monocyte ratio (LMR) in digestive system cancer patients remains controversial. The aim of this study was to quantify the prognostic impact of this biomarker and assess its consistency in digestive system tumors.Methods.We searched “PubMed,” “Embase,” and “CBM” for published eligible studies before June 2016 and conducted a meta-analysis to estimate the pooled hazard ratios (HRs) for disease recurrence and mortality focusing on LMR. Subgroup analyses, meta-regression, and sensitivity analyses were also performed.Results.A total of 22 cohort studies enrolling 12829 patients with digestive system cancer were included. The summary results showed that lower LMR was significantly associated with worse overall survival (OS), cancer-specific survival (CSS), and tumor disease or recurrence-free survival (DFS/RFS) in analyses using the studies reporting HRs either by the univariate analyses (HR = 1.32, HR = 1.35, and HR = 1.26 for OS, CSS, and DFS/RFS, resp.) or by multivariate analyses (HR = 1.21, HR = 1.18, and HR = 1.26 for OS, CSS, and DFS/RFS, resp.).Conclusion.Our results support the fact that decreased LMR indicates worse prognosis in multiple digestive system tumors.

scholarly journals The Impact of Vitamin D Level on COVID-19 Infection: Systematic Review and Meta-Analysis

2021 ◽  
Vol 9 ◽  
Author(s):  
Amare Teshome ◽  
Aynishet Adane ◽  
Biruk Girma ◽  
Zeleke A. Mekonnen
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Conclusive Evidence ◽  
Qualitative Synthesis ◽  
Vitamin D Levels ◽  
Coronavirus Infection ◽  
Sufficient Vitamin ◽  
The Impact

Background: Coronavirus disease (COVID-19) is a respiratory and systemic disorder caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or novel Coronavirus (nCoV). To date, there is no proven curative treatment for this virus; as a result, prevention remains to be the best strategy to combat coronavirus infection (COVID-19). Vitamin D deficiency (VDD) has been proposed to play a role in coronavirus infection (COVID-19). However, there is no conclusive evidence on its impact on COVID-19 infection. Therefore, the present review aimed to summarize the available evidence regarding the association between Vitamin D levels and the risk of COVID-19 infection.Methods: A systematic literature search of databases (PUBMED/MEDLINE, Cochrane/Wiley library, Scopus, and SciELO) were conducted from May 15, 2020, to December 20, 2020. Studies that assessed the effect of vitamin D level on COVID-19/SARS-2 infection were considered for the review. The qualities of the included studies were evaluated using the JBI tools. Meta-analysis with a random-effects model was conducted and odds ratio with their 95%CI were reported. This systematic review and meta-analysis are reported according to the preferred reporting items for systematic review and meta-analysis (PRISMA) guideline.Results: The electronic and supplementary searches for this review yielded 318 records from which, only 14 of them met the inclusion criteria. The qualitative synthesis indicated that vitamin D deficient individuals were at higher risk of COVID-19 infection as compared to vitamin D sufficient patients. The pooled analysis showed that individuals with Vitamin-D deficiency were 80% more likely to acquire COVID-19 infection as compared to those who have sufficient Vitamin D levels (OR = 1.80; 95%CI: 1.72, 1.88). Begg's test also revealed that there was no significant publication bias between the studies (P = 0.764). The subgroup analysis revealed that the risk of acquiring COVID-19 infection was relatively higher in the case-control study design (OR = 1.81).Conclusions: In conclusion, low serum 25 (OH) Vitamin-D level was significantly associated with a higher risk of COVID-19 infection. The limited currently available data suggest that sufficient Vitamin D level in serum is associated with a significantly decreased risk of COVID-19 infection.

scholarly journals Connective Tissue Growth Factor in Digestive System Cancers: A Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Feng Zhao ◽  
Chan Li ◽  
Yun Wu ◽  
Jianling Xia ◽  
Ming Zeng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Digestive System ◽  
Meta Analysis ◽  
Tissue Growth ◽  
Node Metastasis ◽  
The Impact

Aim. A meta-analysis was conducted to estimate the impact of connective tissue growth factor (CTGF) on outcomes in patients with digestive system cancers. Methods. A systemic literature survey was performed by searching the Cochrane Library and PubMed databases for articles that evaluated the impact of CTGF on outcomes in patients with digestive system cancers. Hazard ratios and 95% confidence intervals were calculated for prognostic factors, overall and recurrence-free survival using RevMan 5.3 software. Results. This meta-analysis was conducted to evaluate a total of 11 studies that included 1730 patients. The results showed that elevated CTGF expression was significantly correlated with advanced age, larger tumor size, multiple tumors, and vascular invasion. Subgroup analysis by cancer type revealed increased risk for lymph node metastasis and advanced tumor node metastasis (TNM) stage in gastric cancer, compared with colorectal cancer. An unfavorable effect of elevated CTGF levels on overall survival was found in patients with hepatocellular carcinoma and patients with gastric cancer, while survival was improved in colorectal cancer patients with high CTGF expression, compared to those with normal levels of CTGF. Conclusions. Elevated CTGF expression may be a novel biomarker for disease status and predicted survival outcomes in patients with specific digestive system cancers.

scholarly journals Clinicopathological and Prognostic Significance of LINC00673 in Human Malignancy: A Review and Meta-analysis

2021 ◽  
Author(s):  
Yurong Zhu ◽  
Zhifa Zhang ◽  
Hui Peng ◽  
Weiping Li ◽  
Shaowei Hu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Distant Metastasis ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Clinicopathological Parameters ◽  
Tumour Stage ◽  
Malignant Tumours ◽  
Node Metastasis ◽  
T Stage

Background: We conducted this research to investigate the relationship between linc00673 expression and prognosis and clinicopathological parameters in human malignancies. Methods: The PubMed, Embase, WOS and CNKI databases were used to collect eligible research data before January 4, 2021. Meta-analysis was performed using Stata 12.0 software. Pooled ORs (odds ratios) or HRs (hazard ratios) and their 95% CIs were calculated to evaluate the association of linc00673 expression with survival outcomes and clinical parameters. Results: We finally included 17 articles and a total of 1539 cases for the meta-analysis. The results indicated that linc00673 was significantly correlated with T stage (P=0.006), tumour stage (P&lt;0.001), lymph node metastasis (P&lt;0.001), and distant metastasis ( P&lt;0.001). In addition, the results suggested that elevated linc00673 expression predicted a poor overall survival time (P=0.034) and acted as an independent prognostic factor (P&lt;0.001) for OS in patients with malignancy. Although potential evidence of publication bias was found in the studies on OS in relation to tumour stage in the multivariate analysis, the trim-and-fill analysis confirmed that the results remained stable. Conclusion: Overexpression of linc00673 was significantly correlated with shorter OS time in patients with malignant tumours. Moreover, the increased expression level of linc00673 was significantly correlated with T stage, tumour stage, lymph node metastasis, and distant metastasis. The results presented in this article revealed that linc00673 might be involved in the progression and invasion of malignancy and serve as a novel prognostic biomarker and potential therapeutic target for malignancy.

scholarly journals Role of neutrophil-to-lymphocyte ratio as a prognostic biomarker in patients with breast cancer receiving neoadjuvant chemotherapy: a meta-analysis

BMJ Open ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. e047957
Author(s):  
Qiong Zhou ◽  
Jie Dong ◽  
Qingqing Sun ◽  
Nannan Lu ◽  
Yueyin Pan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Fixed Effects ◽  
Prognostic Biomarker ◽  
Meta Analysis ◽  
Neutrophil To Lymphocyte Ratio ◽  
Cochrane Library ◽  
Clinicopathological Parameters ◽  
Lymphocyte Ratio ◽  
The Impact

ObjectiveThe neutrophil-to-lymphocyte ratio (NLR) is recognised as a suitable prognostic biomarker in patients with breast cancer. Nevertheless, the efficacy of this biomarker in predicting the pathological complete response (pCR) and survival in patients with breast cancer receiving neoadjuvant chemotherapy (NACT) is still controversial. This meta-analysis aimed to identify the association between baseline NLR and the prognosis of patients with breast cancer treated with NACT.DesignMeta-analysis.Data sourcesRelevant literature published before 1 May 2021 was searched using the Cochrane Library, Embase, PubMed and the Web of Science databases.Eligibility criteriaAll studies involving patients with breast cancer treated with NACT and peripheral blood pretreatment NLR recorded as a dichotomous variable were included.Data extraction and synthesisTwo researchers independently extracted and evaluated OR/HR and its 95% CIs of survival outcomes and clinicopathological parameters.ResultsA total of 19 studies were identified. From each study, the impact of NLR on the pCR, OR and HR, with their 95% CIs were extracted and combined using either a random or fixed-effects model. The results indicate that a higher pCR in patients with a low NLR (OR 1.620, 95% CI 1.209 to 2.169, p＜0.001). In addition, an elevated NLR predicted lower disease-free survival (HR 2.269, 95% CI 1.557 to 3.307, p<0.001) and overall survival (HR 1.691, 95% CI 1.365 to 2.096, p<0.001) in patients with breast cancer treated with NACT.ConclusionsNLR is a suitable biomarker for predicting pCR and survival in patients with breast cancer receiving NACT.

MiR-139 in digestive system tumor diagnosis and detection: Bioinformatics and meta-analysis

2018 ◽  
Vol 485 ◽  
pp. 33-41 ◽  
Author(s):  
Yu-Hui Wang ◽  
Jia Ji ◽  
Hong Weng ◽  
Bi-Cheng Wang ◽  
Fu-Bing Wang
Keyword(s):  
Digestive System ◽  
Meta Analysis ◽  
Tumor Diagnosis ◽  
System Tumor

scholarly journals Evidence on Physical Activity and the Prevention of Frailty and Sarcopenia Among Older People: A Systematic Review to Inform the World Health Organization Physical Activity Guidelines

2020 ◽  
Vol 17 (12) ◽  
pp. 1247-1258 ◽  
Author(s):  
Juliana S. Oliveira ◽  
Marina B. Pinheiro ◽  
Nicola Fairhall ◽  
Sarah Walsh ◽  
Tristan Chesterfield Franks ◽  
...  
Keyword(s):  
Physical Activity ◽  
Confidence Interval ◽  
Observational Studies ◽  
Meta Analysis ◽  
Conclusive Evidence ◽  
Adverse Outcomes ◽  
World Health ◽  
Preventive Strategy ◽  
Age Related ◽  
The Impact

Background: Frailty and sarcopenia are common age-related conditions associated with adverse outcomes. Physical activity has been identified as a potential preventive strategy for both frailty and sarcopenia. The authors aimed to investigate the association between physical activity and prevention of frailty and sarcopenia in people aged 65 years and older. Methods: The authors searched for systematic reviews (January 2008 to November 2019) and individual studies (January 2010 to March 2020) in PubMed. Eligible studies were randomized controlled trials and longitudinal studies that investigated the effect of physical activity on frailty and/or sarcopenia in people aged 65 years and older. The Grading of Recommendations Assessment, Development and Evaluation approach was used to rate certainty of evidence. Results: Meta-analysis showed that physical activity probably prevents frailty (4 studies; frailty score pooled standardized mean difference, 0.24; 95% confidence interval, 0.04–0.43; P = .017, I2 = 57%, moderate certainty evidence). Only one trial investigated physical activity for sarcopenia prevention and did not provide conclusive evidence (risk ratio 1.08; 95% confidence interval, 0.10–12.19). Five observational studies showed positive associations between physical activity and frailty or sarcopenia prevention. Conclusions: Physical activity probably prevents frailty among people aged 65 years and older. The impact of physical activity on the prevention of sarcopenia remains unknown, but observational studies indicate the preventive role of physical activity.

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