The Safety of Early Administration of Oral Fluid Following General Anesthesia in Children Undergoing Tonsil Operation: A Prospective Randomized Controlled Trial

Abstract Background: The feasibility and safety of giving a small amount of water to children in the recovery period after tonsillectomy under general anesthesia to reduce the thirst and its associated restlessness reaction remain unknown. Methods: This study was approved by our institutional ethics committee, and which adhered to CONSORT guidelines. Pediatric patients undergoing tonsil surgery who met the inclusion and exclusion criteria of our study were randomized into the experimental and control groups. In the experimental group, patients were given a small amount of water instantly after recovering from the general anesthesia, which included the recovery of cough and deglutition reflex, and attaining grade V of muscle strength. The control group was given a small amount of water 4 to 6 hours after the operation. The incidence of nausea and vomiting and the degree of thirst relief were measured and compared between the two groups. Results：300 patients were randomized into each group. There was no significant difference in the incidence of nausea and vomiting 20 minutes after drinking water between the two groups (P>0.05). The thirst score of children over 5 years old in the experimental group was significantly lower than that of the control group (P<0.05). Conclusion: The early administration of a small amount of oral fluid in children undergoing tonsil surgery and recovering from the general anesthesia is not only safe but also effective in reducing postoperative thirst. Trial registration: Current Controlled Trials ChiCTR1800020058, 12-12-2018.

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Ketorolac tromethamine pretreatment suppresses sufentanil-induced cough during general anesthesia induction: a prospective randomized controlled trial

10.21203/rs.3.rs-20425/v1 ◽

2020 ◽

Author(s):

Zhen Tian ◽

Bei Hu ◽

Min Miao ◽

Lulu Zhang ◽

Lin Wang ◽

...

Keyword(s):

General Anesthesia ◽

Elective Surgery ◽

Controlled Trial ◽

Recovery Period ◽

Control Group ◽

Anesthesia Induction ◽

Observation Group ◽

Ketorolac Tromethamine ◽

Clinical Trial Registry ◽

Significant Difference

Abstract Background: To observe the effect about pretreatment of ketorolac tromethamine on sufentanil-induced cough in general anesthesia patients. Methods: 102 patients were screened, and a total of 90 patients were scheduled for elective surgery under general anesthesia. 90 patients were randomly divided into two groups: the control group（C group）and the observation group（KT group）. 5 minutes before anesthesia induction, observation group were given ketorolac tromethamine 0.5mg/kg intravenously within 3 s, while the control group were given the same amount of normal saline intravenously. All patients were given a sufentanil bolus of 0.5 ug/kg（within 3 s）intravenously,1 minute later, propofol 2.5mg/kg, vecuronium 0.15mg/kg were injected intravenously, and endotracheal intubation was guided by laryngoscope. The number of coughs that occurred within 1 min after sufentanil injection were recorded. The mean arterial pressure (MAP)，heart rate (HR) and pulse oxygen saturation(SpO2) were recorded at T0 (immediately before pretreatment), T1 (5 minutes after pretreatment), T2（before intubation），T3 (1 min after intubation) and T4 (5 min after intubation).The incidence of adverse reactions were analyzed. Results: Within 1 min after sufentanil injection, the incidence and severity of cough in KT group was significantly lower than that in C group ( P < 0.05). At the time points of T0, T1, T2, T3 and T4, there was no significant difference in MAP, HR and SpO2 between the two groups ( P > 0.05). And there was no significant difference in the dosage of sufentanil, propofol, remifentanil and vecuronium, incidence of nausea and vomiting, delay of recovery, dizziness, drowsiness and respiratory depression between the two groups( P > 0.05). However, there were significant differences in the number of restlessness during waking period ( P < 0.05). Conclusion: Pretreatment of intravenous ketorolac tromethamine can significantly reduce the incidence of sufentanil-induced cough during induction period of general anesthesia patients, and can also significantly reduce the restlessness during recovery period of patients. Trial registration: Chinese Clinical Trial Registry (registration number# ChiCTR2000030287; date of registration: 27/02/2020).

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The effect of foot reflexology on chemotherapy-induced nausea and vomiting in digestive or lung cancer patients: a randomized controlled trial (Preprint)

10.2196/preprints.25648 ◽

2020 ◽

Author(s):

Audrey Murat-Ringot ◽

Pierre Jean Souquet ◽

Fabien Subtil ◽

Florent Boutitie ◽

Marie Preau ◽

...

Keyword(s):

Cancer Patients ◽

Controlled Trial ◽

Nausea And Vomiting ◽

Control Group ◽

Digestive Cancer ◽

Complementary Medicines ◽

Antiemetic Drugs ◽

Platinum Based Chemotherapy ◽

Significant Difference ◽

Delayed Nausea

BACKGROUND Cancer is a chronic disease with an incident worldwide had been 24.5 million and 9.6 million deaths in 2017. Lung and colorectal cancer are the most common cancer for both sexes and according to national and international recommendations platinum-based chemotherapy is the reference adjuvant treatment. This chemotherapy can be moderately to highly emetogenic. Despite antiemetic therapy, chemotherapy-induced nausea and vomiting may persist. Moreover, cancer patient are increasingly interested in alternative and complementary medicines and express the desire that non-pharmacological treatments be used in hospitals. Among alternative and complementary medicines, foot reflexology decreases significantly the severity of chemotherapy-induced nausea and vomiting in breast cancer patients. OBJECTIVE The primary objective of the present study was to assess the benefits of foot reflexology as a complement to conventional treatments on severity of acute chemotherapy-induced nausea and vomiting in digestive or lung cancer patients. The secondary objectives assessed were the frequency and severity of delayed chemotherapy-induced nausea and vomiting, quality of life, anxiety, and self-esteem. METHODS The present study was conducted between April 2018 and April 2020 in French University Hospital. This is an open-label randomized controlled trial. Participants are randomized into two groups: 40 to interventional group (conventional care with foot reflexology) and 40 to control group (conventional care without foot reflexology). Foot reflexology sessions (30 minutes) are performed on an outpatient or inpatient. Eligible participants are patients with a lung or digestive cancer with indication for platinum-based chemotherapy. RESULTS The severity of acute nausea and vomiting was assessed with a visual analogue scale during the second cycle of chemotherapy. A significant increase of at least 2 points was observed for control group (20.6%, P = 0.01). Across all cycle, the foot reflexology group showed a trend towards less frequent delayed nausea (P=0.28), a significantly less frequent consumption of antiemetic drugs (P=0.04), and no significant difference for vomiting (P=0.99); there was a trend towards a perception of stronger severity for delayed nausea in the control group (P=0.39). According to quality of life and anxiety, there was no significant difference between the interventional group and the control group (P=0.32 and P=0.53 respectively). CONCLUSIONS In conclusion, the present study results indicated that foot reflexology decreased significantly the severity of acute nausea and consumption of antiemetic drugs in lung and digestive cancer patients. No side effects from foot reflexology have been noted. In order to better respond to a desire of patients for non-pharmacological treatments and CAMs to be used in hospitals to improve their care, the results of this study showed that foot reflexology seems to be a promising complement to conventional antiemetic drugs. To assess the performance of this intervention in routine practice, a larger study with several health care centers would be relevant with a cluster RCT. CLINICALTRIAL The present study registered with clinicaltrials.gov: NCT03508180 (28/06/2018) INTERNATIONAL REGISTERED REPORT RR2-10.2196/17232

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Does soft tissue mobilization assist static stretching to improve hamstring flexibility? A randomized controlled trial

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2019-0288 ◽

2020 ◽

Vol 0 (0) ◽

Cited By ~ 1

Author(s):

Shibili Nuhmani

Keyword(s):

Soft Tissue ◽

Controlled Trial ◽

Knee Extension ◽

Repeated Measure ◽

Control Group ◽

Static Stretching ◽

Significant Difference ◽

Hamstring Flexibility ◽

Soft Tissue Mobilization ◽

Experimental Group

AbstractObjectivesObjective of the study is to investigate whether Soft tissue mobilization (STM) can assist with static stretching to improve hamstring flexibly.MethodsThe design of the study was repeated measure design. The study was conducted at the physical therapy laboratory of Jamia Hamdard University, New Delhi. Participants included 78 healthy males with hamstring tightness, randomly assigned to either the control group (static stretching) or the experimental group (STM and static stretching). The experimental group received five sets of four different STM techniques, followed by two sets of 30-s static stretches 3 days per week over the course of 12 weeks. The control group received 5 min of sham ultrasound with an inactive probe prior to static stretching. Active knee extension test (AKE) was the outcome measure.ResultsBoth groups showed significant improvement in AKE compared with the baseline measurements. With ingroup analysis showed a significant difference in AKE across all measured time periods (weeks 4, 8, and 12) with pre-test in both groups (p<0.05). No significant difference in AKE improvement was found between groups (p>0.05).ConclusionThe results of this study show that STM prior to static stretching does not significantly improve hamstring flexibility among healthy individuals. Although this study cannot be generalized, the results may be useful for evidence-based practice in the management of hamstring tightness.

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Effectiveness Of Topical Application Of Chlorhexidine And Prevailing Practices On Episiotomy Wound Among Postnatal Mothers

Asian Journal of Health Sciences ◽

10.15419/ajhs.v2i1.422 ◽

2014 ◽

Vol 2 (1) ◽

Author(s):

Rincy Michael ◽

Soney N Toppo ◽

Varsha Hariharan

Keyword(s):

Wound Healing ◽

Topical Application ◽

Controlled Trial ◽

Demographic Data ◽

Assessment Scale ◽

Research Centre ◽

Control Group ◽

Significant Difference ◽

Postnatal Mothers ◽

Experimental Group

Puerperium is a period when the mother experiences intense physical and emotional stress due to exhaustion, anxiety and excitement. Each mother has to adjust to physical changes in her own body due to involution and lactation as well as cope up with the new demands on her time and emotions made by the new born baby. Episiotomy, despite evidences that it is an unnecessary intervention, is one of the most common surgical procedures performed during the second stage of labour, especially in primigravida woman. Thus, a randomized controlled trial to assess the effectiveness of topical application of chlorhexidine and prevailing practices on episiotomy wound among postnatal mothers at selected hospital of Indore was undertaken. True experimental approach with pre test post test research design was adopted. Simple random sampling was taken to select 40 postnatal mothers with episiotomy wound and three days postpartum hospital stay in Choithram Hospital & Research Centre, Indore as per the inclusion criteria. Data was collected with help of questionnaire for socio demographic data and obstetrical data and the wound healing was assessed by REEDA wound healing assessment scale. Samples in the experimental group were applied with chlorhexidine on episiotomy wound and the samples in the control group received routine care with betadine or nadoxin. Post assessment score was taken on third day (evening) by REEDA wound assessment scale. Finding of the study related to effectiveness of chlorhexidine among postnatal mothers in experimental group revealed that there was a significant difference in the healing of episiotomy wound by the application of chlorhexidine among postnatal mothers in experimental group at t19 = 11.40 at the level of p< 0.001. Hence it was inferred that topical application of chlorhexidine on episiotomy wound promotes wound healing.

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Expectant Vomiting of Lung Cancer Patients Using Positron Emission Tomography-Computed Tomography Image Analysis and Continuous Nursing Theory

Journal of Medical Imaging and Health Informatics ◽

10.1166/jmihi.2020.3143 ◽

2020 ◽

Vol 10 (9) ◽

pp. 2236-2241

Author(s):

Chengyi Zhou ◽

Junru Wang ◽

Min Tao ◽

Zhiqin Zhou ◽

Wei Yang ◽

...

Keyword(s):

Lung Cancer ◽

Health Knowledge ◽

Standard Uptake Value ◽

Nausea And Vomiting ◽

Control Group ◽

Ct Image ◽

Pet Ct ◽

Significant Difference ◽

Negative Coping ◽

Experimental Group

Objective: The objective is to study the effect of continuous nursing on the vomiting of patients with expectant vomiting of lung cancer, and to establish a three-dimensional segmentation model of PET-CT image, so as to provide an effective nursing intervention for patients with expectant vomiting of lung cancer. Methods: In this study, the sampling method is adopted. We collected 68 patients (over 18 years old) diagnosed with lung cancer from May 2016 to June 2018 as the study subjects. Patients are divided into experimental group and control group. Before discharge, the patients in the control group are given general discharge guidance and health knowledge guidance. The patients in the experimental group are treated with continuous nursing until the next admission, except for general discharge guidance and health knowledge guidance. The cycle is a period of intermittent chemotherapy. According to the general data questionnaire designed by the researchers themselves, the criteria of acute and subacute toxicity of anticancer drugs developed by the World Health Organization (WHO), and the simple coping style questionnaire, the data are collected. SPSS 22.0 is used for analysis. The rank sum test is used in the grading of expected nausea and vomiting. The score of self coping ability is compared within the group by paired sample t-test, and P < 0.05 is statistically significant. Results: First, before continuous nursing, there is no significant difference in the expected nausea and vomiting between the two groups (P = 0.299). After continuous nursing, in the experimental group, nausea and vomiting is significantly improved (P < 0.001). Second, the positive and negative coping scores of the two groups are 15.98±1.11 and 16.99±1.23, respectively. There is no significant difference between the two groups (P > 0.05). After continuous nursing, the experimental group is compared with the control group. There is a significant difference between positive coping score (19.21±2.12) and negative coping score (16.27±1.53) (P < 0.01). Thirdly, the pixels with the standard uptake value (SUV) > 1/4 of the maximum standard uptake value (SUVmax) are selected as the basic tumor range, which can accurately predict the tumor size and range. Conclusion: PET-CT image analysis and continuous nursing can reduce the degree of nausea and vomiting in patients with lung cancer expectant vomiting, predict the size of lung cancer tumor, improve the patients’ self-response ability and the cure rate of tumor, which is worth promoting in patients with lung cancer expectant vomiting.

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Modulation of the human immune status by spinal thermal massage: a non-randomized controlled study

10.22514/sv.2021.144 ◽

2021 ◽

Keyword(s):

Quality Of Life ◽

Nk Cells ◽

Nk Cell ◽

Controlled Trial ◽

Controlled Study ◽

Control Group ◽

Randomized Controlled ◽

Significant Difference ◽

Experimental Group

Thermal and massage therapies have long been used to control pain. Although spinal thermal massage (STM) has been used worldwide, its effectiveness has not been proven in a controlled clinical study. We here conducted a non-randomized controlled trial to assess the pain-relieving and immunomodulatory effects of STM in old-aged patients experiencing pain or disability. The experimental group was treated with STM five times a week for 8 weeks and rehabilitative regular care (RRC). The control group was treated with only RRC. Pain and immunological parameters were tested before treatment and after 4 and 8 weeks of treatment. The scores of three pain parameters were lowered by STM, and the differences between the groups were statistically significant at the two time points (p < 0.01). Quality of life determined using the 3-level EuroQol five-dimensional questionnaire scores was significantly higher in patients in the experimental group than those in the control group. Effect sizes (ES) were in the range of medium to large in the pain-related measures (0.54–1.22). The total leukocyte counts and the proportions of lymphocytes and subsets were not significantly different between the groups, whereas the proportions of monocytes and natural killer (NK) cells were higher in the experimental group than in the control group after 8 weeks (p < 0.05). The production of interleukin (IL)-4 and interferon γ in T cells was not significantly different between the groups, whereas the production of IL-2 was high in the control group. However, there was a significant increase in IFN-γ production by NK cells in the experimental group (at 4 weeks, p < 0.05). ES were medium in the immunological measures (0.53–0.68). No significant difference was observed in the production of proinflammatory cytokines, IL-1β, tumor necrosis factor α, or IL-6 between the groups. In conclusion, STM treatment has a positive effect on subjective pain and quality of life. It also enhanced NK cell proportion and activity, suggesting that STM may be beneficial in the prevention of viral diseases and cancer in old-aged people.

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Effectiveness of yoga on anxiety, depression and stress level of breast cancer patients undergoing chemotherapy

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20175511 ◽

2017 ◽

Vol 6 (1) ◽

pp. 74

Author(s):

Kamli Prakash ◽

Sunil Saini

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Stress Level ◽

Controlled Trial ◽

Control Group ◽

Research Approach ◽

Breast Cancer Patients ◽

Significant Difference ◽

Anxiety Depression ◽

Experimental Group

Background: Breast cancer has ranked number one cancer among Indian females. Women undergoing chemotherapy experience many side effects including alteration in their body image. The present study assessed effectiveness of yoga on anxiety, depression and stress level of breast cancer patients undergoing chemotherapy.Methods: Quantitative Research approach and Randomized Clinical Controlled Trial with Time series design was adopted in the present study. The consecutive sampling technique was done to recruit 100 breast cancer patients fulfilling the eligibility criteria. Recruited patients were randomized to control (N=52) and experiment (N=48) groups by concealed randomization. Written informed consent was taken from each participant. Baseline data was collected during cycle one by using Anxiety depression and stress scale. The patients in the experimental group were taught Diaphragmatic breathing, systematic relaxation and alternate nostril breathing and Joints and Gland neck and shoulder exercises, and were instructed to practice them twice daily at home. They were supervised in practicing these when they received second, third, fourth, fifth and sixth cycles of chemotherapy. Participants in control group received routine care. Data was again collected after 21 days during second, third, fourth, fifth and sixth cycles of chemotherapy.Results: Analysis revealed that at the baseline breast cancer patients in control and experimental group were homogenous in terms of their Sociodemographic and anxiety depression and stress scores. After the yoga intervention the experimental group showed statistically significant difference in anxiety scores from control group during second, third and sixth cycles (p 0.01, p 0.02, p 0.02), in depression score during the second, third, fourth, fifth and sixth cycles (p 0.02, p 0.02, p 0.02, p 0.001, p 0.000), and in stress scores during third cycle (p 0.01) of chemotherapy.Conclusions: On the basis of findings of the study it was concluded that yoga was effective in reducing the anxiety, depression and stress of breast cancer patients undergoing chemotherapy. Therefore, it is recommended as complementary therapy for patients receiving treatment for cancer.

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TELENURSING FOR THE CONTROL OF CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING: A RANDOMIZED CLINICAL TRIAL

Texto & Contexto - Enfermagem ◽

10.1590/1980-265x-tce-2018-0404 ◽

2019 ◽

Vol 28 ◽

Author(s):

Andressa Carneiro França ◽

Andrea Bezerra Rodrigues ◽

Maria Isis Freire de Aguiar ◽

Renan Alves Silva ◽

Fernanda Macedo Cartaxo Freitas ◽

...

Keyword(s):

Clinical Trial ◽

Controlled Trial ◽

Nursing Intervention ◽

Nausea And Vomiting ◽

Rank Test ◽

Control Group ◽

Telephone Intervention ◽

Clinical Trial Registry ◽

Experimental Group ◽

Antineoplastic Chemotherapy

ABSTRACT Objective: to verify the effectiveness of telenursing in the control of nausea and vomiting induced by antineoplastic chemotherapy. Method: a randomized controlled trial of 61 cancer patients undergoing outpatient chemotherapy treatment, randomized into experimental group and control group. Nausea and vomiting were evaluated by the instrument Multinational Association on Supportive Care in Cancer. The telephone intervention was performed four times after chemotherapy. To verify the effects of this on the variables, the Mann-Whitney test and Student's t-test were used. Wilcoxon signed-rank test was applied to confirm the hypothesis of differences in the pre- and post-test intragroup scores. Results: the groups were homogeneous regarding sociodemographic and clinical characteristics. The experimental group showed a statistically significant reduction in the occurrence of nausea (p=0.0089), in the degree of nausea, in two moments, between 24 hours and three days, and three days and five days (p=0.007 and p=0.009, respectively), in the occurrence of vomiting (p=0.008) and in the number of vomiting episodes (p=0.020). Conclusion: telephone intervention is a potential nursing intervention to reduce nausea and vomiting associated with antineoplastic chemotherapy. Brazilian Clinical Trial Registry: RBR-6s8qm5.

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Effects of mechanical bed massage on biochemical markers of exercise-induced back muscle fatigue in athletes: A randomized controlled trial

Journal of Back and Musculoskeletal Rehabilitation ◽

10.3233/bmr-181347 ◽

2020 ◽

Vol 33 (5) ◽

pp. 793-800

Author(s):

Houyong Zhong ◽

Wichai Eungpinichpong ◽

Xingze Wang ◽

Uraiwan Chatchawan ◽

Sawitri Wanpen ◽

...

Keyword(s):

Creatine Kinase ◽

Muscle Fatigue ◽

Controlled Trial ◽

Collegiate Athletes ◽

Serum Cortisol ◽

Control Group ◽

Back Muscle ◽

Significant Difference ◽

Exercise Induced ◽

Experimental Group

BACKGROUND: Many previous studies have explored the effects of manual massage on back muscle fatigue, and most of the mechanical massage techniques imitate manual massage. However, it is unknown whether mechanical and manual massage have the same functions for exercise-induced back muscle fatigue. OBJECTIVE: To investigate the effects of mechanical bed massage on the biochemical markers of exercise-induced back muscle fatigue in male collegiate athletes. METHODS: Twenty-eight male collegiate athletes who met the experimental criteria were recruited in this randomized controlled trial, and randomly assigned to a mechanical bed massage group (experimental group) or resting group (control group). The subjects performed eight bouts of reverse sit-up in the prone position and received 20 minutes of the intervention. Creatine kinase, blood lactate, and serum cortisol levels were measured at baseline, after fatigue, after intervention, and after 24 hours. RESULTS: The level of serum cortisol of the control group was significantly higher than that of the experimental group after the intervention (p< 0.05). The comparison of the two groups for blood lactate levels showed no significant differences at any of the measurement time-points (p> 0.05). There was no significant difference in creatine kinase levels immediately after the intervention (p> 0.05), but a significant difference in creatine kinase level was observed between the two groups 24 hours later (p< 0.05). CONCLUSIONS: Significant differences were observed between mechanical bed massage and rest condition on serum cortisol and creatine kinase for exercise-induced muscle fatigue. Therefore, mechanical bed massage may reduce stress and muscle damage for the athlete after training or competition.

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Family education for people with schizophrenia in Beijing, China

The British Journal of Psychiatry ◽

10.1192/bjp.187.4.339 ◽

2005 ◽

Vol 187 (4) ◽

pp. 339-345 ◽

Cited By ~ 60

Author(s):

Zheng Li ◽

David Arthur

Keyword(s):

Controlled Trial ◽

Intervention Group ◽

Family Education ◽

Control Group ◽

Large Hospital ◽

Significant Difference ◽

Symptom Scores ◽

Randomised Controlled ◽

Beijing China ◽

Experimental Group

BackgroundMuch of China lacks well-developed services for people with schizophrenia and their families, and most of the existing services focus on hospitals. There is a need for culturally sensitive family treatments offered by nurses.AimsTo conduct a longitudinal experimental study examining the effect of patient and family education in a sample of Chinese people with schizophrenia.MethodA randomised controlled trial was conducted in a large hospital with a sample of 101 patients with schizophrenia and their families. Data were collected at admission and at discharge, and then at 3 and 9 months after discharge. The intervention group received family education, and data on their knowledge about schizophrenia, symptoms, functioning, psychosocial behaviour, relapse and medication adherence were collected and compared with the control group.ResultsThere was a significant improvement in knowledge about schizophrenia in the experimental group and a significant difference in symptom scores and functioning at 9 months after discharge. Patients who were non-adherent to medication regimens were more likely to relapse.ConclusionsFamily education on schizophrenia by nurses in China was effective in improving knowledge and promoting improvement in patients' symptoms.

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