scholarly journals Exploring the Diversity of the Human Blood Virome

2021 ◽  
Author(s):  
María Cebriá-Mendoza ◽  
María A. Bracho ◽  
Cristina Arbona ◽  
Luís Larrea ◽  
Wladimiro Díaz ◽  
...  
Keyword(s):  
Human Blood ◽  
Large Fraction ◽  
Plasma Samples ◽  
Healthy Donors ◽  
Lower Extent ◽  
Pathogenic Viruses ◽  
Enrichment Protocol ◽  
The Common ◽  
New Perspective ◽  
Shed Light

Abstract Metagenomics is greatly improving our ability to discover new viruses, as well as their possible associations with disease. However, metagenomics has also changed our understanding of viruses in general. The vast expansion of currently known viral diversity has revealed a large fraction of non-pathogenic viruses, and offers a new perspective in which viruses function as important components of many ecosystems. In this vein, studies of the human blood virome are often motivated by the search for new viral diseases, especially those associated with blood transfusions. However, these studies have revealed the common presence of apparently non-pathogenic viruses in blood, in particular human anelloviruses and, to a lower extent, human pegiviruses (HPgV). To shed light on the diversity of the human blood virome, we subjected pooled plasma samples from 587 healthy donors in Spain to a viral enrichment protocol followed by massive parallel sequencing. This showed that anelloviruses were clearly the major component of the blood virome and showed remarkable diversity. In total, we assembled 332 complete or near-complete anellovirus genomes, 50 of which could be considered new species. HPgV was much less frequent, but we nevertheless recovered 17 different isolates that we subsequently used for characterizing the diversity of this virus. In-depth investigation of the human blood virome should help to elucidate the ecology of these viruses, and to unveil potentially associated diseases.

scholarly journals Exploring the Diversity of the Human Blood Virome

Viruses ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2322
Author(s):  
María Cebriá-Mendoza ◽  
María A. Bracho ◽  
Cristina Arbona ◽  
Luís Larrea ◽  
Wladimiro Díaz ◽  
...  
Keyword(s):  
Human Blood ◽  
Large Fraction ◽  
Plasma Samples ◽  
Healthy Donors ◽  
Lower Extent ◽  
Pathogenic Viruses ◽  
Enrichment Protocol ◽  
The Common ◽  
New Perspective ◽  
Shed Light

Metagenomics is greatly improving our ability to discover new viruses, as well as their possible associations with disease. However, metagenomics has also changed our understanding of viruses in general. The vast expansion of currently known viral diversity has revealed a large fraction of non-pathogenic viruses, and offers a new perspective in which viruses function as important components of many ecosystems. In this vein, studies of the human blood virome are often motivated by the search for new viral diseases, especially those associated with blood transfusions. However, these studies have revealed the common presence of apparently non-pathogenic viruses in blood, particularly human anelloviruses and, to a lower extent, human pegiviruses (HPgV). To shed light on the diversity of the human blood virome, we subjected pooled plasma samples from 587 healthy donors in Spain to a viral enrichment protocol, followed by massive parallel sequencing. This showed that anelloviruses were clearly the major component of the blood virome and showed remarkable diversity. In total, we assembled 332 complete or near-complete anellovirus genomes, 50 of which could be considered new species. HPgV was much less frequent, but we, nevertheless, recovered 17 different isolates that we subsequently used for characterizing the diversity of this virus. In-depth investigation of the human blood virome should help to elucidate the ecology of these viruses, and to unveil potentially associated diseases.

Fibrinogen-Fibrin-Related Antigen Pattern in Human Blood

1974 ◽  
Vol 32 (02/03) ◽  
pp. 266-276
Author(s):  
Carl D. Jacobsen ◽  
John C. Hoak ◽  
Kenneth K. WU ◽  
Glenna L. Fry
Keyword(s):  
Human Blood ◽  
Plasma Samples

SummaryIn serum from patients with DIC at least 3 different FR-antigenic components could be found. It was difficult to demonstrate these components in the corresponding plasma samples. It is possible that a portion of these antigens formed as a result of in vitro clotting despite the presence of proteolytic inhibitors. These results suggest that the interpretation of “increased split products in serum” may be more complex than current concepts indicate.

Effect of Aspirin on the Thrombelastogram of Human Blood

1973 ◽  
Vol 30 (03) ◽  
pp. 494-498 ◽  
Author(s):  
G de Gaetano ◽  
J Vermylen
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Platelet Function ◽  
Human Blood ◽  
Platelet Rich Plasma ◽  
Plasma Samples ◽  
Release Reaction ◽  
Platelet Release

SummaryThrombelastograms of both native blood and re-calcified platelet-rich plasma samples taken from subjects given a single oral dose of aspirin (1 gram) were not significantly different from the pretreatment recordings. Aspirin also did not modify the thrombelastogram when preincubated in vitro with platelet-rich plasma at concentrations inhibiting the platelet “release reaction” by collagen. Thrombelastography therefore cannot evaluate the effect of aspirin on platelet function.

El Concepto De La lingüística Cognitiva En La Poesía Traducida Análisis Semántico Según La Teoría del Esquema Básico De La Referencia

2021 ◽  
Vol 29 ◽  
Author(s):  
Ahmed Hameed Abdulmajeed Abeer Hussein Abid
Keyword(s):  
Cognitive Linguistics ◽  
Semantic Analysis ◽  
Research Work ◽  
Speech Community ◽  
Search For Meaning ◽  
Basic Scheme ◽  
Scheme Theory ◽  
The Common ◽  
Symmetry Relations ◽  
Shed Light

This research work is part of a project to get an M.A. degree. Some of the linguistic sciences specialized in the search for meaning in the text, such as semantics, pragmatics, cognitive linguistics and etc. will be clarified. Besides, we shed light on the elements of semantic analysis with examples according to the basic scheme theory of reference, which indicates that the language is of a fictional nature. As it is a variety of similarity and symmetry relations between the form of the word and its meaning, whether it is phonetic or written or related to metaphor, metonymy or analogy, and it is not a random relationship. In all these genres, a very important role is played by imaginative comprehension, which subsequently acquires a traditional character and spreads due to the common collective understanding of the word among speakers of the speech community.

scholarly journals The Influence of Rational Dimension in the GPH-MILF Peace Process

2018 ◽  
pp. 145-152 ◽  
Keyword(s):  
Community Involvement ◽  
Peace Process ◽  
The Philippines ◽  
Strategic Interactions ◽  
Actor Model ◽  
Peace Agreement ◽  
The Government ◽  
Rational Factor ◽  
New Perspective ◽  
Shed Light

Resolution of the so-called “Bangsamoro Question” rests at the heart of the peace process between the Government of the Philippines (GPH) and the Moro Islamic Liberation Front (MILF) in the Southern Philippines, also known as the Bangsamoro homeland. Inspired by Allison and Zelikow’s conceptualization of Rational Actor Model (RAM), this paper analyzed how rational factor contributed to the conclusion of the Comprehensive Agreement on Bangsamoro (CAB) in 2014 and eventually enshrined into the Philippine Constitution through the approval of the Bangsamoro Organic Law (BOL) on July 27, 2018. This paper argued that the success of the GPH-MILF peace process does not only depend on the sincerity of the administrations of both then President Aquino III and current President Duterte, international support or commitment, pressure from civil societies and community involvement as what many commentators provided. As shown in this paper, the rational factor and its dimension significantly affected actors’ strategic interactions and the GPH-MILF peace process per se. The findings offered a new perspective for conflict-resolution and shed light on how rational dimension impacted both actors’ strategic interactions, which led to the conclusion of the GPH-MILF peace agreement. This clearly indicated that rational dimension greatly influenced GPH and MILF’s strategic interactions and thereby took flexible attitudes to resolve outstanding issues between them which consequently led to the signing of the CAB and ultimately the ratification of the BOL in 2018.

scholarly journals Integrated foucault: Another look at discourse and power

2018 ◽  
Vol 29 (4) ◽  
pp. 533-544
Author(s):  
Marija Velinov
Keyword(s):  
Discursive Practices ◽  
Starting Point ◽  
The Common ◽  
Shed Light ◽  
Distinct Field ◽  
Three Phases

This paper argues that there is continuity in Foucault?s thought, as opposed to the common division of his work into three phases, each marking a distinct field of research - discourse, power, subject. The idea is that there are no radical turns in his work that justify this division; rather, there is a shift of focus: all crucial concepts are present (more or less [in]explicitly) in all periods of his thought and in all of his undoubtedly differently-toned and oriented works. This is shown through examining the characteristics of archaeology and genealogy, their relation, as well as the relation of discursive practices and strategies of power to knowledge. The retrospective and (re)interpretation intend to shed light on the constant interplay between concepts that demonstrate continuity in Foucault?s thought. The viewpoint, based in the integrity of Foucault?s work, offers a better starting point for understanding certain aspects of his theories.

scholarly journals No cell is an island: circulating T cell:monocyte complexes are markers of immune perturbations

2018 ◽  
Author(s):  
Julie G. Burel ◽  
Mikhail Pomaznoy ◽  
Cecilia S. Lindestam Arlehamn ◽  
Daniela Weiskopf ◽  
Ricardo da Silva Antunes ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
T Cell ◽  
Immune Responses ◽  
Human Blood ◽  
Significant Proportion ◽  
Complex Frequency ◽  
The Common ◽  
First Time ◽  
High Resolution Microscopy

AbstractOur results highlight for the first time that a significant proportion of cell doublets in flow cytometry, previously believed to be the result of technical artefacts and thus ignored in data acquisition and analysis, are the result of true biological interaction between immune cells. In particular, we show that cell:cell doublets pairing a T cell and a monocyte can be directly isolated from human blood, and high resolution microscopy shows polarized distribution of LFA1/ICAM1 in many doublets, suggesting in vivo formation. Intriguingly, T cell:monocyte complex frequency and phenotype fluctuate with the onset of immune perturbations such as infection or immunization, reflecting expected polarization of immune responses. Overall these data suggest that cell doublets reflecting T cell-monocyte in vivo immune interactions can be detected in human blood and that the common approach in flow cytometry to avoid studying cell:cell complexes should be revisited.

scholarly journals ANALYSIS OF “THE FUNDAMENTAL DICTIONARY OF THE ENVIRONMENT DICOENVIRO” IN COMPARISON WITH ELECTRONIC RESOURCES FRAMENET, PROPBANK, VERBNET IN THE FRAMEWORK OF MODERN THEORETICAL LEXICOGRAPHIC PARADIGM

2021 ◽  
pp. 166-173
Author(s):  
Kalinichenko T.M.
Keyword(s):  
Internet Resource ◽  
Common Language ◽  
Electronic Resources ◽  
Function Annotation ◽  
Specialized Language ◽  
Semantic Frames ◽  
The Common ◽  
Syntactic Function ◽  
New Perspective ◽  
Specialized Languages

The purpose of the article is to establish the possibilities of functioning of the terminological Internet resource “The Fundamental Dictionary of the Environment DiCoEnviro”, to examine its methods to carry out a comparative analysis with electronic resources FrameNet, Propbank, VerbNet to open a new perspective of the perception of the meaning of words in common and specialized languages in the framework of modern theoretical lexicographic paradigm.Methods. The complex linguo-pragmatic descriptive method and the techniques of observation, comparison, generalization and interpretation helped to characterize the work of the terminological Internet resource DiCoEnviro and electronic resources FrameNet, Propbank, VerbNet, to identify phenomena in them; the extraction of terminological units for the formation of the results materials is made by the method of continuous sampling.Results. The article highlights the work of the terminological Internet resource DiCoEnviro in comparison with electronic resources FrameNet, Propbank, VerbNet, which offer mainly information about the common language. It is found that in DiCoEnviro the participant is defined by the type, role, is expressed by syntactic group, each context contains a description of syntactic function. Annotation of contexts in DiCoEnviro is performed using the Oxigen XML editor, while users view annotations in HTML format when visiting the DiCoEnviro website.Conclusions. The article presents the work of scientists in the field of lexicography, namely electronic dictionaries; it shows a study of the terminological Internet resource DiCoEnviro and the principles of annotation of terms in it. The purpose of the DiCoEnviro project is traced; previous works of FrameNet, Propbank, VerbNet are presented, which offer mainly information about common language, while DiCoEnviro includes vocabulary of specialized environmental language; examples of annotations from these projects are given and analyzed. The method used in DiCoEnviro and based on explanatory and combinatorial lexicology and partly on the theory of semantic frames is considered in details.Key words: annotation, frames, terms, explanatory and combinatorial lexicology, specialized language. Мета статті – встановити можливості функціонування термінологічного інтернет-ресурсу «Фундаментальний слов-ник навколишнього середовища DiCoEnviro», розглянути його методи для здійснення порівняльного аналізу з електронни-ми ресурсами FrameNet, Propbank, VerbNet, щоб відкрити нову перспективу сприйняття значення слова у загальновживаній та спеціалізованій мовах у рамках сучасної теоретичної лексикографічної парадигми.Методи. Комплексний лінгвопрагматичний описовий метод і прийоми спостереження, порівняння, узагальнення та інтер-претації допомогли охарактеризувати роботу термінологічного інтернет-ресурсу DiCoEnviro і електронних ресурсів FrameNet, Propbank, VerbNet, виявити явища в них; виокремлення термінологічних одиниць для формування матеріалів результатів зро-блено методом суцільної вибірки.Результати. У статті висвітлено роботу термінологічного інтернет-ресурсу DiCoEnviro порівняно з електронними ресур-сами FrameNet, Propbank, VerbNet, які пропонують в основному інформацію про загальновживану мову. З’ясовано, що в DiCoEnviro учасник визначається своїм типом, роллю, виражається синтаксичною групою, кожен контекст містить опис синтаксичної функції. Анотування контекстів у DiCoEnviro виконується за допомогою редактора XML Oxigen, тоді як корис-тувачі, коли відвідують вебсайт DiCoEnviro, дивляться анотування у форматі HTML.Висновки. У статті презентовано роботи науковців у галузі лексикографії, а саме електронних словників; показано дослі-дження термінологічного інтернет-ресурсу DiCoEnviro і принципів анотування термінів у ньому. Простежено мету проєк-ту DiCoEnviro; представлені попередні роботи FrameNet, Propbank, VerbNet, які пропонують в основному інформацію про загальновживану мову, тоді як DiCoEnviro включає у себе лексику спеціалізованої мови навколишнього середовища; наведено і проаналізовано приклади анотування з цих проєктів. Докладно розглянуто методику, яка застосовується в DiCoEnviro і ґрун-тується на пояснювальній і комбінаторній лексикології і частково на теорії семантичних фреймів.Ключові слова: анотування, фрейми, терміни, пояснювальна і комбінаторна лексикологія, спеціалізована мова

The Handbook of Language Assessment Across Modalities

2021 ◽  
Keyword(s):  
Second Language ◽  
Language Assessment ◽  
Spoken Language ◽  
Assessment Literacy ◽  
Signed Language ◽  
Key Issues ◽  
Relevant Field ◽  
The Common ◽  
New Perspective ◽  
First Time

In Language Assessment Across Modalities: Paired-Papers on Signed and Spoken Language Assessment, volume editors Tobias Haug, Wolfgang Mann, and Ute Knoch bring together—for the first time—researchers, clinicians, and practitioners from two different fields: signed language and spoken language. The volume examines theoretical and practical issues related to 12 topics ranging from test development and language assessment of bi-/multilingual learners to construct issues of second-language assessment (including the Common European Framework of Reference [CEFR]) and language assessment literacy in second-language assessment contexts. Each topic is addressed separately for spoken and signed language by experts from the relevant field. This is followed by a joint discussion in which the chapter authors highlight key issues in each field and their possible implications for the other field. What makes this volume unique is that it is the first of its kind to bring experts from signed and spoken language assessment to the same table. The dialogues that result from this collaboration not only help to establish a shared appreciation and understanding of challenges experienced in the new field of signed language assessment but also breathes new life into and provides a new perspective on some of the issues that have occupied the field of spoken language assessment for decades. It is hoped that this will open the door to new and exciting cross-disciplinary collaborations.

scholarly journals Demystifying Social Bots: On the Intelligence of Automated Social Media Actors

2020 ◽  
Vol 6 (3) ◽  
pp. 205630512093926 ◽  
Author(s):  
Dennis Assenmacher ◽  
Lena Clever ◽  
Lena Frischlich ◽  
Thorsten Quandt ◽  
Heike Trautmann ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Social Media ◽  
Public Opinion ◽  
Research Effort ◽  
Online Media ◽  
Social Media Platforms ◽  
New Perspective ◽  
High Degree ◽  
Supportive Nature ◽  
Shed Light

Recently, social bots, (semi-) automatized accounts in social media, gained global attention in the context of public opinion manipulation. Dystopian scenarios like the malicious amplification of topics, the spreading of disinformation, and the manipulation of elections through “opinion machines” created headlines around the globe. As a consequence, much research effort has been put into the classification and detection of social bots. Yet, it is still unclear how easy an average online media user can purchase social bots, which platforms they target, where they originate from, and how sophisticated these bots are. This work provides a much needed new perspective on these questions. By providing insights into the markets of social bots in the clearnet and darknet as well as an exhaustive analysis of freely available software tools for automation during the last decade, we shed light on the availability and capabilities of automated profiles in social media platforms. Our results confirm the increasing importance of social bot technology but also uncover an as yet unknown discrepancy of theoretical and practically achieved artificial intelligence in social bots: while literature reports on a high degree of intelligence for chat bots and assumes the same for social bots, the observed degree of intelligence in social bot implementations is limited. In fact, the overwhelming majority of available services and software are of supportive nature and merely provide modules of automation instead of fully fledged “intelligent” social bots.

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