scholarly journals Association between deposit of abdominal adipose tissues and metabolic abnormality in a Chinese population

2021 ◽  
Author(s):  
Xuhui Zhang ◽  
Qiannan Chen ◽  
Xiaohui Sun ◽  
Qiong Wu ◽  
Zongxue Cheng ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Area Under The Curve ◽  
Density Lipoprotein ◽  
Predictive Ability ◽  
Metabolic Abnormality ◽  
Predictive Values ◽  
Men And Women ◽  
Abdominal Adipose Tissue ◽  
Net Reclassification Improvement

Abstract BackgroundPrevious studies indicated that deposit of abdominal adipose tissue associated with the abnormalities of cardiometabolic components. However, the results were inconsistent on the effects of subcutaneous adipose tissue (SAT) and difference between men and women. The aim of this study was to examine the associations of VAT, SAT with metabolic status and the different effects between male and female. Methods1388 eligible subjects were recruited from the baseline investigation of metabolic syndrome investigation in China. Areas of abdominal VAT and SAT were determined by nuclear magnetic resonance imaging (MRI). Total triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) were measured by biochemical auto-analyzer. Metabolic abnormality (MA) was defined more than one of abnormally metabolic components, which were based on the definition of metabolic syndrome (IDF 2005). Multiple logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (95%CI). The predictive values were assessed with area under the curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI), respectively. ResultsSubjects with MA had higher levels of VAT in both of men and women, and higher levels of SAT in men than those with metabolic normality (MN) (P< 0.05). Different associations of SAT in women depended of levels of BMI. Higher levels of VAT were significantly correlated with higher risks for MA (p for trend <0.05). Comparing with the subjects of the first quartile (Q1) of VAT, OR in fourth quartile (Q4) was 6.537 (95% CI= 3.394 -12.591) in men and 3.364 (95% CI=1.898-5.962) in women. However, no significance was found in SAT. In men, VAT improved the predictive value of MA with the AUC of 0.727 (95% CI= 0.687-0.767), and NRI of 0.139 (95%CI=0.070-0.208) and 0.106 (95%CI=0.038-0.173), IDI of 0.074 (95%CI = 0.053-0.095) and 0.046 (95%CI=0.026-0.066) comparing with BMI and WC, respectively. Similar results were found in women.Conclusions VAT and SAT linked increased risks for metabolic abnormality in men no matter in the BMI＜24kg/m2 or in BMI≥24kg/m2, but in women, SAT only increased the risk of MA in BMI≥24kg/m2.Deposit of abdominal adipose tissue associated with the metabolic abnormalities. VAT improved the predictive ability of MA.

scholarly journals Prevalence and Predictors of Metabolic Syndrome among Patients with Bronchial Asthma: A Cross Sectional Study

2021 ◽  
Vol 15 (1) ◽  
pp. 14-18
Author(s):  
Abdellah H.K. Ali
Keyword(s):  
Metabolic Syndrome ◽  
Blood Sugar ◽  
Bronchial Asthma ◽  
Density Lipoprotein ◽  
Patient Characteristics ◽  
Cross Sectional Study ◽  
Metabolic Abnormality ◽  
Fasting Blood Sugar ◽  
Cross Sectional ◽  
Asthma Patients

Background: Recent studies have reported the epidemiological link between Metabolic Syndrome (MS) and asthma, but it has rarely been studied in Egypt. The study aimed to investigate the prevalence of MS and its predictors among asthma patients in Egypt. Methods: In total, 320 patients with bronchial asthma were included. The following were assessed: spirometric evaluation, anthropometric indices, blood pressure, fasting blood sugar and serum lipid profile. We analyzed the correlation between metabolic scores and patient characteristics. Predictors of MS were identified using logistic regression analysis. Results: The prevalence of MS was 57.5% in asthma patients. For asthma patients, low High-Density Lipoprotein (HDL) and abdominal obesity were the commonest metabolic abnormality. Waist circumference, Fasting Blood Sugar (FBS) and triglyceride correlated significantly with asthma (P ‹ 0.05). FBS and DBP were the best predictors of MS. Conclusion: MS is frequent in asthma patients in Egypt. Obesity and lipid abnormalities were the commonest metabolic abnormality. Screening of these patients for components of metabolic syndrome should be a part of routine workup.

Abstract 193: Contribution of Visceral and Epicardial Adipose Tissues to the Variation in the Cardiometabolic Risk of Apparently Healthy Young Adults

Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Elianne De Larochelliere ◽  
Julie Côté ◽  
Marie-Kristelle Ross ◽  
Vénique Dion-Roy ◽  
Philippe Pibarot ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Cardiometabolic Risk ◽  
Multivariable Analysis ◽  
Density Lipoprotein ◽  
Healthy Adults ◽  
Visceral Adiposity ◽  
Adipose Tissues ◽  
Abdominal Adipose Tissue ◽  
Cardiometabolic Profile ◽  
Apparently Healthy

OBJECTIVE: Relative contributions of abdominal versus epicardial adipose tissues to the cardiometabolic profile of young and healthy adults are unknown. We investigated the associations between subcutaneous abdominal adipose tissue (SAT), visceral abdominal adipose tissue (VAT) and epicardial adipose tissue (EAT) with markers of the cardiometabolic profile in young and apparently healthy males and females. METHOD AND RESULTS: Two hundred and eighty young and apparently healthy subjects (48% (134 of 280) male; age 18 to 35 years; BMI <30 kg/m2) underwent magnetic resonance imaging after voluntary recruitment in the community. We quantified SAT, VAT and EAT. Plasma cardiometabolic risk profile was assessed for each subject (blood pressure, lipid profile, fasting glucose). Associations with markers of the cardiometabolic profile were stronger for VAT and EAT than for SAT. In multivariable regression analyses including all three adipose tissues and taking into account gender and age, only VAT maintained significant associations to systolic and diastolic blood pressure, and plasma low-density lipoprotein cholesterol, total/high-density lipoprotein cholesterol ratio, triglycerides and apolipoproteins B/A1 ratio. In an effort to identify the strongest office-based predictor of visceral adiposity in this young and apparently healthy young adult sample, we determined that while BMI, waist circumference (WC) and waist-to-hip ratio were all associated to VAT in univariable analyses (p<0.05 for all), only WC remained independently associated to VAT in multivariable analysis (p<0.001). Concurrently, WC was also an independent predictor of EAT in multivariable analysis (p<0.001). CONCLUSION - Because visceral adipose tissues - EAT, and to a greater extent VAT - are more strongly and widely associated with the cardiometabolic profile than is SAT, we believe that assessing visceral adiposity is relevant in young and apparently healthy adults. Beyond simply measuring BMI, the addition of WC measurement in young and apparently healthy adults improves the prediction of visceral adiposity.

Abstract 3733: Postprandial Free Fatty Acid Metabolism During Fenofibrate Treatment Predicts Postprandial Lipid And Lipoprotein Changes

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Robert S Rosenson
Keyword(s):  
Metabolic Syndrome ◽  
Test Meal ◽  
Low Density Lipoprotein ◽  
Area Under The Curve ◽  
Density Lipoprotein ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
The Metabolic Syndrome ◽  
Ldl Particles ◽  
Postprandial Triglycerides

Objective: To determine the effects of fenofibrate (160 mg/d) on fasting and postprandial non-esterified fatty acids (NEFA) and lipoproteins in subjects with hypertriglyceridemia and the metabolic syndrome. Methods: Fifty-nine subjects with fasting hypertriglyceridemia (≥1.7 mmol/L and <6.9 mmol/L) and two or more of the Adult Treatment Panel III criteria of the metabolic syndrome were randomized to fenofibrate (160 mg/d) or placebo in a double-blind controlled clinical trial. A standardized fat load (50 g/m 2 ) was given after a 12 h fast. Blood specimens were obtained at fasting and 3.5 h and 8 h after the test meal. Results: After the test meal, postprandial (area under the curve) NEFA increased (mean ± SEM) by 11.2 ± 5.1% in the placebo group; in contrast NEFA decreased by 18.6 ± 3.8% in the fenofibrate group ( P =0.0001). No differences in fasting NEFA were observed between groups ( P =0.16). Fenofibrate reduced postprandial triglycerides (−45.4%, P <0.0001) and significantly decreased postprandial large (−40.8%, P <0.0001) and medium (−49.5%, p<0.0001) very low-density lipoprotein (VLDL) particles, as well as small LDL (−40.3%, P <0.0001) and total LDL particles (−19.0%, P <0.005). Reduction in NEFA (AUC) correlated with reductions in postprandial triglycerides (r=0.73, P <0.0001), non-HDL-C (r=0.67, P <0.0001) and with increases in HDL-C (r=0.38, P <0.01). The reduction in NEFA was more strongly correlated with decreased large VLDL (r=0.72, P <0.0001) than medium VLDL (r=0.34, P <0.02) or small VLDL particles (r=0.22, P <0.13). Postprandial reductions in NEFA were also correlated with lowering of small LDL (r=0.53, P <0.0001) and total LDL particles (r=0.60, P <0.0001). Conclusions: Treatment with fenofibrate significantly decreases postprandial NEFA and the reductions in NEFA are highly correlated with reductions in triglycerides, non-HDL-C and an increase in HDL-C. Postprandial NEFA are an important predictor of postprandial lipoprotein changes in subjects with hypertriglyceridemia.

scholarly journals Circulating CRP Levels Are Associated with Epicardial and Visceral Fat Depots in Women with Metabolic Syndrome Criteria

2019 ◽  
Vol 20 (23) ◽  
pp. 5981 ◽  
Author(s):  
Federico Carbone ◽  
Maria Stefania Lattanzio ◽  
Silvia Minetti ◽  
Anna Maria Ansaldo ◽  
Daniele Ferrara ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Epicardial Fat ◽  
Enzyme Linked Immunosorbent Assay ◽  
P Value ◽  
Ectopic Fat ◽  
Men And Women ◽  
Fat Depots ◽  
Hs Crp

Sexual dimorphism accounts for significant differences in adipose tissue mass and distribution. However, how the crosstalk between visceral and ectopic fat depots occurs and which are the determinants of ectopic fat expansion and dysfunction remains unknown. Here, we focused on the impact of gender in the crosstalk between visceral and epicardial fat depots and the role of adipocytokines and high-sensitivity C-reactive protein (hs-CRP). A total of 141 outward patients (both men and women) with one or more defining criteria for metabolic syndrome (MetS) were consecutively enrolled. For all patients, demographic and clinical data were collected and ultrasound assessment of visceral adipose tissue (VFth) and epicardial fat (EFth) thickness was performed. Hs-CRP and adipocytokine levels were assessed by enzyme-linked immunosorbent assay (ELISA). Men were characterized by increased VFth and EFth (p-value < 0.001 and 0.014, respectively), whereas women showed higher levels of adiponectin and leptin (p-value < 0.001 for both). However, only in women VFth and EFth significantly correlated between them (p = 0.013) and also with leptin (p < 0.001 for both) and hs-CRP (p = 0.005 and p = 0.028, respectively). Linear regression confirmed an independent association of both leptin and hs-CRP with VFth in women, also after adjustment for age and MetS (p = 0.012 and 0.007, respectively). In conclusion, men and women present differences in epicardial fat deposition and systemic inflammation. An intriguing association between visceral/epicardial fat depots and chronic low-grade inflammation also emerged. In women Although a further validation in larger studies is needed, these findings suggest a critical role of sex in stratification of obese/dysmetabolic patients.

scholarly journals A Delayed Modified ICH Score Outperforms Baseline Scoring in Acute Intracerebral Hemorrhage

2019 ◽  
Vol 10 (3) ◽  
pp. 217-220
Author(s):  
Ronda Lun ◽  
Vignan Yogendrakumar ◽  
Dylan Blacquiere ◽  
Michel Shamy ◽  
Grant Stotts ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Functional Outcome ◽  
Area Under The Curve ◽  
Predictive Ability ◽  
Patient Characteristics ◽  
Prognostic Scores ◽  
Secondary Outcome ◽  
Predictive Values ◽  
Poor Outcome ◽  
Acute Intracerebral Hemorrhage

The Modified Intracerebral Hemorrhage (MICH) score is a simple tool created to provide prognostication in basal ganglia hemorrhages. Current prognostic scores, including the MICH, are based on the assessment of baseline patient characteristics, failing to account for significant developments, such as intraventricular extension and clinical deterioration, which may occur over the first 72 hours. We propose to validate the MICH in all hemorrhage locations and hypothesize that its calculation at 72 hours will outperform its baseline counterpart with respect to predicting mortality and functional outcome. We performed a retrospective analysis of collated data from the Virtual International Stroke Trials Archive database. Primary outcome was 90-day mortality. Secondary outcome was poor outcome (modified Rankin Scale 4-6) at 90 days. Receiver operating characteristic curves were generated looking at the predictive ability of the MICH score for mortality and poor outcome, at baseline and at 72 hours. Competing curves were assessed with nonparametric methods. A total of 226 patients were included, with a 90-day mortality of 22.5%. The MICH scores calculated at 72 hours were more predictive of mortality than at baseline (area under the curve [AUC]: 0.89 [95% confidence interval [CI]: 0.83-0.94] vs 0.78 [95% CI: 0.70-0.85]), P < .01. The MICH scores at 72 hours similarly better predicted functional outcome (AUC: 0.78 [95% CI: 0.72-0.84] vs AUC: 0.72 [95% CI: 0.66-0.78]), P = .047. The MICH score has positive prognostic value for mortality and poor functional outcome in all hemorrhage locations. Delaying its calculation resulted in higher predictive values for both and suggests that delaying discussions around withdrawal of care may result in more accurate prognostication in acute intracerebral hemorrhage.

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