scholarly journals Association Between MUC1 rs4072037 Polymorphism and Helicobacter Pylori in Patients With Gastric Cancer

2021 ◽  
Author(s):  
Ramin Shekarriz ◽  
hadi jabbari ◽  
Reza Alikhani ◽  
Reza Alizadeh Navaei ◽  
Mohammad Bagher Hashemi‑Soteh
Keyword(s):  
Gastric Cancer ◽  
Genetic Model ◽  
Protective Role ◽  
Mazandaran Province ◽  
Northern Iran ◽  
H Pylori ◽  
Acquired Immune Responses ◽  
And Control ◽  
The Relationship ◽  
Increased Susceptibility

Abstract Background: The MUC1 gene encodes glycoproteins attached to cell membrane that play a protective role in gastric cancer and protect epithelial surfaces against external factors such as H. pylori. H. pylori infection can induce a cascade of innate and acquired immune responses in gastric mucosa. This study investigated the relationship between rs4072037G>A polymorphism of MUC1 gene and increased susceptibility to H. pylori infection in patients with gastric cancer in Mazandaran province, northern Iran.Method: A case-control study was conducted in 99 patients with gastric cancer (H. pylori positive and negative) and 98 controls (H. pylori positive and negative) without gastric cancer (confirmed by pathological biopsy samples obtained during endoscopy). H. pylori infection was diagnosed by histological examination using Giemsa staining. Genomic DNA extracted from peripheral blood was analyzed by PCR-RFLP technique.Results: Analysis of all genetic models showed no significant relationship between rs4072037G>A polymorphism and risk of gastric cancer (GC). We investigated the relationship between H. pylori infection and rs4072037G>A polymorphism in increasing the susceptibility to gastric cancer in both positive and negative H. pylori groups (including case and control groups). The genetic model of GA/GG and H. pylori- positive versus GA/GG and H. pylori-negative showed a significantly increased susceptibility to gastric cancer (OR=0.251, CI: 0.128-0.493, p=0.000).Conclusion: These findings indicate that rs4072037G>A polymorphism may interact with H. pylori infection to increase the risk of GC.

scholarly journals The correlation between lncRNAs and Helicobacter pylori in gastric cancer

2019 ◽  
Vol 77 (9) ◽  
Author(s):  
Narges Dastmalchi ◽  
Seyed Mahdi Banan Khojasteh ◽  
Mirsaed Miri Nargesi ◽  
Reza Safaralizadeh
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Molecular Mechanisms ◽  
Gastrointestinal Diseases ◽  
Mechanisms Of Action ◽  
Molecular Pathways ◽  
Gastric Diseases ◽  
Non Coding Rnas ◽  
H Pylori ◽  
The Relationship

ABSTRACT Helicobacter pylori infection performs a key role in gastric tumorigenesis. Long non-coding RNAs (lncRNAs) have demonstrated a great potential to be regarded as effective malignancy biomarkers for various gastrointestinal diseases including gastric cancer (GC). The present review highlights the relationship between lncRNAs and H. pylori in GC. Several studies have examined not only the involvement of lncRNAs in H. pylori-associated GC progression but also their molecular mechanisms of action. Among the pertinent studies, some have addressed the effects of H. pylori infection on modulatory networks of lncRNAs, while others have evaluated the effects of changes in the expression level of lncRNAs in H. pylori-associated gastric diseases, especially GC. The relationship between lncRNAs and H. pylori was found to be modulated by various molecular pathways.

Prognostic Nomogram on Clinicopathologic Features and Serum Uric Acid for Precancerous Lesions and Gastric Cancer

2021 ◽  
Author(s):  
Shanshan Tang ◽  
Ying Chen ◽  
Chenhong Fu ◽  
Xin Xie ◽  
Ziyu Song ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Precancerous Lesions ◽  
Multiple Logistic Regression Analysis ◽  
Precancerous Lesion ◽  
Multiple Logistic Regression ◽  
Diagnosis Rate ◽  
H Pylori ◽  
The Relationship

Abstract The relationship between Uric acid (UA) and malignant tumor are still confusing. Gastric cancer(GC) is recognized to be closely related to Helicobacter pylori (H. pylori) infection, early diagnosis rate is very low. In this study, we aimed to investigate the relationship between H. pylori and hyperuricemia (HUA), and evaluate the predictive value of serum uric acid (SUA) in gastric precancerous lesion (GPL) and gastric cancer (GC). This retrospective study included 486 patients who underwent gastroscopy (155 controls, 272 GPL, 59 GC patients). The risk factors for GPL and GC were identified by multiple logistic regression analysis and nomogram was constructed to evaluate the ability of SUA to predict the risk of these diseases based on SUA score. We found that in healthy controls, HUA is positively correlated with H. Pylori (+). SUA was an independent risk factor for GPL and GC. Verification shows that the nomogram was better fitted for GC than for GPL. In conclusion, our study established nomogram based on SUA to predict the risk of GPL and GC, suggested that the incidence of GPL and GC is higher in H. pylori (+) HUA patients, so early intervention and vigilance should be raised.

scholarly journals Are Iranian Sulfur Mustard Gas-Exposed Survivors More Vulnerable to SARS-CoV-2? Some Similarity in Their Pathogenesis

2020 ◽  
pp. 1-7
Author(s):  
Gholamreza Farnoosh ◽  
Mostafa Ghanei ◽  
Hossein Khorramdelazad ◽  
Gholamhossein Alishiri ◽  
Alireza Jalali Farahani ◽  
...  
Keyword(s):  
Immune System ◽  
Infection Prevention ◽  
Sulfur Mustard ◽  
Infection Prevention And Control ◽  
Mustard Gas ◽  
History Of ◽  
And Control ◽  
The Relationship ◽  
Increased Susceptibility ◽  
Gas Exposure

ABSTRACT Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged as a health problem worldwide. It seems that COVID-19 is more lethal for Iranian veterans with a history of exposure to mustard gas. There are some similarities in the pathogenesis of SARS-CoV-2 and mustard gas in immune system disruption and pulmonary infection. SARS-CoV-2 and mustard gas inducing oxidative stress, immune system dysregulation, cytokine storm, and overexpression of angiotensin-converting enzyme II (ACE2) receptor in lungs that act as functional entry receptors for SARS-CoV-2. Moreover, Iranian survivors of mustard gas exposure are more susceptible and vulnerable to COVID-19. It is suggested that the principles of COVID-19 infection prevention and control be adhered to more stringently in Iranian survivors of mustard gas exposure than others who have not been exposed to mustard gas. Therefore, in this review, we discuss the different pathologic aspects of lung injury caused by mustard gas and also the relationship between this damage and the increased susceptibility of Iranian mustard gas exposed survivors to COVID-19.

scholarly journals Analysis of Gene Expression of miRNA-106b-5p and TRAIL in the Apoptosis Pathway in Gastric Cancer

Genes ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 393
Author(s):  
Jéssica Pereira ◽  
Mônica Santos ◽  
Roger Delabio ◽  
Mônica Barbosa ◽  
Marília Smith ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Gene Expression Analysis ◽  
Gastric Diseases ◽  
Apoptosis Pathway ◽  
Cancer Pathways ◽  
Cancer Group ◽  
Mirna 106B ◽  
H Pylori ◽  
The Relationship

Helicobacter pylori (H. pylori) is one of the main causes of gastric gancer. TNF-related apoptosis-inducing ligand (TRAIL) is a protein able to promote apoptosis in cancer cells, however not in gastric cancer, which presents resistance to apoptosis via TRAIL. It is believed that MicroRNA-106b-5p might be involved in this resistance, although its role in Gastric Cancer is unclear. We aimed to determine the expression of microRNA-106b-5p and TRAIL in patients with gastric diseases, infected by H. pylori, and understand the relationship between these genes and their role in apoptosis and the gastric cancer pathways. H. pylori was detected by PCR, gene expression analysis was performed by real-time-qPCR, and bioinformatics analysis was performed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Cytoscape software. A total of 244 patients were divided into groups (Control, Gastritis, and Cancer); H. pylori was detected in 42.2% of the samples. The cancer group had a poor expression of TRAIL (p < 0.0001) and overexpression of microRNA-106b-5p (p = 0.0005), however, our results confirmed that these genes are not directly related to each other although both are apoptosis-related regulators. Our results also indicated that H. pylori decreases microRNA-106b-5p expression and that this is a carcinogenic bacterium responsible for gastric diseases.

scholarly journals Prevalence of H. pylori Infection in Relatives of Peruvian Patients with Gastric Cancer

2021 ◽  
Vol 6 (1) ◽  
pp. 53-57
Author(s):  
Miluska Castillo ◽  
Luis A. Bernabe ◽  
Carlos A. Castaneda ◽  
Nancy Suarez ◽  
Fernando Barreda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Tissue Sample ◽  
Gastric Tissue ◽  
Infection Rates ◽  
Urease Test ◽  
H Pylori ◽  
The Relationship

Objective: The aim of this study was to determine the relationship between Helicobacter pylori (H. pylori) infection in relatives and patients with gastric cancer (GC).Methods: H. pylori infection was evaluated by the breath urease test in 171 relatives and by qPCR technique in gastric tissue of 61 patients (n=45 for GC and n=16 for non-GC). Results: There were included 137 relatives of GC patients and 34 of non-GC. The median age of the relatives of patients with a gastric tissue sample was 39 years (10-86). Infection was found in 60.2% (n=103) relatives. There were no higher H. pylori infection rates in relatives of patients with gastric cancer (62% vs 62.9%, p=0.33), H. pylori infection (60% vs 60%, p=0.96), or metaplasia (58.8% vs 61.8%, p=0.71). Conclusion: The prevalence of infection in relatives of GC patients is high in our population but not associated with H. pylori presence in the paired case.

The relationship between H. pylori infection and gastric cancer: a review

2020 ◽  
pp. 267-270
Author(s):  
Radad Alqahtani ◽  
Hasan Albarqi ◽  
Faisal Alqarqah ◽  
Osama Alzahrani ◽  
Maram Alabdali ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
H Pylori ◽  
The Relationship

scholarly journals Survey of anaemia andHelicobacter pyloriinfection in adolescent girls in Suihua, China and enhancement of iron intervention effects byH. pylorieradication

2011 ◽  
Vol 108 (2) ◽  
pp. 357-362 ◽  
Author(s):  
Wei Xia ◽  
Xin Zhang ◽  
Jiajia Wang ◽  
Caihong Sun ◽  
Lijie Wu
Keyword(s):  
Adolescent Girls ◽  
Intervention Group ◽  
Fe Deficiency ◽  
Control Group ◽  
Colloidal Bismuth Subcitrate ◽  
Bismuth Subcitrate ◽  
H Pylori ◽  
And Control ◽  
The Relationship ◽  
Colloidal Bismuth

In the present study, we investigated the prevalence of anaemia and Fe deficiency anaemia (IDA) and explored the relationship betweenHelicobacter pyloriinfection and IDA in adolescent girls. A total of 1037 adolescent girls from Suihua, China were enrolled. Hb, serum ferritin (SF), serum transferrin receptor (sTfR) and serum IgG antibodies toH. pyloriwere measured. Participants with IDA and co-existingH. pyloriinfection (n80) who had an intake of >25 mg/d of Fe were assigned randomly to the intervention and control groups. Patients in the intervention group were administered a 12-week course of oral EDTA–Na–Fe (60 mg Fe/dose, three times a week) and a 2-week course of colloidal bismuth subcitrate, amoxicillin and metronidazole. Subjects in the control group were administered EDTA–Na–Fe alone. Hb, SF and sTfR were reassessed 3 months after the 12-week regimen ended. Prevalence of anaemia, Fe deficiency (defined as SF < 12·0 μg/l), IDA andH. pyloriinfection in the population of 1037 was 19·5, 40·4, 17·1 and 31·2 %, respectively. The prevalence ofH. pyloriinfection in the IDA group was 46·9 %, while the non-anaemic group had 28·1 % prevalence. A significant increase in Hb and SF and a decrease in sTfR value were found in the intervention group and theH. pylori-negative group. Findings suggest that IDA is still one of the prominent problems in adolescent girls. There is an association betweenH. pyloriinfection and IDA. Treatment ofH. pyloriinfection is associated with a more rapid response to oral Fe therapy.

scholarly journals Association betweenHelicobacter pyloriInfection and Chronic Urticaria: A Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Huiyuan Gu ◽  
Lin Li ◽  
Min Gu ◽  
Guoxin Zhang
Keyword(s):  
Chronic Urticaria ◽  
Observational Studies ◽  
Detection Method ◽  
Meta Analysis ◽  
Influential Factor ◽  
Increased Risk ◽  
Potential Factors ◽  
H Pylori ◽  
And Control ◽  
The Relationship

Background. Some studies have shown the possible involvement ofHelicobacter pylori(H. pylori) infection in chronic urticaria, but the relationship remains controversial. The aim of this meta-analysis was to quantitatively assess the association betweenH. pyloriinfection and chronic urticaria.Methods. Observational studies comparing the prevalence ofH. pyloriinfection in patients with chronic urticaria and control subjects were identified through a systematic search in MEDLINE and EMBASE up to July 2014.H. pyloriinfection was confirmed by serological or nonserological tests. For subgroup analyses, studies were separated by region, publication year, andH. pyloridetection method to screen the potential factors resulting in heterogeneity.Results. 16 studies involving 965 CU cases and 1235 controls were included. Overall, the prevalence ofH. pyloriinfection was higher in urticarial patients than in controls (OR = 1.66; 95% CI: 1.12–2.45;P=0.01). This result persisted in subanalysis of nine high-quality studies (OR = 1.36; 95% CI: 1.03–1.80;P=0.03). Subgroup analysis showed that detection method ofH. pyloriis also a potential influential factor for the overall results.Conclusions. Our present meta-analysis suggests thatH. pyloriinfection is significantly, though weakly, associated with an increased risk of chronic urticaria.

scholarly journals The Evolving Epidemiology ofHelicobacter pyloriInfection and Gastric Cancer

2003 ◽  
Vol 17 (suppl b) ◽  
pp. 18B-20B ◽  
Author(s):  
Jia-Qing Huang ◽  
Richard H Hunt
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Increased Risk ◽  
H Pylori ◽  
The Relationship

The relationship betweenHelicobacter pyloriinfection and the risk of gastric cancer has been well established in the last decade. Four metaanalyses have found that the infection increases the risk of noncardia gastric cancer by 2- to 6-fold compared with noninfected control populations. However, the role ofcagAstrains ofH pyloriin relation to gastric cancer has not been evaluated systematically. We undertook a meta-analysis of epidemiological studies examining the relationship between infection withcagA-positive strains ofH pyloriand the risk of gastric cancer, and found that patients who are seropositive forcagAstrains ofH pyloriare at an increased risk for developing noncardia gastric cancer compared with those withH pyloriinfection alone. Therefore, searching forcagA-positive strains ofH pylorimay help identify populations at a greater risk for developing gastric cancer.

scholarly journals Function of Non-coding RNA in Helicobacter pylori-Infected Gastric Cancer

2021 ◽  
Vol 8 ◽  
Author(s):  
Chao Wang ◽  
Yiyang Hu ◽  
Huan Yang ◽  
Sumin Wang ◽  
Bo Zhou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Tumor Progression ◽  
Digestive System ◽  
Non Coding Rna ◽  
Gastric Cancer Treatment ◽  
Multiple Levels ◽  
New Perspective ◽  
H Pylori ◽  
The Relationship

Gastric cancer is a common malignant tumor of the digestive system. Its occurrence and development are the result of a combination of genetic, environmental, and microbial factors. Helicobacter pylori infection is a chronic infection that is closely related to the occurrence of gastric tumorigenesis. Non-coding RNA has been demonstrated to play a very important role in the organism, exerting a prominent role in the carcinogenesis, proliferation, apoptosis, invasion, metastasis, and chemoresistance of tumor progression. H. pylori infection affects the expression of non-coding RNA at multiple levels such as genetic polymorphisms and signaling pathways, thereby promoting or inhibiting tumor progression or chemoresistance. This paper mainly introduces the relationship between H. pylori-infected gastric cancer and non-coding RNA, providing a new perspective for gastric cancer treatment.

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