scholarly journals The Comparison of Breast Cancer in Southern China and America: a Multicentre Study in China Versus SEER Database

2021 ◽  
Author(s):  
Yingjie Niu ◽  
Fan Zhang ◽  
Dong Chen ◽  
Guolin Ye ◽  
Yong Li ◽  
...  
Keyword(s):  
Tumor Size ◽  
Southern China ◽  
Developed Countries ◽  
The United States ◽  
Positive Lymph Node ◽  
Lymph Node Status ◽  
Seer Database ◽  
Ki 67 ◽  
Treatment Information ◽  
The Difference

Abstract Background and Objective: There are different characteristics of BC in developing countries and developed countries. We intend to study the factors which influence the survival and prognosis of BC between southern China and the United States. Methods: To study the two groups BC patients in southern China from 2001 to 2016 and SEER database from 1975 to 2016. To register, collect and analyze the clinicopathological features and treatment information. Results: Our study found that there are significant differences in tumor size, positive lymph node status and KI-67 between southern China and SEER cohort (P<0.000). Conclusions: The age, tumor size, positive-node and KI-67 may cause the difference of morbidity and mortality of BC patients in southern China and SEER cohort.

scholarly journals The Comparison of Breast Cancer in Southern China and America: A Multicentre Study in China Versus SEER Database

2021 ◽  
Author(s):  
Yingjie Niu ◽  
Fan Zhang ◽  
Dong Chen ◽  
Guolin Ye ◽  
Yong Li ◽  
...  
Keyword(s):  
Tumor Size ◽  
Southern China ◽  
Developed Countries ◽  
The United States ◽  
Positive Lymph Node ◽  
Lymph Node Status ◽  
Seer Database ◽  
Ki 67 ◽  
Treatment Information ◽  
The Difference

Abstract Background and Objective: There are different characteristics of BC in developing countries and developed countries. We intend to study the factors which influence the survival and prognosis of BC between southern China and the United States. Methods: To study the two groups BC patients in southern China from 2001 to 2016 and SEER database from 1975 to 2016. To register, collect and analyze the clinicopathological features and treatment information. Results: Our study found that there are significant differences in tumor size, positive lymph node status and KI-67 between southern China and SEER cohort (P<0.000). Conclusions: The age, tumor size, positive-node and KI-67 may cause the difference of morbidity and mortality of BC patients in southern China and SEER cohort.

scholarly journals The Characteristics Comparison of Breast Cancer Patients in Southern China and America: A Multicentre Study in China Versus SEER Database

2020 ◽  
Author(s):  
Yingjie Niu ◽  
Fan Zhang ◽  
Dong Chen ◽  
Guolin Ye ◽  
Yong Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Tumor Size ◽  
Southern China ◽  
The United States ◽  
Morbidity And Mortality ◽  
Lymph Node Status ◽  
Seer Database ◽  
Breast Cancer Patients ◽  
Ki 67

Abstract Background and Objective: The morbidity and mortality of breast cancer are increasing in recent years, which had become the second main cause of cancer death in women. However, there are different characteristics of breast cancer in developing countries and developed countries. What’s more, it has not reported the comparison of breast cancer between southern China and the United States. We intend to compare the age, different stages and grades of tumor and treatment methods, in order to study the factors which influence the survival and prognosis of breast cancer patients. Methods: To study the two groups which have been diagnosed with breast cancer in southern China from 2001 to 2016 and SEER database from 1975 to 2016. To register, collect and analyze the clinicopathological features and treatment information. To follow up the patients who have been diagnosed before 2016. Kaplan-Meier method was used to evaluate disease-free survival (DFS) and overall survival (OS). Results: Young breast cancer patients accounted for 19.8% and 6.14% respectively in southern China and SEER cohort. The early diagnostic rate of breast cancer is high in southern China, but still lower than SEER cohort. Our study found that there are significant differences in tumor size and positive lymph node status between southern China and SEER cohort (P=0.000), which notably affect the OS of breast cancer patients (P=0.018 and P=0.000). Furthermore, KI-67 is also an important prognostic factor of breast cancer patients in southern China, which also affect the OS of patients (P=0.034). In treatment, there are also significant differences between the two regions. In southern China, there are 4.91% of breast cancer patients performed breast conserving surgery and 95.09% patients performed mastectomy. But in SEER cohort, there are only 4.91% patients preformed breast surgery. Conclusions: The age, tumor size, positive-node and KI-67 may cause the difference of morbidity and mortality of breast cancer patients in southern China and SEER cohort. Overall, the prognosis of breast cancer patients in SEER cohort is better than southern China.

Luminal A and Luminal B subtypes in patients with breast cancer 65 years of age and older.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 549-549
Author(s):  
Robert Konigsberg ◽  
Georg Pfeiler ◽  
Nicole Hammerschmid ◽  
Tatjana Klement ◽  
Christian Dittrich
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Endocrine Therapy ◽  
Tumor Size ◽  
Lymph Node Status ◽  
Primary Therapy ◽  
Luminal A ◽  
Ki 67 ◽  
Luminal B ◽  
Significant Difference

549 Background: In 2011, the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer (bc) suggested the distinction between Luminal A and Luminal B subtypes. In Luminal A patients (pts) endocrine therapy seems to be sufficiently effective, whereas in Luminal B pts the additional application of chemotherapy should be considered. It is currently unknown, whether the risk stratification into Luminal A and B is comparably or more discriminatory than the established pathologic tumor size (pT) and lymph node (pN) status in pts ≥ 65 years. This analysis evaluates the discriminatory capacity of the new distinction between Luminal A and B and the established prognostic factors in bc pts ≥ 65 years treated with endocrine therapy only. Methods: Clinico-pathological data of 190 bc pts ≥ 65 years diagnosed between 1998 and 2004 were retrospectively analyzed. Pts were classified as Luminal A [ER (+) and/ or PR (+) and Her/2neu (-) and Ki-67 < 14%] or Luminal B [ER (+) and/ or PR (+) and Her2 (-) and Ki-67 ≥ 14%]. The Kaplan-Meier method was used to assess the progression-free survival (PFS) and overall survival (OS) estimates. Differences in survival between groups were tested for significance by the log-rank test. Results: Median age was 74 years (65–92 years) and median time of follow-up was 69 months (0–134 months). 68.9% and 31.1% pts had Luminal A and B subtypes, respectively. 73.3% and 26.7% of pts had pT1 and pT2 tumors, respectively. 79.7% and 20.3% of pts had pN0 and pN1 status, respectively. Overall, median PFS was 33 months. No significant difference regarding PFS could be detected between Luminal A and B pts, between pT1 and pT2 tumors and between pN0 and pN1 status (p=0.458; 0.172; 0.156), respectively. Overall, median OS was not reached. No significant difference regarding OS could be detected between Luminal A and B pts, between pT1 and pT2 tumors and between pN0 and pN1 status (p=0.328; 0.951; 0.976), respectively. Conclusions: In bc pts ≥ 65 years treated with endocrine therapy only, neither the recently consented dichotomization into Luminal A and B subtypes nor pathologic tumor size and lymph node status could be confirmed to be discriminative as propagated in the 2011 St. Gallen Consensus for the overall bc population.

scholarly journals Immunohistochemical study of P53 protein expression in different prostate cancer Gleason grading groups

2020 ◽  
Vol 24 (2) ◽  
pp. 145-155 ◽  
Author(s):  
G. Y. Kudryavtsev ◽  
L. V. Kudryavtseva ◽  
L. M. Mikhaleva ◽  
Y. Y. Kudryavtseva ◽  
N. A. Solovyeva ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Proliferative Activity ◽  
Immunohistochemical Study ◽  
P53 Protein ◽  
Public Health Problem ◽  
Developed Countries ◽  
Ki 67 ◽  
P53 Expression ◽  
Gleason Grading ◽  
The Difference

Prostate cancer (PC) remains an urgent public health problem, especially in developed countries. The use of immunohistochemical research methods in addition to the morphological classification of prostate adenocarcinomas allows a more accurate diagnosis and prognosis of the disease. The aim of the study is to identify isoforms of P53 using clones of mouse antibodies (D-07 and Y5; Epitomics, USA) in prostate cancer with different proliferative activity and the degree of malignancy. Materials and Methods: The work included surgical material for prostate resection and prostatectomy, as well as biopsy specimens (56 cases in total). An immunohistochemical study was carried out with the Ki-67 marker, as well as with mouse monoclonal antibodies (D-07 and Y5) to the P53 protein, interacting with its wild and mutant isoforms. The significance of the difference in the samples was determined using the Mann-Whitney U-test, correlation relationships were determined using the Spearman coefficient. Results: Expression of P53 upon interaction with antibodies D-07 and Y5 was determined in 56.3% and 39.6%, respectively. A statistically significant direct correlation was found between the severity of P53 expression when interacting with Y5 antibodies and the degree of tumor differentiation (rs = 0.567, p 0.05), as well as between the expression level of this protein and tumor proliferative activity (rs = 0.698, p 0.05). Conclusion: Antibodies of clone D-07, interacting with both wild and mutant isoforms of P53 protein, show positive expression in adenocarcinomas of all degrees. Expression of the mutant P53 protein is most pronounced in low-differentiated carcinomas and correlates with high proliferative activity of tumor cells, which may be associated with a loss in the induction of P53-dependent apoptosis.

scholarly journals The Progressive Public Measures of Saudi Arabia to Tackle Covid-19 and Limit Its Spread

2021 ◽  
Vol 18 (2) ◽  
pp. 783
Author(s):  
Anwar A. Sayed
Keyword(s):  
Saudi Arabia ◽  
Descriptive Study ◽  
Developed Countries ◽  
The United States ◽  
Fatality Rate ◽  
Religious Activities ◽  
The Public ◽  
The Difference ◽  
The Government ◽  
Novel Coronavirus

Since the beginning of the global novel coronavirus disease (Covid-19) pandemic, the response of governments has varied significantly across the world. This was one of the main reasons behind the difference in the disease fatality rates between countries. In this study, the public progressive measures taken in Saudi Arabia (SA) are described in detail. This is a descriptive study in which measures were retrieved via the government official news agency—Saudi Press Agency (SPA). The total number of Covid-19 cases and its fatality rate were obtained/calculated from the Saudi Ministry of Health (MoH) official Covid-19 port, as well as the WHO COVID-19 dashboard. SA took active measures in order to interrupt the spread of Covid-19 which were strict, rapid, and progressive in nature. Social distancing was at the heart of almost every measure taken by the government. The main themes of these interventions are as follows: travel bans, suspending religious activities, closure of non-essential shops, enforcing changes at workplaces, and imposing curfews. This was followed by the gradual return to working life with various precautions to prevent a spike in the number of cases. The imposed measures in SA succeeded in reducing the burden of Covid-19 and its fatality rate. Comparatively, the fatality rate in SA was significantly lower compared to developed countries with better healthcare infrastructure such as the United States and United Kingdom.

A review of literature on women’s leadership in higher education in developed countries and in Vietnam: Barriers and enablers

2021 ◽  
pp. 174114322110214
Author(s):  
Greeni Maheshwari
Keyword(s):  
Higher Education ◽  
Literature Review ◽  
Women Leaders ◽  
Participation Rate ◽  
Developed Countries ◽  
The United States ◽  
Women's Leadership ◽  
Barriers And Enablers ◽  
Leadership In Higher Education ◽  
The Difference

The purpose of this paper is to provide a review of the literature on women’s leadership in higher education in the last 20 years. This literature review employed a systematic review of 64 articles published worldwide with 28 articles specifically published in Australia, Canada, New Zealand, the United Kingdom, the United States and Vietnam. The aim of the study is to determine if there are any differences in barriers and enablers of women leaders between the developed countries chosen for this study and Vietnam in higher education and how the countries are progressing towards gender equality. The study concluded that most of the research in women’s leadership in higher education had been done in the US and Canada, with a dearth of literature on women’s leadership in higher education in Asia, and only six studies have been done in Vietnam till 2019, with only two studies done before 2017. The findings suggested that women leaders in developed countries and Vietnam still face almost the same challenges as in the past but, with family support, these challenges are becoming less in Vietnam. Mentor support was found to be an enabler in other developed countries which was missing in Vietnam. Vietnam is gaining importance in research in women’s leadership in higher education, which may be due to an increased female labour participation rate and higher growth in gross domestic product rates. The future of women leaders seems to be bright, especially in Vietnam, due to higher female educational attainment. There is a small number of literature review studies on barriers and enablers in the field of women leaders in higher education comparing developed nations and a developing country. Hence, the current study aims to fill this gap to provide an overview of the difference between the enablers and barriers faced by women leaders between developed countries and Vietnam.

scholarly journals Incidence, demographics, and survival of patients with primary pituitary tumors: a SEER database study in 2004–2016

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Cheng Chen ◽  
Yu Hu ◽  
Liang Lyu ◽  
Senlin Yin ◽  
Yang Yu ◽  
...  
Keyword(s):  
Overall Survival ◽  
Pituitary Adenoma ◽  
Incidence Rate ◽  
Tumor Size ◽  
Pituitary Adenomas ◽  
Pituitary Tumors ◽  
The United States ◽  
Reliable Estimate ◽  
Seer Database ◽  
Factors Associated

AbstractComprehensive investigations on the incidence and prognosis of pituitary tumors are still lacking. The present study aims to summarize the incidence, demographics, and survival outcome of pituitary adenoma on a population-based level. This study includes all pituitary adenomas reported in the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2016 in the United States. Extensive clinical and demographic characteristics were extracted and submitted to group comparisons. The standardized incidence rate was calculated and stratified by year at diagnosis, age/sex and age/treatment groups. The Kaplan–Meier analysis and multivariable regressions were performed to identify the factors associated with overall survival. A total of 47,180 pituitary tumors were identified, including 47,030 typical adenomas, 111 uncertain behavior pituitary adenomas, and 39 pituitary carcinomas. The overall standardized incidence rate was 4.8 cases per 100,000 person-years and the annual incidence rate continually trended upwards, with a peak seen in 2015. We noticed a bimodal age-related distribution in females and a unimodal distribution in males. In the multivariate regression analysis, the factors associated with prolonged survival included typical adenoma, younger age, and smaller tumor size. Whereas, black and male patients had worse overall survival. Our study provides a reliable estimate on the incidence of pituitary adenoma and confirms that the annual standardized incidence rate is increasing. Pituitary adenomas have a satisfactory long-term prognosis and age, tumor size, and tumor subtypes are related to overall survival. Though statistically significant, our inferential findings should be constrained within the limitations of SEER database.

scholarly journals Holistic Analysis of Coronavirus Literature: A Scientometric Study of the Global Publications Relevant to SARS-CoV-2 (COVID-19), MERS-CoV (MERS) and SARS-CoV (SARS)

2020 ◽  
pp. 1-8
Author(s):  
Engin Şenel ◽  
Fatih Esad Topal
Keyword(s):  
United States ◽  
Southern China ◽  
Developed Countries ◽  
The United States ◽  
The United Kingdom ◽  
Scientometric Evaluation ◽  
Novel Coronavirus ◽  
Almost All ◽  
Source Countries ◽  
Scientometric Study

ABSTRACT Objectives: In late December 2019, a cluster of patients with pneumonia caused by an unknown pathogen was reported from Wuhan, Hubei Province, China. The pathogen has been identified as a novel coronavirus, severe acute respiratory syndrome 2 (SARS-CoV-2) and the disease has been named as coronavirus disease 2019 (COVID-19). The objective of this study was to perform the first holistic scientometric evaluation of coronavirus publications. Methods: Our main source for this study was Web of Science Collection database. All items published between 1980 and 2019 were included. A distribution map of global production in coronavirus literature and scientometric networks were generated. Results: The United States, China, Germany, the United Kingdom, and Netherlands were the most productive countries. Publications in coronavirus literature have been produced from almost every country in the world, except for some countries in Asia and Africa. Conclusion: While in the 1980s, the United States and developed countries from Europe were major source countries and the virus was identified only as an animal disease in the literature and its biological and genetic structure was investigated, in the 2000s, China became a major contributor of coronavirus literature because the SARS outbreak originated from southern China. Almost all most-cited publications in this period are related to SARS and the ACE2 protein.

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