scholarly journals Assessment of Epidemiological Profile and Clinical Characteristics of Head and Neck Cancers among Patients of Tertiary Hospital in North Western India: A 10-Year Retrospective Study

2019 ◽  
Vol 4 (4) ◽  
Author(s):  
Shveta Mahajan ◽  
Rajeev Gupta ◽  
Vanita Sareen ◽  
Vikas Kakar
Keyword(s):  
Retrospective Study ◽  
Head And Neck ◽  
Clinical Characteristics ◽  
Tertiary Hospital ◽  
Head And Neck Cancers ◽  
Western India ◽  
Epidemiological Profile ◽  
North Western

scholarly journals Diagnosis and treatment delay of head and neck cancers during COVID-19 era in a tertiary care academic hospital: what should we expect?

2021 ◽  
Author(s):  
Pietro De Luca ◽  
Antonella Bisogno ◽  
Vito Colacurcio ◽  
Pasquale Marra ◽  
Claudia Cassandro ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Head And Neck ◽  
Retrospective Analysis ◽  
Tertiary Care ◽  
Diagnostic Delay ◽  
Treatment Delay ◽  
Head And Neck Cancers ◽  
Control Measures ◽  
Academic Hospital ◽  
The Impact

Abstract Background Since the spreading of SARS-CoV-2 from China, all deferrable medical activities have been suspended, to redirect resources for the management of COVID patients. The goal of this retrospective study was to investigate the impact of COVID-19 on head and neck cancers’ diagnosis in our Academic Hospital. Methods A retrospective analysis of patients treated for head and neck cancers between March 12 and November 1, 2020 was carried out, and we compared these data with the diagnoses of the same periods of the 5 previous years. Results 47 patients were included in this study. We observed a significative reduction in comparison with the same period of the previous 5 years. Conclusions Our findings suggest that the COVID-19 pandemic is associated with a decrease in the number of new H&N cancers diagnoses, and a substantial diagnostic delay can be attributable to COVID-19 control measures.

scholarly journals Molecular Tumor Subtypes of HPV-Positive Head and Neck Cancers: Biological Characteristics and Implications for Clinical Outcomes

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2721
Author(s):  
Tingting Qin ◽  
Shiting Li ◽  
Leanne E. Henry ◽  
Siyu Liu ◽  
Maureen A. Sartor
Keyword(s):  
Head And Neck ◽  
Stromal Cells ◽  
Clinical Characteristics ◽  
Molecular Subtypes ◽  
Squamous Cell Carcinomas ◽  
Head And Neck Cancers ◽  
Molecular Signatures ◽  
Tumor Subtypes ◽  
Mesenchymal Differentiation ◽  
High Incidence

Until recently, research on the molecular signatures of Human papillomavirus (HPV)-associated head and neck cancers mainly focused on their differences with respect to HPV-negative head and neck squamous cell carcinomas (HNSCCs). However, given the continuing high incidence level of HPV-related HNSCC, the time is ripe to characterize the heterogeneity that exists within these cancers. Here, we review research thus far on HPV-positive HNSCC molecular subtypes, and their relationship with clinical characteristics and HPV integration into the host genome. Different omics data including host transcriptomics and epigenomics, as well as HPV characteristics, can provide complementary viewpoints. Keratinization, mesenchymal differentiation, immune signatures, stromal cells and oxidoreductive processes all play important roles.

Gabapentin for the treatment of pain related to radiation-induced mucositis in patients with head and neck cancers treated with intensity modulated radiation therapy (IMRT)

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 16513-16513 ◽  
Author(s):  
V. Bar Ad ◽  
S. Both ◽  
P. Dutta ◽  
H. Quon
Keyword(s):  
Radiation Therapy ◽  
Retrospective Study ◽  
Head And Neck ◽  
Pain Control ◽  
Radiation Treatment ◽  
Pain Medication ◽  
Head And Neck Cancers ◽  
Median Dose ◽  
Concomitant Boost ◽  
Radiation Induced

16513 Background: Gabapentin has been reported to effectively treat multiple neuropathic pain syndromes. This retrospective study evaluates the efficacy of gabapentin for the treatment of pain related to radiation induced mucositis, in patients with head and neck cancers, treated with radiation therapy (RT). Methods: This retrospective study includes 30 pts with head and neck cancers, treated with RT, without concomitant or induction chemotherapy. IMRT planning was performed using a concomitant boost technique with a median dose of 54 Gy, 63 Gy, and 66 Gy delivered to the low risk clinical tumor volume (CTV), high risk CTV and boost target volume, respectively, using 30- 34 fractions. The dose of gabapentin was gradually increased starting on the second week of RT from 600 mg/day to the dose of 2700 mg/d over the course of one week. Narcotic pain medication (Roxicodone) was prescribed as needed. Results: 26 (86%) pts required no pain medication during the first two weeks of RT, despite the presence of grade 1 and/or 2 mucositis in 24 of them. During the third and fourth weeks of RT, 28 (93%) pts were treated with a median dose of 2700 mg/day of gabapentin, with only 3 (10%) pts requiring low dose narcotic pain medication, 15–30 mg/day of Roxicodone, added to gabapentin for adequate pain control, despite grade 2 or higher mucositis in 22 pts. During weeks 5 and 6, 28 (93%) pts continued to be treated with a median dose of 2700 mg/day of gabapentin with only 10 (35%) pts requiring 15–40 mg/day of Roxicodone, in addition to gabapentin for pain control, despite the presence of grade 2 or higher mucositis in 23 pts. Only 3% of the pts in this group had delay in RT delivery. Gabapentin was well tolerated with only 13% of pts experiencing mild side effects (somnolence, nausea, or vomiting), which were managed with reducing the dose or changing the dosing schedule. Conclusions: Gabapentin is effective and well-tolerated for the treatment of mucositis-induced pain related to radiation treatment in patients with head and neck cancers, treated with IMRT. We further demonstrate that the use of gabapentin at doses of 2700 mg per day can reduce or eliminate the need for narcotic pain medication. No significant financial relationships to disclose.

scholarly journals Clinical Profile of Paediatric Head and Neck Cancers at a Tertiary Hospital in Tanzania

2020 ◽  
Vol 3 (1) ◽  
pp. 11-20
Author(s):  
Zephania Saitabau Abraham ◽  
Enica Richard Massawe ◽  
Aveline Aloyce Kahinga ◽  
Kassim Babu Mapondella ◽  
Willybroad Augustine Massawe ◽  
...  
Keyword(s):  
Head And Neck ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Head And Neck Cancers ◽  
Clinical Profile ◽  
Childhood Cancers ◽  
Cross Sectional ◽  
Paediatric Patients ◽  
Clinical Stages ◽  
Night Sweats

Background Paediatric head and neck cancers represent an important group of childhood cancers that require maximum attention at large. They are often diagnosed at advanced clinical stages at Muhimbili National Hospital (MNH). Objective To describe the clinical profile of paediatric head and neck cancers at a tertiary hospital in Tanzania Method A hospital based descriptive cross-sectional study was conducted involving 180 paediatric patients. Data were analyzed using SPSS program version 21. Results A total of 180 paediatric patients were recruited where 61.1% were males and 38.9% were females. Majority belonged to the age group 0-5 years (53.9%). A total of 10 primary anatomical sites were found with the neck (cervical lymph node) predominating (36.1%), followed by the orbit/eye (34.4%) and the least anatomical sites were oral cavity (1.1%) and parapharyngeal space (0.5%). Leukocoria (93.9%), red eye (93.9%) and orbital cellulitis (77.6%) predominated in retinoblastoma but in patients with lymphomas, predominant features were night sweats (100%), weight loss (100%) and fevers (95.8%). Conclusion The clinical profile depicted in this study appears to correlate with advanced clinical stages. Keywords: Paediatric; Head; Neck Cancers; Muhimbili; Tanzania

scholarly journals Epidemiological Profile of the Head- Neck Pathologies in a Peripheral Referral Institute

2019 ◽  
Vol 27 (2) ◽  
pp. 113-120
Author(s):  
Sabyasachi Ghosh ◽  
Tarak Nath Saha ◽  
Indranil Sen
Keyword(s):  
Head And Neck ◽  
Histopathological Examination ◽  
Neck Region ◽  
Head And Neck Cancers ◽  
Base Line ◽  
Age Group ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Epidemiological Profile ◽  
Head Neck

Introduction   Head and neck lesions encompass a multitude of disorders which can be broadly classified into two groups: Benign and Malignant. Overall 57.5% of global head and neck cancers comes from Asia itself and India alone constitutes 30% of it. Therefore, it is of prime essence that need based and coordinated research for understanding the threats to the nation from chronic diseases such as head and neck cancers and ways to defy such threats should gain the utmost importance. The present study attempts to present the epidemiological profile of the patients attending a peripheral referral institute of this state with head-neck pathologies and has undergone a histopathological examination of their lesions within a period of three years period (2016-18) based on the histopathological evidences. Materials and Methods The accumulated data regarding the aforesaid patients as per records of the histopathological reports available in the Department of Pathology was used as the primary material and the interrelation of different epidemiological parameters were studied using the statistical methods Results Six hundred and eighty seven cases from the head and neck region were analysed during this three-year period. Age range was from 3 years to 96 years with maximum cases in the age group of 20-29 years (16.1%). The Male: Female ratio in our study was 1.34:1 (Males 394, Females 293). In this study, 38.8% benign, 32.46% malignant, 25.32% inflammatory and 3.3% congenital cases were recorded. Maximum number of benign lesions was in the age group of 10-39 years. Malignancies were noted to be higher in ages 40 years and above. Squamous cell carcinoma was the most common malignancy observed. Conclusion  Specific data obtained like this from histopathological records is helpful in evaluating patterns of head and neck lesions and augment the base line data of institute and the region.

Endovascular Management of Patients with Head and Neck Cancers Presenting with Acute Hemorrhage: A Single-Center Retrospective Study

2016 ◽  
Vol 40 (4) ◽  
pp. 510-519 ◽  
Author(s):  
P. P. Vilas Boas ◽  
L. H. de Castro-Afonso ◽  
L. M. Monsignore ◽  
G. S. Nakiri ◽  
F. V. de Mello-Filho ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Head And Neck ◽  
Head And Neck Cancers ◽  
Endovascular Management ◽  
Single Center ◽  
Acute Hemorrhage

scholarly journals Incidence of Lymphatic Metastasis to Neck Nodes Level IIb in Neck Dissection for Head and Neck Cancers: A Retrospective Study

2014 ◽  
Vol 5 (3) ◽  
pp. 99-103
Author(s):  
Faisal Al Zahrani ◽  
Khalid Al-Qahtani ◽  
Mohammed Alshahrani ◽  
Khamis Almufargi ◽  
Abdullah Alkhudhayri ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Lymph Nodes ◽  
Head And Neck ◽  
Neck Dissection ◽  
Lymphatic Metastasis ◽  
Head And Neck Cancers ◽  
Surgical Removal ◽  
Selective Neck Dissection ◽  
Fisher Exact Test ◽  
Lymph Nodes Metastasis

ABSTRACT Introduction Selective neck dissection (SND) is performed to prevent head and neck cancers metastasis. We tried to determine the incidence of level IIb lymph nodes metastasis and it is associations in head and neck cancers for selection of patients requiring SND. Materials and methods A retrospective study was conducted on 57 patients who underwent surgical removal of the head and neck tumor by 84 neck dissections. Fisher exact test was used to measure the association between positive IIb nodes and the other variables. Results Nine (15.8%) of 57 patients showed level IIb lymph nodes metastasis comprising 10.71% of the 84 neck dissections. Six (66.66%) were associated with oral cavity cancers, 8 (88.9%) with squamous cell carcinoma (SCC), 6 (66.66%) with T4 tumor. Five (55.6%) were N2b, and 7 (77.8%) were found in N+ necks. All (100%) positive IIb nodes were associated with metastatic level IIa. Significant associations were found betweenpositive IIbnodesand N2b (p= 0.005), clinically N+ necks (p = 0.005) and IIa (p < 0.01). Conclusion The incidence of level IIb nodes metastasis is high so they should be removed in any oral tumor, SCC, advanced staging, N+ necks or positive IIa lymph nodes metastasis. How to cite this article Al zahrani F, Al-Qahtani K, Alshahrani m, Almufargi K, Alkhudhayri A, Obad l, Islam T. Incidence of lymphatic metastasis to Neck Nodes level IIb in Neck Dissection for Head and Neck Cancers: A Retrospective Study. Int J Head Neck Surg 2014;5(3):99-103.

Sign in / Sign up

Export Citation Format

Share Document